Patents by Inventor Hakon Hakonarson

Hakon Hakonarson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Topical formulation for intradermal application and uses thereof
    Patent number: 12582637
    Abstract: The invention provides compositions comprising a topical formulation of donepezil and methods of use thereof for intradermal applications.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: March 24, 2026
    Assignee: ARCTIC THERAPEUTICS HF
    Inventors: Hakon Hakonarson, Charlly Kao, Edward T. Kisak, John M. Newsam, Avadhesh S. Kushwaha
  • METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS
    Publication number: 20260076953
    Abstract: This disclosure relates to the identification of a subset of mGluR network gene CNVs that are predictive of efficacy of treatment with fasoracetam, as well as the identification of an mGluR network gene CNV that is predictive of an increased likelihood of having ADHD as well as having certain symptoms associated with ADHD.
    Type: Application
    Filed: September 22, 2025
    Publication date: March 19, 2026
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Garry A. Neil, Liza Squires, Hakon Hakonarson
  • GPCR LATROPHILIN-3 AS BIOMARKER FOR DETECTING INCREASED RISK FOR MILD BRAIN INJURY AND METHODS OF USE THEREOF FOR DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20260071276
    Abstract: Compositions and methods for diagnosis and treatment of increased risk for mild traumatic brain injury are disclosed.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 12, 2026
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon HAKONARSON, Christina MASTER, Kristy ARBOGAST
  • Identification of novel loci in asthma and methods of use thereof for the diagnosis and treatment of asthma
    Patent number: 12545948
    Abstract: Compositions for the diagnosis and treatment of asthma are disclosed.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: February 10, 2026
    Assignee: The Children'S Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Berta Almoguera, Lyam M. Vazquez, Patrick M.A. Sleiman
  • GENOMIC ALTERATIONS ASSOCIATED WITH SCHIZOPHRENIA AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20260022420
    Abstract: Compositions and methods for the detection and treatment of schizophrenia are provided.
    Type: Application
    Filed: April 11, 2025
    Publication date: January 22, 2026
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Joseph Glessner, Struan F.A. Grant
  • Compositions and methods for the diagnosis and treatment of lymphatic system disorders
    Patent number: 12509729
    Abstract: Compositions and methods for the diagnosis and treatment of lymphatic anomaly are disclosed.
    Type: Grant
    Filed: July 28, 2022
    Date of Patent: December 30, 2025
    Assignee: THE CHILDREN'S HOSPTAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Dong Li, Lifeng Tian, Kenny Nguyen, Patrick Sleiman
  • COMPOSITIONS AND METHODS OF TREATING SEPSIS IN PATIENTS USING ANTI-LIGHT ANTIBODIES
    Publication number: 20250306031
    Abstract: The present disclosure relates to methods of treating sepsis or septic conditions in patients who have heightened LIGHT, IL-18 levels or biomarkers listed herein which can be treated with molecules that inhibit biomarker activity.
    Type: Application
    Filed: May 2, 2022
    Publication date: October 2, 2025
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Hakon HAKONARSON, Huiqi QU, Scott WEISS, Patrick SLEIMAN, Nuala MEYER
  • Compositions and methods for the diagnosis and treatment of lymphatic system disorders
    Patent number: 12365946
    Abstract: Compositions and methods for the diagnosis and treatment of lymphatic anomaly are disclosed.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: July 22, 2025
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Yoav Dori, Dong Li, Michael March, Charlly Kao, Christoph Seiler
  • ASSOCIATION OF RARE RECURRENT GENETIC VARIATIONS TO ATTENTION-DEFICIT, HYPERACTIVITY DISORDER (ADHD) AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20250129423
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Application
    Filed: August 30, 2024
    Publication date: April 24, 2025
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Joseph Glessner, Josephine Elia, Hakon Hakonarson
  • METHODS OF DIAGNOSING AND TREATING TOURETTE SYNDROME
    Publication number: 20250127771
    Abstract: Methods and uses for diagnosing and treating Tourette syndrome are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 23, 2024
    Publication date: April 24, 2025
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ATTENTION DEFICIT DISORDER AND 22Q SYNDROME
    Publication number: 20250120962
    Abstract: This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities with a nonselective activator of metabotropic glutamate receptors, such as fasoracetam, for example, in subjects having a genetic alteration in at least one metabotropic glutamate receptor (mGluR) network gene.
    Type: Application
    Filed: September 18, 2024
    Publication date: April 17, 2025
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Association of genetic variations to diagnose and treat attention-deficit hyperactivity disorder (ADHD)
    Patent number: 12139762
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Grant
    Filed: February 16, 2023
    Date of Patent: November 12, 2024
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Berta Almoguera, Lyam Vazquez, Patrick Sleiman
  • Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22Q syndrome
    Patent number: 12121514
    Abstract: This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities with a nonselective activator of metabotropic glutamate receptors, such as fasoracetam, for example, in subjects having a genetic alteration in at least one metabotropic glutamate receptor (mGluR) network gene.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: October 22, 2024
    Inventors: Hakon Hakonarson, Charlly Kao
  • Compositions and methods targeting the Th2 pathway for the treatment of asthma
    Patent number: 12091708
    Abstract: Compositions and methods for diagnosing and treating asthma and asthma patients a Th2 high asthma phenotype are disclosed.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: September 17, 2024
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Patrick Sleiman
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ANOREXIA NERVOSA AND BINGE EATING DISORDER
    Publication number: 20240189295
    Abstract: This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).
    Type: Application
    Filed: February 20, 2024
    Publication date: June 13, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS
    Publication number: 20240156801
    Abstract: This disclosure relates to the identification of a subset of mGluR network gene CNVs that are predictive of efficacy of treatment with fasoracetam, as well as the identification of an mGluR network gene CNV that is predictive of an increased likelihood of having ADHD as well as having certain symptoms associated with ADHD.
    Type: Application
    Filed: June 7, 2023
    Publication date: May 16, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Garry A. Neil, Liza Squires, Hakon Hakonarson
  • METHODS OF DIAGNOSING AND TREATING ANXIETY DISORDER
    Publication number: 20240100036
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 28, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING CONDUCT DISORDER
    Publication number: 20240075022
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 7, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • ASSOCIATION OF RARE RECURRENT GENETIC VARIATIONS TO ATTENTION-DEFICIT, HYPERACTIVITY DISORDER (ADHD) AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20230407399
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Application
    Filed: March 7, 2023
    Publication date: December 21, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Joseph Glessner, Josephine Elia, Hakon Hakonarson
  • GENETIC ALTERATIONS ASSOCIATED WITH EOSINOPHILIC ESOPHAGITIS AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF DISEASE
    Publication number: 20230357849
    Abstract: Compositions and methods for the treatment and diagnosis of eosinophilic esophagitis are disclosed.
    Type: Application
    Filed: September 8, 2021
    Publication date: November 9, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Patrick Sleiman, Xiao Chang