Patents by Inventor Haiying Zhang
Haiying Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170242620Abstract: Provided are a data block storage method, a data query method and a data modification method. The data block storage method splits file content of a data block to be stored, to generate at least two pieces of file content of the split data block. The file content of the data block to be split comprises at least one character set which is the smallest unit of the file content indicating the meaning of the data block to be split, the character set comprises a plurality of characters, each piece of file content of the split data block comprises a portion of the characters of the same character set. Even if another person obtains a portion of the data content after splitting, it would not be possible to parse effective content; and the split file content is stored in at least two independent storage systems, improving data security.Type: ApplicationFiled: September 28, 2015Publication date: August 24, 2017Applicant: Beijing Gupanchuangshi Science and Technology Development Co., Ltd.Inventors: Haiying Zhang, Haiyan Zhou
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Publication number: 20170175200Abstract: The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double-stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.Type: ApplicationFiled: April 1, 2015Publication date: June 22, 2017Inventors: David C. LYDEN, Hector Peinado SELGAS, Haiying ZHANG, Basant Kumar THAKUR, Annette BECKER, Jacqueline BROMBERG
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Patent number: 9532426Abstract: An adjustment method for LED backlight brightness, comprising the following steps of: if the current LED backlight brightness is greater than a preset value, maintaining the PWM duty ratio as the maximum value, and adjusting the LED backlight brightness by adjusting an LED conduction current (S10); and if the current LED backlight brightness is not greater than the pre-set value, maintaining the LED conduction current to be constant, and adjusting the LED backlight brightness by adjusting the change of the PWM duty ratio between the maximum value and the minimum value (S20). This method can improve the light-emitting efficiency of LEDs, reduce backlight loss, and reduce the noise generated by an LED drive circuit.Type: GrantFiled: January 15, 2014Date of Patent: December 27, 2016Assignee: Shenzhen TCL New Technology Co., Ltd.Inventors: Dong Wen, Jianshe Qin, Jianqiang Li, Yong Yang, Haiying Zhang, Dexiang Zuo
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Patent number: 9266983Abstract: The present disclosure provides a catalyst composition for ethylene oligomerization including an imino ferrous complex shown in Formula (I) as the main catalyst, an aluminum-containing cocatalyst, water, and an organic solvent: According to the present disclosure, a higher oligomerization activity can be obtained with the catalyst composition than with a catalyst composition system in the prior art which contains no water. Moreover, when the catalyst composition according to the present disclosure is used, a high selectivity of ?-olefins is obtainable. Besides, the catalyst composition according to the present disclosure can enable rapid initiation, stable operation, and good repeatability of the oligomerization reaction. According to the present disclosure, a high oligomerization activity can be obtained even at a rather low ratio of Al/Fe, or at a low reaction temperature.Type: GrantFiled: April 16, 2014Date of Patent: February 23, 2016Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATIONInventors: Tonglin Li, Mingfang Zheng, Jun Liu, Huaijie Wang, Haiying Zhang, Weizhen Li, Jilong Wang, Yuling Piao
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Patent number: 9266982Abstract: Provided are a process for preparing an N ortho acyl substituted nitrogen-containing heterocyclic compound and an aminal iron (II) complex thereof, and the use of the complexes obtained by the process in an olefin oligomerization catalyst. The N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is for example 2-acyl-1,10-phenanthroline or 2,6-diacetyl pyridine as shown in formula b, and the N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is produced by a reaction of a precursor thereof in a substituted or unsubstituted nitrobenzene. Preferably the precursor shown in formula I in the present invention is produced by 1,10-phenanthroline reacting with trialkyl aluminum, or a halogenoalkyl aluminum RnAIXm, or a substituted or unsubstituted benzyl lithium Ph?CH2Li, followed by hydrolysis.Type: GrantFiled: December 1, 2011Date of Patent: February 23, 2016Assignees: China Petroleum & Chemical Corporation, Beijing Research Institute of Chemical Industry, China Petroleum & Chemical CorporatinInventors: Jun Liu, Mingfang Zheng, Weizhen Li, Haiying Zhang, Huaijie Wang, Yu Zhou, Tonglin Li, Lan Zhao, Hongfei Wu, Mingjun Xie, Chunhong Wu, Zhiguang Jia, Yanping Qi, Jilong Wang
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Publication number: 20150299136Abstract: Compounds, pharmaceutically acceptable salts, isomers, or prodrugs thereof, of the invention are disclosed, which are useful as modulators of the activity of liver X receptors (LXR). Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.Type: ApplicationFiled: May 4, 2015Publication date: October 22, 2015Applicants: BRISTOL-MYERS SQUIBB COMPANY, EXELIXIS PATENT COMPANY LLCInventors: Brett B. Busch, William C. Stevens, JR., Ellen K. Kick, Haiying Zhang, Venkataiah Bollu, Richard Martin, Raju Mohan
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Publication number: 20150218651Abstract: The present invention is directed to methods of diagnosing, prognosing, and monitoring cancer in a subject. These methods involves selecting a subject having cancer, and obtaining, from the selected subject, a sample containing exosomal DNA. The presence or absence of one or more mutations in BRAF and/or EGFR is detected in the exosomal DNA sample from the subject, and a diagnosis and/or prognosis of the cancer is given based on the detection of the one or more mutations in BRAF and/or EGFR. The present invention further relates to methods of treating a subject having cancer and/or monitoring a subject response to therapy based on the detection of one or more mutations in BRAF and/or EGFR in the exosomal DNA sample.Type: ApplicationFiled: August 16, 2013Publication date: August 6, 2015Applicant: Cornell UniversityInventors: David C. Lyden, Hector Peinado Selgas, Haiying Zhang, Jacqueline Bromberg
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Publication number: 20140316087Abstract: The present disclosure provides a catalyst composition for ethylene oligomerization including an imino ferrous complex shown in Formula (I) as the main catalyst, an aluminum-containing cocatalyst, water, and an organic solvent: According to the present disclosure, a higher oligomerization activity can be obtained with the catalyst composition than with a catalyst composition system in the prior art which contains no water. Moreover, when the catalyst composition according to the present disclosure is used, a high selectivity of ?-olefins is obtainable. Besides, the catalyst composition according to the present disclosure can enable rapid initiation, stable operation, and good repeatability of the oligomerization reaction. According to the present disclosure, a high oligomerization activity can be obtained even at a rather low ratio of Al/Fe, or at a low reaction temperature.Type: ApplicationFiled: April 16, 2014Publication date: October 23, 2014Applicants: CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATIONInventors: Tonglin Li, Mingfang Zheng, Jun Liu, Huaijie Wang, Haiying Zhang, Weizhen Li, Jilong Wang, Yuling Piao
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Publication number: 20140163081Abstract: Compounds, pharmaceutically acceptable salts, isomers, or prodrugs thereof, of the invention are disclosed, which are useful as modulators of the activity of liver X receptors (LXR). Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.Type: ApplicationFiled: November 21, 2013Publication date: June 12, 2014Applicants: Exelixis Patent Company LLC, BRISTOL-MYERS SQUIBB COMPANYInventors: Brett B. Busch, William C. Stevens, JR., Ellen K. Kick, Haiying Zhang, Venkataiah Bollu, Richard Martin, Raju Mohan
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Patent number: 8618154Abstract: Compounds, pharmaceutically acceptable salts, isomers, or prodrugs thereof, of the invention are disclosed, which are useful as modulators of the activity of liver X receptors (LXR). Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.Type: GrantFiled: May 26, 2010Date of Patent: December 31, 2013Assignees: Bristol-Myers Squibb Company, Exelixis Patent Company LLCInventors: Brett B. Busch, William C. Stevens, Jr., Ellen K. Kick, Haiying Zhang, Venkataiah Bollu, Richard Martin, Raju Mohan
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Publication number: 20130267708Abstract: Provided are a process for preparing an N ortho acyl substituted nitrogen-containing heterocyclic compound and an aminal iron (II) complex thereof, and the use of the complexes obtained by the process in an olefin oligomerization catalyst. The N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is for example 2-acyl-1,10-phenanthroline or 2,6-diacetyl pyridine as shown in formula b, and the N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is produced by a reaction of a precursor thereof in a substituted or unsubstituted nitrobenzene. Preferably the precursor shown in formula I in the present invention is produced by 1,10-phenanthroline reacting with trialkyl aluminum, or a halogenoalkyl aluminum RnAlXm, or a substituted or unsubstituted benzyl lithium 2Li, followed by hydrolysis.Type: ApplicationFiled: December 1, 2011Publication date: October 10, 2013Inventors: Jun Liu, Mingfang Zheng, Weizhen Li, Haiying Zhang, Huaijie Wang, Yu Zhou, Tonglin Li, Lan Zhao, Hongfei Wu, Wingjun Xie, Chunhong Wu, Zhiguang Jia, Qi Yanping, Jilong Wang
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Publication number: 20130018214Abstract: The present invention provides a catalyst composition for the ethylene oligomerization, which comprises 2-imino-1,10-phenanthroline coordinated iron (II), cobalt (II) or nickel (II) chloride as main catalyst and triethylaluminum as cocatalyst. The present invention also provides a process for oligomerization of ethylene is provided, wherein a catalyst composition comprising 2-imino-1,10-phenanthroline coordinated iron (II), cobalt (II) or nickel (II) chloride as main catalyst and triethylaluminum as cocatalyst is used, and the molar ratio of aluminum in the cocatalyst to central metal in the main catalyst ranges from 30 to less than 200. According to the present invention, another process for oligomerization of ethylene is also provided, wherein a catalyst composition comprising 2-imino-1,10-phenanthroline coordinated iron (II), cobalt (II) or nickel (II) chloride as main catalyst and triethylaluminum as cocatalyst is used, and the temperature of ethylene oligomerization ranges from ?10 to 19° C.Type: ApplicationFiled: March 30, 2011Publication date: January 17, 2013Applicant: China Petroleum & Chemical CorporationInventors: Mingfang Zheng, Weizhen Li, Huaijie Wang, Jun Liu, Haiying Zhang, Yu Zhou, Tonglin Li, Lan Zhao, Jilong Wang, Hongfei Wu, Yuling Piao, Junlong Sui
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Patent number: 8304719Abstract: A method for identifying and characterizing components of interest in complex samples includes subjecting both a sample and its control samples to chromatography/high resolution mass spectrometry analysis to detect ions of the samples. The method includes defining sections of control sample data within specified chromatographic fluctuation time and mass precision windows around each ion or each group of the same ions of question in the test sample data. The defined sections of the control sample data are examined and the maximal intensities are subtracted from respective ions in the test sample. Components of interest are determined from the resultant data of the test sample. The method can be used for identifying molecular ions and/or their fragment ions for components of interest in complex samples.Type: GrantFiled: February 20, 2010Date of Patent: November 6, 2012Inventors: Xin Wang, Haiying Zhang
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Publication number: 20120071534Abstract: Compounds, pharmaceutically acceptable salts, isomers, or prodrugs thereof, of the invention are disclosed, which are useful as modulators of the activity of liver X receptors (LXR). Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.Type: ApplicationFiled: May 26, 2010Publication date: March 22, 2012Inventors: Brett B. Busch, William C. Stevens, JR., Ellen K. Kick, Haiying Zhang, Venkataiah Bollu, Richard Martin, Raju Mohan
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Publication number: 20100213368Abstract: A method for identifying and characterizing components of interest in complex samples includes subjecting both a sample and its control samples to chromatography/high resolution mass spectrometry analysis to detect ions of the samples. The method includes defining sections of control sample data within specified chromatographic fluctuation time and mass precision windows around each ion or each group of the same ions of question in the test sample data. The defined sections of the control sample data are examined and the maximal intensities are subtracted from respective ions in the test sample. Components of interest are determined from the resultant data of the test sample. The method can be used for identifying molecular ions and/or their fragment ions for components of interest in complex samples.Type: ApplicationFiled: February 20, 2010Publication date: August 26, 2010Inventors: Xin Wang, Haiying Zhang
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Patent number: 7381568Abstract: A method for detecting and identifying metabolites in biological samples includes subjecting the samples to high resolution mass spectrometry (MS) analysis to detect ions of the molecular species. Mass defect values for the detected ions are determined. The method also includes specifying a predetermined range for mass defect values. Detected ions having mass defect values falling outside the specified range are discarded and those with mass defect values falling within the predetermined range are retained. Species of interest are determined from the retained values. The species of interest include drug metabolites or impurities and/or degradants of a known pharmaceutical sample.Type: GrantFiled: June 2, 2004Date of Patent: June 3, 2008Assignee: Bristol-Myers Squibb CompanyInventors: Haiying Zhang, Kenneth L. Ray, Donglu Zhang
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Publication number: 20050272168Abstract: A method for detecting and identifying metabolites in biological samples includes subjecting the samples to high resolution mass spectrometry (MS) analysis to detect ions of the molecular species. Mass defect values for the detected ions are determined. The method also includes specifying a predetermined range for mass defect values. Detected ions having mass defect values falling outside the specified range are discarded and those with mass defect values falling within the predetermined range are retained. Species of interest are determined from the retained values. The species of interest include drug metabolites or impurities and/or degradants of a known pharmaceutical sample.Type: ApplicationFiled: June 2, 2004Publication date: December 8, 2005Inventors: Haiying Zhang, Kenneth Ray, Donglu Zhang