Patents by Inventor Gwo-Jenn Shen

Gwo-Jenn Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pseudomonas sp. ATCC No. 49794 alcohol dehydrogenase
    Patent number: 5385833
    Abstract: The present invention provides a substantially pure culture of Pseudomonas sp. strain PED having the ATCC designation 49794. Processes for making R-configured alcohols and for transferring a hydride ion from an R-configured alcohol to the pro-R face of NAD using PED alcohol dehydrogenase isolated and purified from Pseudomonas sp. strain PED are also provided.
    Type: Grant
    Filed: February 26, 1992
    Date of Patent: January 31, 1995
    Assignee: The Scripps Research Institute
    Inventors: Curt W. Bradshaw, Chi-Huey Wong, Gwo-Jenn Shen
  • KDO Aldolase and condensation reactions employed therewith
    Patent number: 5358859
    Abstract: Aureobacterium barkerei strain KDO-37-2 (ATCC 49977) KDO aldolase (EC 4.1.2.23) isolated therefrom are disclosed. The DKDO aldolase is further disclosed to have a broad substrate specificity with respect to its reverse reaction, i.e. the condensation of aldoses with pyruvate to form a wide range of 2-keto-3-deoxy-onic acids, including 2-keto-3-deoxy-nonulosonic acid, 2-keto-3-deoxy-octulosonic acid, 2-keto-3-deoxy-heptulosonic acid, and 2-keto-3-deoxy-hexulosonic acid. In particular, 3-deoxy-D-manno-2-octulosonic acid (D-KDO), a vital component of lipopolysaccharides found in the bacterial outer membrane may be synthesized from D-arabinose and pyruvate in 67% yield. Additionally, protected forms of the KDO aldolase products, e.g. hexaacetyl 2-keto-3-deoxy-nonulosonic acid and pentaacetyl 2-keto-3-deoxy-octulosonic acid, may be decarboxylated to form the corresponding 2-deoxy-aldoses, e.g. 2-deoxy-octulose and 2-deoxy-heptulose respectively.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: October 25, 1994
    Assignee: The Scripps Research Institute
    Inventors: Chi-Huey Wong, Takeshi Sugai, Gwo-Jenn Shen
  • Method and composition for synthesizing sialylated glycosyl compounds
    Patent number: 5278299
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: January 11, 1994
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Chi-Huey Wong, Yoshitaka Ichikawa, Gwo-Jenn Shen
  • Bacillus sp. A30-1 ATCC no. 53841
    Patent number: 5166069
    Abstract: A thermostable lipase is produced by aerobically culturing a microorganism having the identifying characteristics of Bacillus sp.A30-1 ATCC No. 53841 on a nutrient medium under growth conditions until a recoverable lipolytic activity is detectable and thereafter isolating the thermostable lipase. The thermostable lipase has an optimum temperature of about 60.degree. C. and an optimum pH of about 9.5.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: November 24, 1992
    Assignee: Michigan Biotechnology Institute
    Inventors: Gwo-Jenn Shen, Kailash C. Srivastava, Yongxiang Wang, Henry Y. Wang
  • Essentially purified, thermostable and alkalophilic lipase from Bacillus Sp. A30-1 ATCC 53841
    Patent number: 5093256
    Abstract: A thermostable lipase is produced by aerobically culturing a microorganism having the identifying characteristics of Bacillus sp. A30-1 ATCC No. 53841 on a nutrient medium under growth conditions until a recoverable lipolytic activity is detectable and thereafter isolating the thermostable lipase. The thermostable lipase has an optimum pH of 9.5, an isoelectric point of 5.15, a molecular weight of about 65,000 and retaining approximately 100% of its original activity upon being heated at 75.degree. C. for 30 minutes.
    Type: Grant
    Filed: February 22, 1989
    Date of Patent: March 3, 1992
    Inventors: Gwo-Jenn Shen, Kailash C. Srivastava, Yongxiang Wang, Henry Y. Wang