Abstract: Methods for correcting a non-uniform power response of a radiofrequency (“RF”) transmit coil used in magnetic resonance imaging (“MRI”) are described. Transmit power response data for an RF transmit coil are processed to compute RF amplitude scaling factors for the RF transmit coil as a function of transmit frequency offset. The RF amplitude scaling factors can be used to correct transmitted RF power, and thus flip angle, to be more uniform over a range of transmit frequency offsets, as may be encountered when imaging with lower field MRI systems or MRI systems with high strength or asymmetric gradients.

Abstract: A method of generating adjusted image data to compensate for modality-induced distortion includes, at a processor: receiving a three-dimensional image captured with a first imaging modality and including (i) distorted surface image data depicting a surface of an object and (ii) distorted volume image data depicting a volume of the object; extracting the distorted surface image data from the three-dimensional image; receiving reference surface image data captured with a second imaging modality and depicting the surface of the object; determining a surface transformation for registering the distorted surface image data with the reference surface image data; determining a volume transformation informed by the surface transformation; generating an adjusted three-dimensional image by applying the volume transformation to the three-dimensional image; and storing the adjusted three-dimensional image in the memory.

Abstract: A method of imaging an implant device in a computing device is provided. The computing device includes a processor interconnected with a memory and a display. The method includes, at the processor: obtaining a first magnetic resonance (MR) image of a patient tissue, the first MR image containing a first magnetic field strength indicator; responsive to the implant device being inserted in the patient tissue, obtaining a second MR image of the patient tissue, the second MR image containing a second magnetic field strength indicator smaller than the first magnetic field strength indicator; registering the second MR image with the first MR image; generating a composite image from the first MR image and the second MR image; and presenting the composite image on the display.

Abstract: Some implementations provide a method for safe operation of a magnetic resonance imaging (MRI) system, the method including: determining, at least in part by using a sensor device, location information that indicates a location of an MR-incompatible object relative to the MRI system, the MRI system generating a polarizing magnetic field for imaging a subject; based on the determined location information, determining, by a control unit associated with the MRI system, that the MR-incompatible object poses an operational hazard to the MRI system; and in response to determining that the MR-incompatible object poses an operational hazard to the MRI system, reducing, by the control unit, a strength of the polarizing magnetic field.

Abstract: A medical navigation system is provided for registering a patient for a medical procedure with the medical navigation system using fiducial markers. The fiducial markers are placed on the patient prior to a 3D scan and the fiducial markers each have a target for use with a tracking system. The medical navigation system comprises a 3D scanner, a tracking system, a display, and a controller electrically coupled to the 3D scanner, the tracking system, and the display. The controller has a processor coupled to a memory.

Abstract: A method of maintaining patient registration in surgical navigation includes: obtaining a patient position in a tracking system frame of reference, based on a fiducial marker array affixed in a first position relative to the patient; receiving an initial surface scan depicting the patient and the fiducial array; responsive to receiving an intraoperative image depicting the patient: obtaining a position, in the tracking system frame of reference, of the fiducial array affixed in a second position relative to the patient; receiving a secondary surface scan depicting the patient and the fiducial array; detecting a deviation in a position of the fiducial marker array relative to the patient between the initial and secondary surface scans; and applying the deviation to the position of the patient to generate an updated position of the patient in the tracking system frame of reference, based on the fiducial array affixed in the second position.

Abstract: A medical imaging system for illuminating tissue samples using three-dimensional structured illumination microscopy is port-based surgery is provided. The system comprises: an image sensor; a mirror device; zoom optics; a light modulator; a processor; and collimating optics configured to convey one or more images from the modulator to the mirror, the mirror configured to convey the images to the zoom optics, the zoom optics configured: to convey the image(s) from the mirror to a tissue sample; and convey one or more resulting images, formed by the image(s) illuminating the sample, back to the mirror, which conveys the resulting image(s) from the zoom optics to the image sensor, and, the processor configured to control the modulator to form the image(s), the image(s) including at least one pattern selected to interact with the sample to generate different depth information in each of resulting image(s).

Abstract: Some implementations provide a system that includes: a main magnet including a bore and configured to generate a substantially uniform magnetic field in the bore; one or more gradient coils configured to perturb the substantially uniform magnetic field in the bore, wherein perturbing the substantially uniform magnetic field results in a first varying magnetic field outside of the bore; and one or more shielding units located outside of the bore and configured to generate a second varying magnetic field con figured to attenuate the first varying magnetic field outside of the bore.

Abstract: A method of generating adjusted image data to compensate for modality-induced distortion includes, at a processor: receiving a three-dimensional image captured with a first imaging modality and including (i) distorted surface image data depicting a surface of an object and (ii) distorted volume image data depicting a volume of the object; extracting the distorted surface image data from the three-dimensional image; receiving reference surface image data captured with a second imaging modality and depicting the surface of the object; determining a surface transformation for registering the distorted surface image data with the reference surface image data; determining a volume transformation informed by the surface transformation; generating an adjusted three-dimensional image by applying the volume transformation to the three-dimensional image; and storing the adjusted three-dimensional image in the memory.

Abstract: A method of correcting warping of an acquired image in an MRI system, caused by non-linearities in gradient field profiles of gradient coils is set forth, comprising a) constructing a computer model representing conducting pathways for each gradient coil in said MRI system; b) calculating a predicted magnetic field at each point in space for each said gradient coil in said model; c) measuring actual magnetic field at each point in space for each said gradient coil in said MRI system; d) verifying accuracy of said model by comparing said predicted magnetic field to said actual magnetic field at each said point in space and in the event said model is not accurate then repeating a)-d), and in the event said model is accurate then; constructing a distortion map for mapping coordinates in real space to coordinates in warped space of said acquired image based on deviations of said predicted magnetic field from linearity; and unwarping said warping of the acquired image using said distortion map.

Abstract: A magnetic resonance imaging (MRI) system is provided for imaging immune response of soft tissue to therapy by, prior to therapy, administering a contrast agent to the soft tissue; imaging a region of interest using delta relaxation enhanced magnetic resonance (DREMR) to define a functional section; selectively sampling local cells in the functional section; conducting immuno-assay analysis on the sampled local cells; and following therapy, further imaging said region of interest using DREMR to assess immune response of said cells to therapy.

Abstract: A magnetic resonance imaging (MRI) system is provided. The system includes a main field magnet generating a main magnetic field B0. Moreover, the system further includes radio frequency (RF) receiver coils including a first combination of two coils, the two coils of the first combination decoupled based on quadrature decoupling such that the two coils of the first combination are able to receive signals orthogonal to each other and to B0. The two coils can be butterfly coils, the loop plane of the butterfly coils arranged along a surface, the longitudinal axis of the butterfly coils being substantially orthogonal and crossing at substantially midpoint. The surface can be substantially orthogonal to B0 and be curved. The first of the two coils can also be a loop coil and the second of the two coils a butterfly coil.

Abstract: Some implementations provide a method for safe operation of a magnetic resonance imaging (MRI) system, the method including: determining, at least in part by using a sensor device, location information that indicates a location of an MR-incompatible object relative to the MRI system, the MRI system generating a polarizing magnetic field for imaging a subject; based on the determined location information, determining, by a control unit associated with the MRI system, that the MR-incompatible object poses an operational hazard to the MRI system; and in response to determining that the MR-incompatible object poses an operational hazard to the MRI system, reducing, by the control unit, a strength of the polarizing magnetic field.

Abstract: Systems and methods relating to patch antennas and signal combiner circuits. The invention relates to a circuit with discrete capacitors, inductors and amplifiers arrayed in an arrangement with 2 input ports and one output port. The circuit provides a high degree of reverse electrical isolation between the input ports and the output at the radio frequency. The circuit provides an output that is the vector sum of signals present at the first and second input ports. The circuit additionally provides for introduction of a 90 degree phase shift into either of the two inputs. This circuit can be used with dual feed patch antennas.

Abstract: A system and method of acquiring an image at a magnetic resonance imaging (MRI) system is provided. Accordingly, an analog signal based on a pulse sequence and a first gain is obtained. The analog signal is converted into a digitized signal. A potential quantization error is detected in the digitized signal based on a boundary. When the detection is affirmative, a replacement analog signal based on the pulse sequence is received. At least one portion of the replacement analog signal can be based on an adjusted gain. The adjusted gain is a factor of the first gain. The replacement analog signal is digitized into a replacement digitized signal. At least one portion of the replacement digitized signal corresponding to the at least one portion of the replacement analog signal is adjusted based on a reversal of the factor.

Abstract: A method for operating a magnetic resonance imaging (MRI) system that includes: accessing data indicating a first region for imaging a portion of a subject, the portion being placed in a main magnet of the MRI system and the main magnet generating a magnetic field; selecting, from a group of available shimming coils, a first subset of shimming coils arranged and configured such that, when the shimming coils in the first subset are driven, a homogeneity of the magnetic field at the first region is increased; and driving the shimming coils in the selected first subset of shimming coils without driving other shimming coils in the group of available shimming coils such that the homogeneity of the magnetic field at the first region increases relative to the homogeneity of the magnetic field at the first region when the shimming coils of the selected first subset are not driven.

Abstract: A medical navigation system is provided for performing at least part of an assessment of a non-living body. The medical navigation system comprises a positioning device having a positioning arm with an end effector at the end of the positioning arm, an imaging device coupled to the end effector, and a controller electrically coupled to the positioning device and the imaging device. The controller has a processor coupled to a memory and a display. The controller is configured to generate a signal to move the positioning arm to position the imaging device through a range of motion to perform a scan of a surface of the body and receive and save as data in the memory signals generated by the imaging device during the range of motion.

Abstract: Some implementations provide a method that includes: placing a human subject on a moveable platform located in a room with a magnetic resonance imaging (MRI) scanner and a radiation therapy machine; moving the platform into a first position such that the human subject is positioned to be imaged by MRI; operating the MRI scanner while the platform is in the first position to obtain an image of the human subject; moving the platform into a second position such that the human subject is in position to receive radiation therapy from the radiation therapy machine; reducing the magnetic field such that the magnetic field at the radiation therapy machine is below a threshold value; and while the platform is in the second position and the magnetic field at the radiation therapy machine is below the threshold value, operating the radiation therapy machine to perform radiation therapy on the human subject.

Abstract: Systems and methods relating to patch antennas. A patch antenna has a substrate, a resonant metal plate at one side of the substrate, and a ground plane at the other opposite side of the substrate. Two feed pins are used to couple the antenna to other circuitry. The feed pins pass through the substrate and holes in at the ground plane. The feed pins are physically disconnected from both the resonant metal plate and the ground plane. The feed pins are capacitively coupled to the resonant metal plate to provide an electronic connection between other circuitry and the patch antenna.

Abstract: A method of data acquisition at a magnetic resonance imaging (MRI) system is provided. The system receives at least a portion of raw data for an image, and detects anomalies in the portion of raw data received. When anomalies are detected, the system can correct those anomalies dynamically, without waiting for a new scan to be ordered. The system can attempt to scan the offending portion of the raw data, either upon detection of the anomaly or at some point during the scan. The system can also correct anomalies using digital correction methods based on expected values. The anomalies can be detected based on variations from thresholds, masks and expected values all of which can be obtained using one of the ongoing scan, previously performed scans and apriori information relating to the type of scan being performed.