Abstract: The present invention is directed to methods of diagnosing, prognosing, and managing treatment of cancer in a subject. These methods involve selecting a subject having cancer and obtaining, from the selected subject, a population of either exomeres having a diameter less than 50 nm, small exosomes having a diameter of 60-80 nm, or large exosomes having a diameter of 90-120 nm.

Abstract: A data acquisition circuit board and an equipment monitoring system are provided. The data acquisition circuit board includes a power supply module configured to perform voltage conversion and supply a power supply signal; a micro-processing unit coupled to the power supply module; a data acquisition module coupled to the micro-processing unit; and a data transmission unit coupled to the power supply module and the micro-processing unit; wherein the micro-processing unit receives and processes data acquired by the data acquisition module, and outputs processed results to the data transmission unit, which transmits the processed results wirelessly.

Abstract: The present invention relates to a novel tryptophan hydroxylase inhibitor and a pharmaceutical composition including same, wherein the novel tryptophan hydroxylase inhibitor has an excellent inhibitory effect on TPH1, and thus can be usefully used for the prevention or treatment of disorders, such as metabolic disorders, cancer, digestive or cardiovascular system disorders, related to TPH1 activity. In particular, the novel tryptophan hydroxylase inhibitor has an excellent treatment effect on inflammatory bowel disorders, and thus can be usefully used for the treatment of inflammatory bowel disorder.

Abstract: An optical imaging film includes: a focusing layer, having two or more focusing structures; and a graphic layer, having two or more sub-graphics, and at least part of the sub-graphics are configured as a partial pattern of a preset graphic. The focusing layer is adapted to the graphic layer, and the focusing structures are provided corresponding to the sub-graphics, such that the optical imaging film presents an image of the preset graphic with a magnifying effect. The graphic layer of the optical imaging film includes a plurality of sub-graphics, and each of the plurality of the sub-graphics interacts with the corresponding focusing structure to form an image with a magnifying effect. Therefore, the sub-graphic is relatively large, thereby increasing the size of the images. That is, the optical imaging film can increase the magnification of the preset graphic.

Abstract: The present invention relates to a cancer immunotherapy adjuvant, wherein the adjuvant, when administered in combination with a cancer immunotherapy agent, activates the function of immune factors without causing in vivo side effects, to exhibit the effect of enhancing the kit for anticancer effect of the cancer immunotherapy agent, and thus can be effectively used as a cancer immunotherapy adjuvant.

Abstract: The present invention is directed to methods of diagnosing, prognosing, and monitoring cancer in a subject. These methods involves selecting a subject having cancer, and obtaining, from the selected subject, a sample containing exosomal DNA. The presence or absence of one or more mutations in BRAF and/or EGFR is detected in the exosomal DNA sample from the subject, and a diagnosis and/or prognosis of the cancer is given based on the detection of the one or more mutations in BRAF and/or EGFR. The present invention further relates to methods of treating a subject having cancer and/or monitoring a subject response to therapy based on the detection of one or more mutations in BRAF and/or EGFR in the exosomal DNA sample.

Abstract: The present invention is directed to methods of diagnosing, prognosing, and managing treatment of cancer in a subject.

Abstract: The present invention relates to a novel tryptophan hydroxylase inhibitor and a pharmaceutical composition including same, wherein the novel tryptophan hydroxylase inhibitor has an excellent inhibitory effect on TPH1, and thus can be usefully used for the prevention or treatment of disorders, such as metabolic disorders, cancer, digestive or cardiovascular system disorders, related to TPH1 activity. In particular, the novel tryptophan hydroxylase inhibitor has an excellent treatment effect on inflammatory bowel disorders, and thus can be usefully used for the treatment of inflammatory bowel disorder.

Abstract: The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double-stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.

Abstract: The present invention discloses a CLALS protein, its coding gene and use in predicting the herbicide resistance of a watermelon. The herbicide resistance of a watermelon to be tested in which “the amino acid residue at position 190 from N-terminus of the CLALS protein is only a non-proline residue” or a watermelon to be tested in which “the amino acid residue at position 190 from N-terminus of the CLALS protein is a non-proline residue and a proline residue” is stronger than that of a watermelon to be tested in which “the amino acid residue at position 190 from N-terminus of the CLALS protein is only a proline residue”. Experiments have shown that the type of the amino acid residue at position 190 from the N-terminus of CLALS protein can be used as a detection target to predict the herbicide resistance of a watermelon to be tested. The invention has great application value.

Abstract: A data acquisition circuit board and an equipment monitoring system are provided. The data acquisition circuit board includes a power supply module configured to perform voltage conversion and supply a power supply signal; a micro-processing unit coupled to the power supply module; a data acquisition module coupled to the micro-processing unit; and a data transmission unit coupled to the power supply module and the micro-processing unit; wherein the micro-processing unit receives and processes data acquired by the data acquisition module, and outputs processed results to the data transmission unit, which transmits the processed results wirelessly.

Abstract: Provided are a data block storage method, a data query method and a data modification method. The data block storage method splits file content of a data block to be stored, to generate at least two pieces of file content of the split data block. The file content of the data block to be split comprises at least one character set which is the smallest unit of the file content indicating the meaning of the data block to be split, the character set comprises a plurality of characters, each piece of file content of the split data block comprises a portion of the characters of the same character set. Even if another person obtains a portion of the data content after splitting, it would not be possible to parse effective content; and the split file content is stored in at least two independent storage systems, improving data security.

Abstract: An operational control method of a flexible display device for controlling the flexible display device is disclosed, and the method includes: detecting an action performed by a user to the device, the action including one or any combination of bending, folding, edge deforming and shape recovering; and analyzing a characteristic value of the action, and performing a corresponding system function when the characteristic value of the action satisfies a preset condition.

Abstract: An operational control method of a flexible display device for controlling the flexible display device is disclosed, and the method includes: detecting an action performed by a user to the device, the action including one or any combination of bending, folding, edge deforming and shape recovering; and analyzing a characteristic value of the action, and performing a corresponding system function when the characteristic value of the action satisfies a preset condition.

Abstract: Provided are a data block storage method, a data query method and a data modification method. The data block storage method splits file content of a data block to be stored, to generate at least two pieces of file content of the split data block. The file content of the data block to be split comprises at least one character set which is the smallest unit of the file content indicating the meaning of the data block to be split, the character set comprises a plurality of characters, each piece of file content of the split data block comprises a portion of the characters of the same character set. Even if another person obtains a portion of the data content after splitting, it would not be possible to parse effective content; and the split file content is stored in at least two independent storage systems, improving data security.

Abstract: The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double-stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.