Patents by Inventor Guillermo Bazan
Guillermo Bazan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11713318Abstract: Compositions and methods of making and using thereof are provided with a specific antimicrobial activity and efficacy toward Gram-positive and Gram-negative bacteria and low levels of toxicity toward mammalian cells. The compositions include water-soluble molecules characterized by a hydrophobic interior fragment and side groups containing cationic groups. A class of these molecules is provided with variations in the length of the internal conjugated segment and in other molecular features, which impact the efficacy and toxicity. The substituents on the cationic functional group, the structural variations on the solubilizing group, and the length of the conjugated segment are important features affecting the antimicrobial property and the non-toxicity to mammalian cells of the composition.Type: GrantFiled: March 21, 2019Date of Patent: August 1, 2023Assignee: The Regents Of The University Of CaliforniaInventors: Guillermo Bazan, Zichao Zhang, Alex Moreland, Michael J. Mahan, Douglas M. Heithoff, Jakkarin Limwongyut, Chenyao Nie
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Publication number: 20210017179Abstract: Compositions and methods of making and using thereof are provided with a specific antimicrobial activity and efficacy toward Gram-positive and Gram-negative bacteria and low levels of toxicity toward mammalian cells. The compositions include water-soluble molecules characterized by a hydrophobic interior fragment and side groups containing cationic groups. A class of these molecules is provided with variations in the length of the internal conjugated segment and in other molecular features, which impact the efficacy and toxicity. The substituents on the cationic functional group, the structural variations on the solubilizing group, and the length of the conjugated segment are important features affecting the antimicrobial property and the non-toxicity to mammalian cells of the composition.Type: ApplicationFiled: March 21, 2019Publication date: January 21, 2021Inventors: Guillermo Bazan, Zichao Zhang, Alex Moreland, Michael J. Mahan, Douglas M. Heithoff, Jakkarin Limwongyut, Chenyao Nie
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Patent number: 8227691Abstract: Processing additives, as well as related compositions, photovoltaic cells, photovoltaic modules, and methods, are disclosed.Type: GrantFiled: October 23, 2008Date of Patent: July 24, 2012Assignee: The Regents of the University of CaliforniaInventors: Guillermo Bazan, Christoph Brabec, Russell Gaudiana, Alan J. Heeger, Markus Koppe, Jae Kwan Lee, Wanli Ma, Mauro Morana, Markus Scharber, David Waller
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Publication number: 20090108255Abstract: Processing additives, as well as related compositions, photovoltaic cells, photovoltaic modules, and methods, are disclosed.Type: ApplicationFiled: October 23, 2008Publication date: April 30, 2009Inventors: Guillermo Bazan, Christoph Brabec, Russell Gaudiana, Alan J. Heeger, Markus Koppe, Jae Kwan Lee, Wanli Ma, Mauro Morana, Markus Scharber, David Waller
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Publication number: 20080064042Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.Type: ApplicationFiled: September 12, 2007Publication date: March 13, 2008Inventors: Guillermo Bazan, Brent Gaylord, Shu Wang
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Publication number: 20080051533Abstract: A catalyst is disclosed for the polymerization and co-polymerization of olefins with functionalized monomers. The catalyst is formed from a combination of two neutral metal complexes, L(iPr2)M(CH2Ph)(PMe3) [L=N-(2,6-diisopropylphenyl)-2-(2,6-diisopropylphenylimino)propanamide] and M(COD)2 (COD=cyclooctadiene). The catalyst displays a unique mode of action and performs at ambient conditions producing high molecular weight polyolefins and co-polymers with functional groups. The polymerized olefins include ethylene, ?-olefins and functionalized olefins.Type: ApplicationFiled: August 20, 2007Publication date: February 28, 2008Inventors: Guillermo Bazan, Prasenjit Ghosh
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Publication number: 20070274357Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.Type: ApplicationFiled: September 17, 2004Publication date: November 29, 2007Applicant: The Regents of the University of CaliforniaInventors: Guillermo Bazan, Bin Liu, Xiong Gong, Alan Heeger, Wanll Ma, Parameswar Iyer
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Publication number: 20070225456Abstract: Novel phosphine-free non-ionic single catalysts, and method for making such catalysts, for the homo-polymerization and copolymerization of olefins such as ethylene, a-olefins and functionalized olefins without the use of additional co-activators, are disclosed. These phosphine-free non-ionic single catalysts are also active for co-polymerization of olefins with monomers with polar functionalities. The catalyst of this invention comprise of a late transition metal with a chelating monoanionic ligand, an R group and a neutral 2 electron donor ligand. Catalysts are prepared by the oxidative addition of benzylhalide (halide=Cl, Br or I) to an appropriate metal source in the presence of a stabilizing agent, such as nitrogen based ligands, followed by the addition of the deprotonated form of the chelating ligand.Type: ApplicationFiled: January 5, 2007Publication date: September 27, 2007Inventors: Guillermo Bazan, Rene' Rojas
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Publication number: 20070149732Abstract: Described are novel monomers bearing functionalities capable of initiating control free radical reactions, and a novel process using these initiating monomers in the co-polymerization of an olefin for the formation of well-controlled polyethylene graft polymers where the graft component is derived from controlled free radical polymerization reactions. The initiating monomers are produced by combining an amount of 5-norbornen-2-ol with a hydride or amine for a predetermined amount of time to form a mixture; and adding an amount of an alkyl or acyl halide to said mixture. Polymerization of an olefin with an initiating monomer is conducted in the presence of a metal compound, where the metal compound is comprised of a Group VIII transition metal complex.Type: ApplicationFiled: January 18, 2007Publication date: June 28, 2007Inventors: Guillermo Bazan, Robert Coffin
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Publication number: 20070088130Abstract: Methods, compositions and articles of manufacture involving cationic conjugated conformationally flexible polymers are provided. A method for the synthesis of cationic water-soluble polymers with linkages along the polymer main chain structure which disrupt the ability of the polymers to form extended-rod structures is provided. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: November 21, 2006Publication date: April 19, 2007Applicant: The Regents of the University of CaliforniaInventors: Guillermo Bazan, Bin Liu
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Publication number: 20060247384Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.Type: ApplicationFiled: September 6, 2005Publication date: November 2, 2006Applicant: The Regents of the University of CaliforniaInventors: Guillermo Bazan, Bin Liu
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Publication number: 20060216734Abstract: The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore.Type: ApplicationFiled: January 10, 2006Publication date: September 28, 2006Applicant: The Regents of the University of CaliforniaInventors: Guillermo Bazan, Bin Liu
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Publication number: 20060208235Abstract: Chromophores having two-photon or other multi-photon absorptivity. The chromophores are based on a structure of four stilbenoid groups attached to a paracyclophane core, where each stilbenoid group comprises a nitrogen-containing organic group attached by its nitrogen atom to a stilbenoid arm. In particular embodiments, at least one of the stilbenoid groups includes a sulfonium, ammonium, selenium, iodonium or phosphonium moiety. The chromophores have utility as photo-polymerization initiators and two-photon fluorophores for biological imaging.Type: ApplicationFiled: September 28, 2004Publication date: September 21, 2006Inventors: Guillermo Bazan, Bernhard Koehler, Hadjar Benmansour, Janice Hong, Han Woo, Alexander Mikhailovsky, Hideki Gorohmaru, Shuuichi Maeda, T. Kojima, Motoyuki Shigeiwa
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Publication number: 20060204984Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.Type: ApplicationFiled: January 31, 2006Publication date: September 14, 2006Applicant: The Regents of University of CaliforniaInventors: Guillermo Bazan, Bin Liu
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Publication number: 20060202616Abstract: Multilayer polymer light-emitting diodes (PLEDs) are demonstrated using semiconducting polymers blended with organometallic emitters as the emissive layer and one or both of an electron transport layer and a hole transparent layer on the appropriate electron injection and hole injection sides of the emissive layer. The transport layers reduce energy potential gaps between the hole injection electrode and the emissive polymer and between the electron injection electrode and the emissive polymer. A solvent-processing based procedure for preparing these devices is also disclosed It uses nonpolar solvent-based solutions of emissive polymers to form the emissive layer and polar solvent-based solutions to form the transport layers to minimize etching and other undesirable interactions as the multiple layers are being laid down.Type: ApplicationFiled: March 1, 2006Publication date: September 14, 2006Applicant: The Regents of the University of CaliforniaInventors: Xiong Gong, Alan Heeger, Daniel Moses, Guillermo Bazan, Shu Wang
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Publication number: 20060183140Abstract: The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore.Type: ApplicationFiled: January 10, 2006Publication date: August 17, 2006Applicant: The Regents of the University of CaliforniaInventors: Guillermo Bazan, Bin Liu
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Publication number: 20060094827Abstract: A method of preparing a polymer having a tapered block copolymer structure. The method comprises polymerizing a first olefin monomer and a different second olefin monomer in the presence of a catalyst supporting living or quasi-living polymerization. In certain embodiments, the catalyst comprises two neutral metal complexes. In preferred embodiments, a tapered block copolymer structure is formed by adding one monomer in a single batch at the start of the polymerization reaction, and adding a second monomer throughout the course of the reaction. The present invention also provides polymers having one or more tapered block copolymer sections, and compositions based on these polymers.Type: ApplicationFiled: August 19, 2005Publication date: May 4, 2006Inventors: Guillermo Bazan, Steve Diamanti, Edward Kramer, Vikram Khanna, Glenn Frederickson, Atsushi Hotta
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Publication number: 20060079647Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.Type: ApplicationFiled: September 6, 2005Publication date: April 13, 2006Applicant: The Regents of the University of CaliforniaInventors: Guillermo Bazan, Bin Liu
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Publication number: 20060054886Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymers may desirably comprise monomers which alter their conductivity properties. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.Type: ApplicationFiled: September 6, 2005Publication date: March 16, 2006Applicant: The Regents of the University of CaliforniaInventors: Guillermo Bazan, Alan Heeger, Parameswar Iyer, Bin Liu
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Publication number: 20050073245Abstract: White light-emitting electrophosphorescent polymeric light-emitting diodes (PLEDs) are demonstrated using semiconducting polymers blended with organometallic emitters as emissive materials in a common region. These materials may be cast from solution. The CIE coordinates, the color temperatures and the color rendering indices of the white emission are insensitive to the brightness, applied voltage and applied current density.Type: ApplicationFiled: October 6, 2003Publication date: April 7, 2005Inventors: Xiong Gong, Wanli Ma, Jacek Ostrowski, Guillermo Bazan, Daniel Moses, Alan Heeger