Abstract: An assembly and a method are provided for manufacturing a joined assembly. A method for manufacturing includes fitting together and datuming a beam and a node, wherein at least one of the beam and the node is formed with an aperture, and wherein a cylindrical interface is formed between the beam and node. Further, the method includes advancing a mechanical fastener through the aperture to temporarily hold the beam and the node in an engagement. Also, the method includes injecting a structural adhesive into the cylindrical interface between the beam and the node. The method includes final joining the beam and the node by curing the structural adhesive.

Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.

Abstract: A system for refining a six degrees of freedom pose estimate of a target object based on a one-dimensional measurement includes a camera and a range-sensing device. The range-sensing device is configured to determine an actual distance measured between the range-sensing device and an actual point of intersection. The range-sensing device projects a line-of-sight that intersects with the target object at the actual point of intersection. The system also includes one or more processors in electronic communication with the camera and the range-sensing device and a memory coupled to the processors. The memory stores data into one or more databases and program code that, when executed by the processors, causes the system to predict the six degrees of freedom pose estimate of the target object. The system also determines a revised six degrees of freedom pose estimate of the target object based on at least an absolute error.

Abstract: The present invention is directed to novel compounds of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof. Pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, are also described. The invention is also directed to use of the compounds of Formula (I) for treating a condition in a mammal associated with AhR imbalance, such as an inflammatory disease or disorder.

Abstract: An embodiment of a storage device for medical products includes a cabinet defining an enclosure having a plurality of compartments. In addition, the storage device includes a plurality of storage containers, each storage container configured to be inserted into a corresponding one of the plurality of compartments. Further, the storage device includes an actuation assembly including a plurality of arms that are configured to engage the plurality of storage containers so as to secure the plurality of storage containers in the plurality of compartments. Still further, the storage device includes a release mechanism that is configured to simultaneously actuate each of the plurality of arms to release the plurality of storage containers from the plurality of compartments.

Abstract: Various embodiments of the present technology relate to systems and methods to determine fill levels in a fuel extraction and storage environment. In some examples, a system comprises a thermal imaging device, a machine learning interface, and a machine learning engine. The thermal imaging device generates a thermal image that depicts fuel storage equipment. The machine learning interface generates feature vectors based on the thermal image that depicts the fuel storage equipment and feeds the feature vectors to a machine learning engine. The machine learning engine ingests the feature vectors, generates a machine learning output that indicates a fill level for the fuel storage equipment based on the feature vectors, and transfers the machine learning output.

Abstract: The present disclosure provides processes for controlled high-throughput preparation of lipid nanoparticle with defined parameters, e.g., processes for preparing lipid nanoparticles (LNPs), using a T-Mixer (e.g., a T-Mixer as described herein). The present disclosure also provides lipid nanoparticle solutions (LNP solutions) and lipid nanoparticles (LNPs) being prepared by the processes.

Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.

Abstract: Techniques for suggesting media assets, the technique including: requesting a set of candidate media assets for a set of user media items based on a knowledge graph metadata network describing the set of user media items; receiving metadata for the set of candidate media assets; determining one or more sets of ranked media assets based on the received metadata; and outputting the determined one or more sets of ranked media assets.

Abstract: Disclosed herein is a method for communicating between platforms, comprising the steps of initializing a first platform and a second platform; optically tracking a movement of the second platform by the first platform; and optically communicating bi-directionally between the first platform and the second platform. Disclosed herein is an optical communication device comprising various elements including but not limited to: a processor configured to provide at least a tracking mode and a communications mode; an input-output interface coupled to the processor; an electro-optic controller coupled to the input-output interface; an acquisition-tracking portion coupled to the electro-optic controller; and a communication portion coupled to the electro-optic controller.

Abstract: A catheter device for crossing occlusions includes an elongate catheter shaft, a rotatable tip configured to rotate relative to the elongate catheter shaft, a drive shaft, and an OCT imaging sensor. The rotatable tip includes a central guidewire lumen, a distal grinding surface, and a fluted portion. The distal grinding surface can be substantially perpendicular to the guidewire lumen and include divots and sharp points that form pyramidal features, where the sharp points extend distally from the distal grinding surface. The fluted portion can have flutes extending around a circumference of the rotatable tip proximal to the distal grinding surface. The fluted portion may not include the divots and sharp points that form the pyramidal features of the distal grinding surface.

Abstract: A distributed control system and method for decentralized, collaborative platform navigation, routing, and/or control are disclosed employing a distributed, factorized positioning, navigation, and timing chain that can link platforms or nodes having local sensors together by their local inertial and ranging measurements. In the distributed, factorized PNT chain, each platform maintains and contributes local measurements as states to a set of dynamically assigned parent node for a platform cluster, each parent nodes and associated clusters links to at least one other parent node aggregates the states of the platforms in the cluster and passes/propagates states of a linked clustered.

Abstract: Provided are lipid nanoparticle compositions, and processes for their preparation, which are useful for the delivery of therapeutic or prophylactic agents to airway epithelium in patients.

Abstract: An assembly and a method are provided for manufacturing a joined assembly. A method for manufacturing includes fitting together and datuming a beam and a node, wherein at least one of the beam and the node is formed with an aperture, and wherein a cylindrical interface is formed between the beam and node. Further, the method includes advancing a mechanical fastener through the aperture to temporarily hold the beam and the node in an engagement. Also, the method includes injecting a structural adhesive into the cylindrical interface between the beam and the node. The method includes final joining the beam and the node by curing the structural adhesive.

Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.

Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.

Abstract: Provided are empty lipid nanoparticle compositions, and processes for their preparation, which are useful in the preparation of therapeutic or prophylactic lipid nanoparticle compositions comprising a therapeutic or prophylactic agent including, for example, nucleic acids such as mRNA.

Abstract: A method of stabilizing a marking process speed in a printing system, the printing system including a vacuum transport belt and at least one sheet onto which marking material is directly applied to print sheets, the method including printing an image on the sheet, receiving, from a sensor, data related to the image, determining, based on the data, at least one actual dimension of the image, determining if the at least one actual dimension of the image is equal to a target dimension of the image, and if the at least one actual dimension is not equal to the target dimension, adjusting one or more components of the printing system.

Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.