Abstract: Provided are conjugates including a targeting moiety that binds to a cell surface molecule of a target cell and a target cell surface-editing enzyme. Also provided are compositions and kits that include the conjugates, as well as methods of using the conjugates. Methods of making conjugates are also provided.

Abstract: Embodiments of the disclosure provide a data transmission method. The method can include receiving a first packet sent by a virtual private network user, wherein the first packet carries a first destination address that does not belong to an address range that has been configured for a virtual private network where the virtual private network user is located, converting the first destination address to a second destination address, generating a second packet according to the second destination address and the first packet, and sending the second packet outside the virtual private network where the virtual private network user is located.

Abstract: A computer-implemented method for generating contours of anatomy based on user click points includes a computer displaying an image comprising an anatomical structure and receiving a first user selection of a first click point at a first position on an outward facing edge of the anatomical structure. The computer applies a contour inference algorithm to generate an inferred contour around the outward facing edge based on the first position. Following generation of the inferred contour, the computer receives a second user selection of a second click point at a second position on the image. Then, the computer creates a visual indicator on a segment of the inferred contour between the first position and the second position as indicative of the user's confirmation of accuracy of the segment.

Abstract: Embodiments of the present invention provide a method for changing configurations at a client device is presented.

Abstract: A method and an apparatus of generating rule tables for a virtual dedicated network, and a routing method are disclosed. The method includes determining virtual switches which act as switching nodes in a virtual dedicated network based on topological structure information of the virtual dedicated network; and using network identifiers of the virtual switches as keywords to configure and generate rule tables of the virtual dedicated network, the rule tables including at least the keywords which act as addresses of the switching nodes in the rule tables. The embodiments of the present disclosure can greatly reduce the number of table items in a rule table in a virtual dedicated network, and reduce the number of table items of transfer nodes and an amount of data of management and control nodes, thus effectively improving the system performance.

Abstract: Devices and methods for forming a device are disclosed. The method includes providing a crystalline-on-insulator substrate having a bulk substrate and a surface substrate separated by a buried insulator layer. The surface substrate is defined with a device region. A transistor having a gate is formed in the device region. A first diffusion region is formed adjacent to a first side of the gate and a second diffusion region is formed adjacent to and displaced away from a second side of the gate. At least a first drift isolation region is formed in the surface substrate adjacent to and underlaps the second side of the gate. A drift well is formed in the surface substrate encompassing the first drift isolation region. A device isolation region surrounding the device region is formed in the surface substrate. The device isolation region includes a second depth which is deeper than a first depth of the first drift isolation region.

Abstract: The present invention relates to a composition as a transforming growth factor (TGF)-? suppressor which comprises an effective amount of guanidine compound or a pharmaceutically acceptable salt. More particularly, the present invention relates to a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-? suppressor, wherein the composition is characterized by suppression or reduction of TGF-? activity which is a cause of disease. The present invention relates to a method of treating various TGF-? associated diseases, the method comprising administering to the subject a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-? suppressor which can prevent or treat TGF-? associated diseases by suppressing or reducing TGF-? activity.

Abstract: Devices and methods for forming a device are disclosed. The method includes providing a crystalline-on-insulator substrate having a bulk substrate and a surface substrate separated by a buried insulator layer. The surface substrate is defined with a device region. A transistor having a gate is formed in the device region. A first diffusion region is formed adjacent to a first side of the gate and a second diffusion region is formed adjacent to and displaced away from a second side of the gate. At least a first drift isolation region is formed in the surface substrate adjacent to and underlaps the second side of the gate. A drift well is formed in the surface substrate encompassing the first drift isolation region. A device isolation region surrounding the device region is formed in the surface substrate. The device isolation region includes a second depth which is deeper than a first depth of the first drift isolation region.

Abstract: Disclosed are a method and apparatus for closing a terminal, where a terminal acquires in real time an image in a preset range around the terminal, and if there is no human facial image detected in the acquired image, then the terminal will start a timer; and if a length of time recorded by the timer reaches a first preset length of time, and there is no human facial image detected in the image acquired throughout the length of time recorded by the timer, then the terminal will be closed.

Abstract: A method and apparatus for operating a portable radio communication device is provided. The portable radio communication device receives communications on a primary channel and a secondary channel during a dual-watch mode of operation. The portable radio communication device determines whether the portable radio communication device is proximate to a subject. The portable radio communication device suppresses audio from communications of one of the two channels and plays audio from communications of the other channel when the portable communication device is proximate to the subject. Additionally, the portable radio communication device allows transmission to occur only over the channel in which communication is not suppressed when the portable communication device is proximate to the subject.

Abstract: A tool configured for adjusting a plurality of pressing heads of an auxiliary welding machine and a method for operating the same are disclosed. The tool includes: a support; a limiting mechanism disposed on the support, wherein the limiting mechanism has a limiting groove for receiving a top end of at least one of the plurality of pressing head. It is possible to adjust the plurality of pressing heads of the auxiliary welding machine more conveniently and accurately using the above tool.

Abstract: The present disclosure provides a method and device for playing a 3D source on a smart TV. Sources in smart TV system have flag bit information. The method includes: when receiving a request for playing a designated source, determining whether the designated source is a 3D source; if yes, determining a synthesis manner of the designated source, and modifying flag bit information of the designated source according to the synthesis manner; and when receiving a poll request sent from an underlying synthesis module, returning the modified flag bit information to the underlying synthesis module, so that when finding that the flag bit information is modified, the underlying synthesis module sends an instruction for playing the 3D source to a play module to notify the play module to synthesize the 3D source using a synthesis manner corresponding to the modified flag bit information and play the 3D source.

Abstract: This present disclosure discloses a method and apparatus for processing 3D setting information in a smart TV, wherein a same global 3D setting function is shared by different applications in the smart TV, a system-global environment variable is preset in the global 3D setting function; and the method includes: presenting a 3D setting user interface upon reception of a 3D setting invocation request in a current application; modifying the value of the system-global environment variable according to a selection result of a user upon reception of the selection result at an operation entry in the 3D setting user interface; and switching, by the core display process of the operating system, a play state of the a video in response to a changing value of the system-global environment variable while polling the system-global environment variable. The disclosure can achieve global 3D setting.

Abstract: Embodiments of the present invention provide a method for changing configurations at a client device is presented.

Abstract: A method and apparatus for operating a portable radio communication device is provided. The portable radio communication device receives communications on a primary channel and a secondary channel during a dual-watch mode of operation. The portable radio communication device determines whether the portable radio communication device is proximate to a subject. The portable radio communication device suppresses audio from communications of one of the two channels and plays audio from communications of the other channel when the portable communication device is proximate to the subject. Additionally, the portable radio communication device allows transmission to occur only over the channel in which communication is not suppressed when the portable communication device is proximate to the subject.

Abstract: A data quality management system includes a rules repository configured to store profiling data quality rules, cleansing data quality rules, and linking data that links profiling data quality rules to cleansing data quality rules. The data quality management system also includes a rules management module configured to manage the rules repository. The data quality management system further includes a data quality job management module configured to migrate data quality rules from the rules repository to a data quality processing system and manage a data quality process performed by the data quality processing system using the migrated data quality rules.

Abstract: Methods for forming FIN-shaped field effect transistors (FINFETs) capable of withstanding high voltage applications and the resulting devices are disclosed. Embodiments include forming a source and a drain on a substrate, forming a thin body (FIN) on the substrate and connecting the source and the drain, forming a gate over top and side surfaces of a first part of the FIN, thereby defining a drain-side FIN region of the FIN between the gate and the drain, and forming a shielding region over top and side surfaces of a second part of the FIN in the drain-side FIN region.