Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

Abstract: Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to which thousands of copies of DNA identical in sequence to the original are bound. This population of beads then corresponds to a one-to-one representation of the starting DNA molecules. Variation within the original population of DNA molecules can then be simply assessed by counting fluorescently-labeled particles via flow cytometry. Millions of individual DNA molecules can be assessed in this fashion with standard laboratory equipment. Moreover, specific variants can be isolated by flow sorting and employed for further experimentation.

Abstract: A method and system for generating a job alert. According to embodiments of the present invention, before a target job is processed, a characteristic of input and output of the target job in at least one stage is determined through analyzing a historical job, and a resource overhead associated with the processing of the target job is calculated based on the characteristic of input and output. Then, an alert for the target job is generated in response to the resource overhead exceeding a predetermined threshold. In such manner, an alert for the target job can be proactively generated before the resource overhead problem occurs, so as to enable an administrator or developer to discover a fault in advance and adopt measures actively to avoid loss and damage to the intermediate results or output data when the target job is processed.

Abstract: An imager may include an array of pixels. The pixel array may be arranged in rows and columns. Each pixel of the pixel array may include a photodiode that is coupled to a floating diffusion region by a transfer gate. A source-follower transistor may be coupled between the floating diffusion region and a pixel output node. The imager may include ramp circuitry that provides a ramp signal to the floating diffusion region. A capacitor interposed between the ramp circuitry and the floating diffusion region may be used in conveying the ramp signal to the floating diffusion region. The pixel may be coupled to a comparator that is implemented using separate circuitry or may include portions of the pixel.

Abstract: Expression of GLUD1, GLUD2, or both is tested in gliomas, leukemias, or suspected gliomas and leukemias. Up-regulation of expression is found in IDH1/IDH2 mutant cancers. Inhibition of GLUD1, GLUD2, or both can be used therapeutically to inhibit cancer growth. Assays for GLUD1, GLUD2, or both GLUD1 expression can measure RNA or protein or enzyme activity, for example.

Abstract: A method, system and computer readable storage medium for replicating database data of heterogeneous data type are disclosed. The method includes determining the data type of an element of heterogeneous data type to be replicated. The element is packed into a predetermined transfer format as an opaque data type, based on the determined data type, and replicated to a replication server. The replication server is instructed to not modify the element noted as opaque.

Abstract: We surveyed 1,230 tumors of 60 different types and found that tumors could be divided into types with low (<15%) and high (?15%) frequencies of TERT promoter mutations. The nine TERT-high tumor types almost always originated in tissues with relatively low rates of self renewal, including melanomas, liposarcomas, hepatocellular carcinomas, urothelial carcinomas, squamous cell carcinomas of the tongue, medulloblastomas, and subtypes of gliomas (including 83% of primary glioblastoma, the most common brain tumor type). TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages. In addition to their implications for understanding the relationship between telomeres and tumorigenesis, TERT mutations provide a biomarker for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.

Abstract: A scheduling method includes: determining whether a valid time interval is shorter than a first time interval; and when the valid time interval is smaller than the first time interval, performing a search for a time length of N predetermined search cycles. In each of the predetermined search cycles, N consecutive TD-SCDMA sub-frames are regarded as a group, and one fixed sub-frame in the group is selected for the search. In the N predetermined search cycles, the fixed sub-frames selected from the group in respective predetermined search cycles are different. N is a natural number greater than or equal to 2.

Abstract: A support for the display device includes a base portion, a stand portion, and a first bent portion between the base portion and the stand portion. The support further includes a wire passage defined through the base portion, the stand portion, and the first bent portion. One end of the wire passage can be connected to edges of the base portion, and define a first opening. The other end of the wire passage can be connected to a fastening end of the stand portion, and define a second opening coupled to the first opening. A plurality of the storage devices and power lines can be coupled to the first opening, so it is convenient to plug in or unplug the storage devices and power line. The present disclosure also provides a display device.

Abstract: The present invention relates to a polycyclohexylene-dimethylene terephthalate resin composition, more specifically to an economical, high color-resistant, flame-retardant polycyclohexylene-dimethylene terephthalate resin composition containing a non-halogen flame retardant aid, bis(2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-oxo-4-hydroxymethyl)phenylphosphonate. Further, a flame-retardant molded article using features of a resin composition according to the present invention may be used as various electrical and electronic components including display or automobile parts.

Abstract: A volatile material dispensing system (100) includes a base (104) and a refill (102) attached to the base (104). The refill (102) includes a substrate (108) having a volatile material thereon. The dispensing system (100) further includes a cover (106). In an inactive state, the refill (102) is compressed within the cover (106) and the cover (106) is attached to the base (104) and in an active state, the cover (106) is removed from the base and the refill (102) automatically expands such that the volatile material is released from the substrate (108) and into the ambient environment.

Abstract: IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous) have been made from a robust cell line, HCT116. The IDH1 gene-defective cell lines can be used to determine the effect of IDH1R132H on cell biology, tumorigenesis, and cellular metabolic profiles. These cell lines can be used to test potential therapeutic targets and to screen potential therapeutic agents. Kits and xenografts are also contemplated.

Abstract: Electronic devices may include image sensors having image pixel arrays with image pixels arranged in pixel rows and pixel columns. Each pixel column may be coupled to a column line having column readout circuitry. The column readout circuitry on each column line may include signal processing circuitry and a latch circuit. The latch circuit on each column line may be used to selectively enable and disable the signal processing circuitry on that column line. Each latch circuit may be coupled to first and second signal lines for globally enabling and disabling the signal processing circuitry on all of the column lines. Each latch circuit may be coupled to column decoder circuitry. The column decoder circuitry may provide a column-select signal to latch circuits on a chosen subset of column lines that enables the signal processing circuitry on those column lines by setting those latch circuits.

Abstract: Electronic devices may include image sensors having image sensor pixels that are coupled to analog-to-digital converters (ADCs). Each ADC may be a sub-ranged ramp ADC that uses a first set of reference voltages to determine a coarse code and a second set of ramping voltages to determine a fine code. In the presence of parasitic capacitances, the reference voltages and the ramp voltages exhibit mismatch that causes the ADC to exhibit non-idealities such as missing codes. Calibration operations may be performed that involve obtaining a first code at a first predetermined input voltage level and obtaining a second code at a second predetermined input voltage level. A code correction value can then be computed based on the first and second codes. The code correction value can be selectively applied to the final ADC code to correct for missing codes.

Abstract: An imager may include an array of pixels. The pixel array may be arranged in rows and columns. Each pixel of the pixel array may include a photodiode that is coupled to a floating diffusion region by a transfer gate. A source-follower transistor may be coupled between the floating diffusion region and a pixel output node. The imager may include ramp circuitry that provides a ramp signal to the floating diffusion region. A capacitor interposed between the ramp circuitry and the floating diffusion region may be used in conveying the ramp signal to the floating diffusion region. The pixel may be coupled to a comparator that is implemented using separate circuitry or may include portions of the pixel.

Abstract: IDH1-mutant cell lines and xenografts (e.g., IDH1R132H heterozygous and IDH1R132H homozygous) are derived from human glioblastoma multiforme (GBM) samples. Methods use said cells and xenografts as tools for determining the impact of IDH1R132H on cancer properties including cellular morphology, tumorigenesis, DNA, apoptosis, and metabolic profiles. Methods also use these cell lines for the screening and identification of candidate therapeutic targets.

Abstract: A metal gate electrode for a field emission device includes a plurality of metal strips. Some of the metal strips are arranged substantially along a first direction, and other metal strips are arranged substantially along a second direction substantially perpendicular to the first direction. The metal strips are connected to each other to define a plurality of rectangular apertures through which electrons can pass.

Abstract: A kind of photosensitive carbon nanotube slurry is disclosed. The photosensitive carbon nanotube slurry includes a first mixture and a second mixture. The first mixture includes carbon nanotubes, conducting particles, and a first organic carrier. The second mixture includes a photo polymerization monomer, a photo initiator, and a second organic carrier. The weight percentage of the first mixture and the second mixture ranges from about 50% to about 80% and about 20% to about 50%, respectively. Methods for making the photosensitive carbon nanotube slurry and methods for making cathode emitters using the photosensitive carbon nanotube slurry are also disclosed.