Abstract: The present disclosure relates to a film pasting assembly which comprises a base film provided with an annular first adhesive layer and a second adhesive layer, a first release film comprising a first annular portion and a first handle portion for arranging on the first adhesive layer, and a second release film comprising a second annular portion and a second handle portion for arranging on the second adhesive layer. The inner circumference of the first annular portion is equal to the outer circumference of the second annular portion. The first release film and the second release film may be torn apart respectively for product pasting. The success rate, efficiency of product assembly and yield of products may be improved. The first release film and the second release film may be processed by a same raw material for cost saving.

Abstract: Methods and systems described herein involve using long cell-free DNA fragments to analyze a biological sample from a pregnant subject. The status of methylated CpG sites and single nucleotide polymorphisms (SNPs) is often used to analyze DNA fragments of a biological sample. A CpG site and a SNP are typically separated from the nearest CpG site or SNP by hundreds or thousands of base pairs. Finding two or more consecutive CpG sites or SNPs on most cell-free DNA fragments is improbable or impossible. Cell-free DNA fragments longer than 600 bp may include multiple CpG sites and/or SNPs. The presence of multiple CpG sites and/or SNPs on long cell-free DNA fragments may allow for analysis than with short cell-free DNA fragments alone. The long cell-free DNA fragments can be used to identify a tissue of origin and/or to provide information on a fetus in a pregnant female.

Abstract: Methods and systems described herein involve using long cell-free DNA fragments to analyze a biological sample from a pregnant subject. The status of methylated CpG sites and single nucleotide polymorphisms (SNPs) is often used to analyze DNA fragments of a biological sample. A CpG site and a SNP are typically separated from the nearest CpG site or SNP by hundreds or thousands of base pairs. Finding two or more consecutive CpG sites or SNPs on most cell-free DNA fragments is improbable or impossible. Cell-free DNA fragments longer than 600 bp may include multiple CpG sites and/or SNPs. The presence of multiple CpG sites and/or SNPs on long cell-free DNA fragments may allow for analysis than with short cell-free DNA fragments alone. The long cell-free DNA fragments can be used to identify a tissue of origin and/or to provide information on a fetus in a pregnant female.

Abstract: A 1H-pyrazolo[4,3-H]quinazoline compound represented by formula (I) can be used for treating cell proliferation dysfunction, and is an broad-spectrum and strongly-active inhibitor for a cell cyclin-dependent kinase (CDK).

Abstract: The present invention discloses a vacuum bottle with a plurality of liquid outputs. The present invention includes a bottle body. A rotary liquid output mechanism arranged above the bottle body. The rotary liquid output mechanism includes a rotary massage head, a rotary press head that is fastened with a fastener of the massage head, a down-pressure valve that is matched with the rotary press head for movement, a connection sleeve that is used to limit movement of the down-pressure valve, and a connection tube and pump bodies that are used to pump liquid.

Abstract: Systems and methods for using determination of base modification in analyzing nucleic acid molecules and acquiring data for analysis of nucleic acid molecules are described herein. Base modifications may include methylations. Methods to determine base modifications may include using features derived from sequencing. These features may include the pulse width of an optical signal from sequencing bases, the interpulse duration of bases, and the identity of the bases. Machine learning models can be trained to detect the base modifications using these features. The relative modification or methylation levels between haplotypes may indicate a disorder. Modification or methylation statuses may also be used to detect chimeric molecules.

Abstract: Provided are heteroarylquinazoline compounds represented by general formula (X), which can be used for treating cell proliferation disorders. The compounds are effective inhibitors of cyclin-dependent kinases (CDKs) and can effectively inhibit CDK2, CDK4, CDK6 and CDK9 kinases.

Abstract: A system or method for vehicle-side control of a multi-pile charging session, the system comprising: (a) a plurality of charging piles (10A), each charging pile (10A) including a supply equipment communication controller (10B); and (b) a vehicle electrical system for an electric vehicle with a master battery control unit (18) in data communication with a plurality of battery control units (BCU0, BCU1, BCU2). The master battery control unit (18) is configured to coordinate two or more independent charging sessions through the battery control units (BCU0, BCU1, BCU2) during each multi-pile charging session. Each independent charging session is managed with an independent protocol message exchange through a BCU-to-SECC communication pathway (22) established by power line communication.

Abstract: The present disclosure relates to a method for controlling thermoplasticity and toughness of a redox-modified plant fiber, comprising following steps: (1) pretreating a plant fiber; (2) obtaining an oxidation-modified plant fiber by adding an oxidant solution, then filtering, and washing; and obtaining the redox-modified plant fiber by adding a reductant solution, then filtering, and washing; and (3) fully mixing a plasticizer with the redox-modified plant fiber; the plasticizer being a hydroxyl plasticizer, an ionic liquid plasticizer, a deep eutectic solvent, an ester plasticizer, an amine plasticizer, a glycidyl plasticizer, or an inorganic salt plasticizer. The method according to the present disclosure can improve the toughness of the redox-modified plant fiber material, reduce the processing temperature of the plant fiber material, and broaden the processing window of the plant fiber material.

Abstract: The present disclosure relates to a film pasting assembly which comprises a base film provided with an annular first adhesive layer and a second adhesive layer, a first release film comprising a first annular portion and a first handle portion for arranging on the first adhesive layer, and a second release film comprising a second annular portion and a second handle portion for arranging on the second adhesive layer. The inner circumference of the first annular portion is equal to the outer circumference of the second annular portion. The first release film and the second release film may be torn apart respectively for product pasting. The success rate, efficiency of product assembly and yield of products may be improved. The first release film and the second release film may be processed by a same raw material for cost saving.

Abstract: Systems and methods for using determination of base modification in analyzing nucleic acid molecules and acquiring data for analysis of nucleic acid molecules are described herein. Base modifications may include methylations. Methods to determine base modifications may include using features derived from sequencing. These features may include the pulse width of an optical signal from sequencing bases, the interpulse duration of bases, and the identity of the bases. Machine learning models can be trained to detect the base modifications using these features. The relative modification or methylation levels between haplotypes may indicate a disorder. Modification or methylation statuses may also be used to detect chimeric molecules.

Abstract: A method for simulating a candle flame with at least one computing device. The method may include controlling at least one lighting element according to at least a current wind value and a current flame value. The method may include controlling the current wind value and the current flame value by iteratively determining whether a first event occurred. When the first event is determined to have occurred, the method may include setting the current wind value to a random wind value and then changing the current wind value toward a baseline wind value. When the first event is determined to have not occurred, the method may include changing the current wind value toward the baseline wind value, determining whether a second event occurred. When the second event is determined to have occurred, the method may include setting the current flame value to a random flame value.

Abstract: Methods and systems described herein involve using long cell-free DNA fragments to analyze a biological sample from a pregnant subject. The status of methylated CpG sites and single nucleotide polymorphisms (SNPs) is often used to analyze DNA fragments of a biological sample. A CpG site and a SNP are typically separated from the nearest CpG site or SNP by hundreds or thousands of base pairs. Finding two or more consecutive CpG sites or SNPs on most cell-free DNA fragments is improbable or impossible. Cell-free DNA fragments longer than 600 bp may include multiple CpG sites and/or SNPs. The presence of multiple CpG sites and/or SNPs on long cell-free DNA fragments may allow for analysis than with short cell-free DNA fragments alone. The long cell-free DNA fragments can be used to identify a tissue of origin and/or to provide information on a fetus in a pregnant female.

Abstract: Isoxazolo[5,4-H]quinazoline compounds represented by general formula (I), which can be used to treat cell proliferation disorders, and are effective cyclin-dependent kinase (CDK) inhibitors.

Abstract: Systems and methods for determining base modifications using electrical signals and other data is described herein. Embodiments can make use of features derived from electrical signals related to sequencing, such as those acquired from using a nanopore, that are affected by the various base modifications, as well as an identity of nucleotides in a window around a target position whose methylation status is determined. Other features may include a vector of statistical values of a segment of the electrical signal corresponding to the nucleotide and a statistical value of the electrical signal in a window in a region of the nucleic acid molecule. The detected base modifications can be used for additional analysis of a biological sample.

Abstract: Systems and methods for using determination of base modification in analyzing nucleic acid molecules and acquiring data for analysis of nucleic acid molecules are described herein. Base modifications may include methylations. Methods to determine base modifications may include using features derived from sequencing. These features may include the pulse width of an optical signal from sequencing bases, the interpulse duration of bases, and the identity of the bases. Machine learning models can be trained to detect the base modifications using these features. The relative modification or methylation levels between haplotypes may indicate a disorder. Modification or methylation statuses may also be used to detect chimeric molecules.

Abstract: Provided is a 1H-imidazo[4,5-h]quinazoline compound of formula (I).

Abstract: Provided in the present invention are 1H-[1, 2, 3]triazolo[4, 5-h] quinazoline compounds of general formula (I), which can be used for treating cell proliferative disorders. The new compounds of the present invention are effective inhibitors of cyclin-dependent kinases (CDK).

Abstract: Methods and systems described herein involve using long cell-free DNA fragments to analyze a biological sample from a pregnant subject. The status of methylated CpG sites and single nucleotide polymorphisms (SNPs) is often used to analyze DNA fragments of a biological sample. A CpG site and a SNP are typically separated from the nearest CpG site or SNP by hundreds or thousands of base pairs. Finding two or more consecutive CpG sites or SNPs on most cell-free DNA fragments is improbable or impossible. Cell-free DNA fragments longer than 600 bp may include multiple CpG sites and/or SNPs. The presence of multiple CpG sites and/or SNPs on long cell-free DNA fragments may allow for analysis than with short cell-free DNA fragments alone. The long cell-free DNA fragments can be used to identify a tissue of origin and/or to provide information on a fetus in a pregnant female.

Abstract: A 1H-pyrazolo[4,3-H]quinazoline compound represented by formula (I) can be used for treating cell proliferation dysfunction, and is an broad-spectrum and strongly-active inhibitor for a cell cyclin-dependent kinase (CDK).