Abstract: Provided herein are bioactive molecule conjugates, preparation methods and use thereof, particularly bioactive molecule conjugates (such as antibody-drug conjugates and small molecule drug conjugates) obtained by improved coupling of a drug and a targeting moiety, as well as their preparation method and use for the treatment of a disease associated with an abnormal cell activity.

Abstract: Quantum sensors provide excellent performance combining high sensitivity with spatial resolution. Unfortunately, they can only detect signal fields at frequencies in a few accessible ranges, typically low frequencies up to the experimentally achievable control field amplitudes and a narrow window around their resonance frequencies. Fortunately, arbitrary-frequency signals can be detected by using the sensor qubit as a quantum frequency mixer, enabling a variety of sensing applications. The technique leverages nonlinear effects in periodically driven (Floquet) quantum systems to achieve quantum frequency mixing of the signal and an applied AC bias field. The frequency-mixed field can be detected using Rabi and CPMG sensing techniques with the bias field. Frequency mixing can distinguish vectorial components of an oscillating signal field, thus enabling arbitrary-frequency vector magnetometry.

Abstract: 2-hydroxy-5-[2-(4-(trifluoromethylphenyl)ethylamino)]benzoic acid crystal forms and a preparation method therefor are proposed. Crystal form I is a monoclinic crystal system, which has a Pc space group and can be obtained by slow cooling, evaporating the solvent at a constant temperature, evaporating the solvent at an increased temperature, or adding an anti-solvent. Crystal form II is a triclinic crystal system, which has a P1 space group and can be obtained by rapid cooling or freeze-drying. According to the method, the process is simple, costs are low, and the yield exceeds 90%; and the crystal forms of the crystal forms I and II have high purity, the crystal shapes thereof are intact, and have excellent fluidity, facilitating preparation, particularly the preparation of a pharmaceutical preparation for preventing and/or treating degenerative diseases of the central nervous system. Furthermore, the two crystal forms have a better apparent solubility than that of raw materials.

Abstract: Provided is a method for preparing Rebaudioside J using an enzymatic method, comprising using rebaudioside A as a substrate, and making the substrate, in the presence of a glycosyl donor, react under the catalysis of a UDP-glycosyltransferase-containing recombinant cell and/or UDP-glycosyltransferase prepared therefrom to generate Rebaudioside J.

Abstract: Provided are a bovine rotavirus fusion protein and calf diarrhea multivalent vaccine. The bovine rotavirus fusion protein contains a VP6 fragment, wherein the VP6 fragment contains an amino acid sequence as represented by SEQ ID NO. 4, and at least one loop region of the following (a)˜(c) is substituted with an antigenic epitope derived from bovine coronavirus and/or an antigenic epitope derived from E. coli: (a) amino acid residues of sites 168-177; with an amino acid sequence as represented by SEQ ID NO. 1; (b) amino acid residues of sites 194-205; with an amino acid sequence as represented by SEQ ID NO. 2; and (a) amino acid residues of sites 296-316, with an amino acid sequence as represented by SEQ ID NO. 3, The bovine rotavirus fusion protein contains a plurality of antigenic epitopes, and can enable a host to generate a plurality of antibodies after immunizing the host.

Abstract: An improved low-toxicity and high-efficiency orthoester mixture pharmaceutical adjuvant, a preparation method thereof, and a topical sustained release drug delivery formulation including the same are provided.

Abstract: Some aspects of this disclosure include apparatuses and methods for implementing backup link establishment and operation for multi-link wireless communication networks such as a wireless local area network (WLAN). Some aspects relate to an electronic device including a transceiver configured to communicate over a wireless network and a processor communicatively coupled to the transceiver. The processor receives a message including information associated with a backup link from a second electronic device. The processor further receives data associated with data traffic from the second electronic device on a primary link of the wireless network. In response to a quality of the primary link being below a threshold, the processor receives a notification frame from the second electronic device on the backup link and receives additional data associated with the data traffic from the second electronic device on the backup link or on an other link informed by the notification frame.

Abstract: A method for recycling waste polyester, in particular to a method for recycling waste polyester by a modified alcoholysis method to recycle waste polyester to prepare dimethyl terephthalate (DMT), is provided and belongs to waste polyester recycling technology field. The waste polyester after dewatering and deoxygenation treatment is used as a raw material, in the step of feeding in melted state the alcoholysis agent is added in the melted waste polyester for preliminary alcoholysis, and the alcoholysis agent is ethylene glycol. On one hand, alcoholysis reaction occurs when the waste polyester raw material are melted, and at the same time, the viscosity of the melted material is reduced. Thus, the melted material remains melted at the alcoholysis temperature and is not easy to solidify again after entering the alcoholysis tank, ensuring that the alcoholysis is carried out under homogeneous conditions.

Abstract: The present disclosure belongs to the technical field of PVC foam co-extruded sheets, and particularly relates to a wide low-temperature impact-resistant and bending-resistant PVC foam co-extruded sheet and a preparation method thereof. The PVC foam co-extruded sheet of the present disclosure includes a core layer and a skin layer. Raw materials of the core layer include PVC resin powder, a silicon-acrylic composite low-temperature toughening and reinforcing agent, a filler, a foaming regulator I, a white foaming agent, a calcium-zinc stabilizer, a cold-resistant plasticizer, stearic acid, polyethylene wax, and oxidized polyethylene wax.

Abstract: An impact-resistant balanced hydro-cylinder with pressure relief and buffering protection comprises a cylinder body (11), a piston (13), a piston rod (14), and a first valve core (21) and a second valve core (51) slidable relative to the cylinder body (11). A closed first gas cavity (22) and a closed second gas cavity (52) are respectively formed between the two valve cores and inner walls of two opposite ends of the cylinder body (11). A closed first oil cavity (32) and a closed second oil cavity (42) are respectively formed between the two valve cores and two end faces of the piston (13). A through hole (33) for the first oil cavity and a through hole (43) for the second oil cavity are respectively provided in the positions on the cylinder body (11) corresponding to the first oil cavity (32) and the second oil cavity (42).

Abstract: A camera device including a housing, and a radio frequency circuit, a communications module, and a heating drive circuit that are disposed in the housing. The housing is provided with a window panel, and the window panel is provided with a hole to form a window. The window is provided with a window lens capable of receiving and transmitting a radio frequency signal, and the window lens is provided with a first terminal. The radio frequency circuit is connected to the communications module, and the radio frequency circuit and the heating drive circuit are provided with a common second terminal. The first terminal is electrically connected to the second terminal, to form a radio frequency channel including the communications module, the radio frequency circuit, and the window lens, and a heating channel including the heating drive circuit and the window lens.

Abstract: A heat dissipation structure for a belt starter generator (BSG) which reduces the temperature of one or more ground screws used to connect a printed circuit board (PCB) to a cooling device of the BSG. The PCB is part of an inverter, and the inverter of the BSG is grounded using two ground screws that fix the PCB to the cooling device. A heat dissipation bridge is connected to the two ground screws, the PCB, and the cooling device. The heat dissipation bridge is connected to the grounds screws such that the heat dissipation bridge is located and in contact with an area of the cooling device where the coolant is flowing through a flow cavity. The heat dissipation bridge absorbs the colder temperature from the cooling device therefore lowers the temperatures of the ground screws to a safe level for the components of the PCB.

Abstract: Disclosed is a catalyst useful for producing organic amines by catalytic amination, its preparation and application thereof, wherein the catalyst comprises an inorganic porous carrier containing aluminum and/or silicon and an active metal component supported on the carrier, the active metal component comprises at least one metal selected from the group consisting of Group VIII and Group IB metals, and the carrier has an ammonia adsorption capacity of 0.25 to 0.65 mmol/g, as measured by NH3-TPD test. The catalyst has an improved performance, when used for producing organic amines by catalytic amination.

Abstract: Disclosed are a catalyst useful for producing organic amines by catalytic amination its preparation and application thereof, which catalyst comprising an inorganic porous carrier containing aluminum and/or silicon, and an active metal component supported on the carrier, the active metal component comprising at least one metal selected from Group VIII and Group IB metals, wherein the carrier has an L acid content of 85% or more relative to the total of the L acid and B acid contents. The catalyst shows an improved catalytic performance when used for producing organic amines by catalytic amination.

Abstract: The present invention discloses a hydrological model considering the uncertainty of a runoff production structure and a method for quantifying influence on a surface-subsurface hydrological process. The present invention quantifies the uncertainty of runoff production structures including a surface runoff structure, an interflow structure and a base flow structure by using parameters, and constructs a hydrological model considering the uncertainty of a runoff production structure by combining an added confluence module. Compared with an original hydrological model, the hydrological model has higher precision, which is capable to quantify the uncertainty of surface runoff, interflow and base flow of the runoff production structure and its impact on the surface-subsurface hydrological process, better improve precision of runoff simulation, and enhance understanding and cognition of the basic rule of a hydrological physical process.

Abstract: A fully-automated sushi making apparatus, comprising a fixed plate (1), a container module (2), an annular shielding module (3), a center shielding module (4), a dispensing module (7), a ring-shaped isolation module (5), a cylindrical pushing module (6), an extraction module (8), a recovery module (9), and a controller (10). The controller controls vertical drive units (52, 62, 81) and horizontal drive units (31, 41, 51, and 61) to drive the connected annular shielding module, ring-shaped isolation module, and cylindrical pushing module to perform layerwise removal of rice from the container module, then drives the center shielding module, the dispensing module, and the cylindrical pushing module to add sushi ingredients into the hollow center of the rice removed from the container module, and finally drives the extraction module, the annular shielding module, and the center shielding module to move in unison to extract the completed sushi.

Abstract: An anti-coking equipment, a preparation method therefor, and the use thereof. The preparation method comprises: bringing a low-oxygen partial pressure gas into contact with an equipment for reaction to obtain an anti-coking equipment containing an oxide film on the inner surface, wherein the dew point of the low-oxygen partial pressure gas is -40° C. to 40° C. A dense and stable oxide film is formed on the inner surface of the equipment prepared by the method, which can inhibit or slow down the catalytic coking phenomenon, reduce the degree of equipment carburization, and prolong the service life of the equipment.

Abstract: A power-driven tool may include a clutch mechanism selectively provides for engagement between and transmission mechanism and an output mechanism of the tool. The clutch mechanism may include a variable rate, or a dual rate biasing mechanism. mechanism that transmits power from a motor to an output device. A speed selection mechanism may be coupled to the transmission mechanism, to control a speed reduction through the transmission mechanism, and an output speed of the tool. The transmission mechanism may employ a compound, stepped, planetary gear assembly, to provide for an axially compact arrangement of transmission mechanism components, to reduce an axial length of the tool. The speed selection mechanism may employ a multi-staged grounding device, corresponding to the reduced axial length of the transmission mechanism.

Abstract: In some examples, a system includes a transceiver configured to receive surveillance messages from Y target vehicles, where Y is an integer greater than two. The system includes processing circuitry configured to determine predicted positions of the Y target vehicles based on the surveillance messages. The processing circuitry is also configured to determine reported positions of the Y target vehicles based on later received surveillance messages. The processing circuitry is further configured to determine that respective differences between the respective predicted position and the respective reported position for X of the Y target vehicles is greater than a threshold distance. The processing circuitry is configured to determine that Global Navigation Satellite System interference has occurred in response to determining that X divided by Y is greater than a threshold level.

Abstract: A ground weather center may transmit information requests that carry at least one meteorological specific triggering command. An airborne system may translate the triggering command into detectable meteorological conditions and may arm the trigger(s) for specific weather sensors accordingly and downlink information upon the airborne system detects the triggering conditions. By using such a triggering command, the airborne system may be able transmit the same amount of valuable information with less bandwidth by reducing the number of redundant downlinked packets.