Patents by Inventor Guido Guglielmi

Guido Guglielmi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050021023
    Abstract: A method and system for positioning a detachment zone and an implant, such as a vaso-occlusive coil or a stent, attached thereto in a body. A catheter is inserted within a vascular cavity in the body. The implant is attached to a distal end of a delivery member using a temporary connection, such as an electrolytic, mechanical, hydraulic, heat-sensitive or Radio Frequency (RF) sensitive connection, with an insulation member between the wire and the implant. The delivery member, temporary connection and implant are advanced through the catheter. An electrical condition, such as current, voltage and impedance, related to the position of the temporary connection in the catheter is monitored with an electrical measurement device or sensor. The electrical condition changes when the temporary connection reaches or exits a predetermined location, for example, the distal end of the catheter and contacts a conductive component of the body, such as blood in an aneurysm.
    Type: Application
    Filed: July 23, 2003
    Publication date: January 27, 2005
    Inventors: Guido Guglielmi, Joseph Eder
  • Patent number: 6620152
    Abstract: This is an implant for placement in the human body and a wire coupled to the implant for placing that implant. In the illustrated embodiment, it is an implant for use in the vasculature of the human body and is used to occlude a cavity in that vasculature as a portion of a treatment regimen. The implant itself is a component of a deployment device in which the implant is detached from the wire using electrolytic disintegration when a current is applied to the wire. The implant is electrically isolated from active participation in the electrolytic disintegration which occurs when a current is applied to the wire. Such isolation and minimization of the conductive pathway from the placement apparatus to the body's fluids appears to enhance the susceptibility of a selected portion of the wire to electrolysis to provide for quick erosion and detachment of the implant from the wire.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: September 16, 2003
    Assignee: The Regents of the University of California
    Inventor: Guido Guglielmi
  • Publication number: 20020151883
    Abstract: This is an implant for placement in the human body and a wire coupled to the implant for placing that implant. In the illustrated embodiment, it is an implant for use in the vasculature of the human body and is used to occlude a cavity in that vasculature as a portion of a treatment regimen. The implant itself is a component of a deployment device in which the implant is detached from the wire using electrolytic disintegration when a current is applied to the wire. The implant is electrically isolated from active participation in the electrolytic disintegration which occurs when a current is applied to the wire. Such isolation and minimization of the conductive pathway from the placement apparatus to the body's fluids appears to enhance the susceptibility of a selected portion of the wire to electrolysis to provide for quick erosion and detachment of the implant from the wire.
    Type: Application
    Filed: June 13, 2002
    Publication date: October 17, 2002
    Inventor: Guido Guglielmi
  • Patent number: 6425893
    Abstract: This is an implant for placement in the human body and a wire coupled to the implant for placing that implant. In the illustrated embodiment, it is an implant for use in the vasculature of the human body and is used to occlude a cavity in that vasculature as a portion of a treatment regimen. The implant itself is a component of a deployment device in which the implant is detached from the wire using electrolytic disintegration when a current is applied to the wire. The implant is electrically isolated from active participation in the electrolytic disintegration which occurs when a current is applied to the wire. Such isolation and minimization of the conductive pathway from the placement apparatus to the body's fluids appears to enhance the susceptibility of a selected portion of the wire to electrolysis to provide for quick erosion and detachment of the implant from the wire.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: July 30, 2002
    Assignee: The Regents of the University of California
    Inventor: Guido Guglielmi
  • Patent number: 6083220
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: July 4, 2000
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 6066133
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: May 23, 2000
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 6011995
    Abstract: Hyperthermic treatment of tissue such as cancer tumors, is realized by providing an ohmic heating element on the distal tip of a catheter endovascularly inserted upstream of the tissue. Electrical power is provided to the element for a selected time and degree to raise the temperature of blood to a thermally mediating level such as 42.degree. C., but not to heat the blood so that distal tissues downstream are adversely affected. The element comprises a helical coil heater disposed proximate to the end of a catheter and within an expandable cage. The cage can be selectively deployed by expanding it to maintain the coil out of contact with the vessel walls while still allowing free blood flow. Alternatively a guidewire within an expandable cage can be disposed within the same catheter wherein the heating coil has been wound onto the guidewire or the guidewire is uninsulated at that portion within the cage serves as an electrode to directly heat the blood.
    Type: Grant
    Filed: December 29, 1997
    Date of Patent: January 4, 2000
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Cheng Ji
  • Patent number: 6010498
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: January 4, 2000
    Assignee: The Regents of the University of California
    Inventor: Guido Guglielmi
  • Patent number: 5976131
    Abstract: An apparatus is provided for electrocoagulating blood and tissue at an occlusion site by means of application of an alternating signal or current through a detachable partially insulated coil on the end of a microcatheter. A Guglielmi Detachable Coil (GDC) is preferably used in the combination with damped radio frequency energy to cause local heating at the location of the coil but without local ohmicly heated tissue damage or hot spots. Damping of the radio frequency energy facilitates the avoidance of hot spots. Once carbonization of blood at the detachment zone of the GDC coil occurs, the impedance of the entire system increases. The impedance increase is detected to automatically turn off the alternating current and then to apply a direct current to electrolytically detach the GDC coil from the microcatheter.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: November 2, 1999
    Assignee: The Regents of the University at California
    Inventors: Guido Guglielmi, Cheng Ji
  • Patent number: 5976126
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: November 2, 1999
    Assignee: The Regents of the University of California
    Inventor: Guido Guglielmi
  • Patent number: 5947963
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: September 7, 1999
    Assignee: The Regents of the University of California
    Inventor: Guido Guglielmi
  • Patent number: 5947962
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: September 7, 1999
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 5944714
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: August 31, 1999
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 5928226
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: July 27, 1999
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 5925037
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: July 20, 1999
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 5919187
    Abstract: A thrombus is generated in an aneurysm, arteriovenous malformation or fistula by means of a catheter having an insulated heating coil coupled to an insulated delivery wire. In one embodiment, two delivery wires are coupled to heating coils to provide a closed circuit. The heating coils may be in the form of a double helix or a single helix in combination with a straight heating coil. The heating coils are permanently connected to the delivery wires. Alternatively, a single insulated heating coil may be attached to a single insulated delivery wire with a uninsulated coil attached to the tip of the insulated heating coil. The electrical circuit is then made through the heating coil and non-insulated electrode coil into the vascular system and to a body electrode. A catheter may also be used for heating blood within the vascular system which is directly flowed into a tumoral mass for the purposes of thermal treatment of cancer.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: July 6, 1999
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Cheng Ji
  • Patent number: RE41029
    Abstract: An artery, vein, aneurysms vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: December 1, 2009
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: RE42625
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: August 16, 2011
    Assignee: The Regents of the University of California
    Inventor: Guido Guglielmi
  • Patent number: RE42662
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: August 30, 2011
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: RE42756
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: September 27, 2011
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka