Patents by Inventor Han Chung

Han Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES, BINDING FRAGMENTS, AND METHODS OF USE
    Publication number: 20200115465
    Abstract: The present disclosure relates to anti-SSEA4 antibodies and bindings fragments thereof comprising specific complementarity determining regions capable of high affinity binding to SSEA4 molecules and SSEA4-associated expressing tumor cells, such as breast cancer, pancreatic cancer, and renal cancer cells. The anti-SSEA4 antibodies and binding fragments induce ADCC or CDC effects in the targeted tumor cells and inhibit and/or reduce the cancer/tumor proliferation. The present disclosure also provides anti-SSEA4 antibodies and binding fragments thereof as a pharmaceutical composition for treating cancer. In addition, the anti-SSEA4 antibodies and binding fragments are useful in the diagnosis of cancers.
    Type: Application
    Filed: December 30, 2019
    Publication date: April 16, 2020
    Inventors: Nan-Horng LIN, Chiu-Chen HUANG, Chien-Yu CHEN, Kuo-Ching CHU, Chi-Huey WONG, Han-Chung WU
  • ELECTROSTATIC DISCHARGE HANDLING FOR LATERAL TRANSISTOR DEVICES
    Publication number: 20200091137
    Abstract: A semiconductor transistor device includes a source region, a gate region having a p-type gate region and an n-type gate region, and a drain region having a p-type drain region and an n-type drain region. The p-type gate region, the n-type gate region, the p-type drain region, and the n-type drain region are positioned to provide, in response to an electrostatic discharge (ESD) voltage, a drain-to-gate ESD current path to at least partially discharge the ESD voltage.
    Type: Application
    Filed: September 17, 2018
    Publication date: March 19, 2020
    Applicant: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLC
    Inventor: Han-Chung TAI
  • MANAbodies AND METHODS OF USING
    Publication number: 20200079854
    Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.
    Type: Application
    Filed: May 16, 2018
    Publication date: March 12, 2020
    Inventors: Emily Han-Chung Hsiue, Qing Wang, Bert Vogelstein, Kenneth W. Kinzler, Shibin Zhou, Jacqueline Douglass, Michael S. Hwang, Nickolas Papadopoulos
  • ELECTRONIC DEVICE
    Publication number: 20200060036
    Abstract: The disclosure discloses an electronic device, and the electronic device includes: a housing, a waterproof structure, a functional module, and a driving member. The housing has an inner surface and an opening connected to each other. The waterproof structure has a first end surface, a second end surface, and a side wall connecting the first end surface and the second end surface. The first end surface tightly connected with the inner surface in a sealing manner. The functional module is disposed inside the waterproof structure. The driving member is located in the housing, and is configured to drive the functional module to move toward or away from the opening.
    Type: Application
    Filed: August 1, 2019
    Publication date: February 20, 2020
    Inventors: Chui-Hung CHEN, Chia-Min CHENG, Ching-Yuan YANG, Cheng-Han CHUNG
  • FUNCTIONAL ASSEMBLY AND ELECTRONIC DEVICE
    Publication number: 20200059542
    Abstract: A functional assembly is provided. The functional assembly includes a functional module and a lifting assembly. The lifting assembly is fixed in the housing and configured to drive the functional module to move. In addition, the functional assembly further includes a rotating assembly. The rotating assembly is connected to the functional module.
    Type: Application
    Filed: August 14, 2019
    Publication date: February 20, 2020
    Inventors: Chui-Hung CHEN, Ching-Yuan YANG, Cheng-Han CHUNG, Chia-Min CHENG
  • EPITOPE-SUBSTITUTED VACCINE FOR USE IN IMPROVING SAFETY AND IMMUNOGENICITY AGAINST DENGUE VIRUSES
    Publication number: 20200031875
    Abstract: Isolated mutant dengue virus E protein variants are disclosed. The variant comprises an amino acid sequence that is at least 80% identical to SEQ ID NO: 1 and has one or more amino acid residue substitutions at position corresponding to Asn8 (N8), Arg9 (R9), Val12 (V 12) and/or Glu13 (E13). The variant may comprise an amino acid sequence that is at least 90% identical to the SEQ ID NO: 1 and lack an infection-enhancing antibody-binding motif comprising the amino acid sequence of SEQ ID NO: 28 at domain I. An isolated nucleic acid sequence encoding the variant, a plasmid expressing the variant, a plasmid expressing a virus-like particle comprising the variant, a DNA vaccine, and a method of detecting the presence of a dengue virus in a biological sample are also disclosed.
    Type: Application
    Filed: October 10, 2019
    Publication date: January 30, 2020
    Applicant: ACADEMIA SINICA
    Inventors: HAN-CHUNG WU, CHUNG-TAO TANG
  • Antibodies, binding fragments, and methods of use
    Patent number: 10538592
    Abstract: The present disclosure relates to anti-SSEA4 antibodies and bindings fragments thereof comprising specific complementarity determining regions capable of high affinity binding to SSEA4 molecules and SSEA4-associated expressing tumor cells, such as breast cancer, pancreatic cancer, and renal cancer cells. The anti-SSEA4 antibodies and binding fragments induce ADCC or CDC effects in the targeted tumor cells and inhibit and/or reduce the cancer/tumor proliferation. The present disclosure also provides anti-SSEA4 antibodies and binding fragments thereof as a pharmaceutical composition for treating cancer. In addition, the anti-SSEA4 antibodies and binding fragments are useful in the diagnosis of cancers.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: January 21, 2020
    Assignee: CHO PHARMA, INC.
    Inventors: Nan-Horng Lin, Chiu-Chen Huang, Chien-Yu Chen, Kuo-Ching Chu, Chi-Huey Wong, Han-Chung Wu
  • MULTILAYER COMPOSITE MEMBRANE
    Publication number: 20190388845
    Abstract: A multilayer composite membrane consists essentially of a porous support layer, an inorganic porous layer, a polymer porous layer, and a separation layer. The inorganic porous layer consists of inorganic particles and is disposed on the porous support layer. The polymer porous layer is disposed on the inorganic porous layer. The separation layer is disposed on the polymer porous layer.
    Type: Application
    Filed: December 10, 2018
    Publication date: December 26, 2019
    Applicant: Industrial Technology Research Institute
    Inventors: Li-Han Chung, Min-Fei Tsai, Guan-You Lin, Yen-Cheng Li
  • Angiopoietin-like 4 and a method of its use in wound healing
    Patent number: 10517075
    Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: December 24, 2019
    Assignee: Nanyang Technological University
    Inventors: Nguan Soon Tan, Han Chung Kelvin Chong
  • Isolated adipose-derived mesenchymal stem cells treated with angelica extract or butylidenephthalide, and wherein the cells have an increased mitochondrial membrane potential and a decreased level of IL-8, and methods for treating parkinson's disease
    Patent number: 10493105
    Abstract: A cell for treating neurodegenerative disease treated with angelica extract is provided. The pharmaceutical composition comprises the cell for treating neurodegenerative disease and can significantly increase and recover the number of dopaminergic neurons to achieve the goal for treating neurodegenerative disease.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: December 3, 2019
    Assignee: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD
    Inventors: Shinn-Zong Lin, Horng-Jyh Harn, Shih-Ping Liu, Han-Chung Cheng, Chi-Tang Tu
  • Peptides for diagnosis and treatment of cancer
    Patent number: 10487119
    Abstract: A method of peptide histochemical diagnosis to detect the peptide binding protein in the cancer tissue is described. This peptide binding specifically to tumor cells is linked to the dextran coated iron oxide nanoparticle. The peptide linked dextran coated iron oxide nanoparticle can be used to bind to the formalin-fixed and paraffin-embedded tumor surgical specimens, and the method of present disclosure can be used to evaluate the efficacy of peptide-targeted chemotherapy for treatment of cancer patients.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: November 26, 2019
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Chin-Tarng Lin, Han-Chung Wu
  • Epitope-substituted vaccine for use in improving safety and immunogenicity against dengue viruses
    Patent number: 10487120
    Abstract: Isolated mutant dengue virus E protein variants are disclosed. The variant comprises an amino acid sequence that is at least 80% identical to SEQ ID NO: 1 and has one or more amino acid residue substitutions at position corresponding to Asn8 (N8), Arg9 (R9), Val12 (V12) and/or Glu13 (E13). The variant may comprise an amino acid sequence that is at least 90% identical to the SEQ ID NO: 1 and lack an infection-enhancing antibody-binding motif comprising the amino acid sequence of SEQ ID NO: 28 at domain I. An isolated nucleic acid sequence encoding the variant, a plasmid expressing the variant, a plasmid expressing a virus-like particle comprising the variant, a DNA vaccine, and a method of detecting the presence of a dengue virus in a biological sample are also disclosed.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: November 26, 2019
    Assignee: Academia Sinica
    Inventors: Han-Chung Wu, Chung-Tao Tang
  • Coaxial cable connector
    Patent number: 10381791
    Abstract: A coaxial cable connector configured to be mounted to an externally threaded connector, comprising a nut portion having an inner thread configured to engage with an outer thread of said externally threaded connector, an inner-sleeve portion coaxially arranged with said nut and a first sleeve coaxially arranged with said nut, wherein said first sleeve comprises an inner flange radially on an outer wall of said inner-sleeve portion, characterized in that: when said nut is rotated relatively to said first sleeve, said inner-sleeve portion is rotated relatively to said first sleeve.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: August 13, 2019
    Assignee: EZCONN CORPORATION
    Inventor: Han-Chung Chen
  • Method of treating autoimmune disease by administering antibodies to interleukin-6
    Patent number: 10370443
    Abstract: The present disclosure provides antibodies that bind to human interleukin-6 (IL6). The antibodies can modulate IL6 signaling and thus used in treatment or prevention of IL6 associated diseases or disorders, particularly inflammatory disorder, rheumatoid arthritis (RA), angiogenesis, and cancer.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: August 6, 2019
    Assignee: Fountain Biopharma Inc.
    Inventors: Tong-Young Lee, Han-Chung Wu, Tanny Chen Tsao, Willie Lin
  • Method for improving mitochondria and method for promoting cell division of stem cell
    Patent number: 10342834
    Abstract: The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: July 9, 2019
    Assignee: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.
    Inventors: Han-Chung Cheng, Chi-Tang Tu, Szu-Ting Liu
  • METHOD OF FABRICATING FERROELECTRIC FIELD-EFFECT TRANSISTOR
    Publication number: 20190198638
    Abstract: The disclosed technology generally relates to methods of fabricating a semiconductor device, and more particularly to methods of fabricating a ferroelectric field-effect transistor (FeFET). According to one aspect, a method of fabricating a FeFET includes forming a layer stack on a gate structure, wherein forming the layer stack comprises a ferroelectric layer followed by forming a sacrificial stressor layer. The method additionally includes heat-treating the layer stack to cause a phase transition in the ferroelectric layer. The method additionally includes, subsequent to the heat treatment, replacing the sacrificial stressor layer with a two-dimensional (2D) material channel layer. The method further includes forming a source contact and a drain contact contacting the 2D material channel layer.
    Type: Application
    Filed: December 11, 2018
    Publication date: June 27, 2019
    Inventors: Jan Van Houdt, Hanns Christoph Adelmann, Han Chung Lin
  • COMPOSITIONS AND METHODS FOR TREATMENT AND DETECTION OF CANCERS
    Publication number: 20190177435
    Abstract: Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.
    Type: Application
    Filed: November 8, 2018
    Publication date: June 13, 2019
    Inventors: Chi-Huey Wong, Tsui-Ling Hsu, Yi-Wei Lou, Chih-Wei Lin, Shih-Chi Yeh, Chung-Yi Wu, Han-Chung Wu
  • PRESSURE VESSEL EQUIPPED WITH PERMEATED GAS DISCHARGING STRUCTURE
    Publication number: 20190162365
    Abstract: The present disclosure relates to a pressure vessel equipped with a permeated gas discharging structure, the pressure vessel including a nozzle boss into and from which a gas flows and is discharged; a liner coupled to a flange portion of the nozzle boss and provided with a space formed therein for receiving fluid; a discharge path forming part configured to form a gas discharging path from the nozzle boss side along an outer surface of the liner in a central axial direction; and a composite material provided at outer sides of the liner and the discharge path forming part
    Type: Application
    Filed: April 5, 2017
    Publication date: May 30, 2019
    Applicants: Hyundai Motor Company, KIA Motors Corporation
    Inventors: Jae Han CHUNG, Hyun Joon LEE, Ki Ho HWANG, Gye Hyoung YOO, Seok Bong HEO, Jong Lyul Kim
  • METHOD FOR IMPROVING MITOCHONDRIA AND METHOD FOR PROMOTING CELL DIVISION OF STEM CELL
    Publication number: 20190142889
    Abstract: The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.
    Type: Application
    Filed: January 8, 2019
    Publication date: May 16, 2019
    Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO.,LTD.
    Inventors: Han-Chung CHENG, Chi-Tang TU, Szu-Ting LIU
  • Expansion card with homogenized light output and light-homogenizing device thereof
    Patent number: 10288791
    Abstract: An expansion card with homogenized light outputs and light-homogenizing device thereof are disclosed. The expansion card includes a circuit board and a light-homogenizing device. The circuit board includes a light-emitting device disposed on a first side edge. The light-homogenizing device includes a light-guiding body, a light-diffusion element, and a light-turning element. The light-guiding body includes a light-input side and a light-output side opposite to each other, and the light-input side is adjacent to the first side edge. The light-diffusion element is disposed on the light-input side of the light-guiding body and opposite to the light-emitting device. The light-diffusion element and the light-out side are configured to diffuse the light beams entering into the light-guiding body from the light-emitting device and form a light-transmitting path.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: May 14, 2019
    Assignee: APACER TECHNOLOGY INC.
    Inventors: Hua-Min Tseng, Ming-Han Chung, Wen-Chin Wu, Chien-Pang Chen