Patents by Inventor Guoxian Wu

Guoxian Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20230277534
    Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: August 25, 2022
    Publication date: September 7, 2023
    Inventors: Prabha N. Ibrahim, Chao Zhang, Wayne Spevak, Jiazhong Zhang, Guoxian Wu, Jack Lin, Hanna Cho, Marika Nespi, Songyuan Shi, Todd Ewing, Ying Zhang
  • Compounds and methods for EP300 or CBP modulation and indications therefor
    Patent number: 11446287
    Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein A1, A2, A3, A4, R4, X1, X2, and X3 are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: September 20, 2022
    Assignee: Opna Immuno-Oncology SA
    Inventors: Wayne Spevak, John Buell, Zuojun Guo, Hiroaki Inagaki, Yongil Jin, Phuongly Pham, Songyuan Shi, Jack Walleshauser, Jeffrey Wu, Guoxian Wu, Chao Zhang, Jiazhong Zhang, Ying Zhang
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 11337976
    Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 24, 2022
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Chao Zhang, Wayne Spevak, Jiazhong Zhang, Guoxian Wu, Jack Lin, Hanna Cho, Marika Nespi, Songyuan Shi, Todd Ewing, Ying Zhang
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20210353602
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: July 9, 2021
    Publication date: November 18, 2021
    Inventors: Guoxian Wu, Jiazhong Zhang, Yong-Liang Zhu, Chao Zhang, Prabha N. Ibrahim, Songyuan Shi, Wayne Spevak, Dean R. Artis, James Tsai
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20210346358
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: July 9, 2021
    Publication date: November 11, 2021
    Inventors: Guoxian Wu, Jiazhong Zhang, Yong-Liang Zhu, Chao Zhang, Prabha N. Ibrahim, Songyuan Shi, Wayne Spevak, Dean R. Artis, James Tsai
  • Compounds and methods for IDO and TDO modulation, and indications therefor
    Patent number: 11149011
    Abstract: Disclosed are compounds of Formula (I) and (Ia): or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R4, R5, R6, and R7 are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: October 19, 2021
    Assignee: Plexxikon Inc.
    Inventors: Jiazhong Zhang, Hannah Powers, Aaron Albers, Phuongly Pham, Guoxian Wu, John Buell, Wayne Spevak, Zuojun Guo, Jack Walleshauser, Ying Zhang
  • COMPOUNDS AND METHODS FOR EP300 or CBP MODULATION AND INDICATIONS THEREFOR
    Publication number: 20210315872
    Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein A1, A2, A3, A4, R4, X1, X2, and X3 are as described in any of the embodiments described in this disclosure; compositions thereof, and uses thereof.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 14, 2021
    Inventors: Wayne Spevak, John Buell, Zuojun Guo, Hiroaki Inagaki, Yongil Jin, Phuongly Pham, Songyuan Shi, Jack Walleshauser, Jeffrey Wu, Guoxian Wu, Chao Zhang, Jiazhong Zhang, Ying Zhang
  • COMPOUNDS AND METHODS FOR CD73 MODULATION AND INDICATIONS THEREFOR
    Publication number: 20210198239
    Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R1, R2, R3, A, L, and G are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Application
    Filed: December 4, 2020
    Publication date: July 1, 2021
    Inventors: Mark Vander Wal, John Buell, Xinping Han, Yongil Jin, Guoxian Wu, Songyuan Shi, Wayne Spevak, Jack Walleshauser, Jiazhong Zhang, Ying Zhang, Zuojun Guo
  • Compounds and methods for CDK8 modulation and indications therefor
    Patent number: 10703757
    Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, X3, X4, X5, X6, X7 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: July 7, 2020
    Assignee: Plexxikon Inc.
    Inventors: Guoxian Wu, Aaron Albers, John Buell, Elizabeth A. Burton, Phuongly Pham, Hannah Powers, Songyuan Shi, Wayne Spevak, Jeffrey Wu, Jiazhong Zhang
  • Heterocyclic compounds and uses thereof
    Patent number: 10519177
    Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 31, 2019
    Assignee: Plexxikon Inc.
    Inventors: Jiazhong Zhang, John Buell, Katrina Chan, Prabha N. Ibrahim, Jack Lin, Phuongly Pham, Songyuan Shi, Wayne Spevak, Guoxian Wu, Jeffrey Wu
  • Compounds and methods for IDO and TDO modulation, and indications therefor
    Patent number: 10508085
    Abstract: Disclosed are compounds of Formula I(a): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, R5, R6, R7, G1, G2 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: December 17, 2019
    Assignee: Plexxikon Inc.
    Inventors: Jiazhong Zhang, Hannah Powers, Aaron Albers, Phuongly Pham, Guoxian Wu, John Buell, Wayne Spevak, Zuojun Guo, Jack Walleshauser, Ying Zhang
  • COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20190300487
    Abstract: Disclosed are compounds of Formula (I) and (Ia): or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R4, R5, R6, and R7 are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Application
    Filed: March 19, 2019
    Publication date: October 3, 2019
    Inventors: Jiazhong Zhang, Hannah Powers, Aaron Albers, Phuongly Pham, Guoxian Wu, John Buell, Wayne Spevak, Zuojun Guo, Jack Walleshauser, Ying Zhang
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 10426760
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: October 1, 2019
    Assignee: Plexxikon Inc.
    Inventors: Guoxian Wu, Jiazhong Zhang, Yong-Liang Zhu, Chao Zhang, Prabha N. Ibrahim, Songyuan Shi, Wayne Spevak, Dean R. Artis, James Tsai
  • Compounds and methods for kinase modulation
    Patent number: 10428067
    Abstract: Disclosed are compounds having a compound of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, compositions thereof, and uses thereof.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: October 1, 2019
    Assignee: Plexxikon Inc.
    Inventors: Chao Zhang, Guoxian Wu, Wayne Spevak, Zuojun Guo, Ying Zhang
  • COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR
    Publication number: 20190263800
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit an or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
    Type: Application
    Filed: October 1, 2018
    Publication date: August 29, 2019
    Inventors: Jiazhong Zhang, Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Guoxian Wu, Hongyao Zhu, Marika Nespi, Chao Zhang
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20190209536
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: August 8, 2018
    Publication date: July 11, 2019
    Inventors: Guoxian Wu, Jiazhon Zhang, Yong-Liang Zhu, Chao Zhang, Prabha N. Ibrahim, Songyuan Shi, Wayne Spevak, Dean R. Artis, James Tsai
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20190175567
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: August 22, 2018
    Publication date: June 13, 2019
    Inventors: Guoxian Wu, Jiazhong Zhang, Yong-Liang Zhu, Chao Zhang, Prabha N. Ibrahim, Songyuan Shi, Wayne Spevak, Dean R. Artis, James Tsai
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 10301280
    Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: May 28, 2019
    Assignee: Plexxikon Inc.
    Inventors: Guoxian Wu, Katrina Chan, Todd Ewing, Prabha N. Ibrahim, Jack Lin, Marika Nespi, Wayne Spevak, Ying Zhang
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 10227357
    Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: March 12, 2019
    Assignee: Plexxikon Inc.
    Inventors: Jack Lin, John Buell, Katrina Chan, Todd Ewing, Prabha Ibrahim, Marika Nespi, Phuongly Pham, Songyuan Shi, Wayne Spevak, Guoxian Wu, Jiazhong Zhang, Ying Zhang
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 10160747
    Abstract: Disclosed are compounds of Formula I(b): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Ring A, Ring HD, J, each T, R3, R4, R5, each R7, and m are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: December 25, 2018
    Assignee: Plexxikon Inc.
    Inventors: Jack Lin, Prabha N. Ibrahim, Aaron Albers, John Buell, Zuojun Guo, Phuongly Pham, Hannah Powers, Songyuan Shi, Wayne Spevak, Guoxian Wu, Jiazhong Zhang, Ying Zhang, Jeffrey Wu