Patents by Inventor Hakon Hakonarson

Hakon Hakonarson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Association of genetic variations to diagnose and treat attention-deficit hyperactivity disorder (ADHD)
    Patent number: 12139762
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Grant
    Filed: February 16, 2023
    Date of Patent: November 12, 2024
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Berta Almoguera, Lyam Vazquez, Patrick Sleiman
  • Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22Q syndrome
    Patent number: 12121514
    Abstract: This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities with a nonselective activator of metabotropic glutamate receptors, such as fasoracetam, for example, in subjects having a genetic alteration in at least one metabotropic glutamate receptor (mGluR) network gene.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: October 22, 2024
    Inventors: Hakon Hakonarson, Charlly Kao
  • Compositions and methods targeting the Th2 pathway for the treatment of asthma
    Patent number: 12091708
    Abstract: Compositions and methods for diagnosing and treating asthma and asthma patients a Th2 high asthma phenotype are disclosed.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: September 17, 2024
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Patrick Sleiman
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ANOREXIA NERVOSA AND BINGE EATING DISORDER
    Publication number: 20240189295
    Abstract: This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).
    Type: Application
    Filed: February 20, 2024
    Publication date: June 13, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS
    Publication number: 20240156801
    Abstract: This disclosure relates to the identification of a subset of mGluR network gene CNVs that are predictive of efficacy of treatment with fasoracetam, as well as the identification of an mGluR network gene CNV that is predictive of an increased likelihood of having ADHD as well as having certain symptoms associated with ADHD.
    Type: Application
    Filed: June 7, 2023
    Publication date: May 16, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Garry A. Neil, Liza Squires, Hakon Hakonarson
  • METHODS OF DIAGNOSING AND TREATING ANXIETY DISORDER
    Publication number: 20240100036
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 28, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING CONDUCT DISORDER
    Publication number: 20240075022
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 7, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • ASSOCIATION OF RARE RECURRENT GENETIC VARIATIONS TO ATTENTION-DEFICIT, HYPERACTIVITY DISORDER (ADHD) AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20230407399
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Application
    Filed: March 7, 2023
    Publication date: December 21, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Joseph Glessner, Josephine Elia, Hakon Hakonarson
  • GENETIC ALTERATIONS ASSOCIATED WITH EOSINOPHILIC ESOPHAGITIS AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF DISEASE
    Publication number: 20230357849
    Abstract: Compositions and methods for the treatment and diagnosis of eosinophilic esophagitis are disclosed.
    Type: Application
    Filed: September 8, 2021
    Publication date: November 9, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Patrick Sleiman, Xiao Chang
  • Methods of diagnosing and treating conduct disorder
    Patent number: 11806340
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: November 7, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Methods of diagnosing and treating anxiety disorder
    Patent number: 11806341
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: October 28, 2021
    Date of Patent: November 7, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charily Kao
  • Nonselective metabotropic glutamate receptor activators for treatment of anorexia nervosa and binge eating disorder
    Patent number: 11779577
    Abstract: This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: October 10, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charily Kao
  • ASSOCIATION OF GENETIC VARIATIONS TO DIAGNOSE AND TREAT ATTENTION-DEFICIT HYPERACTIVITY DISORDER (ADHD)
    Publication number: 20230313304
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Application
    Filed: February 16, 2023
    Publication date: October 5, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Berta Almoguera, Lyam Vazquez, Patrick Sleiman
  • GENOMIC ALTERATIONS ASSOCIATED WITH SCHIZOPHRENIA AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20230304094
    Abstract: Compositions and methods for the detection and treatment of schizophrenia are provided.
    Type: Application
    Filed: March 28, 2023
    Publication date: September 28, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Joseph Glessner, Struan F.A. Grant
  • COMPOSITIONS AND METHODS FOR ENHANCING WEIGHT LOSS
    Publication number: 20230304018
    Abstract: Compositions and methods for the detection and treatment of obesity and other neurological disorders are provided.
    Type: Application
    Filed: October 17, 2022
    Publication date: September 28, 2023
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Rahul Pandey, Marina Bakay, Heather Hain
  • Methods for use in the diagnosis of autoimmune diseases
    Patent number: 11718877
    Abstract: This disclosure provides new genetic targets, diagnostic methods, and therapeutic treatment regimens for multiple autoimmune disorders, including pediatric autoimmune disorders that are co-inherited and genetically shared. The disclosure, for example, provides methods of diagnosing or determining a susceptibility for one or more autoimmune diseases and methods of determining treatment protocols for patients with one or more autoimmune diseases based on determining if the patients have genetic alterations in particular genes.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: August 8, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Yun Rose Li, Brendan Keating
  • Methods of diagnosing and treating ADHD in biomarker positive subjects
    Patent number: 11684617
    Abstract: This disclosure relates to the identification of a subset of mGluR network gene CNVs that are predictive of efficacy of treatment with fasoracetam, as well as the identification of an mGluR network gene CNV that is predictive of an increased likelihood of having ADHD as well as having certain symptoms associated with ADHD.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: June 27, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Garry A. Neil, Liza Squires, Hakon Hakonarson
  • Association of genetic variations to diagnose and treat attention-deficit hyperactivity disorder (ADHD)
    Patent number: 11591656
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: February 28, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Berta Almoguera, Lyam Vazquez, Patrick Sleiman
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS
    Publication number: 20230048706
    Abstract: Compositions and methods for the diagnosis and treatment of lymphatic anomaly are disclosed.
    Type: Application
    Filed: July 28, 2022
    Publication date: February 16, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Dong Li, Lifeng Tian, Kenny Nguyen, Patrick Sleiman
  • CXR4 as a susceptibility locus in juvenile idiopathic arthritis (JIA) and methods of use thereof for the treatment and diagnosis of the same
    Patent number: 11499194
    Abstract: Compositions and methods useful for the diagnosis and treatment of juvenile idiopathic arthritis are disclosed.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: November 15, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Terri H. Finkel, Haitao Zhang, Hakon Hakonarson