Abstract: Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

Abstract: An integrated circuit includes a saw-tooth generator including a saw tooth node configured to have a saw-tooth voltage generated thereon; and a first switch having a first end connected to the saw tooth node. The integrated circuit further includes a second switch coupled between an output node and an electrical ground, wherein the first switch and the second switch are configured to operate synchronously. A first current source is connected to the saw tooth node. A second current source is connected to the output node.

Abstract: An integrated circuit includes a saw-tooth generator including a saw tooth node configured to have a saw-tooth voltage generated thereon; and a first switch having a first end connected to the saw tooth node. The integrated circuit further includes a second switch coupled between an output node and an electrical ground, wherein the first switch and the second switch are configured to operate synchronously. A first current source is connected to the saw tooth node. A second current source is connected to the output node.

Abstract: A boost converter includes an input terminal and an output terminal. A first switch is connected between a first intermediate node and a reference potential node. An inductive component is connected between the input terminal and the first intermediate node. A rectifying component is connected between the first intermediate node and a second intermediate node. A multi-state module is connected between the second intermediate node and the output terminal, and has at least a low resistance state and a high resistance state. A control module is coupled to the output terminal, the first switch and the multi-state module, and is operable in response to an output voltage to control the first switch and the multi-state module so that the first switch is open and the multi-state module is in the high resistance state if the output voltage is lower than a threshold value.

Abstract: 5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.

Abstract: The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: A polycrystalline abrasive composite cutter, including a tool body with a top cutting surface and a flank surface. The composite cutter, joined to a substrate, constitute a shear cutter for a PDC bit, roller-cone bit insert, or other tool that can be highly useful for petroleum drilling or other applications. The body of the polycrystalline abrasive composite cutter includes a plurality of polycrystalline abrasive layers (90) and a plurality of arresting layers (100). The polycrystalline abrasive layers (90) and the arresting layers (100) are arranged to alternate throughout the tool body in a direction normal to the top cutting surface (92) and in a direction normal to a flank surface (94).

Abstract: Disclosed is a single switch integrated electronic ballast circuit for a fluorescent lamp, comprising an input for receiving a rectified DC voltage; a power factor correction portion for shaping the input line current to substantially a sinusoidal waveform and in phase with the rectified voltage, wherein the power factor correction portion includes capacitors; an energy storage portion for storing energy during dimming operations of the fluorescent lamp, wherein the capacitors also form part of the energy storage portion; an inverter with a resonant tank forming a resonant circuit for converting the DC voltage to an AC voltage to be delivered to the lamp; and a single switch for: 1) shaping the input line current to a substantially sinusoidal waveform as part of the power factor correction portion; and 2) providing a square voltage waveform across the input of the resonant circuit resulting in a substantially symmetrical waveform across the output of the resonant circuit.

Abstract: A system that incorporates teachings of the present disclosure may include, for example, a mobile voice over internet protocol communication device, comprising a controller operable to register with a voice over internet protocol call processing system by way of a wireless fidelity access point operating in a cluster of wireless fidelity access points, and re-register with the voice over Internet Protocol call processing system by way of the wireless fidelity access point in response to receiving a re-registration request upon expiration of a timer having a period determined from one or more usage characteristics of the cluster by the mobile voice over Internet Protocol communication device. Additional embodiments are disclosed.

Abstract: A system that incorporates teachings of the present disclosure may include, for example, a mobile Voice over IP (VoIP) communication device (MVCD) having a controller element to register with a VoIP call processing system by way of a Wireless Fidelity (WiFi) access point operating in a cluster of WiFi access points each having cell coverage area, and re-register with the VoIP call processing system by way of the WiFi access point in response to receiving a re-registration request upon expiration of a timer having a period determined from one or more behavioral attributes of the MVCD. Additional embodiments are disclosed.

Abstract: An integrated circuit includes a saw-tooth generator including a saw tooth node configured to have a saw-tooth voltage generated thereon; and a first switch having a first end connected to the saw tooth node. The integrated circuit further includes a second switch coupled between an output node and an electrical ground, wherein the first switch and the second switch are configured to operate synchronously. A first current source is connected to the saw tooth node. A second current source is connected to the output node.

Abstract: An integrated circuit includes a DC-DC converter, which includes an inductor; a first transistor coupled to the inductor and configured to pass an inductor current to the inductor; and a second transistor forming a current mirror with the first transistor. The integrated circuit further includes an operational amplifier. The operational amplifier includes a first input node and a second input node. The first input node is configured to couple to a drain of the first transistor when the first transistor is turned on, and decoupled from the drain of the first transistor when the first transistor is turned off. The second input node is coupled to a drain of the second transistor.

Abstract: A zero current detector for a DC-DC converter includes a first transistor having a drain, a gate, and a source for sensing the voltage of a first terminal of a power transistor; a second transistor having a drain, a gate, and a source for sensing the voltage of a second terminal of a power transistor; and a third transistor having a coupled gate and drain for receiving a reference current that is coupled to the gates of the first and second transistors and a source coupled to the source of the first transistor, wherein an output signal is provided by the drains of the first and second transistors. A load is coupled to the drains of the first and second transistors. The zero current detector also includes a fourth transistor having a current path coupled between the source of the second transistor and the second terminal of the power transistor and a gate for receiving a control signal.

Abstract: A polycrystalline abrasive composite cutter, including a tool body with a top cutting surface and a flank surface. The composite cutter, joined to a substrate, constitute a shear cutter for a PDC bit, roller-cone bit insert, or other tool that can be highly useful for petroleum drilling or other applications. The body of the polycrystalline abrasive composite cutter includes a plurality of polycrystalline abrasive layers (90) and a plurality of arresting layers (100). The polycrystalline abrasive layers (90) and the arresting layers (100) are arranged to alternate throughout the tool body in a direction normal to the top cutting surface (92) and in a direction normal to a flank surface (94). According to the design, the arresting layers (100) can be oriented so as to substantially arrest crack propagation through the polycrystalline abrasive material.

Abstract: A zero current detector for a DC-DC converter includes a first transistor having a drain, a gate, and a source for sensing the voltage of a first terminal of a power transistor; a second transistor having a drain, a gate, and a source for sensing the voltage of a second terminal of a power transistor; and a third transistor having a coupled gate and drain for receiving a reference current that is coupled to the gates of the first and second transistors and a source coupled to the source of the first transistor, wherein an output signal is provided by the drains of the first and second transistors. A load is coupled to the drains of the first and second transistors. The zero current detector also includes a fourth transistor having a current path coupled between the source of the second transistor and the second terminal of the power transistor and a gate for receiving a control signal.

Abstract: Methods and apparatus to manage a bonded digital subscriber line (DSL) service are disclosed. A disclosed example method comprises collecting data representative of bandwidth usage for two or more applications serviced by a bonded set of subscriber lines; analyzing historical activity of the two or more applications based on the collected bandwidth usage data; and selecting a first digital subscriber line (DSL) line profile for a first wire pair in the set of subscriber lines, the set of subscriber lines forming a single DSL communication link.

Abstract: A system that incorporates teachings of the present disclosure may include, for example, a mobile Voice over IP (VoIP) communication device (MVCD) having a controller element to register with a VoIP call processing system by way of a Wireless Fidelity (WiFi) access point operating in a cluster of WiFi access points each having cell coverage area, and re-register with the VoIP call processing system by way of the WiFi access point in response to receiving a re-registration request upon expiration of a timer having a period determined from one or more behavioral attributes of the MVCD. Additional embodiments are disclosed.

Abstract: A multicast test of an Internet Protocol (IP) network is performed with an initial multicast probing frequency. The multicast probing frequency of the multicast test is increased, and an impairment of the IP network based on the multicast test is detected based on the multicast test. Based on detecting the impairment, a unicast test is performed at one or more segments of the IP network. Based on the unicast test, an impaired segment of the IP network is identified.

Abstract: A load balancer assigns a mobile registration request to a mobile communication processing server (MCPS) based on an amount of free space in a visitor location register (VLR) of the MCPS. In an embodiment, the load balancer assigns the mobile registration request to the MCPS with a probability equal to the amount of free space in the VLR divided by a total amount of free space in a plurality of VLRs of a plurality of MCPSs, the plurality of MCPSs including the MCPS.

Abstract: A method of accessing a network from an embedded device is provided. Information is provided, specifying corresponding relationship between at least one category notation and at least one data type. A string is received. At least one keyword is extracted from the string. A category notation is extracted from the string. Addresses of web pages containing the keyword are searched from a database storing the addresses of web pages containing data type corresponding to the category notation.