Abstract: The present disclosure relates to the field of genetic engineering, in particular to a recombinant human 2Ig-B7-H3 protein encoding gene, a protein, a recombinant vector, and a pharmaceutical composition including the gene or protein. The recombinant human 2Ig-B7-H3 protein encoding gene comprises a nucleotide sequence shown in SEQ ID NO:1.

Abstract: The present disclosure relates to the field of bio-pharmacy, in particular, to an expression and/or overexpression vector, a pharmaceutical composition and a method for preparing the same. The expression and/or overexpression vector of the present disclosure includes a human glucokinase mutant-encoding gene and an adeno-associated virus vector. The pharmaceutical composition of the present disclosure includes virus particles obtained by packaging the expression and/or overexpression vector. After the pharmaceutical composition of the present disclosure is injected into an animal, an obvious expression and/or overexpression of a glucokinase mutant may occur, which has a good blood glucose level lowering effect, and provides a powerful new approach for controlling/stabilizing blood glucose level and/or preventing and treating glucose metabolism disorders, especially for preventing and treating diabetes.

Abstract: The present disclosure provides a unit grouping method and device, a storage medium, and an electronic device. The method includes: in response to a grouping instruction, an operation state for grouping the at least one unit in a predetermined display area is activated; in response to a first selection instruction, at least one target unit to be grouped is selected from the at least one unit; in response to a second selection instruction, a target group is selected from at least one pre-created group; and the at least one target unit to be grouped is grouped into the target group. By means of embodiments of the present disclosure, the problems of small player operation space and low game operability in the related art are solved.

Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).

Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).

Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).

Abstract: A focusing method includes: acquiring an image of a current frame; and performing auto focusing by using a target area in an image of a previous frame as a focusing area in the image of the current frame, the image of the previous frame is an image of a preceding frame adjacent to the current frame, the target area in the image of the previous frame is an area where a target subject is located, the target subject is obtained by inputting the image of the previous frame into a subject detection model and performing subject detection, and the subject detection model is a model trained in advance based on at least visible light images, center weight maps and corresponding labeled subjects for a same scene.

Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).

Abstract: Systems and methods are disclosed that receiving ground traffic data from a traffic computer, and enhanced vision system, EVS, imaging data from at least one EVS camera. A target area is determined in the EVS imaging data based on position data of the ground traffic data. Graphics processing is performed that is confined to the target area to enhance visibility of ground traffic in the EVS imaging data in the target area, thereby generating enhanced EVS imaging data. The graphics processing is selected from at least one of contrast enhancement, edge detection and template matching and highlighting of an outline of the ground traffic. A display is generated that is to be displayed on the display device based on the enhanced EVS imaging data and the EVS imaging data.

Abstract: A method for image coding, an electronic device and a computer-readable storage medium. The method includes: an object region is acquired from a reference image; a pixel block forming the reference image is acquired, and multiple sets of coded data for the pixel are obtained by coding the pixel block in multiple coding modes respectively, each set corresponding to a respective one of the multiple coding modes; a cost parameter of the pixel block is determined based on a relative position relationship between the pixel block and the object region; a coding cost in each of the multiple coding modes for the pixel block, is obtained according to the cost parameter of the pixel block and the coded data in the coding mode; and a set of coded data corresponding to the coding mode with a lowest coding cost is determined as target coded data for the pixel block.

Abstract: The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides. In certain embodiments, the compounds have improved water-solubility, and are suitable for use in connection with peptide sequencing methodologies.

Abstract: Methods of sequencing molecules based on luminescence lifetimes and/or intensities are provided. In some aspects, methods of sequencing nucleic acids involve determining the luminescence lifetimes, and optionally luminescence intensities, of a series of luminescently labeled nucleotides incorporated during a nucleic acid sequencing reaction.

Abstract: A method and device for image processing, a method for training an object detection model are provided in the present disclosure. In the method for image processing, a visible light image is acquired. A central weight map corresponding to the visible light image is generated. Weight values represented by the central weight map gradually decrease from a center to an edge of a visible light image. The visible light image and the central weight map are inputted into an object detection model to obtain an object region confidence map. The object detection model is a model obtained by training according to multiple set of training data, each set of which includes a visible light image, a central weight map and a corresponding labeled object mask pattern for a same scenario. A target object in the visible light image is determined according to the object region confidence map.

Abstract: A focusing method includes: acquiring an image of a current frame; and performing auto focusing by using a target area in an image of a previous frame as a focusing area in the image of the current frame, the image of the previous frame is an image of a preceding frame adjacent to the current frame, the target area in the image of the previous frame is an area where a target subject is located, the target subject is obtained by inputting the image of the previous frame into a subject detection model and performing subject detection, and the subject detection model is a model trained in advance based on at least visible light images, center weight maps and corresponding labeled subjects for a same scene.

Abstract: A method for image coding, an electronic device and a computer-readable storage medium. The method includes: an object region is acquired from a reference image; a pixel block forming the reference image is acquired, and multiple sets of coded data for the pixel are obtained by coding the pixel block in multiple coding modes respectively, each set corresponding to a respective one of the multiple coding modes; a cost parameter of the pixel block is determined based on a relative position relationship between the pixel block and the object region; a coding cost in each of the multiple coding modes for the pixel block, is obtained according to the cost parameter of the pixel block and the coded data in the coding mode; and a set of coded data corresponding to the coding mode with a lowest coding cost is determined as target coded data for the pixel block.

Abstract: A method for providing Electronic Circuit Breaker (ECB) data onboard an aircraft is provided. The method obtains a current checklist applicable to current operations of the aircraft, by a processor communicatively coupled to an ECB system associated with the aircraft; obtains mapping data comprising mappings of aviation checklists mapped to associated ECB data, by the processor; identifies a subset of the ECB data associated with the current checklist, based on the mapping data, by the processor, wherein the current checklist includes a plurality of checklist tasks, and wherein the subset comprises at least one of the plurality of ECL tasks that includes an ECB instruction; filters the current checklist to create a filtered ECB list of the at least one of the plurality of checklist tasks, by the processor; and presents the filtered ECB list, via an ECB display onboard the aircraft.

Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.

Abstract: Methods of sequencing molecules based on luminescence lifetimes and/or intensities are provided. In some aspects, methods of sequencing nucleic acids involve determining the luminescence lifetimes, and optionally luminescence intensities, of a series of luminescently labeled nucleotides incorporated during a nucleic acid sequencing reaction.

Abstract: A method for providing Electronic Circuit Breaker (ECB) data onboard an aircraft is provided. The method obtains a current checklist applicable to current operations of the aircraft, by a processor communicatively coupled to an ECB system associated with the aircraft; obtains mapping data comprising mappings of aviation checklists mapped to associated ECB data, by the processor; identifies a subset of the ECB data associated with the current checklist, based on the mapping data, by the processor, wherein the current checklist includes a plurality of checklist tasks, and wherein the subset comprises at least one of the plurality of ECL tasks that includes an ECB instruction; filters the current checklist to create a filtered ECB list of the at least one of the plurality of checklist tasks, by the processor; and presents the filtered ECB list, via an ECB display onboard the aircraft.

Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.