Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.

Abstract: A method for processing data structures with the aid of networked semantic units includes: acquiring a data structure, and generating, modifying, deleting and storing semantic structure units and networking them on the basis of the acquired data structure while using a knowledge base comprised of a network of semantic knowledge units. Semantic structure units and their network are classified in iterative steps. Based on this classification, a specific processing is activated which modifies a respective semantic structure unit and a particular partial network.

Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.

Abstract: The invention relates to novel sulfonamides of general formula (I) where the substituents R1, R2, R3, R4, A and X have the given meanings, pharmaceutical compositions containing them, and a method of using them as antiviral agents, in particular against cytomegaloviruses.

Abstract: The present invention relates to novel sulphonamides of the general formula (I) in which the substituents R1, R2, R3, R4 and A and X are as defined in claim 1 and other claims, and also to processes for their preparation and to their use as antiviral agents, in particular against cytomegaloviruses.

Abstract: Novel imidazotriazinones of general formula a method for the production and the pharmaceutical use thereof are disclosed.

Abstract: Provided is a method for sequencing DNA, which comprises: (a) obtaining a target DNA population comprising one or more single-stranded DNAs to be sequenced, each of which is present in a unique amount and bears a primer to provide a double-stranded portion of the DNA for ligation thereto; (b) contacting the DNA population with an array of hybridisation probes, each probe comprising a label cleavably attached to a known base sequence of predetermined length, the array containing all possible base sequences of that predetermined length; (c) removing all unligated probes; followed by the steps of: (d) cleaving the ligated probes to release each label; (e) recording the quantity of each label; and (f) activating the extended double-stranded portion to enable ligation thereto; wherein (g) steps (b) to (f) are repeated in a cycle for a sufficient number of times to determine the sequence of the or each single-stranded DNA by determining the sequence of release of each label.

Abstract: The invention relates to imidazo[1,3,5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.

Abstract: A method for characterizing DNA, which comprises: (i) providing a population of DNA fragments, each fragment having cleavably attached thereto a mass label for identifying a feature of that fragment; (ii) separating the fragments on the basis of their length; (iii) cleaving each fragment in a mass spectrometer to release its mass label; and (iv) determining each mass label by mass spectrometry to relate the feature of each fragment to the length of the fragment.

Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.

Abstract: The invention relates to novel benzofuran derivatives, to processes for preparing them and to their uses in medicaments.

Abstract: Novel imidazotriazinones of general formula a method for the production and the pharmaceutical use thereof are disclosed.

Abstract: The present invention relates to a vibration-resistant accumulator with a housing (20), which comprises one or more cell boxes (16) each with a plate block (15) with positive and negative plate groups (14a, 14b), with the individual plates (1a, 1b) in a plate block (15) separated from one another by separators (6), the plates (1a, 1b) of each plate group (14a, 14b) having lugs (2a, 2b) and being connected together electrically by cell connectors (3a, 3b).

Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.

Abstract: The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.

Abstract: The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and dyslipidaemias.

Abstract: The invention relates to novel triazolotriazinones of the general formula and to a method for their production and pharmaceutical use thereof.

Abstract: The invention relates to novel sulfonamides of general formula (I) where the substituents R1, R2, R3, R4, A and X have the given meanings, pharmaceutical compositions containing them, and a method of using them as antiviral agents, in particular against cytomegaloviruses.

Abstract: Novel imidazotriazinones of general formula (I), a method for the production and the pharmaceutical use thereof are disclosed.

Abstract: What is disclosed is a computer-implemented method for finding objects which are based on data structures, the method comprising the following steps: announcing a selection of objects; generating and/or invalidating a characterization of one object or several objects of the selection, with characterization being effected by means of an item of characterization information; calculating weights of the objects of the selection and/or of objects located in a vicinity of the characterized objects based on the characterization information, weights already calculated, and/or weights already stored; and modifying the selection and continuing the method from the first step until objects to be found are contained in the selection, until the method is interrupted, or until a given or calculated number of method steps has been carried out, with the possibility of terminating or interrupting the method after any one of the preceding steps.