Abstract: A method for computer-aided detection of microcalcification clusters using a digital computer obtains digital mammography data for a single view image and normalizes and filters the image data to reduce noise. A first mask is generated and applied to the image data for defining the breast structure, forming a first cropped image. A second mask is generated and applied to the image data for defining muscle structure, forming a second cropped image. An artifact mask corresponding to vascular calcifications and known imaging artifacts is generated and applied to the first and second cropped images, defining first and second artifact-masked cropped images. In a repeated sequence, portions of each artifact-masked cropped image are processed using an enhancement algorithm and reducing edge effects to obtain a set of microcalcification cluster candidates and suspected microcalcification clusters.

Abstract: A method for uniformly planarizing a wafer that includes determining a first wafer warped value at a first zone on the wafer, determining a second wafer warped value at a second zone on the wafer, and calculating a pressure difference based on the first and second wafer warped values at the first and second zones is provided. The method also includes performing a chemical mechanical polishing of the wafer, applying a first pressure based on the first wafer warped value to the wafer at the first zone during the chemical mechanical polishing, and applying a second pressure based on the second wafer warped value to the wafer at the second zone during the chemical mechanical polishing, a difference between the first pressure and the second pressure based on the pressure difference.

Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.

Abstract: A method for computer-aided detection of microcalcification clusters obtains digital mammography data for a single view image and normalizes and filters the image data to reduce noise. A first mask is generated and applied to the image data for defining the breast structure, forming a first cropped image. A second mask is generated and applied to the image data for defining muscle structure, forming a second cropped image. An artifact mask corresponding to vascular calcifications and known imaging artifacts is generated and applied to the first and second cropped images, defining first and second artifact-masked cropped images. In a repeated sequence, portions of each artifact-masked cropped image are processed using an enhancement algorithm and reducing edge effects to obtain a set of microcalcification cluster candidates and suspected microcalcification clusters.

Abstract: A method for computer-aided detection of microcalcification clusters using a digital computer obtains digital mammography data for a single view image and normalizes and filters the image data to reduce noise. A first mask is generated and applied to the image data for defining the breast structure, forming a first cropped image. A second mask is generated and applied to the image data for defining muscle structure, forming a second cropped image. An artifact mask corresponding to vascular calcifications and known imaging artifacts is generated and applied to the first and second cropped images, defining first and second artifact-masked cropped images. In a repeated sequence, portions of each artifact-masked cropped image are processed using an enhancement algorithm and reducing edge effects to obtain a set of microcalcification cluster candidates and suspected microcalcification clusters.

Abstract: Novel capsule imaging devices, systems and methods are provided for in vivo imaging applications, such as for gastrointestinal applications. A swallowable video imaging device, such as a capsule, can be used with a light filter for in vivo illumination of a target tissue that has absorbed a previously administered biological probe. The target tissue can be distinguished in images transmitted from the video imaging device. Quantification of the signal intensity of fluorescence can be used to assess how progressed the target tissue may be. The target tissue can be therapeutically treated to shrink or kill the target tissue.

Abstract: A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating chronic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having chronic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing chronic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g., Nav1.8) can be repressed.

Abstract: The present invention provides a Luo Han Guo whole fruit extract prepared by a process that includes extracting the peel and pulp of Luo Han Guo fruits by boiling water. The resulting whole fruit extract can be formulated into a sugar-free, low calorie, low glycemic index syrup or jam comprising the Luo Han Guo whole fruit extract and sugar alcohols (polyols).

Abstract: The present invention provides a natural sweetener composition comprising powdered extracts of Luo Han Guo whole fruits, mogrosides, and one or more dietary fiber. In one embodiment, extracts obtained from Luo Han Guo whole fruits are first made into powder form. Mogrosides and/or mogroside-V are then added to the powder extract, which is further formulated with dietary fiber such as inulin into a natural sweetener composition.

Abstract: The present invention provides a natural sweetener composition comprising powdered extracts of Luo Han Guo whole fruits, mogrosides, and one or more dietary fiber. In one embodiment, extracts obtained from Luo Han Guo whole fruits are first made into powder form. Mogrosides and/or mogroside-V are then added to the powder extract, which is further formulated with dietary fiber such as inulin into a natural sweetener composition.

Abstract: The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPAR?2, LPL and ?P2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual.

Abstract: An electronic device comprises a substrate and an electrical contact in contact with the dielectric layer and electrically coupled with at least one resistor, a substrate carrier including an electrical trace electrically coupled to the electrical contact, a polymer enclosing the electrical contact, and a substantially planar film disposed over the electrical contact.

Abstract: The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.

Abstract: The present invention provides a method of preparing whole fruit extract from the fruits of the Curcubitaceae family. The method includes extracting the peel and pulp of whole fruits by boiling water. In one embodiment, there is provided Luo Han Guo whole fruit extract. The resulting whole fruit extract can be formulated into a sugar-free or no sugar added, low calorie, low glycemic index syrup or jam comprising, e.g. the Luo Han Guo whole fruit extract and sugar alcohols (polyols).

Abstract: A method for normalizing an image of tissue from a patient. The image type is determined, then the background content values in the image data are distinguished from tissue content values according to the image type. Noise is reduced in the background content values. A look-up table is formed for remapping tissue content values to a predetermined range. Tissue content values are remapped according to the look-up table to provide a normalized image.

Abstract: An illuminated ornament with musical candle works by lighting a candle. The two twisted pieces of conductor wire, which are embedded in the candle and separated from a set of cotton candlewick, will be melted together by candle flame so that the electronic circuit, which is connected with tow pieces of conductor wire from candle, is closed. As a result of the lighted candle, the illuminated ornament with musical candle will play music and shine immediately.

Abstract: Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.

Abstract: Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.

Abstract: A method of characterizing a mass within a digital mammogram. A region of interest is identified that includes the mass and surrounding tissue. A border outline of the mass is identified. A rectangular image is formed wherein each column of the image is formed by repetition of steps. A vector is employed for each of a set of ray angles, wherein the vector extends from a central point of the mass and intersects the border outline at an intersection point. A starting pixel along the vector is identified, between the intersection point and the central point, at a first distance before the intersection point. An ending pixel along the vector is identified at a second distance beyond the intersection point. Pixels along the vector, from the starting pixel to the ending pixel, are remapped as the respective column in the rectangular image. Texture features are extracted from the formed rectangular image.

Abstract: The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.