Patents by Inventor Gyula Hadlaczky

Gyula Hadlaczky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL METHOD TO LOAD A MAMMALIAN ARTIFICIAL CHROMOSOME WITH MULTIPLE GENES
    Publication number: 20140295501
    Abstract: The invention provides for a system for uploading genes of interest into an artificial chromosome expression system (ACE) that has been engineered to include multiple sites for site-specific, recombination directed integration, whereby a second or further gene of interest can be loaded onto the ACE by a targeting vector, through the acceptor recombination site(s) on said ACE.
    Type: Application
    Filed: November 15, 2013
    Publication date: October 2, 2014
    Inventors: Róbert Katona, Gyula Hadlaczky, Katalin Fodor, Tünde Praznovszky, Péter Blazsó, Andor Udvardy, Gyöngyi Mózesné Holló, Judit Keresö
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Patent number: 8389802
    Abstract: Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the nucleic acids.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: March 5, 2013
    Assignees: The Biological Research Center of the Hungarian Academy of Sciences, Glaxo Group Limited
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Patent number: 8288610
    Abstract: Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the nucleic acids.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: October 16, 2012
    Assignees: The Biological Research Center of the Hungarian Academy of Sciences, Glaxo Group Limited
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20090263898
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, methods for amplification of nucleic acids and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
    Type: Application
    Filed: June 11, 2009
    Publication date: October 22, 2009
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20070061920
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, methods for amplification of nucleic acids and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
    Type: Application
    Filed: November 2, 2006
    Publication date: March 15, 2007
    Inventors: Gyula Hadlaczky, Aladar Szalay
  • Artificial chromosomes, uses thereof and method for preparing artificial chromosomes
    Publication number: 20060150271
    Abstract: Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the nucleic acids.
    Type: Application
    Filed: February 14, 2006
    Publication date: July 6, 2006
    Inventors: Gyula Hadlaczky, Aladar Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20060095984
    Abstract: Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the nucleic acids.
    Type: Application
    Filed: November 21, 2005
    Publication date: May 4, 2006
    Inventors: Gyula Hadlaczky, Aladar Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20050153909
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
    Type: Application
    Filed: May 16, 2002
    Publication date: July 14, 2005
    Inventors: Gyula Hadlaczky, Aladar Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20040163147
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, methods for amplification of nucleic acids and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
    Type: Application
    Filed: March 24, 2004
    Publication date: August 19, 2004
    Inventor: Gyula Hadlaczky
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20040143861
    Abstract: Methods for preparing cells that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided methods for producing transgenic plants and animals using the artificial chromosomes and the resulting transgenic organisms are provided.
    Type: Application
    Filed: February 18, 2004
    Publication date: July 22, 2004
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Patent number: 6743967
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heteroaromatic are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: June 1, 2004
    Assignees: Chromos Molecular Systems Inc., The Biological Research Center of the Hungarian Academy of Sciences
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20030108914
    Abstract: Methods for amplification of nucleic acids in cells are provided. Also provided are nucleic acid molecules for amplification.
    Type: Application
    Filed: August 14, 2002
    Publication date: June 12, 2003
    Inventor: Gyula Hadlaczky
  • Artificial chromosomes, uses therof and methods for preparing artificial chromosomes
    Publication number: 20030101480
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for production of transgenic plants, are also provided.
    Type: Application
    Filed: November 1, 2002
    Publication date: May 29, 2003
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20030083293
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, methods for amplification of nucleic acids and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
    Type: Application
    Filed: May 16, 2002
    Publication date: May 1, 2003
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20030033617
    Abstract: Methods for preparing cell lines and transgenic animals that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
    Type: Application
    Filed: April 17, 2001
    Publication date: February 13, 2003
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20020160410
    Abstract: Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the the nucleic acids.
    Type: Application
    Filed: April 17, 2002
    Publication date: October 31, 2002
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Publication number: 20020160970
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, methods for amplification of nucleic acids and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
    Type: Application
    Filed: March 5, 2001
    Publication date: October 31, 2002
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • ARTIFICIAL CHROMOSOMES, USES THEREOF AND METHODS FOR PREPARING ARTIFICIAL CHROMOSOMES
    Publication number: 20010008025
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
    Type: Application
    Filed: June 12, 1998
    Publication date: July 12, 2001
    Inventors: GYULA HADLACZKY, ALADAR A. SZALAY
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Patent number: 6077697
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: June 20, 2000
    Assignees: Chromos Molecular Systems, Inc., The Biological Research Center of the Hungarian Academy of Sciences
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Patent number: 6025155
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
    Type: Grant
    Filed: August 7, 1996
    Date of Patent: February 15, 2000
    Assignees: Chromos Molecular Systems, Inc., The Biological Research Center of the Hungarian Academy of Sciences
    Inventors: Gyula Hadlaczky, Aladar A. Szalay