Patents by Inventor H. Michael Shepard

H. Michael Shepard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PH20 polypeptide variants, formulations and uses thereof
    Patent number: 12600959
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: March 5, 2025
    Date of Patent: April 14, 2026
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • ANTIBODIES AND ENONOMERS
    Publication number: 20260077053
    Abstract: The subject invention provides a composition comprising an enomomer which comprises a) a carrier molecule, and b) at least one aptamer, wherein the carrier molecule is an antibody, an antigen-binding moiety, a serum protein, an intracellular protein, a messenger RNA (mRNA) or human serum albumin.
    Type: Application
    Filed: November 18, 2025
    Publication date: March 19, 2026
    Inventor: H. Michael Shepard
  • OLIGO-TRAP FUSION PROTEINS (OFPs) AND USES THEREOF
    Publication number: 20250388650
    Abstract: Chimeric polypeptides comprising extracellular domains (ECDs), modified ECDs and portions thereof, and modified multimerization domains, such as modified Fc's are provided. “Growth factor ligand traps” (GFTs or oligo-traps) comprising the chimeric polypeptides, and methods of making and using them are provided.
    Type: Application
    Filed: September 3, 2025
    Publication date: December 25, 2025
    Inventors: H. Michael Shepard, Pei JIN
  • Antibodies and enonomers
    Patent number: 12472266
    Abstract: The subject invention provides a composition comprising an enomomer which comprises a) a carrier molecule, and b) at least one aptamer, wherein the carrier molecule is an antibody, an antigen-binding moiety, a serum protein, an intracellular protein, a messenger RNA (mRNA) or human serum albumin.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: November 18, 2025
    Assignee: Enosi Therapeutics Corporation
    Inventor: H. Michael Shepard
  • PH20 polypeptide variants with a modification at position 324 of the PH20 polypeptide and a method of making thereof
    Patent number: 12371685
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: June 23, 2023
    Date of Patent: July 29, 2025
    Assignee: HALOZYME, INC.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 POLYPEPTIDE VARIANTS, FORMULATIONS AND USES THEREOF
    Publication number: 20250197832
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: March 5, 2025
    Publication date: June 19, 2025
    Inventors: Ge WEI, H. Michael SHEPARD, Qiping ZHAO, Robert James CONNOR
  • PH20 POLYPEPTIDE VARIANTS, FORMULATIONS AND USES THEREOF
    Publication number: 20250197835
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: March 5, 2025
    Publication date: June 19, 2025
    Inventors: Ge WEI, H. Michael SHEPARD, Qiping ZHAO, Robert James Cannor
  • PH20 POLYPEPTIDE VARIANTS, FORMULATIONS AND USES THEREOF
    Publication number: 20250197833
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: March 5, 2025
    Publication date: June 19, 2025
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 POLYPEPTIDE VARIANTS, FORMULATIONS AND USES THEREOF
    Publication number: 20250197836
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: March 5, 2025
    Publication date: June 19, 2025
    Inventors: Ge WEI, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 POLYPEPTIDE VARIANTS, FORMULATIONS AND USES THEREOF
    Publication number: 20250197834
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: March 5, 2025
    Publication date: June 19, 2025
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 POLYPEPTIDE VARIANTS, FORMULATIONS AND USES THEREOF
    Publication number: 20250154488
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: June 28, 2024
    Publication date: May 15, 2025
    Inventors: Ge WEI, H. Michael SHEPARD, Qiping ZHAO, Robert James CONNOR
  • PH20 polypeptide variants, formulations and uses thereof
    Patent number: 12264345
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: July 19, 2024
    Date of Patent: April 1, 2025
    Assignee: HALOZYME, INC.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 POLYPEPTIDE VARIANTS, FORMULATIONS AND USES THEREOF
    Publication number: 20250051747
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: October 22, 2024
    Publication date: February 13, 2025
    Inventors: Ge Wei, H. Michael Shepard, Qiqing Zhao, Robert James Connor
  • PH20 polypeptide variants, formulations and uses thereof
    Patent number: 12195773
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: May 9, 2024
    Date of Patent: January 14, 2025
    Assignee: HALOZYME, INC.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 polypeptide variants, formulations and uses thereof
    Patent number: 12152262
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: June 23, 2023
    Date of Patent: November 26, 2024
    Assignee: HALOZYME, INC.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 polypeptide variants, formulations and uses thereof
    Patent number: 12123035
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: December 19, 2022
    Date of Patent: October 22, 2024
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 polypeptide variants, formulations and uses thereof
    Patent number: 12110520
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: December 19, 2022
    Date of Patent: October 8, 2024
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 polypeptide variants, formulations and uses thereof
    Patent number: 12104185
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: March 8, 2024
    Date of Patent: October 1, 2024
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 polypeptide variants, formulations and uses thereof
    Patent number: 12104184
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: December 19, 2022
    Date of Patent: October 1, 2024
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • PH20 Polypeptide Variants, Formulations and Uses Thereof
    Publication number: 20240318158
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: May 9, 2024
    Publication date: September 26, 2024
    Inventors: Ge WEI, H. Michael SHEPARD, Qiping Zhao, Robert James CONNOR