Abstract: Disclosed herein are anti-GM-CSF antibodies capable of binding to human GM-CSF and blocking its biological activities. Also provided herein are pharmaceutical compositions comprising the anti-GM-CSF antibodies and therapeutic and diagnostic uses of such antibodies.

Abstract: Isolated mutant dengue virus E protein variants are disclosed. The variant comprises an amino acid sequence that is at least 80% identical to SEQ ID NO: 1 and has one or more amino acid residue substitutions at position corresponding to Asn8 (N8), Arg9 (R9), Val12 (V 12) and/or Glu13 (E13). The variant may comprise an amino acid sequence that is at least 90% identical to the SEQ ID NO: 1 and lack an infection-enhancing antibody-binding motif comprising the amino acid sequence of SEQ ID NO: 28 at domain I. An isolated nucleic acid sequence encoding the variant, a plasmid expressing the variant, a plasmid expressing a virus-like particle comprising the variant, a DNA vaccine, and a method of detecting the presence of a dengue virus in a biological sample are also disclosed.

Abstract: A server system comprises a deck, a front panel arranged on the deck and defining a collecting space; two doors arranged on opposite sides of the deck, and being perpendicular to the front panel; two receiving frame structures arranged between the doors in a back to back arrangement, and configured to receive multiple rows and columns of a plurality of storage drives horizontally, wherein two periphery corridors are each defined between one of the doors and one of the receiving frame structure facing the one door; two circuit boards arranged between the two receiving frame structures, wherein the two circuit boards comprise a plurality of slits, wherein a central corridor is defined between the two circuit boards; a storage cover disposed above the deck over the two periphery corridors, the central corridor, the two receiving frame structures, and the two circuit boards.

Abstract: A functional module is provided. The functional module is applied to an electronic device, and includes a housing, a functional member, and a motor assembly. Both the functional member and the motor assembly are disposed in the housing. The motor assembly includes a motor and an output shaft. The motor is configured to drive the output shaft to rotate. The output shaft protrudes from one side of the housing.

Abstract: A high-pressure composite container having a gastight nozzle structure includes a metal nozzle formed at a side of an inlet of a plastic liner layer that defines an inner layer of the high-pressure composite container; a nozzle insert which is inserted into and attached to the metal nozzle in a direction from an inner side of the plastic liner layer to an outer side of the plastic liner layer; and a nut member fixed to an upper end portion of the nozzle insert.

Abstract: An isolated or a synthetic targeting peptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO: 8 is disclosed. The targeting peptide may be conjugated to a component selected from the group consisting of polymeric micelles, lipoprotein-based drug carriers, nanoparticle drug carriers, a chemotherapeutic agent, a micelle, a liposome, dendrimers, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a prostate cancer cell, a stem cell, and an imaging agent. Also disclosed are a kit for imaging and detecting the presence of prostate cancer cells in vivo or in vitro, and a composition for treating prostate cancer, inhibiting prostate cancer cell growth, inducing prostate cancer cell cytotoxicity, and/or increasing the survival rate in a prostate cancer patient.

Abstract: A method of removing metal ions is provided, which includes contacting a metal removal composition with a solution containing metal ions for removing the metal ions from the solution, wherein the metal removal composition includes a polymer with a chemical structure of: wherein Q is a quinoline-based group, n=90˜450, o=10˜50, and p=0˜20. The metal removal composition has a type of fiber or film. In addition, the metal removal composition has a porosity of 60% to 90%.

Abstract: The present invention provides monoclonal antibodies or the antigen-binding portion thereof, that bind to a feto-embryonic dedifferentiated antigen, such as Leucine-rich Repeat Neuronal Protein 1 (LRRN1), a surface glycoprotein that is expressed abundantly on the surface of human embryonic stem cells prior to differentiation into embryoid bodies. Also disclosed herein are the uses of the novel LRRN1 antibodies.

Abstract: In a first aspect, the present disclosure relates to a method for removing an organic sacrificial material from a 2D material, comprising: providing a target substrate having thereon the 2D material and a layer of the organic sacrificial material over the 2D material, infiltrating the organic sacrificial material with a metal or ceramic material, and removing the organic sacrificial material.

Abstract: A forward osmosis membrane having a high chemical resistance includes a backing layer, a selective layer, and a hydrophilic support layer sandwiched between the backing layer and the selective layer. The hydrophilic support layer includes a plurality of nanostructures, each of which includes a carbon nanotube and a hydrophilic film coated around the carbon nanotube, and has an outer layer defined by the hydrophilic films of the nanostructures to prevent the selective layer from penetrating into the hydrophilic support layer.

Abstract: A method of the present disclosure includes receiving a design layout; performing routing to the design layout to obtain a routed layout including an interconnect structure including a first metal layer, a second metal layer over the first metal layer, a third metal layer over the second metal layer, and a plurality of functional vias; performing optical proximity correction (OPC) operations to the routed layout to obtain an OPC'ed layout; and modifying the OPC'ed layout to obtain a modified layout. The modifying of the routed layout includes inserting a first plurality of dummy vias between the first metal layer and the second metal layer to avoid horizontal bridging between two adjacent metal lines in the first metal layer, and inserting a second plurality of dummy vias between the second metal layer and the third metal layer to avoid vertical coupling to the first plurality of dummy vias.

Abstract: A server system comprises a base, a front panel (13) arranged on the base and defining a collecting space; two doors (16) arranged on opposite sides of the base, and being perpendicular to the front panel; two storage cases (171) arranged between the doors in a back to back arrangement, and configured to receive multiple rows and columns of a plurality of storage drives horizontally, wherein two first corridors are each defined between one of the doors and one of the storage case facing the one door; two circuit boards (18) arranged between the two storage cases, wherein the two circuit boards comprise a plurality of slits, wherein a second corridor is defined between the two circuit boards; a storage cover (121) disposed above the base over the two first corridors, the second corridor, the two storage cases, and the two circuit boards.

Abstract: The disclosure discloses an electronic device, and the electronic device includes: a housing, a waterproof structure, a functional module, and a driving member. The housing has an inner surface and an opening connected to each other. The waterproof structure has a first end surface, a second end surface, and a side wall connecting the first end surface and the second end surface. The first end surface tightly connected with the inner surface in a sealing manner. The functional module is disposed inside the waterproof structure. The driving member is located in the housing, and is configured to drive the functional module to move toward or away from the opening.

Abstract: A functional assembly is provided. The functional assembly includes a functional module and a lifting assembly. The lifting assembly is fixed in the housing and configured to drive the functional module to move. In addition, the functional assembly further includes a rotating assembly. The rotating assembly is connected to the functional module.

Abstract: A use of an emblica extract in preparing a pharmaceutical composition for protecting mitochondria in retina is provided. When the pharmaceutical composition, which comprises the emblica extract, is provided to retinal cells, a use of the pharmaceutical composition comprises improvement of the ability of performing the oxidative phosphorylation for the synthesis of the adenosine triphosphate (ATP) by the mitochondria in the retinal cells under or exposed to ultraviolet light, and improvement of the coupling efficiency of the synthesis of the adenosine triphosphate by the mitochondria.

Abstract: A method of the present disclosure includes receiving a design layout; performing routing to the design layout to obtain a routed layout including an interconnect structure including a first metal layer, a second metal layer over the first metal layer, a third metal layer over the second metal layer, and a plurality of functional vias; performing optical proximity correction (OPC) operations to the routed layout to obtain an OPC'ed layout; and modifying the OPC'ed layout to obtain a modified layout. The modifying of the routed layout includes inserting a first plurality of dummy vias between the first metal layer and the second metal layer to avoid horizontal bridging between two adjacent metal lines in the first metal layer, and inserting a second plurality of dummy vias between the second metal layer and the third metal layer to avoid vertical coupling to the first plurality of dummy vias.

Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.

Abstract: A semiconductor transistor device includes a source region, a gate region having a p-type gate region and an n-type gate region, and a drain region having a p-type drain region and an n-type drain region. The p-type gate region, the n-type gate region, the p-type drain region, and the n-type drain region are positioned to provide, in response to an electrostatic discharge (ESD) voltage, a drain-to-gate ESD current path to at least partially discharge the ESD voltage.

Abstract: The present disclosure provides a thermal-activated pressure relief device of a fuel cell vehicle, the thermal-activated pressure relief device including: a hollow body mounted at an outlet of a hydrogen tank; a hydrogen discharge block having a plurality of first hydrogen discharge holes and mounted and fixed in an upper portion of the hollow body; a hydrogen discharge pipe having a plurality of second hydrogen discharge holes and connected to a bottom of the hydrogen discharge block; a piston fitted on an outer side of the hydrogen discharge pipe to be able to move up and down and to open and close the second hydrogen discharge holes; a stopper mounted in a lower portion of the hollow body and limiting a downward movement distance of the piston; and a melting alloy disposed between the piston and the stopper and melting at a predetermined temperature or more.

Abstract: The present invention provides methods for treating hepatitis B virus (HBV) infection using antibodies which specifically bind to human IFN?.