Patents by Inventor H. Smith

H. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12365606
    Abstract: A method and system treating aqueous effluent from an aqueous stream from at least one of a manufacturing facility, compounding facility or municipal water treatment facility. Reductive and/or oxidative chemical species in an aqueous fluid stream decompose natural hormonal or synthetic hormonal contaminants. The method includes: providing a filter material comprising at least one porous carbon support layer and a silicate wool or glass wool layer in direct contact with the at least one porous carbon support layer having distributed halogens or halides within; passing an electric current through the filter material while directing a contaminated aqueous mass comprising natural hormonal or synthetic hormonal contaminants into contact with the filter material; and adsorbing the hormonal contaminants from the fluid mass onto the filter material in the presence of the electric current, and decomposing the hormonal contaminants.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: July 22, 2025
    Inventors: Kenneth R. Code, Richard H. Smith, Jenny Boutros, Ahmed Moustafa, Alexander Evans, Parastoo Pourrezaei, Laura Patterson-Fortin
  • Publication number: 20250231165
    Abstract: Provided herein are methods and compositions of a surrogate mRNA drug product. The surrogate mRNA drug product is made up of a physical property surrogate, a visual property surrogate, and a chemical property surrogate. The surrogate mRNA drug product has at least one quantitative or qualitative property such as viscosity, turbidity, density, and surface tension that is comparable to and matches the same property of a mRNA drug product comprised of mRNA in a lipid nanoparticle (LNP). The surrogate mRNA drug product, however, does not comprise mRNA or LNP.
    Type: Application
    Filed: October 20, 2022
    Publication date: July 17, 2025
    Applicant: ModernaTX, Inc.
    Inventors: Johnathan Goldman, Satish K. Singh, Anton Zverev Cambridge, Michael H. Smith
  • Patent number: 12362474
    Abstract: Disclosed herein is a method for communicating between platforms, comprising the steps of initializing a first platform and a second platform; optically tracking a movement of the second platform by the first platform; and optically communicating bi-directionally between the first platform and the second platform. Disclosed herein is an optical communication device comprising various elements including but not limited to: a processor configured to provide at least a tracking mode and a communications mode; an input-output interface coupled to the processor; an electro-optic controller coupled to the input-output interface; an acquisition-tracking portion coupled to the electro-optic controller; and a communication portion coupled to the electro-optic controller.
    Type: Grant
    Filed: June 2, 2023
    Date of Patent: July 15, 2025
    Assignee: 4S-Silversword Software and Services, LLC
    Inventors: William Robert Allen Ziegler, Ronald H. Smith
  • Publication number: 20250224081
    Abstract: Various embodiments of the present technology relate to solutions for leak detection in hydrocarbon storage environments. In some examples, a leak identification system confirms sensor outputs in a hydrocarbon storage environment. The leak identification system comprises processing circuitry. The processing circuitry obtains sensor data that characterizes hydrocarbon inputs and hydrocarbon outputs in the hydrocarbon storage environment. The processing circuitry processes the sensor data using a thermodynamic model to determine when a discrepancy exists between the hydrocarbon inputs and the hydrocarbon outputs. The processing circuitry generates feature vectors that represent video data that depicts the hydrocarbon storage environment. The processing circuitry provides the feature vectors as input to a machine learning engine trained to detect hydrocarbon leaks in the hydrocarbon storage environment.
    Type: Application
    Filed: January 7, 2025
    Publication date: July 10, 2025
    Inventors: Mehdi Korjani, David A. Conley, Mark H. Smith
  • Publication number: 20250214046
    Abstract: The present disclosure provides processes for controlled high-throughput preparation of lipid nanoparticle with defined parameters. A cross mixer can include a central region, a first inlet in fluidic communication with the central region, a second inlet in fluidic communication with the central region, a third inlet in fluidic communication with the central region, and an outlet in fluidic communication with the central region, the outlet oriented at an angle of between about 35° and about 120° from the first inlet and an angle of between about 35° and about 120° from the second inlet.
    Type: Application
    Filed: March 31, 2023
    Publication date: July 3, 2025
    Inventors: Benjamin GELDHOF, Chang TIAN, Michael H. SMITH
  • Patent number: 12348906
    Abstract: An emergency dispatch system configured to allow first responders to efficiently utilize video-based systems using static images of a space and to understand a physical layout of the space. The system includes a dispatch processing hub linked via a communications network with client devices. The system further includes data storage storing a static image of a monitored space from a supplemental camera and video of the monitored space from video sources. A map interface generator is provided that is configured for generating a map-based interface for display upon a display device of the client devices. The map-based interface provides access to the static image and to the video. The hub functions to serve the map-based interface to the client devices. The dispatch processing hub responds to user input selecting the static image by providing a view, e.g., a 360-degree view, of the monitored space based on the static image.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: July 1, 2025
    Assignee: Fusus, LLC
    Inventors: Christopher R. Lindenau, David A. Robinson, Jesse H. Smith, Luis Fernando Diaz Velazquez, Cody D. Mullin
  • Publication number: 20250205986
    Abstract: A crafting pad may include an enclosure portion and a multi-layered composite portion. The enclosure portion defines an enclosure pocket and the multi-layered composite portion is retained in the enclosure pocket, according to various embodiments. The crafting pad is generally configured to facilitate heat transfer from a heat press to a workpiece operably engaged against the crafting pad.
    Type: Application
    Filed: March 6, 2023
    Publication date: June 26, 2025
    Applicant: Cricut, Inc.
    Inventors: Yung Tseng Chen, Thomas Crisp, Francois Laine, William H. Smith, Kenneth Sweet
  • Publication number: 20250186657
    Abstract: The present invention provides compositions and methods for modulation of neuronal networks in the CNS and/or PNS. In certain embodiments, the invention includes modulation of existing networks or restoring one or more damaged or lost axonal connections. In one embodiment, the invention comprises a tissue-engineered composition comprising an elongated tubular construct having at least one neuron and axon extending through the core of the construct.
    Type: Application
    Filed: November 19, 2024
    Publication date: June 12, 2025
    Inventors: D. Kacy Cullen, Douglas H. Smith
  • Patent number: 12319684
    Abstract: Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions. The present invention is based on the seminal discovery of a series of potent small molecule agonists of the apelin receptor, which are useful for the treatment of diseases including heart failure, chronic kidney disease, hypertension, and metabolic disorders such as insulin resistance/diabetes and obesity. The compounds disclosed herein are highly specific for the apelin receptor versus the angiotensin II receptor (ATI).
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: June 3, 2025
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Anthony B. Pinkerton, Layton H. Smith
  • Patent number: 12292077
    Abstract: An assembly and a method are provided for manufacturing a joined assembly. A method for manufacturing includes fitting together and datuming a beam and a node, wherein at least one of the beam and the node is formed with an aperture, and wherein a cylindrical interface is formed between the beam and node. Further, the method includes advancing a mechanical fastener through the aperture to temporarily hold the beam and the node in an engagement. Also, the method includes injecting a structural adhesive into the cylindrical interface between the beam and the node. The method includes final joining the beam and the node by curing the structural adhesive.
    Type: Grant
    Filed: May 4, 2023
    Date of Patent: May 6, 2025
    Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Todd H Smith, Joshua Solomon, Ethan Edward Peel Hodge, Joel S Hooton
  • Publication number: 20250114789
    Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.
    Type: Application
    Filed: December 19, 2024
    Publication date: April 10, 2025
    Inventors: Frank B. Myers, III, Clay D. Reber, Taber H. Smith, Faisal S. Maniar
  • Patent number: 12254646
    Abstract: A system for refining a six degrees of freedom pose estimate of a target object based on a one-dimensional measurement includes a camera and a range-sensing device. The range-sensing device is configured to determine an actual distance measured between the range-sensing device and an actual point of intersection. The range-sensing device projects a line-of-sight that intersects with the target object at the actual point of intersection. The system also includes one or more processors in electronic communication with the camera and the range-sensing device and a memory coupled to the processors. The memory stores data into one or more databases and program code that, when executed by the processors, causes the system to predict the six degrees of freedom pose estimate of the target object. The system also determines a revised six degrees of freedom pose estimate of the target object based on at least an absolute error.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: March 18, 2025
    Assignee: The Boeing Company
    Inventors: William K Leach, Leon Nguyen, Fan Hung, Yang Chen, Deepak Khosla, Haden H. Smith
  • Patent number: 12251342
    Abstract: An embodiment of a storage device for medical products includes a cabinet defining an enclosure having a plurality of compartments. In addition, the storage device includes a plurality of storage containers, each storage container configured to be inserted into a corresponding one of the plurality of compartments. Further, the storage device includes an actuation assembly including a plurality of arms that are configured to engage the plurality of storage containers so as to secure the plurality of storage containers in the plurality of compartments. Still further, the storage device includes a release mechanism that is configured to simultaneously actuate each of the plurality of arms to release the plurality of storage containers from the plurality of compartments.
    Type: Grant
    Filed: December 15, 2023
    Date of Patent: March 18, 2025
    Assignee: HELMER SCIENTIFIC, LLC
    Inventors: Thomas J. Larkner, David A. Ferrer, Jesse M. Smith, Dennis H. Smith, Adam A. Cloud, Mark D. Lockwood, Mark G. Loeffelholz, James R. Edwards
  • Patent number: 12252471
    Abstract: The present invention is directed to novel compounds of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof. Pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, are also described. The invention is also directed to use of the compounds of Formula (I) for treating a condition in a mammal associated with AhR imbalance, such as an inflammatory disease or disorder.
    Type: Grant
    Filed: October 20, 2023
    Date of Patent: March 18, 2025
    Assignee: DERMAVANT SCIENCES GMBH
    Inventors: Channa K. Jayawickreme, Susan H. Smith, Cunyu Zhang, William Zuercher
  • Publication number: 20250067400
    Abstract: Various embodiments of the present technology relate to systems and methods to determine fill levels in a fuel extraction and storage environment. In some examples, a system comprises a thermal imaging device, a machine learning interface, and a machine learning engine. The thermal imaging device generates a thermal image that depicts fuel storage equipment. The machine learning interface generates feature vectors based on the thermal image that depicts the fuel storage equipment and feeds the feature vectors to a machine learning engine. The machine learning engine ingests the feature vectors, generates a machine learning output that indicates a fill level for the fuel storage equipment based on the feature vectors, and transfers the machine learning output.
    Type: Application
    Filed: August 25, 2023
    Publication date: February 27, 2025
    Inventors: Mehdi Korjani, Elnaz E. Ramezani, David A. Conley, Mark H. Smith
  • Publication number: 20250049728
    Abstract: The present disclosure provides processes for controlled high-throughput preparation of lipid nanoparticle with defined parameters, e.g., processes for preparing lipid nanoparticles (LNPs), using a T-Mixer (e.g., a T-Mixer as described herein). The present disclosure also provides lipid nanoparticle solutions (LNP solutions) and lipid nanoparticles (LNPs) being prepared by the processes.
    Type: Application
    Filed: December 15, 2022
    Publication date: February 13, 2025
    Inventors: Chang TIAN, Michael H. SMITH, Benjamin GELDHOF
  • Patent number: 12208389
    Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: January 28, 2025
    Assignee: Pfizer Inc.
    Inventors: Frank B. Myers, III, Clay D. Reber, Taber H. Smith, Faisal S. Maniar
  • Patent number: 12174841
    Abstract: Techniques for suggesting media assets, the technique including: requesting a set of candidate media assets for a set of user media items based on a knowledge graph metadata network describing the set of user media items; receiving metadata for the set of candidate media assets; determining one or more sets of ranked media assets based on the received metadata; and outputting the determined one or more sets of ranked media assets.
    Type: Grant
    Filed: May 2, 2022
    Date of Patent: December 24, 2024
    Assignee: Apple Inc.
    Inventors: Nathaniel B. Chapman, Patrick H. Kelly, Eric Circlaeys, Kevin Bessiere, Brian J. Rogosky, Alfredo Ramos-Alvarez, Bruno J. Conejo, Matthias Mauch, Hao Yang, Bruno Di Giorgi, Jeremy P. Bogle, Zachary H. Smith, Betim Deva, Daniel Cartoon, Neil C. Foley, Menelaos D. Kokolios, Lewis Kaneshiro, Jorge A. Herrera Soto, James E. Hewitt, Casey W. Baker, Alexa Rockwell, Alexis H. Durocher, Trevor M. Slaton, Cristina N. Smith
  • Publication number: 20240405871
    Abstract: Disclosed herein is a method for communicating between platforms, comprising the steps of initializing a first platform and a second platform; optically tracking a movement of the second platform by the first platform; and optically communicating bi-directionally between the first platform and the second platform. Disclosed herein is an optical communication device comprising various elements including but not limited to: a processor configured to provide at least a tracking mode and a communications mode; an input-output interface coupled to the processor; an electro-optic controller coupled to the input-output interface; an acquisition-tracking portion coupled to the electro-optic controller; and a communication portion coupled to the electro-optic controller.
    Type: Application
    Filed: June 2, 2023
    Publication date: December 5, 2024
    Applicant: 4S SILVERSWORD SOFTWARE AND SERVICES LLC
    Inventors: WILLIAM ROBERT ALLEN ZIEGLER, RONALD H. SMITH
  • Patent number: D1058756
    Type: Grant
    Filed: November 15, 2023
    Date of Patent: January 21, 2025
    Inventors: Alexander Reed, Nicholas Lee Martinchek, Scott H. Smith, Lee M. Marchetti, Edward A. Gilchrest, Jr., Frank Von Holzhausen