Abstract: This invention offers isoxazole derivatives represented by the following formula (I) in which R1 and R2 each stands for hydrogen, lower alkyl, amino and the like; R3 stands for substituted or unsubstituted aryl or hetero aryl; R4 stands for hydrogen or lower alkyl; R5 stands for substituted or unsubstituted phenyl, furyl and the like; and Y stands for —CH2—, —CO—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof which exhibit excellent p38MAPkinase-inhibiting action with reduced side-effects, and are useful for treating such diseases as chronic rheumatoid arthritis, ulcerative colitis and the like.

Abstract: The invention discloses isoxazole derivatives represented by a formula, in which R1 stands for hydrogen, lower alkyl, amino, halogen, lower alkoxy and the like, R2 stands for substituted or unsubstituted aryl and the like, R3 stands for hydrogen or lower alkyl, R4 stands for substituted or unsubstituted phenyl and the like, and Y stands for —CH2—, —CO—, —CH(CH3)—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof, which have excellent p38MAPkinase inhibitory action.

Abstract: This invention offers isoxazole derivatives represented by the following formula (I) in which R1 and R2 each stands for hydrogen, lower alkyl, amino and the like; R3 stands for substituted or unsubstituted aryl or hetero aryl; R4 stands for hydrogen or lower alkyl; R5 stands for substituted or unsubstituted phenyl, furyl and the like; and Y stands for —CH2—, —CO—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof which exhibit excellent p38MAPkinase-inhibiting action with reduced side-effects, and are useful for treating such diseases as chronic rheumatoid arthritis, ulcerative colitis and the like.

Abstract: The invention discloses treating agents of inflammatory bowel disease, which contain p38MAPkinase inhibitor having properties of antedrug as the active ingredient.

Abstract: The invention discloses isoxazole derivatives represented by a formula, in which R1 stands for hydrogen, lower alkyl, amino, halogen, lower alkoxy and the like, R2 stands for substituted or unsubstituted aryl and the like, R3 stands for hydrogen or lower alkyl, R4 stands for substituted or unsubstituted phenyl and the like, and Y stands for —CH2—, —CO—, —CH(CH3)—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof, which have excellent p38MAPkinase inhibitory action.

Abstract: A printing apparatus has a memory 5 that stores image data for overprinting making it difficult to notice characters printed by overprinting, an image rendering unit 7 that renders image data on the basis of a rendering command of the memory and expands the image data for overprinting, and a printer engine unit 8 that prints and records the image data transmitted from the image rendering unit 7 on a paper. The printer engine unit 8 overprints the image data for overprinting on the printed paper.

Abstract: The invention is an image forming apparatus which transfers an image formed on a photosensitive member 11 onto a transfer material 19 at a transfer position, the apparatus includes: a transfer roller 12 which contacts with the photosensitive member 11 at the transfer position; a power supply circuit 17 which applies constant voltage to the transfer roller 12 when the transfer material 19 is reached at the transfer position; and a CPU 18 which instructs the power supply circuit 17 to do application to the transfer member, wherein at the time when the transfer material 19 is not carried, the power supply circuit 17 applies constant current to the transfer roller 12 at a current value set by the CPU 18, and measures a voltage value during that constant current application, and the CPU 18 sets as a voltage value at the time when transfer is done to the power supply circuit 17 a voltage value that the measured voltage value is added with a compensation voltage value corresponding to the transfer material 19.

Abstract: Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n-Y, —CH2—CH(R4)-(A)n-Y, —CO-B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group.

Abstract: Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n —Y, —CH2 —CH(R4)-(A)n—Y, —CO—B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.

Abstract: Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)—(A)n—Y, —CH2—CH(R4)—(A)n—Y, —CO—B1—A—Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.

Abstract: Aminopyrazole derivatives represented by formula (I), or salts thereof, wherein X1 and X2 are each a hydrogen atom or a halogen atom, or X1 and X2 may be united together to form a lower alkylenedioxy group, Q is a pyridyl group or a quinolyl group, R1 is a hydrogen atom, a substituted or unsubstituted lower alkyl or aryl group, R2 is a hydrogen atom, a lower alkyl group, or an aralkyl group, and R3 represents a hydrogen atom, an organic sulfonyl group, or —C(═Y)—R4 in which R4 is a hydrogen atom or an organic residue and Y is an oxygen or sulfur atom, provided that, when R3 is a hydrogen atom, R1 is a group other than a hydrogen atom and R2 is a hydrogen atom. These amimopyrazole derivatives or their salts have excellent p38MAP kinase inhibiting activities and are hence useful in the prevention or treatment of diseases associated with tumor necrosis sis factor &agr;, interleukin 1, interleukin 6 or cyclooxygenase II.

Abstract: An associative storage comprises two data transmission paths each of which includes a self-running shift register formed in loop fashion. In the respective data transmission paths, data packets each having identification data are transmitted to respective stages of the shift register. The identification data are extracted from the data packets transmitted on the shift registers and compared with each other in a comparing circuit. If and when the identification data of two data packets respectively transmitted on the respective transmission paths are coincident, those two data packets are determined as the data packets to be paired. The data packet pair is read from the data transmission paths.

Abstract: An operator can use a word processor for editing by substituting character strings. The operator can use a designating part of the word processor to identify what portion of a text is to be edited. The portion of the text to be edited is a designated character string. A plurality of substitute strings can be stored in a memory. The substitute character strings can replace the designated character strings. In addition, the designated character string can be placed in a memory to be used later as a substitutive character string.

Abstract: A data transmission apparatus for transmitting data between systems includes: an input data transmission path, an output data transmission path, and a branch data transmission path each constituted by a shift register, each data transmission path has a plurality of data storage circuits and a plurality of transfer control circuits each provided corresponding to each o--stage. The data storage circuit control a self stage data storage circuit in accordance with a control signal from the transfer control circuit of an adjacent stage. An initialization circuit for initializing the device is provided so that data on the data transmission path does not remain at the start of operation of the device.

Abstract: By providing a tag data renewing unit in a data flow-computer, the "delay" function, which is necessary for a digital filter, etc., can be realized, and it is unnecessary to keep the order relation for tokens with respect to first-in/first-out, which must be kept at respective points in a conventional data flow computer, and thereby the architecture of a compiler can be simplified and at the same time the execution time can be shortened.

Abstract: A data processing apparatus includes two data transmission paths formed likewise in a loop fashion. These data transmission paths include a plurality of latch registers connected in a cascade fashion respectively and are constituted as a so-called self-running type shift register wherein each data word constituting a data packet is shifted in sequence provided that a pre-stage register is vacant. Data packets are transmitted in the directions reverse to each other on the two loop-shaped data transmission paths an identification data included in each data packet being transmitted is detected in a section defined as a data packet pair detecting section. The detected identification data are compared in a comparing circuit and, one new data packet is produced from the two data packets in a manner that a data packet is joined from one data transmission path to the other data transmission path.

Abstract: In a data transmission apparatus, a plurality of data processing modules are used and required sequence setting is performed to a port sequencer of input/output ports of each data processing module, and the daisy chain transfer of the selective data transfer, the load distribution data transfer, the collective data transfer is combined between the data processing modules, thereby the data transmission is performed efficiently at high speed.

Abstract: A data processing apparatus includes a self-running type shift register and this shift register includes a plurality of latch registers arranged in a cascade fashion. The latch register latches a data packet on a word basis. In each latch register, a coincidence element is disposed in association therewith and these coincidence elements allow transfer of data from a post-stage latch register provided that a pre-stage latch register is vacant. A data processing element is installed between two latch registers and the data processing element processes operand data from either or both of the two latch register in response to the kind of processing shown by an operation code comprised in the preceding word. The result of processing is transferred to the pre-stage latch register when the pre-stage latch register is placed in the vacant state under control of the coincidence element.

Abstract: In an information processor, input interface units (161, 162) are connected to one ring data bus (191) through jointing units (201, 202) and data processing units (181 and 185) are connected to the ring data bus (191) through jointing units (203 through 206) and branching units (221 through 224). Data processing units (183 through 187) are connected to the other ring data bus (192) through jointing units (207 through 210) and branching units (225 through 228) and output interface units (171, 172) are connected to the other ring data bus (192) through branching units (229, 230). The ring data buses (191, 192) propagate the respective in data through the input interface units (161, 162) while storing such data, and processing the data in any of the data processing units to provide outputs to any of the output interface units (171, 172).

Abstract: A data transmission system comprises an input data transmission line (1), an output data transmission line (4), a branching data transmission line (5) and a jointing data transmission line (7) formed respectively by asynchronous free-running shift registers using a plurality of data latches (101 to 106, 401 & 402, 501 & 502, 701 & 702) and, C elements (111 to 116, 411 & 412, 511 & 512, 711 & 712) respectively. A branching control circuit 3 supplies data to be branched to the branching data transmission line (5) in response to the decision by a branching decision circuit (2) as to the fact that the data to be branched is transmitted on the input data transmission line (1).