Abstract: Co-topo-polymeric indicator compositions and methods for making and using the same are provided. Indicator compositions of the invention include a polymer and undergo a color change, which may be reversible or irreversible, in response to an applied stimulus, e.g., temperature. Aspects of methods of producing the compositions include setting a fluid co-topo-polymeric precursor composition into a solid product and then subjecting the solid product (either immediately or after a delay period) to polymerizing conditions to produce the desired indicator composition. Also provided are indicator devices that include the indicator compositions of the invention. The compositions of the invention find use in a variety of different applications.

Abstract: The invention concerns the use of competitive AMPA receptor antagonists for the treatment, prevention or delay of progression of neuronal ceroid lipofuscinosis.

Abstract: A non-foil packaging laminate for liquid food packaging comprises a core layer of paper or paperboard, outermost liquid tight, heat sealable layers of polyolefin and, applied onto the inner side of the layer of paper or paperboard, an oxygen gas barrier layer formed by liquid film coating of a liquid gas barrier composition and subsequent drying, the liquid composition containing a polymer binder dispersed or dissolved in a liquid medium. The laminate further comprises a layer of a polyolefin-based matrix polymer with inorganic filler particles distributed therein and inorganic particles dispersed also in the gas barrier layer from the liquid gas barrier composition. Also disclosed is a method for manufacturing the packaging laminate and a packaging container made from the packaging laminate.

Abstract: The invention provides flash imaging devices that include an optical change component that undergoes a change in response to an applied stimulus, a substrate and a stimulus element. Also provided are articles that include the subject devices, as well as methods of making and using the same.

Abstract: The present invention relates to novel combinations suitable for the treatment of migraine of various genesis or aetiology, which comprise, as active ingredients, at least one 5-HT1 B/1 D receptor agonist and at least one selective, competitive AMPA receptor antagonist being a 1 H-quinazoline-2,4-dione of formula (I) as defined in the claims; to their preparation; to their use as medicaments and to medicaments comprising them.

Abstract: The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.

Abstract: The present invention relates to novel fatty acid esters of the reversible Iloperidone metabolite P-88-8991, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.

Abstract: The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.

Abstract: Duration monitoring co-topo-polymeric compositions and methods for making and using the same are provided. Indicator compositions of the invention include an organic polymer and undergo a color change, which may be reversible or irreversible, in a time dependent manner following an initiation event. Also provided are indicator devices that include the indicator compositions of the invention. The compositions of the invention find use in a variety of different applications.

Abstract: Direct remote digital/analog printing devices and mediums have been developed, which are capable of directly digitally printing on non-uniform or uniform substrate/mediums. Examples of devices are also capable of recognizing wireless digital or analog signals for processing and printing or directly scanning substrates using information (analog or digitally) encoded. The read/write devices can be remote and operate separately or can be attached to existing communications devices and products.

Abstract: The invention provides composite materials comprising a shape change element and an optical change element, which elements undergo a change in response to an applied stimulus. Also provided are objects that include the subject shape changing materials, as well as methods of making and using the same.

Abstract: An interior lamp can achieve both an excellent illumination function and an excellent illumination effect (providing a comfortable environment) and may possibly provide high merchandizability characteristics. The interior lamp can include an LED light source unit having a substrate and a plurality of white LED lamps and colored LED lamps mounted on the substrate. A cover case can be provided to serve as a light illumination unit. The light illumination unit can include a double-layer structure having a light diffusion layer and a light transmission layer. The light diffusion layer can have a plurality of penetrating holes. The light transmission layer can have a plurality of convex lens portions. The center axes of the penetrating holes and the corresponding lens portions can coincide with corresponding optical axes of the white LED lamps, respectively.

Abstract: Discrete sensing elements are described that can be integrated into dental hygiene products and can provide rapid and direct feedback to a user as to oral environmental status and as to the performance of the intended oral care product. Selectively tuned elements can both sense and report relevant information including usage time, adequacy of performance during use, training for better usage, and/or the physical or biological status as can be measured by direct oral contact. Sensing and reporting mechanisms can be tuned for increased or decreased sensitivities. Sensing elements can comprise one or more discrete optical changes, structural changes, or other physical changes to the dental hygiene product as a means of alerting a user of a stimulus. Use of optical reference colors provides a high level of accuracy and objectivity as to the status of a sensing event. Enabling delivery and application compositions and methods are described.

Abstract: Ingestible compositions comprising a chromic change agent together with methods of making and using them are provided. The chromic change agent alternatively may be associated with the ingestible, such as a packaging material for the ingestible. In response to a triggering event, physical or chemical, the chromic change agent changes color to provide information as to the history of the ingestible, either prior or contemporaneous with use. Depending on the use, the color change agent may be reversible or irreversible. Various solid or liquid ingestible compositions are provided for determining ingestible temperature, storage temperature, user temperature, light exposure, pH change, hydration or solvation change, mechanical stress, and the like, particularly in comestibles. Of particular interest are polydiacetylene polymers that may be formulated to provide compositions having numerous different color transition triggering mechanisms.

Abstract: Compliant liquid-free cleaning compositions and methods for using the same are provided. A composition that is pliable and putty-like that can be rolled and pressed onto dirt to clean the dirt off of a surface is provided. The composition can be used on hands, household surfaces, countertops, or any item displaying dirt. The invention eliminates the need for using water-based or other liquid cleansers.

Abstract: The invention provides flash imaging devices that include an optical change component that undergoes a change in response to an applied stimulus, a substrate and a stimulus element. Also provided are articles that include the subject devices, as well as methods of making and using the same.

Abstract: Stylus-substrate system components include an optical transitioning or color changing substrate and a stylus device/mechanism for inducing the optical transition or color change in the substrate. The optical transitioning or color change substrate possess all of the chemical components necessary to generate a single color or multiple color image, written matter, graphics, markings or recorded information. The stylus device/mechanism possesses the physical, electrical, and/or mechanical means for inducing the single or multi-colored change in the substrate.

Abstract: Ingestible compositions comprising a chromic change agent together with methods of making and using them are provided. The chromic change agent alternatively may be associated with the ingestible, such as a packaging material for the ingestible. In response to a triggering event, physical or chemical, the chromic change agent changes color to provide information as to the history of the ingestible, either prior or contemporaneous with use. Depending on the use, the color change agent may be reversible or irreversible. Various solid or liquid ingestible compositions are provided for determining ingestible temperature, storage temperature, user temperature, light exposure, pH change, hydration or solvation change, mechanical stress, and the like, particularly in comestibles. Of particular interest are polydiacetylene polymers that may be formulated to provide compositions having numerous different color transition triggering mechanisms.

Abstract: The present invention relates to a liquid mixture comprising a first polymer, which is a poly(acid), a second polymer, which is a poly(ether), and at least one salt, wherein the molecular weight of the poly(acid) is in the range of 1000-100,000 Da. The second polymer is selected to be capable of forming immiscible aqueous phases in the presence of the poly(acid) and salt. The poly(acid) may be selected from the group consisting of poly(acrylic acid) and poly(methacrylic acid), and the second synthetic polymer may comprise ethylene oxide. The invention may be used for separation of biomolecules, cells or particles.

Abstract: Combinations which comprise at least one nicotinic acetylcholine alpha 7 receptor agonist and at least one compound selected from the group consisting of (a) conventional antipsychotics (b) atypical antipsychotics (c) cognition, attention and/or memory enhancers (d) and to use of these combinations in the treatment of psychiatric disorders.