Patent number: 6410790
Abstract: 3-amino-3-arylpropan-1-ol compounds of formula I:
R1 and R2 independently denoting C1-6 alkyl, or together denoting a (CH2)2-6 ring optionally substituted by phenyl,
R3 denoting C3-6 alkyl, C3-6 cycloalkyl, aryl optionally containing heteroatoms and optionally substituted by R6 to R8, or a substituted C1-3 alkylphenyl of formula XII:
R4 and R5 independently denoting C1-6 alkyl, C3-6 cycloalkyl, phenyl, benzyl, or phenethyl, or together forming a (CH2)3-6 or CH2CH2OCH2CH2 ring,
R6 to R8 independently denoting H, F, Cl, Br, CHF2, CF3, OH, OCF3, OR14, NR15R16, SR14, phenyl, SO2CH3, SO2CF3, C1-6 alkyl, CN, COOR14, or CONR15R16, or together forming a OCH2O, OCH2CH2O, CH═CHO, CH═C(CH3)O or (CH2)4 ring,
R14 denoting C1-6 alkyl, phenyl, benzyl, or phenethyl,
R15 and R16 independently denoting H, C1-6 alkyl, phenyl, benzyl or phenethyl, and
A denoting optionally substituted aryl optionally containing heteroatoms,
or a diastereomer or enantiomer or pharmaceutica
Type:
Grant
Filed:
April 7, 2000
Date of Patent:
June 25, 2002
Assignee:
Gruenenthal GmbH
Inventors:
Bernd Sundermann, Hagen-Heinrich Hennies, Babette-Yvonne Koegel, Helmut Buschmann
