Abstract: Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.

Abstract: The invention comprises compositions and methods useful for encapsulation and controlled release of guest molecules, such as drugs. Compositions of the present invention comprise a matrix comprising molecules that are non-covalently crosslinked by multi-valent cations, wherein the molecules that are non-covalently crosslinked are non-polymeric, have more than one carboxy functional group, and have at least partial aromatic or heteroaromatic character The compositions are characterized in that a guest molecule may be encapsulated within the matrix and subsequently released.

Abstract: The “Movable Work Table for Long-Arm Quilting Machines” provides a solid movable work area for a Long-Arm Quilting Machine. Designed and developed so that the operator can easily utilize the work surface when require and easily roll it to the side when the machine is quilting. The table provides a large stable work surface for the layout and dusting of the stencil design. Once the stencil design is dusted (or powdered) the table is rolled to the side allowing the operator an unobstructed view of the applied stencil design with the needle of the quilting machine.

Abstract: The Wall “Flush Mount” Quilt Rack is utilized to hang and display quilts on flat wall surfaces. Designed and developed so the hanging quilt uses the wall surface to support and frame the displayed quilt thus producing a more pleasing and appealing display while protecting the quilt from drooping or sagging. While other quilt racks display quilts against the wall they rely on some sort of clipping, or pinching, device to hold the fabric thus causing droops, sages or distortion to the fabric material. The Wall “Flush Mount” Quilt Rack requires a four (4) inch fabric pocket on the back of the quilt, and that, along with the rack, produces a uniform support over the entire length of the quilt eliminating wrinkles, droops, sags or uneven portions on the fabric surface.

Abstract: The Binder Winder is utilized to neatly store a cut quilt binding until ready for installation onto a finished quilt. It was developed to provide a durable safe alternative to flimsy cardboard tubes upon which quilters have relied upon to store their quilt bindings.

Abstract: Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.

Abstract: Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle arrays. The microneedles in the microneedle arrays may be in the form of tapered structures that include at least one channel formed in the outside surface of each microneedle. The microneedles may have bases that are elongated in one direction. The channels in microneedles with elongated bases may extend from one of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles. The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.

Abstract: Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.

Abstract: A preformed object for delivering an active agent for a subject, the preformed object including crosslinked protein, and methods of making and using.

Abstract: Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle arrays. The microneedles in the microneedle arrays may be in the form of tapered structures that include at least one channel formed in the outside surface of each microneedle. The microneedles may have bases that are elongated in one direction. The channels in microneedles with elongated bases may extend from one of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles. The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.

Abstract: A preformed object for delivering an active agent to a subject, the preformed object including crosslinked protein, and methods of making and using.

Abstract: A composition, and method of preparing such a composition, useful for the enhancement of the transdermal delivery of a medicament. The composition includes a medicament suspended in an aqueous solution of lower alcohol, to which solution is added an amount of higher alcohol sufficient to substantially saturate the composition.

Abstract: A novel class of chelated radio-labeled polysaccharide derivatives are useful for diagnosing formed, and forming, blood clots in a vascular system. Novel intermediate metal-binding compounds comprise a water-soluble polysaccharide moiety having an average of at least 0.25 anionic groups per monosaccharide unit, and at least one chelating group derived from amino acids, substituted cyclic acid anhydrides, or carbon disulfide. The intermediate compound is then reacted with a radioactive tracer metal compound.