Abstract: Aspects of the invention include color change compositions having a color former and color developer composition that transitions from a first color state to a second color state upon application of an applied stimulus and an amount of a copolymer sufficient to eliminate background color of the color former and color developer composition during transition from the first color state to the second color state. Methods for preparing and devices employing the color change compositions of the invention are also described.

Abstract: Systems and methods can be used to help discriminate between epileptic and non-epileptic seizures based on a relationship between the postictal heart electrical activity and the preictal heart electrical activity. Also disclosed is an approach to determine an R-R interval by using a time-invariant complex wavelet transform.

Abstract: The invention involves the incorporation and enablement of multiple interactive elements into high-volume consumables products to increase utility, function and features of the consumable product at minimal incremental cost and adjustment to production and manufacturing processes. The invention further reports processes and compositions that enable consumable products with differentiating features which product would otherwise be deficient for their intended use and application.

Abstract: Co-topo-polymeric indicator compositions and methods for making and using the same are provided. Indicator compositions of the invention include a polymer and undergo a color change, which may be reversible or irreversible, in response to an applied stimulus, e.g., temperature. Aspects of methods of producing the compositions include setting a fluid co-topo-polymeric precursor composition into a solid product and then subjecting the solid product (either immediately or after a delay period) to polymerizing conditions to produce the desired indicator composition. Also provided are indicator devices that include the indicator compositions of the invention. The compositions of the invention find use in a variety of different applications.

Abstract: Color change compositions that transition from a first to second color state upon application of an applied stimulus are provided. Also provided are substrates having the compositions on a surface thereof, as well as methods of making and using the compositions.

Abstract: The invention concerns the use of competitive AMPA receptor antagonists for the treatment, prevention or delay of progression of Rasmussen's encephalitis and/or certain forms of epilepsy.

Abstract: Co-topo-polymeric indicator compositions and methods for making and using the same are provided. Indicator compositions of the invention include a polymer and undergo a color change, which may be reversible or irreversible, in response to an applied stimulus, e.g., temperature. Aspects of methods of producing the compositions include setting a fluid co-topo-polymeric precursor composition into a solid product and then subjecting the solid product (either immediately or after a delay period) to polymerizing conditions to produce the desired indicator composition. Also provided are indicator devices that include the indicator compositions of the invention. The compositions of the invention find use in a variety of different applications.

Abstract: The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.

Abstract: Color change compositions that transition from a first to second color state upon application of an applied stimulus are provided. Also provided are substrates having the compositions on a surface thereof, as well as methods of making and using the compositions.

Abstract: Multi-ply thermally printable constructs include a thermal print medium sandwiched between two opaque substrates that are temporarily bonded together to prevent information that is thermally printed through one of the substrates from being viewed until the substrates are separated. The thermal print medium, opaque substrates, and the means for bonding the substrates can take various forms for achieving particular objectives.

Abstract: A cooling garment comprises a phase change material and at least one of: at least one leg portion and at least one arm portion. The phase change material may have a transition temperature between solid and liquid phases of between about 60° F. to about 90° F. The at least one arm portion has the phase change material disposed therein, and the at least one leg portion has the phase change material disposed therein. The arm and leg portions may be attached to a torso portion and shorts portion, respectively, and may be removable therefrom. The cooling garment may include a sensor configured to indicate a cooling capacity of the phase change material. A portable container having a reactivation substance stored therein may be provided to reactivate the phase change material. In one embodiment, the portable container is part of a self-contained breathing apparatus. In another embodiment, the phase change material is submerged in the reactivation substance in the container.

Abstract: The invention concerns the use of competitive AMPA receptor antagonists for the treatment, prevention or delay of progression of spasticity.

Abstract: A non-foil packaging laminate for liquid food packaging comprises a core layer of paper or paperboard, outermost liquid tight, heat sealable layers of polyolefin and, applied onto the inner side of the layer of paper or paperboard, an oxygen gas barrier layer formed by liquid film coating of a liquid gas barrier composition and subsequent drying, the liquid composition containing a polymer binder dispersed or dissolved in a liquid medium. The laminate further comprises a layer of a polyolefin-based matrix polymer with inorganic filler particles distributed therein and inorganic particles dispersed also in the gas barrier layer from the liquid gas barrier composition. Also disclosed is a method for manufacturing the packaging laminate and a packaging container made from the packaging laminate.

Abstract: Discrete sensing elements are described that can be integrated into dental hygiene products and can provide rapid and direct feedback to a user as to oral environmental status and as to the performance of the intended oral care product. Selectively tuned elements can both sense and report relevant information including usage time, adequacy of performance during use, training for better usage, and/or the physical or biological status as can be measured by direct oral contact. Sensing and reporting mechanisms can be tuned for increased or decreased sensitivities. Sensing elements can comprise one or more discrete optical changes, structural changes, or other physical changes to the dental hygiene product as a means of alerting a user of a stimulus. Use of optical reference colors provides a high level of accuracy and objectivity as to the status of a sensing event. Enabling delivery and application compositions and methods are described.

Abstract: Systems and methods can be used to help discriminate between epileptic and non-epileptic seizures based on a relationship between the postictal heart electrical activity and the preictal heart electrical activity. Also disclosed is an approach to determine an R-R interval by using a time-invariant complex wavelet transform.

Abstract: Ingestible compositions comprising a chromic change agent together with methods of making and using them are provided. The chromic change agent alternatively may be associated with the ingestible, such as a packaging material for the ingestible. In response to a triggering event, physical or chemical, the chromic change agent changes color to provide information as to the history of the ingestible, either prior or contemporaneous with use. Depending on the use, the color change agent may be reversible or irreversible. Various solid or liquid ingestible compositions are provided for determining ingestible temperature, storage temperature, user temperature, light exposure, pH change, hydration or solvation change, mechanical stress, and the like, particularly in comestibles. Of particular interest are polydiacetylene polymers that may be formulated to provide compositions having numerous different color transition triggering mechanisms.

Abstract: The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.

Abstract: Co-topo-polymeric indicator compositions and methods for making and using the same are provided. Indicator compositions of the invention include a polymer and undergo a color change, which may be reversible or irreversible, in response to an applied stimulus, e.g., temperature. Aspects of methods of producing the compositions include setting a fluid co-topo-polymeric precursor composition into a solid product and then subjecting the solid product (either immediately or after a delay period) to polymerizing conditions to produce the desired indicator composition. Also provided are indicator devices that include the indicator compositions of the invention. The compositions of the invention find use in a variety of different applications.

Abstract: The present invention relates to a liquid mixture comprising a first polymer, which is a poly(acid), a second polymer, which is a poly(ether), and at least one salt, wherein the molecular weight of the poly(acid) is in the range of 1000-100,000 Da. The second polymer is selected to be capable of forming immiscible aqueous phases in the presence of the poly(acid) and salt. The poly(acid) may be selected from the group consisting of poly(acrylic acid) and poly(methacrylic acid), and the second synthetic polymer may comprise ethylene oxide. The invention may be used for separation of biomolecules, cells or particles.

Abstract: Multi-ply thermally printable constructs include a thermal print medium sandwiched between two opaque substrates that are temporarily bonded together to prevent information that is thermally printed through one of the substrates from being viewed until the substrates are separated. The thermal print medium, opaque substrates, and the means for bonding the substrates can take various forms for achieving particular objectives.