Abstract: The invention described herein relates to diagnostic and treatment methods and compositions useful in the management of disorders, for example cancers, involving NUP214-ABL1 positive T-cell malignancies and methods for treating an individual suffering from a NUP214-ABL1 positive T cell malignancy.

Abstract: In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern.

Abstract: A store for storing value sheets such as banknotes in a stack and for dispensing the value notes from the stack. When more than a single value sheet is dispensed from the stack, the store returns all but one of the value sheets to the stack while moving the stack to reduce friction between the returning value sheet and the topmost value sheet of the stack. Means for securing the stack are also provided: a support for the stack is anchored and/or extra pressure is applied to the stack. The store includes means for indicating when the stack contains more than a predetermined number of value sheets and means for preventing securing of the store when the predetermined number of value sheets is exceeded. A value sheet store with part of a sidewall integrally formed with the lid. A value sheet store which includes a lid attached to a housing by a hinge located on an edge of the housing. Apparatus and a method for determining the height of a stack of value sheets.

Abstract: A store for storing value sheets such as banknotes in a stack and for dispensing the value notes from the stack. When more than a single value sheet is dispensed from the stack, the store returns all but one of the value sheets to the stack while moving the stack to reduce friction between the returning value sheet and the topmost value sheet of the stack. Means for securing the stack are also provided: a support for the stack is anchored and/or extra pressure is applied to the stack. The store includes means for indicating when the stack contains more than a predetermined number of value sheets and means for preventing securing of the store when the predetermined number of value sheets is exceeded. A value sheet store with part of a sidewall integrally formed with the lid. A value sheet store which includes a lid attached to a housing by a hinge located on an edge of the housing. Apparatus and a method for determining the height of a stack of value sheets.

Abstract: A store for storing value sheets such as banknotes in a stack and for dispensing the value notes from the stack. When more than a single value sheet is dispensed from the stack, the store returns all but one of the value sheets to the stack while moving the stack to reduce friction between the returning value sheet and the topmost value sheet of the stack. Means for securing the stack are also provided: a support for the stack is anchored and/or extra pressure is applied to the stack. The store includes means for indicating when the stack contains more than a predetermined number of value sheets and means for preventing securing of the store when the predetermined number of value sheets is exceeded. A value sheet store with part of a sidewall integrally formed with the lid. A value sheet store which includes a lid attached to a housing by a hinge located on an edge of the housing. Apparatus and a method for determining the height of a stack of value sheets.

Abstract: A method and system of testing an overspeed protection system of a turbomachine. The method and system may include providing an overspeed protection system on a turbomachine that may have a single or multiple shafts; determining whether the speed the shaft or shaft(s) exceeds a shutdown value; changing an overspeed trip value of the turbomachine; and determining whether the overspeed protection system would operate to trip the turbomachine.

Abstract: A method and system of testing an overspeed protection system of a turbomachine may include providing an overspeed protection system on a turbomachine having at least one shaft. The method may: determine whether a permissive or permissive(s) is satisfied; initiate an overspeed test; automatically adjusting the speed of a shaft; determining if the speed exceeds an overspeed trip value; and automatically disabling the automatic adjustment of the speed after the test is complete.

Abstract: Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets.

Abstract: A system and method for hermetic packaging of glass sheets, that includes applying to the glass sheets surfaces that will be in contact with other adjacent glass sheets, from the cutting line, an anti-humidity chemical treatment that includes a watery solution from 1 to 2% in weight of a mixture of adipic and malic, adipic and citric, or malic and citric acids 50-50 in a dosage preferably between 100 and 400 mg/m2, to protect glass against condensation humidity or rain. Sprinkling over said surfaces of the glass sheets, 500 to 700 mg/m2 of separating powder of a selected granulometry less than 300 microns, forming a group of glass sheets. Placing a strip of cushioning material, such as the known as Polybubble Plastic, or corrugated cardboard, around the sides of the group of glass sheets, to provide a cushioning condition to the group of glass sheets during shipping and handling.

Abstract: A method and system of testing an overspeed protection system of a turbomachine may include providing an overspeed protection system on a turbomachine having at least one shaft. The method may: determine whether a permissive or permissive(s) is satisfied; initiate an overspeed test; automatically adjusting the speed of a shaft; determining if the speed exceeds an overspeed trip value; and automatically disabling the automatic adjustment of the speed after the test is complete.

Abstract: A method and system of testing an overspeed protection system of a turbomachine. The method and system may include providing an overspeed protection system on a turbomachine that may have a single or multiple shafts; determining whether the speed the shaft or shaft(s) exceeds a shutdown value; changing an overspeed trip value of the turbomachine; and determining whether the overspeed protection system would operate to trip the turbomachine.

Abstract: The present invention is based upon the discovery that endothelial cells exposed to atheroprotectiveflow increase expression of the transcription factor KLF2 via a distinct flow-mediated signaling pathway and that this, in turn, modulates the activity of a series of genes that are responsible for maintaining the cells in an atherosclerosis-resistant state. By carrying out analyses to determine the extent to which endothelial cells are expressing these genes, a determination can be made concerning whether they are in a healthy state and factors can be examined for their effect on this state. In addition, the invention includes microarray plates or slides that can be used in carrying out such analyses.

Abstract: A store for storing value sheets such as banknotes in a stack and for dispensing the value notes from the stack. When more than a single value sheet is dispensed from the stack, the store returns all but one of the value sheets to the stack while moving the stack to reduce friction between the returning value sheet and the topmost value sheet of the stack. Means for securing the stack are also provided: a support for the stack is anchored and/or extra pressure is applied to the stack. The store includes means for indicating when the stack contains more than a predetermined number of value sheets and means for preventing securing of the store when the predetermined number of value sheets is exceeded. A value sheet store with part of a sidewall integrally formed with the lid. A value sheet store which includes a lid attached to a housing by a hinge located on an edge of the housing. Apparatus and a method for determining the height of a stack of value sheets.

Abstract: Arterial and venous smooth muscle cells are molecularly distinct from the earliest stages of angiogenesis through to adulthood. This distinction is revealed by expression on arterial cells (e.g., arterial endothelial cells, arterial smooth muscle cells) of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous cells are necessary for angiogenesis. Expression of EphrinB2 in arterial cells (e.g.

Abstract: A value sheet handling apparatus comprises an actuating mechanism for exerting pressure onto a value sheet so as to move the value sheet, and further comprises detecting means to detect movement of the value sheet with respect to the actuating mechanism, wherein if the detecting means ascertains that the value sheet has not been moved by the actuating mechanism the pressure exerted Onto die flexible media is increased until motion of the value sheet is detected. Additionally or alternatively, the pressure is varied in dependence on the type of the value sheet. The value sheet is dispensed from a stack by buckling the sheet, the rest of the stack being gripped in the area exposed by the buckling of the sheet.

Abstract: A banknote store can remove banknotes individually from a stack by light air pressure extending over a substantial area of the banknote, the banknote then being transportable without needing to move the source of the reduced pressure. Banknotes are added individually by using reduced pressure to hold them against a transport belt before they are deposited on the stack.

Abstract: Manually-insert banknotes are aligned by using a fan to reduce the air pressure above a banknote so that it is pulled into engagement with a drive means which drives the edge of the banknote to a guide, causing the banknote to rotate until the edge is aligned with the guide.

Abstract: A system and method for hermetic packaging of glass sheets, that includes applying to the glass sheets surfaces that will be in contact with other adjacent glass sheets, from the cutting line, an anti-humidity chemical treatment that includes a watery solution from 1 to 2% in weight of a mixture of adipic and malic, adipic and citric, or malic and citric acids 50-50 in a dosage preferably between 100 and 400 mg/m2, to protect glass against condensation humidity or rain. Sprinkling over said surfaces of the glass sheets, 500 to 700 mg/m2 of separating powder of a selected granulometry less than 300 microns, forming a group of glass sheets. Placing a strip of cushioning material, such as the known as Polybubble Plastic, or corrugated cardboard, around the sides of the group of glass sheets, to provide a cushioning condition to the group of glass sheets during shipping and handling.

Abstract: A system (100) for signal processing using one or more filters includes a controller (102) that partitions an impulse response of a filter into a plurality of impulse response blocks and calculates a Discrete Fourier Transform (DFT) of each impulse response block using a Fast Fourier Transform (FFT) algorithm. A processor (104) that is coupled to the controller (102) receives an input sample block including samples of a signal to be processed and receives the DFT of each impulse response block from the controller (102). The processor (104) calculates a DFT of the input sample block using an FFT algorithm, performs a spectral multiplication of the DFT of the input sample block with the DFT of each impulse response block, overlap-adds the blocks resulting from each spectral multiplication to create an output spectral block, performs an inverse FFT on the output spectral block to create an output sample block, and communicates the output sample block.

Abstract: A value sheet handling apparatus comprises an actuating mechanism for exerting pressure onto a value sheet so as to move the value sheet, and further comprises detecting means to detect movement of the value sheet with respect to the actuating mechanism, wherein if the detecting means ascertains that the value sheet has not been moved by the actuating mechanism the pressure exerted onto the flexible media is increased until motion of the value sheet is detected. Additionally or alternatively, the pressure is varied in dependence on the type of the value sheet. The value sheet is dispensed from a stack by buckling the sheet, the rest of the stack being gripped in the area exposed by the buckling of the sheet.