Patents by Inventor Hailiang Chen
Hailiang Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9682040Abstract: The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.Type: GrantFiled: November 10, 2016Date of Patent: June 20, 2017Assignee: Dr. Reddy's Laboratories Ltd.Inventors: Hailiang Chen, Andrew Xian Chen, Dushyanth Surakanti, Franklin Okumu
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Publication number: 20170056326Abstract: The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.Type: ApplicationFiled: November 10, 2016Publication date: March 2, 2017Inventors: Hailiang Chen, Andrew Xian Chen, Dushyanth Surakanti, Franklin Okumu
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Publication number: 20170029430Abstract: Disclosed is a series of analogues of 4H-pyrazolo[1,5-?]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a compound as shown by formula (I) or a pharmaceutically acceptable salt thereof as a PARP inhibitor.Type: ApplicationFiled: March 30, 2015Publication date: February 2, 2017Inventors: Xuehai WANG, Zhaozhong DING, Yong XU, Shuhui CHEN, Lie LI, Gang LI, Ronghua TU, Cailin WANG, Yang YUE, Zhibo ZHANG, Hailiang CHEN, Wenjie SUN, Lu HUANG
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Patent number: 9522169Abstract: The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.Type: GrantFiled: July 7, 2015Date of Patent: December 20, 2016Assignee: Dr. Reddy's Laboratories Ltd.Inventors: Hailiang Chen, Andrew Xian Chen, Dushyanth Surakanti, Franklin Okumu
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Patent number: 9517202Abstract: The present invention is directed to phospholipid compositions and methods of preparation of phospholipid depots that are injectable through a fine needle. The phospholipid depots prepared by the methods described herein comprise nanometer-sized phospholipid particles and exhibit a higher degree of structural order compared to compositions prepared by other methods.Type: GrantFiled: June 14, 2012Date of Patent: December 13, 2016Assignee: LATITUDE PHARMACEUTICALS INC.Inventors: Andrew Xian Chen, Hailiang Chen
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Publication number: 20160038414Abstract: The present application provides parenteral compositions of diclofenac or its pharmaceutically acceptable salt and methods for making and using such compositions. Some of the compositions of the present application has one or more following properties: (1) ready to be injectable, (2) in the form of an oil-in-water emulsion, (3) stable under appropriate storage conditions, (4) containing therapeutically effective amount of diclofenac or its pharmaceutically acceptable salt, (5) sterilizable by filtration (6) containing components acceptable by regulatory agencies (e.g. the FDA), (7) containing low oil content and thus not exacerbating hyerlipidemia, and (8) is neither hyperallergenic nor vein irritating.Type: ApplicationFiled: March 17, 2014Publication date: February 11, 2016Inventors: Franklin Okumu, Andrew X. Chen, Hailiang Chen
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Patent number: 9248098Abstract: The present invention relates to a pharmaceutical composition comprising spicamycin derivatives that vary in their fatty acid side chain moieties and are useful in the treatment of pain. The invention further provides a method of using the pharmaceutical composition to treat pain, including neuropathic pain.Type: GrantFiled: October 9, 2009Date of Patent: February 2, 2016Assignee: DARA BIOSCIENCES, INC.Inventors: John R. Didsbury, Kenneth J. Ingold, Linda Goff Jet, Andrew Xian Chen, Hailiang Chen
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Publication number: 20150306173Abstract: The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.Type: ApplicationFiled: July 7, 2015Publication date: October 29, 2015Inventors: Hailiang Chen, Andrew Xian Chen, Dushyanth Surakanti, Franklin Okumu
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Patent number: 9132144Abstract: The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.Type: GrantFiled: September 23, 2011Date of Patent: September 15, 2015Assignee: Dr. Reddy's Laboratories Ltd.Inventors: Hailiang Chen, Andrew Xian Chen, Dushyanth Surakanti, Franklin Okumu
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Publication number: 20140378381Abstract: The present invention provides an oil-in-water nanoemulsion containing glucagon, an oily phase, and an aqueous phase, wherein the glucagon is physically and chemically stable and the nanoemulsion is suitable for administration by manual injection or by a pump to treat hypoglycemia.Type: ApplicationFiled: June 25, 2014Publication date: December 25, 2014Inventors: Andrew Xian Chen, Norman Keith Orida, Hailiang Chen, Hau Huu Dang
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Patent number: 8877746Abstract: Compositions and methods of making the same for in vivo delivery of lixivaptan to a subject in need thereof are described. The composition includes a substantially water-insoluble pharmacologically active agent (e.g., lixivaptan) and a substantially water-insoluble matrix forming material (e.g., a Vitamin E semi-ester), wherein the pharmacologically active agent is dispersed in said matrix forming material, and wherein the composition delivers said substantially water-insoluble pharmacologically active agent upon exposure to physiological medium.Type: GrantFiled: August 24, 2010Date of Patent: November 4, 2014Assignee: Cardioklne, IncInventors: Hailiang Chen, Andrew Xian Chen, Patricia Frech, Khawla Abu-Izza, Christoph Schmidt
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Publication number: 20140275261Abstract: The present application provides parenteral compositions of diclofenac or its pharmaceutically acceptable salt and methods for making and using such compositions. Some of the compositions of the present application has one or more following properties: (1) ready to be injectable, (2) in the form of an oil-water emulsion, (3) stable under appropriate storage conditions, (4) containing therapeutically effective amount of diclofenac or its pharmaceutically acceptable salt, (5) sterilizable by filtration (6) containing components acceptable by regulatory agencies (e.g. the FDA), (7) containing low oil content and thus not exacerbating hyperlipidemia, and (8) is neither hypoallergenic nor vein irritating.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: DR. REDDY'S LABORATORIES, INC.Inventors: Franklin Okumu, Andrew Xian Chen, Hailiang Chen
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Publication number: 20140249077Abstract: The present invention is directed to compositions and methods of preparation of phospholipid gels.Type: ApplicationFiled: June 8, 2012Publication date: September 4, 2014Applicants: ASTRAZENECA PHARMACEUTICALS LP, AMYLIN PHARMACEUTICALS, LLCInventors: Andrew Xian Chen, Hailiang Chen
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Publication number: 20140155320Abstract: The present invention provides a method of preventing and/or treating a wound infection by introducing to a wound a clear depot comprising a hydrophilic water-soluble pharmaceutically active agent(s) selected from the group consisting of vancomycin, gentamicin, and a mixture thereof, water, a phospholipid, an oil, a pH adjusting agent, and a viscosity modifying agent, wherein the water present in the viscous depot is no more than about 4 wt %, no more than about 2 wt %, or no more than about 0.5 wt % of water relative to the total weight of the depot.Type: ApplicationFiled: October 18, 2011Publication date: June 5, 2014Applicant: DR. REDDY'S LABORATORIES, INC.Inventors: Hailiang Chen, Andrew Xian Chen, Dushyanth Surakanti, Franklin Omuku
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Publication number: 20130079334Abstract: Compositions and methods of making the same for in vivo delivery of lixivaptan to a subject in need thereof are described. The composition includes a substantially water-insoluble pharmacologically active agent (e.g., lixivaptan) and a substantially water-insoluble matrix forming material (e.g., a Vitamin E semi-ester), wherein the pharmacologically active agent is dispersed in said matrix forming material, and wherein the composition delivers said substantially water-insoluble pharmacologically active agent upon exposure to physiological medium.Type: ApplicationFiled: August 24, 2010Publication date: March 28, 2013Inventors: Hailiang Chen, Andrew Xian Chen, Patricia Frech, Khawla Abu-Izza, Christoph Schmidt
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Publication number: 20130045253Abstract: Provided are methods for reducing the excipient load of pharmaceutical formulations containing 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide as the active pharmaceutical ingredient, and compositions related thereto. In particular, provided is a pharmaceutical product comprising 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide and a stabilizer admixed throughout a solid-form unilamellar matrix, wherein the ratio of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide to stabilizer ranges from about 2:3 to about 1:10, and related methods of forming the pharmaceutical product.Type: ApplicationFiled: October 17, 2012Publication date: February 21, 2013Inventors: Andrew Chen, Hailiang Chen, James Cecil Free, Majid Keshtmand, Mohammed Abdul Rahman, Sally Look
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Publication number: 20120316108Abstract: The present invention is directed to compositions and methods of preparation of phospholipid depots that are injectable through a fine needle.Type: ApplicationFiled: June 14, 2012Publication date: December 13, 2012Applicant: Latitude Pharmaceuticals Inc.Inventors: Andrew Xian Chen, Hailiang Chen
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Patent number: 8313766Abstract: Provided are methods for reducing the excipient load of pharmaceutical formulations containing 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide as the active pharmaceutical ingredient, and compositions related thereto. In particular, provided is a pharmaceutical product comprising 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide and a stabilizer admixed throughout a solid-form unilamellar matrix, wherein the ratio of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide to stabilizer ranges from about 2:3 to about 1:10, and related methods of forming the pharmaceutical product.Type: GrantFiled: August 20, 2010Date of Patent: November 20, 2012Inventors: Andrew Chen, Hailiang Chen, James Cecil Free, Majid Keshtmand, Mohammed Abdul Rahman, Sally A. Look
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Publication number: 20120225118Abstract: Compositions and methods of making the same for improving the bioavailability of a substantially water-insoluble pharmacologically active agent are described. The composition includes a substantially water-insoluble pharmacologically active agent, and a substantially water-insoluble matrix forming material comprising enzyme digestible or bile soluble nutrients, wherein the substantially water-insoluble pharmacologically active agent is dispersed in a solid matrix and wherein said pharmacologically active agent in said matrix is substantially free of the original crystalline form.Type: ApplicationFiled: February 23, 2012Publication date: September 6, 2012Applicant: Latitude Pharmaceuticals IncorporatedInventors: Hailiang Chen, Andrew Xian Chen
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Publication number: 20120046220Abstract: The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.Type: ApplicationFiled: September 23, 2011Publication date: February 23, 2012Inventors: Hailiang Chen, Andrew Xian Chen, Dushyanth Surakanti, Franklin Okumu