Abstract: An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single amphiphilic material, such as a polyethoxylated castor oil or derivative thereof, a polyoxyethylene alkyl ether, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene stearate, a block copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide, a block copolymer of polypropylene oxide-polyethylene oxide-polypropylene oxide, a tetra-functional block copolymer of polyethylene oxide-polypropylene oxide, or a tetra-functional block copolymer of polypropylene oxide-polyethylene oxide. A dosage kit that includes the injectable, nonaqueous suspension and a method of administering the injectable, nonaqueous suspension are also disclosed.

Abstract: A branch predictor, has a plurality of memory banks having entries that hold prediction information used to predict a direction of branch instructions fetched and executed by a processor that comprises the branch predictor. A count of events that occur in the processor is provided to hardware logic that performs an arithmetic and/or logical operation, e.g., XOR, on predetermined bits of the count to generate a random value. In response to the processor determining a correct direction of a branch instruction predicted by the branch predictor, the branch predictor uses the random value generated by the hardware logic to make a decision about updating the memory banks. Bits of a branch history pattern, along with the count, may also be used to generate the random value. The event counted may be a retire of an instruction or a cycle of a core or bus clock.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: A branch predictor has a block address useable to access a block of instruction bytes of an instruction cache and first/second byte offsets within the block of instruction bytes. Hashing logic hashes a branch pattern and respective first/second address formed from the block address and the respective first/second byte offsets to generate respective first/second indexes. A conditional branch predictor receives the first/second indexes and in response provides respective first/second direction predictions of first/second conditional branch instructions in the block of instruction bytes. In one embodiment, a branch target address cache (BTAC) provides the byte offsets, and the first/second direction predictions are statically associated with first/second target addresses also provided by the BTAC.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract: An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having a Cmax to Cmin ratio of less than 200 and a lag time less than 0.

Abstract: A method for preparing a graphene/MnO2 porous material having a high infrared emissivity; the method adopts graphene and potassium permanganate as raw materials, and uses a simple ultrasonic dispersion method to uniformly disperse the graphene and the potassium permanganate in the water solution; subsequently, the graphene/MnO2 porous material can be obtained through the hydrothermal reaction; the present invention is simple and easy-operating, and the infrared emissivity of the porous material prepared according to the method of the present invention is 0.94-0.98 at a distance of 8-14 ?m, which is stable, eco-friendly, and can be widely applied to far-infrared products.

Abstract: Disclosed herein are filtration articles comprising a porous ceramic structure comprising a plurality of channels separated by a plurality of porous interior walls, and a nanomembrane disposed on at least a portion of a surface of the porous ceramic structure, wherein the nanomembrane comprises nanoparticles of at least one inorganic oxide, and wherein the nanoparticles are present in a concentration ranging from about 0.001 g/L to about 1 g/L based on the total volume of the porous ceramic structure. Methods for making such filtration articles and methods for filtering a particulate from a fluid using such filtration articles are also disclosed herein.

Abstract: The utility model discloses a circuit for inhibiting single-ended analogue signal noises and a terminal accessory. The circuit includes an input interface module, a differential amplification module, an analogue signal processing module, an isolation module and a control module, wherein the input interface module at least includes an analogue signal line and a digital signal line, the differential amplification module includes differential input ends and an output end; the analogue signal line and the digital signal line of the input interface module are respectively connected to the differential input ends of the differential amplification module, so that the analogue signal line and the digital signal line form a pseudo-differential pair, and the output end of the differential amplification module is connected to the analogue signal processing module; the digital signal line is further connected to the isolation module, and the isolation module is further connected to the control module.

Abstract: An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having Cmax to Cmin ratio less than 200 and lag time less than 0.2.

Abstract: A branch predictor, has a plurality of memory banks having entries that hold prediction information used to predict a direction of branch instructions fetched and executed by a processor that comprises the branch predictor. A count of events that occur in the processor is provided to hardware logic that performs an arithmetic and/or logical operation, e.g., XOR, on predetermined bits of the count to generate a random value. In response to the processor determining a correct direction of a branch instruction predicted by the branch predictor, the branch predictor uses the random value generated by the hardware logic to make a decision about updating the memory banks. Bits of a branch history pattern, along with the count, may also be used to generate the random value. The event counted may be a retire of an instruction or a cycle of a core or bus clock.

Abstract: Devices and methods for using and manufacturing microstructure arrays are described.

Abstract: A branch predictor has a block address useable to access a block of instruction bytes of an instruction cache and first/second byte offsets within the block of instruction bytes. Hashing logic hashes a branch pattern and respective first/second address formed from the block address and the respective first/second byte offsets to generate respective first/second indexes. A conditional branch predictor receives the first/second indexes and in response provides respective first/second direction predictions of first/second conditional branch instructions in the block of instruction bytes. In one embodiment, a branch target address cache (BTAC) provides the byte offsets, and the first/second direction predictions are statically associated with first/second target addresses also provided by the BTAC.

Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

Abstract: An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single amphiphilic material, such as a polyethoxylated castor oil or derivative thereof, a polyoxyethylene alkyl ether, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene stearate, a block copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide, a block copolymer of polypropylene oxide-polyethylene oxide-polypropylene oxide, a tetra-functional block copolymer of polyethylene oxide-polypropylene oxide, or a tetra-functional block copolymer of polypropylene oxide-polyethylene oxide. A dosage kit that includes the injectable, nonaqueous suspension and a method of administering the injectable, nonaqueous suspension are also disclosed.

Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.

Abstract: An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having Cmax to Cmin ratio less than 200 and lag time less than 0.2.

Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.

Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.