Abstract: Disclosed herein are photoactivable fluorophores comprising one or more thiocarbonyl groups as well as conjugates and compositions thereof. The present disclosure also provides methods of preparing photoactivatable fluorophores as well as methods of imaging using the photoactivatable fluorophores, conjugates, and compositions of the present disclosure.

Abstract: A tool configured for adjusting a plurality of pressing heads of an auxiliary welding machine and a method for operating the same are disclosed. The tool includes: a support; a limiting mechanism disposed on the support, wherein the limiting mechanism has a limiting groove for receiving a top end of at least one of the plurality of pressing head. It is possible to adjust the plurality of pressing heads of the auxiliary welding machine more conveniently and accurately using the above tool.

Abstract: A computer-implemented method for generating contours of anatomy based on user click points includes a computer displaying an image comprising an anatomical structure and receiving a first user selection of a first click point at a first position on an outward facing edge of the anatomical structure. The computer applies a contour inference algorithm to generate an inferred contour around the outward facing edge based on the first position. Following generation of the inferred contour, the computer receives a second user selection of a second click point at a second position on the image. Then, the computer creates a visual indicator on a segment of the inferred contour between the first position and the second position as indicative of the user's confirmation of accuracy of the segment.

Abstract: Described are machine vision systems and methods for simultaneous kinematic and hand-eye calibration. A machine vision system includes a robot and a 3D sensor in communication with a control system. The control system is configured to move the robot to poses, and for each pose: capture a 3D image of calibration target features and robot joint angles. The control system is configured to obtain initial values for robot calibration parameters, and determine initial values for hand-eye calibration parameters based on the initial values for the robot calibration parameters, the 3D image, and joint angles. The control system is configured to determine final values for the hand-eye calibration parameters and robot calibration parameters by refining the hand-eye calibration parameters and robot calibration parameters to minimize a cost function.

Abstract: Provided are methods relating to the inhibition of inhibitory immune receptors. Aspects of the present disclosure include methods that include administering to an individual receiving an antibody therapy an inhibitory immune receptor inhibitor. Also provided are compositions and kits that find use, e.g., in practicing the methods of the present disclosure.

Abstract: Provided are conjugates including a targeting moiety that binds to a cell surface molecule of a target cell and a target cell surface-editing enzyme. Also provided are compositions and kits that include the conjugates, as well as methods of using the conjugates. Methods of making conjugates are also provided.

Abstract: Embodiments of the disclosure provide a data transmission method. The method can include receiving a first packet sent by a virtual private network user, wherein the first packet carries a first destination address that does not belong to an address range that has been configured for a virtual private network where the virtual private network user is located, converting the first destination address to a second destination address, generating a second packet according to the second destination address and the first packet, and sending the second packet outside the virtual private network where the virtual private network user is located.

Abstract: A computer-implemented method for generating contours of anatomy based on user click points includes a computer displaying an image comprising an anatomical structure and receiving a first user selection of a first click point at a first position on an outward facing edge of the anatomical structure. The computer applies a contour inference algorithm to generate an inferred contour around the outward facing edge based on the first position. Following generation of the inferred contour, the computer receives a second user selection of a second click point at a second position on the image. Then, the computer creates a visual indicator on a segment of the inferred contour between the first position and the second position as indicative of the user's confirmation of accuracy of the segment.

Abstract: Embodiments of the present invention provide a method for changing configurations at a client device is presented.

Abstract: A method and an apparatus of generating rule tables for a virtual dedicated network, and a routing method are disclosed. The method includes determining virtual switches which act as switching nodes in a virtual dedicated network based on topological structure information of the virtual dedicated network; and using network identifiers of the virtual switches as keywords to configure and generate rule tables of the virtual dedicated network, the rule tables including at least the keywords which act as addresses of the switching nodes in the rule tables. The embodiments of the present disclosure can greatly reduce the number of table items in a rule table in a virtual dedicated network, and reduce the number of table items of transfer nodes and an amount of data of management and control nodes, thus effectively improving the system performance.

Abstract: Devices and methods for forming a device are disclosed. The method includes providing a crystalline-on-insulator substrate having a bulk substrate and a surface substrate separated by a buried insulator layer. The surface substrate is defined with a device region. A transistor having a gate is formed in the device region. A first diffusion region is formed adjacent to a first side of the gate and a second diffusion region is formed adjacent to and displaced away from a second side of the gate. At least a first drift isolation region is formed in the surface substrate adjacent to and underlaps the second side of the gate. A drift well is formed in the surface substrate encompassing the first drift isolation region. A device isolation region surrounding the device region is formed in the surface substrate. The device isolation region includes a second depth which is deeper than a first depth of the first drift isolation region.

Abstract: The present invention relates to a composition as a transforming growth factor (TGF)-? suppressor which comprises an effective amount of guanidine compound or a pharmaceutically acceptable salt. More particularly, the present invention relates to a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-? suppressor, wherein the composition is characterized by suppression or reduction of TGF-? activity which is a cause of disease. The present invention relates to a method of treating various TGF-? associated diseases, the method comprising administering to the subject a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-? suppressor which can prevent or treat TGF-? associated diseases by suppressing or reducing TGF-? activity.

Abstract: Devices and methods for forming a device are disclosed. The method includes providing a crystalline-on-insulator substrate having a bulk substrate and a surface substrate separated by a buried insulator layer. The surface substrate is defined with a device region. A transistor having a gate is formed in the device region. A first diffusion region is formed adjacent to a first side of the gate and a second diffusion region is formed adjacent to and displaced away from a second side of the gate. At least a first drift isolation region is formed in the surface substrate adjacent to and underlaps the second side of the gate. A drift well is formed in the surface substrate encompassing the first drift isolation region. A device isolation region surrounding the device region is formed in the surface substrate. The device isolation region includes a second depth which is deeper than a first depth of the first drift isolation region.

Abstract: Disclosed are a method and apparatus for closing a terminal, where a terminal acquires in real time an image in a preset range around the terminal, and if there is no human facial image detected in the acquired image, then the terminal will start a timer; and if a length of time recorded by the timer reaches a first preset length of time, and there is no human facial image detected in the image acquired throughout the length of time recorded by the timer, then the terminal will be closed.

Abstract: A method and apparatus for operating a portable radio communication device is provided. The portable radio communication device receives communications on a primary channel and a secondary channel during a dual-watch mode of operation. The portable radio communication device determines whether the portable radio communication device is proximate to a subject. The portable radio communication device suppresses audio from communications of one of the two channels and plays audio from communications of the other channel when the portable communication device is proximate to the subject. Additionally, the portable radio communication device allows transmission to occur only over the channel in which communication is not suppressed when the portable communication device is proximate to the subject.

Abstract: A tool configured for adjusting a plurality of pressing heads of an auxiliary welding machine and a method for operating the same are disclosed. The tool includes: a support; a limiting mechanism disposed on the support, wherein the limiting mechanism has a limiting groove for receiving a top end of at least one of the plurality of pressing head. It is possible to adjust the plurality of pressing heads of the auxiliary welding machine more conveniently and accurately using the above tool.