Abstract: A high-speed optical tracking with compression and CMOS windowing for tracking applications that require high-speed and/or low latency when delivering pose (orientation and position) data. The high-speed optical tracking with compression and CMOS windowing generally includes an optical tracking system (10) that sense fiducial (22) and by extension markers (20). The markers can either be integrated on tools (20) handled by an operator (e.g. surgeon) (50) or fixed on the subject to track (e.g. patient) (40). The low-level processing (101, 107, 140) is realized within the tracking system to reduce the overall data to be transferred and considerably reduce the processing efforts. Pose data (127) are finally computed and transferred to a PC/monitor (30,31) or to tablet (60) to be used by an end-user application (130).

Abstract: The optical tracking system for mobile surgical navigation generally includes An Optical Tracking System {10} which is able to sense Fiducials (21) located on Markers (20) via Optical Sensors (11). The Optical Tracking System has processing means to compute the pose (position+translation) of the Markers (2.0) and transfer them to a Tablet computer (40) via Communication Means (30). These metrological data are finally used by a surgical application.

Abstract: A high-speed optical tracking with compression and CMOS windowing for tracking applications that require high-speed and/or low latency when delivering pose (orientation and position) data. The high-speed optical tracking with compression and CMOS windowing generally includes an optical tracking system (10) that sense fiducial (22) and by extension markers (20). The markers can either be integrated on tools (20) handled by an operator (e.g. surgeon) (50) or fixed on the subject to track (e.g. patient) (40). The low-level processing (101, 107, 140) is realized within the tracking system to reduce the overall data to be transferred and considerably reduce the processing efforts. Pose data (127) are finally computed and transferred to a PC/monitor (30,31) or to tablet (60) to be used by an end-user application (130).

Abstract: The present invention relates to a redundant reciprocal tracking system composed of at least two trackers 10. A first tracker is able to sense partial or full pose data (orientation and position) of a second tracker in a first reference frame and the second tracker is able to sense partial or full pose data of the first tracker in a second reference frame. Pose data of first and second trackers are further transferred to a central processor 30, which is able to compute the transformation between first and second reference frame. Data generated by the trackers are such designed that they define an over-determined mathematical system (e.g. more than 6 degrees of freedom in a 3D setup). The over-determined information can be used to qualify and/or improve the transformation of the reference frame. In an embodiment of the invention, the tracking system is an optical one and the over-determined information defines an error metric used to check the validity of the transformation.

Abstract: A high-speed optical tracking with compression and CMOS windowing for tracking applications that require high-speed and/or low latency when delivering pose (orientation and position) data. The high-speed optical tracking with compression and CMOS windowing generally includes an optical tracking system (10) that sense fiducial (22) and by extension markers (20). The markers can either be integrated on tools (20) handled by an operator (e.g. surgeon) (50) or fixed on the subject to track (e.g. patient) (40). The low-level processing (101, 107, 140) is realized within the tracking system to reduce the overall data to be transferred and considerably reduce the processing efforts. Pose data (127) are finally computed and transferred to a PC/monitor (30,31) or to tablet (60) to be used by an end-user application (130).

Abstract: The present invention relates to a redundant reciprocal tracking system composed of at least two trackers 10. A first tracker is able to sense partial or full pose data (orientation and position) of a second tracker in a first reference frame and the second tracker is able to sense partial or full pose data of the first tracker in a second reference frame. Pose data of first and second trackers are further transferred to a central processor 30, which is able to compute the transformation between first and second reference frame. Data generated by the trackers are such designed that they define an over-determined mathematical system (e.g. more than 6 degrees of freedom in a 3D setup). The over-determined information can be used to qualify and/or improve the transformation of the reference frame. In an embodiment of the invention, the tracking system is an optical one and the over-determined information defines an error metric used to check the validity of the transformation.

Abstract: A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

Abstract: A marker including a support with a front surface and a back surface, a light generating element fixed on the back surface of the support, and a device for fixation of the light generating element on the back surface, wherein the support includes at least three openings placed at predetermined positions on the support, wherein the light generating element is fixed on the back surface of the support by the device for fixation to cover the openings such that the light generating element is detectable through the openings by the tracking system, and wherein the light generating element can be placed or removed or replaced during an operation with the device for fixation.

Abstract: A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

Abstract: Test method checks and compensates ion yield variances in a mass spectrometer and includes feeding an eluate of a chromatographic separation to the spectrometer, continuously ad-mixing a separate target analyte solution at known concentration and constant flow rate to the eluate, injecting the mixture into the spectrometer and generating a detector signal for the mixture. A spectrogram is captured which includes an integration line and a mass-spectrographic peak of the target analyte, the integration line being a lasting background signal underlaid to the mass-spectrometric analysis of the eluate, then evaluating the spectrogram by capturing an integrated mass-spectrographic peak area above the integration line and an area which is found under the integrated peak area of the target analyte by perpendicular drop lines from the peak integration line and forming a mathematical relationship from the determined mass-spectrographic areas.

Abstract: A method of selecting pipetting parameters of a pipetting device for dispensing or pipetting a specific volume of a liquid sample, includes a fluid column of a fluid chamber of the pipetting device set into oscillation at the beginning of the aspiration, the pressure is monitored with the pressure transducer in the fluid chamber, and the pressure changes generated during aspiration into measuring signals are recorded. These measuring signals are processed by a computer or micro-processor and reproduced as a pressure curve, which is characteristic for the fluid column with the aspirated liquid sample, and which is compared with known pressure curves. Based on this comparison, pipetting parameters of the pipetting device are selected for the dispense or for pipetting a specific volume of the liquid sample. Selectable pipetting parameters include a speed of a movement of a pump piston of the pipetting device.

Abstract: The present invention relates to a method for classifying a liquid (1) in a known pipetting system for this liquid (1), the method being characterized in that the changes of a selected, measurable, and physically founded virtual parameter are detected as a data set typical for this liquid (1); this typical data set of the selected virtual parameter is compared to corresponding data sets of known liquids, and the liquid (1) is classified on the basis of this comparison. An especially preferred method and a device for classifying a liquid (1) relate to a device which comprises a fluid chamber (2), to which a measuring chamber (3) is connected, whose internal pressure is monitored using a pressure transducer (4). At least a first part (5) of this fluid chamber (2) may be brought into fluid connection with a sample (6) of this liquid (1).

Abstract: Test method checks and compensates ion yield variances in a mass spectrometer and includes feeding an eluate of a chromatographic separation to the spectrometer, continuously ad-mixing a separate target analyte solution at known concentration and constant flow rate to the eluate, injecting the mixture into the spectrometer and generating a detector signal for the mixture. A spectrogram is captured which includes an integration line and a mass-spectrographic peak of the target analyte, the integration line being a lasting background signal underlaid to the mass-spectrometric analysis of the eluate, then evaluating the spectrogram by capturing an integrated mass-spectrographic peak area above the integration line and an area which is found under the integrated peak area of the target analyte by perpendicular drop lines from the peak integration line and forming a mathematical relationship from the determined mass-spectrographic areas.

Abstract: A method, a device, and a test kit for performing this method for determining the volume of a sample of the liquid. In the method, a specific concentration of a chromophoric indicator is provided in this liquid, a sample is separated from the liquid, the optical absorption of the separated sample is measured, and the volume of the separated sample is determined by correlation of the measured optical absorption with the concentration of indicator in this liquid. Ions that generate a color in the sample by complexing with a specific ligand are used as the indicator to stain the liquid.

Abstract: The present invention relates to a method for classifying a liquid (1) in a known pipetting system for this liquid (1), the method being characterized in that the changes of a selected, measurable, and physically founded virtual parameter are detected as a data set typical for this liquid (1); this typical data set of the selected virtual parameter is compared to corresponding data sets of known liquids, and the liquid (1) is classified on the basis of this comparison. An especially preferred method and a device for classifying a liquid (1) relate to a device which comprises a fluid chamber (2), to which a measuring chamber (3) is connected, whose internal pressure is monitored using a pressure transducer (4). At least a first part (5) of this fluid chamber (2) may be brought into fluid connection with a sample (6) of this liquid (1).

Abstract: The storable modular component, especially a storable glass module, is prepared for assembly by gluing to another component without using an additional assembly glue. Along its edge it displays a profiled bead of a latent reactive adhesive which includes predominantly one or more polyurethanes with blocked isocyanate groups, or one or more polyurethane preproducts consisting of polyols and/or polyamines and encapsuled polyisocyanates, or one or more polyurethanes with radically polymerizable groups. In this case the reaction of the adhesive can be initiated at an activation temperature of 70 to 180° C. At the same time, it remains tacky and nonflowing but plastically deformable for a time sufficient for assembly. The stated materials are capable of being activated by being supplied with electrical, electromagnetic or magnetic energy or by infrared radiation. The adhesive may contain magnetizable and/or electrically conductive fillers.

Abstract: The ejection orifice (7) of a micropump including a baseplate (3) of glass and a cover plate (4) of silicon and intended for ejecting small liquid drops, has a diameter of about 50 &mgr;m, and is located in the center of a flat front surface (12) which, in order to avoid accumulations of liquid in the region of the ejection orifice (7), is only 8 times the area thereof and, along a continuous circular edge, is adjacent a lateral surface (13) in the form of an envelope of truncated cone. The front surface (12) and the lateral surface (13) have a surface roughness of not more than N4 and are provided, for example, with a hydrophobic plasma polymer coating.

Abstract: A method, a device, and a test kit for performing this method for determining the volume of a sample of the liquid. In the method, a specific concentration of a chromophoric indicator is provided in this liquid, a sample is separated from the liquid, the optical absorption of the separated sample is measured, and the volume of the separated sample is determined by correlation of the measured optical absorption with the concentration of indicator in this liquid. Ions that generate a color in the sample by complexing with a specific ligand are used as the indicator to stain the liquid.

Abstract: A delivery apparatus has, in a housing (13), a cannula (8) whose rear end is connected to a diluter (17) via a connecting tube (16). A piezoelectric actuator (10) increases in length under the action of a control signal and acts on a membrane (6) pierced by the cannula tip (9) and belonging to an interchangeable polypropylene pipette tip mounted on the delivery apparatus and adhering to the housing (13) by means of a collar (7) resting against said housing, and causing said membrane to sag, with the result that a drop of a sample liquid which was previously sucked in by means of the diluter (17) and whose accurately adjustable volume is between 1 nl and 1 &mgr;l is ejected from an outlet orifice (4). After a pipetting process the pipette tip is ejected by means of a slide (15). If the level of the sample liquid in the pipette tip always remains below the cannula tip (9), virtually no carry-over occurs.

Abstract: The ejection orifice (7) of a micropump including a baseplate (3) of glass and a cover plate (4) of silicon and intended for ejecting small liquid drops, has a diameter of about 50 &mgr;m, and is located in the center of a flat front surface (12) which, in order to avoid accumulations of liquid in the region of the ejection orifice (7), is only 8 times the area thereof and, along a continuous circular edge, is adjacent a lateral surface (13) in the form of an envelope of truncated cone. The front surface (12) and the lateral surface (13) have a surface roughness of not more than N4 and are provided, for example, with a hydrophobic plasma polymer coating.