Abstract: A method for characterizing polypeptides, which comprises: (a) treating a sample comprising a population of one or more polypeptides with a cleavage agent which is known to recognize a specific amino acid residue or sequence in polypeptide chains and to cleave at a cleavage site, whereby the population is cleaved to generate peptide fragments; (b) isolating a population of the peptide fragments which bear at one end a reference terminus comprising either only a C-terminus or only an N-terminus and which bear at the other end the cleavage site proximal to the reference terminus; and c) determining a signature sequence of at least some of the isolated fragments, which signature sequence is the sequence of a predetermined number of amino acid residues running from the cleavage site; wherein the signature sequence and the relative position of the cleavage site to the reference terminus characterize the polypeptide or each polypeptide.

Abstract: The 2-aryl-substituted pyridines are prepared by reacting pyridylaldehydes with organometallic compounds and then selectively reducing the products. The 2-aryl-substituted pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis.

Abstract: The novel 5-hydroxy-alkyl-substituted phenyls are prepared by either reacting the corresponding benzaldehydes with the Grignard compounds and subsequently reducing the other functional groups or by reducing the corresponding benzoic esters by customary methods to give the corresponding hydroxyl compounds. The 5-hydroxy-alkyl-substituted phenyls are suitable for use as active compounds in medicaments, in particular for the treatment of dyslipidaemia.

Abstract: The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The, cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hyperlipoproteinaemia and arteriosclerosis.

Abstract: Bicyclic-fused pyridines are prepared by introducing the appropriate side chain by reaction of the corresponding aldehydes with the aid of Wittig or Grignard reagents. The bicyclic-fused pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosi.

Abstract: The present invention relates to a process for the continuous production of a multi-layer web comprising an exterior covering and a nonwoven material disposed underneath. According to the present invention, a nonwoven material which has been prebonded is used as the starting product, and the steps of additional bonding, calibrating, and smoothing of the nonwoven material and of laminating the nonwoven material and the exterior covering are combined in a single process. The present invention, in addition to achieving a cost advantage, also produces a covering material that provides better sitting conditions, equivalent to the foam backed covering materials with respect to physical textile values yet being easier to recycle and. In addition, recycled textile products can be worked into the covering material of the present invention as reprocessed fibers without losing any advantage.

Abstract: The heterocyclic-fused pyridines are prepared by reaction of the corresponding heterocyclic-fused pyridine aldehydes with appropriately substituted Grignard or Wittig reagents. The heterocyclic-fused pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of dislipidaemia and arteriosclerosis.

Abstract: The 2-aryl-substituted pyridines are prepared by reacting pyridylaldehydes with organometallic compounds and then selectively reducing the products. The 2-aryl-substituted pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis.

Abstract: Peritoneal dialysis device (10) with a balancing chamber (28), which is divided into two balancing chamber halves (32 and 34) by a membrane (30), with an introduction line arrangement (16, 20, 22, 24), a discharge arrangement (22, 24, 20, 62), a catheter line arrangement (36, 38, 42), a valve arrangement (46-52), a pump arrangement (60, 108, 110) and a control unit (82), which switches the balancing chamber halves (32 and 34) in the filling or emptying operation with the aid of the valve arrangement (46-52).The peritoneal dialysis device (10, 106) operates under pressure monitoring volumetrically in the filling phase and pressure-controlled in the emptying phase, and determines the volume of dialysis fluid introduced or discharged from the number of balancing chamber strokes and the ultrafiltration volume from the difference of these.

Abstract: A rivet made of plastic material for securing a plate-like workpiece to a support assembly with an approximately plane surface comprises a shank having a hollow axial passage and at least two axially parallel slots open towards the free end of the shank, the shank portions formed thereby comprising at the outer sides thereof ramp-like portions projecting obliquely outwardly and downwardly, with the axial passage tapering towards the free end of the shank, a first plate-shaped flange at the other end of the shank, the flange having at its under-surface an annular relatively sharp sealing edge engaging the surface of the support assembly when the shank is inserted into an opening of the support assembly, a second plate-shaped flange upon the side of the first flange opposite to the shank and axially spaced thereform, and an expansion member having an annular sealing rib at its upper end, the annular sealing rib being sealingly engaged with the axial passage, when the expansion member is driven into the passage.

Abstract: The reel comprises a two-part core 2 with a shape of a hollow cylinder, with a flange 3 at each of its two ends. The flange 3 and the core 2 are positively engaged in the circumferential and radial direction, and are connected to one another by at least four detachable connection elements per flange 3. By means of this design, large forces and torques can be transferred between the flange 3 and the core 2 so that larger reel diameters of plastic can also be constructed.

Abstract: Between a chrome tanning step and a fat liquor treatment step, a flesh side split leather is subjected to shaving on both its split and flesh sides to a thickness of 1.1 to 2.5 mm, preferably 1.2 to 1.5 mm and is then aftertanned. After a split side dressing of the dried butt, a further shaving operation is effected on the flesh side to a thickness of 0.5 to 1.0 mm, preferably 0.7 to 0.9 mm, whereupon the flesh side is also dressed. The result is a split leather which is particularly effective for use on automotive vehicle dashboards and has low shrinkage even when subjected to high temperature and moisture fluctuations.

Abstract: .beta.-Lactam compounds of the formula ##STR1## wherein R.sup.5 represent cyclopropyl or methyl, useful as antibiotics.

Abstract: An inorganic thin film is deposited on a substrate by sputtering a sputter target by cathode sputtering in the vicinity of the substrate. To produce the target, at least two pulverulent starting components are mixed. The mixture is tempered if a uniform reaction product can be obtained in this process. It is powdered and the powder is deposited on a metallic base by plasma-jet spraying. This produces the target. Preferably, an oxide mixture is tempered which is a starting product for a superconducting ceramic material. In order to convert the thin film deposited to a superconducting state, it is treated for a prolonged time at temperatures of 300.degree.-800.degree. C. in an oxygen-containing atmosphere. The reaction product obtained on tempering may have, for example, the overall composition ZBa.sub.m Cu.sub.n O.sub.x, where 1.5.ltoreq.m.ltoreq.2.5, 2.ltoreq.n.ltoreq.5 and 4.ltoreq.x.ltoreq.

Abstract: A heteroanellated phenylglycine-.beta.-lactam antibiotic of the formula ##STR1## in which R.sup.

Abstract: Heteroannellated penicillins and cephalosporins of the formula ##STR1## in which R.sup.

Abstract: The present invention relates to a continuous process for the enzymatic preparation of isomaltulose. A periplasmatic sucrose-mutase is produced by fermentation of microorganisms which form sucrose-mutase. The cell-free crude enzyme extract is prepared by digestion of the cells and by cross-flow microfiltration. In a single-stage, simultaneous purification and immobilization of the sucrose-mutase from the cell-free crude extract conditioned by diafiltration is obtained by selective bonding to an anionizable carrier matrix. Direct conversion of sucrose into isomaltulose is produced by the sucrose-mutase bonded to the anionizable carrier matrix, preferably in cartridge or cartouche form.

Abstract: Biological material such as microorganisms is immobilized by polymerizing in the presence of the biological material a readily soluble polyetherpolyol having some hydroxyl groups esterified with acrylic and/or methacrylic acid and remaining hydroxyl groups reacted with an isocyanate group-containing derivative of an unsaturated carboxylic acid or a polyfunctional isocyanate. Preferably, the isocyanate derivative of an unsaturated carboxylic acid is isocyanatoethyl acrylate, isocyanatoethyl methacrylate of 4-isocyanato-3-methyl-2-butyl-acrylate and the polyfunctional isocyanate is a diisocyanate or polyisocyanate. Beads can be produced by forming droplets in a water-immiscible medium and polymerizing. Polymerization can be carried out under inert gas in the presence of radical initiators or by irradiation with actinic light.

Abstract: Antibacterially active and animal growth-promoting novel .beta.-lactam compounds of the formula ##STR1## in which R.sup.1 represents the radical ##STR2## Y representing N or CR.sup.9, or Y--R.sup.7 representing >C.dbd.O or >C.dbd.N--R.sup.7,Z representing O, S, or NR.sup.10, andR.sup.2 represents hydrogen or a protective group.

Abstract: Antibacterially active and animal growth-promoting novel .beta.-lactam compounds of the formula ##STR1## in which R.sup.1 represents the radical ##STR2## Y representing N or CR.sup.9, or Y--R.sup.7 representing ##STR3## Z representing O, S, or NR.sup.10, and R.sup.2 represents hydrogen or a protective group.