Patents by Inventor Hal Alper

Hal Alper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240043850
    Abstract: This invention relates to compositions and methods for the production of Type III polyketides using genetically modified oleaginous yeast strains, for example, Yarrowia lipolytica.
    Type: Application
    Filed: October 13, 2023
    Publication date: February 8, 2024
    Inventors: Hal Alper, Kelly Markham, Claire Palmer
  • Publication number: 20230382776
    Abstract: This disclosure provides new filtration systems, filtration media, and processes for removing per- and polyfluoroalkyl substances (PFAS) from PFAS-contaminated water. The filtration systems, filtration media, and processes use a combination an activated carbon and a calcium sulfate which are mixed and immobilized or contained within a filter component such as a filter housing which provides a flow path for the contaminated water. This combination of components can remove PFAS contaminants to concentrations below the level of detection and provides other unexpected benefits as disclosed herein.
    Type: Application
    Filed: December 1, 2022
    Publication date: November 30, 2023
    Applicant: MYCELX TECHNOLOGIES CORPORATION
    Inventor: Hal Alper
  • Patent number: 11820987
    Abstract: This invention relates to compositions and methods for the production of Type III polyketides using genetically modified oleaginous yeast strains, for example, Yarrowia lipolytica.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: November 21, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hal Alper, Kelly Markham, Claire Palmer
  • Patent number: 11654379
    Abstract: This disclosure relates to new filtration systems, granular substrates, granular media and processes that are highly effective for removing suspended oil, particulates and oily particulates from an oil-water mixture. The new filtration media comprises a microporous granular substrate having a combination of specified micro-porosity, hardness and additional characteristics, the substrate being modified by an infused or coated absorption composition. This resulting filtration media displays excellent filtration performance, including outstanding durability and robustness to sustain its excellent performance over a large number of backwash cycles.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: May 23, 2023
    Assignee: MYCELX TECHNOLOGIES CORPORATION
    Inventor: Hal Alper
  • Publication number: 20230112945
    Abstract: This disclosure relates to filtration screens for use in a backwashable granular media bed filtration system. Drop-in retrofit kits for a backwashable granular media bed filtration system comprising one or more filtrations screens are provided herein. Such screens and kits can comprise a media support screen, a backwash filter screen, or a combination thereof. The kit can further comprise an agitator element comprising an impeller having vanes in which the impeller vane surfaces are coated with an abrasion resistant material. Associated filtration systems and processes are also described herein.
    Type: Application
    Filed: October 11, 2021
    Publication date: April 13, 2023
    Applicant: MYCELX TECHNOLOGIES CORPORATION
    Inventors: Hal Alper, Lance Rodeman
  • Publication number: 20220333147
    Abstract: The present invention relates to a composition comprising a 3D printed hydrogel, wherein at least two different populations of cells are embedded in the 3D printed hydrogel. The different populations of cells can produce one or more products. The 3D printed hydrogel can be lyophilized and rehydrated, and the cells can continue to produce the product. Also disclosed are methods of producing a product, and methods of producing a 3D printed hydrogel comprising different populations of cells.
    Type: Application
    Filed: June 25, 2020
    Publication date: October 20, 2022
    Inventors: Hal ALPER, Shuo-Fu YUAN, James WAGNER, Trevor JOHNSTON, Alshakim NELSON
  • Patent number: 10920233
    Abstract: Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: February 16, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: John Blazeck, Andrew Hill, Leqian Liu, Hal Alper
  • Publication number: 20190232195
    Abstract: This disclosure relates to new filtration systems, granular substrates, granular media and processes that are highly effective for removing suspended oil, particulates and oily particulates from an oil-water mixture. The new filtration media comprises a microporous granular substrate having a combination of specified micro-porosity, hardness and additional characteristics, the substrate being modified by an infused or coated absorption composition. This resulting filtration media displays excellent filtration performance, including outstanding durability and robustness to sustain its excellent performance over a large number of backwash cycles.
    Type: Application
    Filed: October 19, 2017
    Publication date: August 1, 2019
    Applicant: MYCELX TECHNOLOGIES CORPORATION
    Inventor: Hal Alper
  • Publication number: 20190078098
    Abstract: This invention relates to compositions and methods for the production of Type III polyketides using genetically modified oleaginous yeast strains, for example, Yarrowia lipolytica.
    Type: Application
    Filed: March 14, 2017
    Publication date: March 14, 2019
    Inventors: Hal Alper, Kelly Markham
  • Publication number: 20180201943
    Abstract: Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.
    Type: Application
    Filed: December 27, 2017
    Publication date: July 19, 2018
    Inventors: John Blazeck, Andrew Hill, Leqian Liu, Hal Alper
  • Patent number: 9951344
    Abstract: Provided herein are exogenous terminator sequences for use in fungi cell transcriptional termination.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: April 24, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Hal Alper, Kathleen Curran
  • Patent number: 9926347
    Abstract: Provided herein are compositions and methods useful for transporting xylose, arabinose and other monosaccharides, into a yeast cell.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: March 27, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Hal Alper, Eric Young
  • Patent number: 9896691
    Abstract: Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: February 20, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: John Blazeck, Andrew Hill, Leqian Liu, Hal Alper
  • Publication number: 20170327850
    Abstract: Genetically engineered oleaginous fungi (e.g., engineered Yarrowia lipolytica) are provided for use in itaconic acid production. In some aspects, the engineered fungi comprise a transgene for expression of a cis-aconitic acid decarboxylase (CAD) enzyme and, optionally, one or more further genetic modifications. Methods and culture systems for production of itaconic acid using such fungi are also provided.
    Type: Application
    Filed: October 29, 2015
    Publication date: November 16, 2017
    Inventors: Hal ALPER, John BLAZECK, Andrew HILL
  • Patent number: 9695223
    Abstract: Provided herein are compositions and methods useful for reducing glucose inhibition in transporting xylose, arabinose and other monosaccharides, into a yeast cell.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: July 4, 2017
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hal Alper, Eric Young, Sunmi Lee
  • Patent number: 9504941
    Abstract: A visual indicator device and method for determining the presence of oily contaminants in an aqueous stream are provided. The device includes a filtration status chamber for receiving and discharging the aqueous stream, and a transparent wall enabling viewing of the chamber interior. A fluid-pervious filtration media within the chamber is infused with an absorption composition at which the contaminant on contact with the media is immobilized. The media has a surface viewable through a transparent wall of the filtration status chamber, and the stream flow path causes the stream to impinge at the media via the surface, whereby the contaminants collect selectively at the media surface and are highly visible through the transparent wall.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: November 29, 2016
    Assignee: MYCELX TECHNOLOGIES CORPORATION
    Inventor: Hal Alper
  • Patent number: 9504956
    Abstract: A visual indicator device and method for determining the presence of oily contaminants in a gaseous stream are provided. The device includes a filtration status chamber for receiving and discharging the gaseous stream, and a transparent wall enabling viewing of the chamber interior. A fluid-pervious filtration media within the chamber is infused with an absorption composition at which the contaminant on contact with the media is immobilized. The media has a surface viewable through a transparent wall of the filtration status chamber, and the stream flow path is such as to cause the stream to impinge at the media via the said surface, whereby the contaminants collect selectively at the media surface and are therefore highly visible through the transparent wall.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: November 29, 2016
    Assignee: MYCELX TECHNOLOGIES CORPORATION
    Inventor: Hal Alper
  • Patent number: 9504946
    Abstract: A method and apparatus are provided for separating droplets of finely aerosolized elemental mercury from a fluid stream in which the droplets are dispersed, particularly a gaseous stream. In the method, a precious metal wire capillary surface or precious metal-coated wire capillary surface is contacted with the gaseous stream, causing the aerosolized droplets to deposit on the capillary surface and by capillary action to coalesce with other of such droplets. The surface is oriented to allow the mercury to flow by gravitational forces and capillary action to the lowermost portions of the surface, where it accumulates and can be collected. Metallic capillary surfaces comprised of finely braided strands of silver, gold, palladium, platinum, or rhodium wire, or wire coated with one or more of these metals, are particularly preferred.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: November 29, 2016
    Assignee: MYCELX TECHNOLOGIES CORPORATION
    Inventor: Hal Alper
  • Publication number: 20160280745
    Abstract: Provided herein are compositions and methods useful for transporting xylose, arabinose and other monosaccharides, into a yeast cell.
    Type: Application
    Filed: November 5, 2014
    Publication date: September 29, 2016
    Inventors: Hal Alper, Eric Young
  • Patent number: 9402392
    Abstract: Viscoelastic compositions capable of preventing microbial proliferation and capable of capturing microbial membrane and cell wall decomposition products are provided. The compositions comprise thermal reaction products of blends of fatty acids derived and isolated from drying and semi-drying oils such as linseed, safflower, and tung oil, with a polymer component such as for example poly (isobutyl methacrylate). These compositions are capable of capturing microbes and controlling their proliferation at a material on which the compositions are deposited, and further capable of absorption or incorporation of lipopolysaccharide and protein membrane materials and endotoxins.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: August 2, 2016
    Assignee: MyCelx Technologies Corporation
    Inventor: Hal Alper