Patents by Inventor Guoxian Wu

Guoxian Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
    Publication number: 20100004222
    Abstract: Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: February 22, 2007
    Publication date: January 7, 2010
    Applicant: Renovis, Inc.
    Inventors: Michael G. Kelly, Carl J. Kaub, John Kincaid, Satyanarayana Janagani, Guoxian Wu, Zhi-Liang Wei, Kiran Sahasrabudhe, Matthew Duncton, Ravindra B. Upasani, Yunfeng Fang, Matthew Cox, Jianhua He
  • PEPTIDYL PRODRUGS AND LINKERS AND STABILIZERS USEFUL THEREFOR
    Publication number: 20090209734
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: March 4, 2009
    Publication date: August 20, 2009
    Applicant: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P.C. McGee, Guoxian Wu, Jimmie Moore, Zhihong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
  • Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
    Patent number: 7576099
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: August 18, 2009
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Matthew Duncton, Kiran Sahasrabudhe, Satyanarayana Janagani, Ravindra B. Upasani, Guoxian Wu, Jianhua He, legal representative, Zhi-Liang Wei, Carl Kaub, YunFeng Fang
  • METHODS OF TREATING CANCER WITH AN ANTIBODY-DRUG CONJUGATE
    Publication number: 20090175888
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: March 2, 2009
    Publication date: July 9, 2009
    Applicant: Medarex, Inc.
    Inventors: Howard P. Ng, Zhihong Li, Danny P.C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Boyd, Thomas J. Lobl
  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Patent number: 7507420
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: March 24, 2009
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhi-Hong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
  • Compounds modulating c-fms and/or c-kit activity and uses therefor
    Publication number: 20090076046
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
    Type: Application
    Filed: November 21, 2007
    Publication date: March 19, 2009
    Inventors: Jiazhong Zhang, Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Guoxian Wu, Hongyao Zhu, Marika Nespi, Chao Zhang
  • Disulfide prodrugs and linkers and stabilizers useful therefor
    Patent number: 7498302
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: March 3, 2009
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Zhi-Hong Li, Danny P. C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Elaine Boyd, Thomas J. Lobl
  • Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
    Publication number: 20080300243
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: February 24, 2006
    Publication date: December 4, 2008
    Inventors: Michael G. Kelly, John Kincaid, Matthew Duncton, Kiran Sahasrabudhe, Satyanarayana Janagani, Ravindra B. Upasani, Guoxian Wu, YunFeng Fang, Zhi-Liang Wei, Carl Kaub, Jianhua He
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20080221148
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: December 20, 2007
    Publication date: September 11, 2008
    Inventors: Prabha N. Ibrahim, Ryan Bremer, Chao Zhang, Jiazhong Zhang, Klaus-Peter Hirth, Guoxian Wu, Hongyao Zhu
  • Amide compounds as ion channel ligands and uses thereof
    Publication number: 20080200524
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: November 1, 2007
    Publication date: August 21, 2008
    Inventors: Michael G. Kelly, Satyanarayana Janagani, Guoxian Wu, John Kincaid
  • Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
    Patent number: 7414131
    Abstract: Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: August 19, 2008
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, Satyanarayana Janagani, Guoxian Wu, John Kincaid, David Lonergan, YunFeng Fang, Zhi-Liang Wei
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20080188514
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: December 20, 2007
    Publication date: August 7, 2008
    Inventors: Guoxian Wu, Wayne Spevak, Songyuan Shi, Hanna Cho, Prabha N. Ibrahim, Chao Zhang, Shenghua Shi, Yong Zhou, Dean Artis, Jiazhong Zhang
  • Amide compounds as ion channel ligands and uses thereof
    Patent number: 7338950
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: March 4, 2008
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, Satyanarayana Janagani, Guoxian Wu, John Kincaid
  • Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
    Patent number: 7312330
    Abstract: Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: December 25, 2007
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, Satyanarayana Janagani, Guoxian Wu, John Kincaid, David Lonergan, YunFeng Fang, Zhi-Liang Wei
  • Compounds modulating c-kit and c-fms activity and uses therefor
    Publication number: 20070032519
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
    Type: Application
    Filed: May 16, 2006
    Publication date: February 8, 2007
    Inventors: Chao Zhang, Jiazhong Zhang, Prabha Ibrahim, Clarence Hurt, Rebecca Zuckerman, Dean Artis, Ryan Bremer, Wayne Spevak, Guoxian Wu, Hongyao Zhu
  • Cytotoxic agents
    Patent number: 7129261
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: October 31, 2006
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P.C. McGee, Oliver L. Saunders, Valeri Martichonok, Guoxian Wu, Zhihong Li, Geoffrey T. Yarranton
  • Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
    Publication number: 20060194801
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: February 24, 2006
    Publication date: August 31, 2006
    Inventors: Michael Kelly, John Kincaid, Matthew Duncton, Kiran Sahasrabudhe, Satyanarayana Janagani, Ravindra Upasani, Guoxian Wu, Yunfeng Fang, Zhi-Liang Wei
  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Patent number: 7087600
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: August 8, 2006
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhihong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
  • Disulfide prodrugs and linkers and stabilizers useful therefor
    Patent number: 6989452
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: January 24, 2006
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Zhihong Li, Danny P. C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Boyd, Thomas J. Lobl
  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Patent number: RE41252
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: April 20, 2010
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhi-Hong Li, Sanjeev Gangwar, Oliver L. Saunder, Irina Astafieva, Valeri Martichonok