Patents by Inventor Hakon Hakonarson

Hakon Hakonarson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DIAGNOSING AND TREATING TOURETTE SYNDROME
    Publication number: 20220296582
    Abstract: Methods and uses for diagnosing and treating Tourette syndrome are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: April 6, 2022
    Publication date: September 22, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Compositions and methods for the diagnosis and treatment of lymphatic system disorders
    Patent number: 11401553
    Abstract: Compositions and methods for the diagnosis and treatment of lymphatic anomaly are disclosed.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: August 2, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Dong Li, Lifeng Tian, Kenny Nguyen, Patrick Sleiman
  • Compositions and methods for treatment of hereditary cystatin C amyloid angiopathy (HCCAA) and other neurodegenerative disorder associated with aberrant amyloid deposits
    Patent number: 11338009
    Abstract: Compositions and methods for the treatment of amyloid deposit diseases, e.g., hereditary cystatin C amyloid angiopathy and other neurodegenerative disorders, are disclosed.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: May 24, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Alvaro Gutierrez-Uzquiza, Michael March
  • METHODS OF DIAGNOSING AND TREATING ANXIETY DISORDER
    Publication number: 20220117954
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 28, 2021
    Publication date: April 21, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING CONDUCT DISORDER
    Publication number: 20220117953
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 27, 2021
    Publication date: April 21, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS
    Publication number: 20220112558
    Abstract: Compositions and methods for the diagnosis and treatment of lymphatic anomaly are disclosed.
    Type: Application
    Filed: September 9, 2019
    Publication date: April 14, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Yoav Dori, Dong Li, Michael March, Charlly Kao, Christoph Seiler
  • Methods of diagnosing and treating Tourette syndrome
    Patent number: 11298347
    Abstract: Methods and uses for diagnosing and treating Tourette syndrome are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: April 12, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • IDENTIFICATION OF PEDIATRIC ONSET INFLAMMATORY BOWEL DISEASE LOCI AND METHODS FOR USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20220056529
    Abstract: Compositions and methods for the detection and treatment of inflammatory bowel disease are provided.
    Type: Application
    Filed: September 3, 2021
    Publication date: February 24, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Jonathan Bradfield, Marcin Imielinski, Struan F.A. Grant
  • Methods of diagnosing and treating autism
    Patent number: 11219617
    Abstract: Methods for diagnosing and treating autism spectral disorders are encompassed. In one embodiment, a patient is diagnosed as having autism spectral disorder if at least one CNV in an mGluR network gene is found in a patient sample. Patients with at least one mGluR network gene CNV are effectively treated with (+)-5-oxo-Dprolinepiperidinamide monohydrate (NS-105).
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: January 11, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Tara Wenger, Charlly Kao, Dexter Hadley, Zhi-liang Wu, Joseph Glessner
  • Methods of diagnosing and treating conduct disorder
    Patent number: 11179378
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: November 23, 2021
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Methods of diagnosing and treating anxiety disorder
    Patent number: 11173153
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: November 16, 2021
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Identification of pediatric onset inflammatory bowel disease loci and methods for use thereof for the diagnosis and treatment of the same
    Patent number: 11111539
    Abstract: Compositions and methods for the detection and treatment of inflammatory bowel disease are provided.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: September 7, 2021
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Jonathan Bradfield, Marcin Imielinski, Struan F. A. Grant
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ANOREXIA NERVOSA AND BINGE EATING DISORDER
    Publication number: 20210267958
    Abstract: This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).
    Type: Application
    Filed: February 12, 2021
    Publication date: September 2, 2021
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Charlly Kao
  • ASSOCIATION OF RARE RECURRENT GENETIC VARIATIONS TO ATTENTION-DEFICIT, HYPERACTIVITY DISORDER (ADHD) AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20210254160
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Application
    Filed: October 7, 2020
    Publication date: August 19, 2021
    Inventors: Joseph Glessner, Josephine Elia, Hakon Hakonarson
  • NOVEL TOPICAL FORMULATION FOR INTRADERMAL APPLICATION AND USES THEREOF
    Publication number: 20210251973
    Abstract: The invention provides compositions comprising a topical formulation of donepezil and methods of use thereof for intradermal applications.
    Type: Application
    Filed: August 29, 2019
    Publication date: August 19, 2021
    Inventors: Hakon HAKONARSON, Charlly KAO, Edward T. KISAK, John M. NEWSAM, Avadhesh S. KUSHWAHA
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ATTENTION DEFICIT DISORDER AND 22Q SYNDROME
    Publication number: 20210205288
    Abstract: This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities with a nonselective activator of metabotropic glutamate receptors, such as fasoracetam, for example, in subjects having a genetic alteration in at least one metabotropic glutamate receptor (mGluR) network gene.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 8, 2021
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS
    Publication number: 20210137909
    Abstract: This disclosure relates to the identification of a subset of mGluR network gene CNVs that are predictive of efficacy of treatment with fasoracetam, as well as the identification of an mGluR network gene CNV that is predictive of an increased likelihood of having ADHD as well as having certain symptoms associated with ADHD.
    Type: Application
    Filed: April 18, 2018
    Publication date: May 13, 2021
    Inventors: Garry A. Neil, Liza Squires, Hakon Hakonarson
  • Nonselective metabotropic glutamate receptor activators for treatment of anorexia nervosa and binge eating disorder
    Patent number: 10918632
    Abstract: This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: February 16, 2021
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Charlly Kao
  • Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22Q syndrome
    Patent number: 10869861
    Abstract: This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities with a nonselective activator of metabotropic glutamate receptors, such as fasoracetam, for example, in subjects having a genetic alteration in at least one metabotropic glutamate receptor (mGluR) network gene.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: December 22, 2020
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Charlly Kao
  • COMPOSITIONS AND METHODS FOR ENHANCING WEIGHT LOSS
    Publication number: 20200385739
    Abstract: Compositions and methods for the detection and treatment of obesity and other neurological disorders are provided.
    Type: Application
    Filed: September 7, 2018
    Publication date: December 10, 2020
    Inventors: Hakon Hakonarson, Rahul Pandey, Marina Bakay, Heather Hain