Abstract: A catheter device for crossing occlusions includes an elongate catheter shaft, a rotatable tip configured to rotate relative to the elongate catheter shaft, a drive shaft, and an OCT imaging sensor. The rotatable tip includes a central guidewire lumen, a distal grinding surface, and a fluted portion. The distal grinding surface can be substantially perpendicular to the guidewire lumen and include divots and sharp points that form pyramidal features, where the sharp points extend distally from the distal grinding surface. The fluted portion can have flutes extending around a circumference of the rotatable tip proximal to the distal grinding surface. The fluted portion may not include the divots and sharp points that form the pyramidal features of the distal grinding surface.

Abstract: An assembly and a method are provided for manufacturing a joined assembly. A method for manufacturing includes fitting together and datuming a beam and a node, wherein at least one of the beam and the node is formed with an aperture, and wherein a cylindrical interface is formed between the beam and node. Further, the method includes advancing a mechanical fastener through the aperture to temporarily hold the beam and the node in an engagement. Also, the method includes injecting a structural adhesive into the cylindrical interface between the beam and the node. The method includes final joining the beam and the node by curing the structural adhesive.

Abstract: A distributed control system and method for decentralized, collaborative platform navigation, routing, and/or control are disclosed employing a distributed, factorized positioning, navigation, and timing chain that can link platforms or nodes having local sensors together by their local inertial and ranging measurements. In the distributed, factorized PNT chain, each platform maintains and contributes local measurements as states to a set of dynamically assigned parent node for a platform cluster, each parent nodes and associated clusters links to at least one other parent node aggregates the states of the platforms in the cluster and passes/propagates states of a linked clustered.

Abstract: Provided are lipid nanoparticle compositions, and processes for their preparation, which are useful for the delivery of therapeutic or prophylactic agents to airway epithelium in patients.

Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.

Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.

Abstract: Provided are empty lipid nanoparticle compositions, and processes for their preparation, which are useful in the preparation of therapeutic or prophylactic lipid nanoparticle compositions comprising a therapeutic or prophylactic agent including, for example, nucleic acids such as mRNA.

Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.

Abstract: A method of stabilizing a marking process speed in a printing system, the printing system including a vacuum transport belt and at least one sheet onto which marking material is directly applied to print sheets, the method including printing an image on the sheet, receiving, from a sensor, data related to the image, determining, based on the data, at least one actual dimension of the image, determining if the at least one actual dimension of the image is equal to a target dimension of the image, and if the at least one actual dimension is not equal to the target dimension, adjusting one or more components of the printing system.

Abstract: Provided herein are agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.

Abstract: The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents —N? or —CH?, X2 represents —CH? or —N?, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.

Abstract: Methods provide device authentication for an intrusion detection system implementing building automation and control network (BACnet) Master-Slave/Token-Passing (MS/TP). An authentication protocol provides countermeasures to vulnerabilities in the BACnet MS/TP physical layer by utilizing an extended message format to cloak device identifiers (IDs). Adversaries are prevented from using known device IDs to gain access to the network. An authenticating device hashes a device identifier of a device to be authenticated combined with a random number. The authenticating device receives a hash of the random number plus the device identifier from the device. The authenticating device compares the hashes and authenticates the device if the hashes match. To transmit the hash, the BACnet MS/TP frame format includes an extended header cyclic redundancy check (CRC) field having bytes reallocated from the data field of the frame format.

Abstract: A downhole power generation system includes a generator that generates AC input power having a variable input voltage that varies based on a rotational rate of a turbine, which in turn is based on a variable flow rate of a fluid flow. An active rectifier converts the AC power having the variable input voltage to DC power having a constant output voltage. This may increase the range of usable input voltages and decrease a number of flow kits used in a downhole drilling assembly.

Abstract: The present invention is directed to novel compounds of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof. Pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, are also described. The invention is also directed to use of the compounds of Formula (I) for treating a condition in a mammal associated with AhR imbalance, such as an inflammatory disease or disorder.

Abstract: Provided herein are elastomeric materials for use in medical devices and methods of making elastomeric materials, the elastomeric materials including a rubber composition and a phase-separating composition. Also provided herein are medical devices including elastomeric materials, the elastomeric materials including a rubber composition and a phase-separating composition.

Abstract: A print job is processed to produce printed output using a printing component of a device. An input/output device (of the device) is controlled by a processor of the device to output signals to finishing equipment. Such finishing equipment is adapted to manipulate the printed output. The processor of the device causes the signals to include an initial signal indicating the start of a data transfer and subsequent signals following the initial signal. The signals can be in industry-standard format or a format compatible with the finishing device.

Abstract: Provided herein are agonists of the apelin receptor of Formula (I): for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.

Abstract: A printing system comprises one or more printheads arranged to eject ink to a deposition region. Print media are held by vacuum suction against a movable support surface, which transports the print media though the deposition region. The vacuum suction is communicated from a vacuum source to the movable support surface via a vacuum plenum. An airflow control system comprises one or more dampers arranged in the vacuum plenum to control airflow between the vacuum source and the movable support surface. The dampers have an adjustable impedance to airflow through the damper. The airflow control system is configured to adjust the impedance of the damper based on a detected condition of the printing system. A detected condition of the printing system may include, for example, a sensed pressure in the vacuum plenum.

Abstract: A processor for supporting secure memory intent is disclosed. The processor of the disclosure includes a memory execution unit to access memory and a processor core coupled to the memory execution unit. The processor core is to receive a request to access a convertible page of the memory. In response to the request, the processor core to determine an intent for the convertible page in view of a page table entry (PTE) corresponding to the convertible page. The intent indicates whether the convertible page is to be accessed as at least one of a secure page or a non-secure page.

Abstract: An emergency dispatch system configured to allow first responders to efficiently utilize video-based systems using static images of a space and to understand a physical layout of the space. The system includes a dispatch processing hub linked via a communications network with client devices. The system further includes data storage storing a static image of a monitored space from a supplemental camera and video of the monitored space from video sources. A map interface generator is provided that is configured for generating a map-based interface for display upon a display device of the client devices. The map-based interface provides access to the static image and to the video. The hub functions to serve the map-based interface to the client devices. The dispatch processing hub responds to user input selecting the static image by providing a view, e.g., a 360-degree view, of the monitored space based on the static image.