Abstract: A method and apparatus for indirect, quantitative estimation of beat-to-beat arterial blood pressure utilizing the individualized rectifying technique. A function TK=H(P) that describes the relationship between Korotkoff's sound delay time Tk and cuff pressure P is obtained by measuring the different cuff pressure P and corresponding Tk in the Korotkoff's sound sensor that is distal to the cuff. Keep the cuff pressure at a constant value Pm, the blood pressure variance can be calculated using the Korotkoff's sound delay time Tkm, according to the function Tk=H(P). The invention can measure the beat-to-beat artery blood pressure indirectly. The technique can be applied to obtain individual coefficient of regress equation for continuous arterial blood pressure measurement by the instantaneous blood pressure fluctuation, which make the rectifying technique more safe, effective and less erroneous. The technique makes the operation of noninvasive continuous blood pressure measurement for long time more practical.

Abstract: A cable connector comprises: an insulative housing, a front portion of the insulative housing is provided with a mating cavity, and a rear portion of the insulative housing is provided with a receiving cavity, a middle portion of the insulative housing is vertically provided with a spacing wall to separate the mating cavity from the receiving cavity in a front-rear direction, the rear portion of the insulative housing is provided with four fixing holes communicating with the receiving cavity; two circuit boards arranged and spaced apart in an up-down direction, each circuit board comprises a mating portion protruding forwardly into the mating cavity and a wire connection portion positioned in the receiving cavity; a plurality of wires electrically connected to the wire connection portions of the circuit boards; an outer molding formed in the receiving cavity by injection molding and correspondingly formed with four fixing protrusions engaging with the four fixing hole; the outer molding covers the wires there

Abstract: Image sensors may include imaging pixels that have comparators to read out image pixel signals. An imaging pixel may include a photodiode, a floating diffusion region, and a transfer transistor that transfers charge from the photodiode to the floating diffusion region. The floating diffusion region may be coupled to a source follower transistor. The source follower transistor may be coupled to a current source. A row select transistor may be interposed between the source follower transistor and the current source. To form an in-column comparator stage and reduce power consumption, an additional transistor may be interposed between the row select transistor and the current source. The additional transistor may be a pMOS transistor and the source follower transistor may be an nMOS transistor. The additional transistor may have a gate that receives a searching voltage that is ramped from a maximum value to a minimum value.

Abstract: Image sensors may include imaging pixels that have comparators to read out image pixel signals. An imaging pixel may include a photodiode, a floating diffusion region, and a transfer transistor that transfers charge from the photodiode to the floating diffusion region. The floating diffusion region may be coupled to a source follower transistor. The source follower transistor may be coupled to a current source. A row select transistor may be interposed between the source follower transistor and the current source. To form an in-column comparator stage and reduce power consumption, an additional transistor may be interposed between the row select transistor and the current source. The additional transistor may be a pMOS transistor and the source follower transistor may be an nMOS transistor. The additional transistor may have a gate that receives a searching voltage that is ramped from a maximum value to a minimum value.

Abstract: An imaging sensor may include an array of imaging pixels and at least two rows of dark pixels. Each imaging pixel may include a photodiode that generates charge in response to incident light. Each dark pixel may include a photodiode that is shielded from incident light by shielding material. The at least two rows of dark pixels may be sampled simultaneously and averaged to obtain an average dark pixel charge level. The average dark pixel charge level may be subtracted from each imaging pixel charge level to correct the imaging pixel charge levels for noise. Each column of dark pixels may include a column line that is coupled to first and second readout circuits. Each column line may be coupled to first and second current sources. Each column line may be coupled to at least one capacitor.

Abstract: The present disclosure relates to methods for treating or preventing obesity and/or nonalcoholic fatty liver diseases (NAFLDs) and/or nonalcoholic steatohepatitis (NASH) using a glucagon receptor blocking agent. In various embodiments, the present disclosure relates to methods for treating or preventing NAFLD/NASH using antigen binding and antagonizing proteins, e.g., fully human antibodies, that specifically bind to and antagonize the function of the human glucagon receptor.

Abstract: Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven anaplastic oligodendrogliomas with chromosome 1p and 19q losses. Among other changes, we found that that CIC (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six of the seven cases and that FUBP1 (far upstream element (FUSE) binding protein) on chromosome 1p was somatically mutated in two of the seven cases. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins.

Abstract: Methods that rapidly, sensitively, and specifically detect mutations in IDH1/2 and the TERT promoter employ amplification of particular portions of the genes that experience frequent and exquisitely localized mutations. The ability to distinguish between sequences that differ only by one nucleotide and which may be present in very low ratios is essential for such an assay.

Abstract: The present disclosure relates to methods for treating type 1 diabetes (T1D) using a glucagon receptor blocking agent. More specifically, the present disclosure relates to methods for treating T1D using substantially lower doses of insulin supple-mentation, or even in the absence of insulin supplementation, using antigen binding and antagonizing proteins, e.g., fully human antibodies that specifically bind to and antagonize the function of the human glucagon receptor.

Abstract: We provide IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous and IDH1R132H homozygous) derived from dissociated human astrocytoma samples. The cells can be used alone or in combination with each other or other cell types as a tool for determining the impact of IDH1R132H on cellular biology, tumorigenesis, and metabolic profiles. The cell lines may be used to test and identify therapeutic targets and to screen for molecular therapeutic agents.

Abstract: Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.

Abstract: The present invention relates to methods for treating or preventing heart failure using a glucagon receptor antagonist or modulator. In various embodiments, the present invention relates to methods for treating post-myocardial infarction heart failure and lateral ventricular (LV) remodeling. In various embodiments, the present invention relates to methods for treating diabetic cardiomyopathy.

Abstract: A scheduling method includes: determining whether a valid time interval is shorter than a first time interval; and when the valid time interval is smaller than the first time interval, performing a search for a time length of N predetermined search cycles. In each of the predetermined search cycles, N consecutive TD-SCDMA sub-frames are regarded as a group, and one fixed sub-frame in the group is selected for the search. In the N predetermined search cycles, the fixed sub-frames selected from the group in respective predetermined search cycles are different. N is a natural number greater than or equal to 2.

Abstract: The present invention relates to a polycyclohexylene-dimethylene terephthalate resin composition, more specifically to an economical, high color-resistant, flame-retardant polycyclohexylene-dimethylene terephthalate resin composition containing a non-halogen flame retardant aid, bis(2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-oxo-4-hydroxymethyl) phenylphosphonate. Further, a flame-retardant molded article using features of a resin composition according to the present invention may be used as various electrical and electronic components including display or automobile parts.

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

Abstract: Illustrative embodiments provide a computer-implemented method for a generic data model for event monitoring integration. The computer-implemented method generates monitor application descriptor data for an identified candidate, identifies a target monitor model specification associated with the identified candidate to form an identified target monitor model specification, and responsive to identifying the target monitor model specification, provides the monitor application descriptor data and the identified target monitor model specification, to a monitor model generator. The computer-implemented method further identifies application elements of the identified candidate to be monitored to form identified elements, and generates the identified monitor model for the identified elements to create a monitor-specific output.

Abstract: Genetic signatures capable of distinguishing among several types of gliomas provide clinically relevant information that can serve as an adjunct to histopathological diagnosis. For example, mutations in the TERT promoter occurred in 74.2% of glioblastomas (GBM), but occurred in a minority of Grade II-III astrocytomas (18.2%). In contrast, IDH1/2 mutations were observed in 78.4% of Grade II-III astrocytomas, but were uncommon in primary GBM. The genetic signatures permit the stratification of the glioma patients into distinct cohorts.

Abstract: A dispensing device for release of an air treatment material includes a semi-permeable substrate having a mesh size between about 15 strands per cm to about 79 strands per cm and a support component for supporting the semi-permeable substrate. The dispensing device releases the air treatment material at a rate of at least about 0.05 mg/hr at about 25° C.

Abstract: Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to which thousands of copies of DNA identical in sequence to the original are bound. This population of beads then corresponds to a one-to-one representation of the starting DNA molecules. Variation within the original population of DNA molecules can then be simply assessed by counting fluorescently-labeled particles via flow cytometry Millions of individual DNA molecules can be assessed in this fashion with standard laboratory equipment. Moreover, specific variants can be isolated by flow sorting and employed for further experimentation.

Abstract: A support for the display device includes a base portion, a stand portion, and a first bent portion between the base portion and the stand portion. The support further includes a wire passage defined through the base portion, the stand portion, and the first bent portion. One end of the wire passage can be connected to edges of the base portion, and define a first opening. The other end of the wire passage can be connected to a fastening end of the stand portion, and define a second opening coupled to the first opening. A plurality of the storage devices and power lines can be coupled to the first opening, so it is convenient to plug in or unplug the storage devices and power line. The present disclosure also provides a display device.