Abstract: Provided is an imidazo[1?;2?:1,6]pyrido[2,3-d]pyrimidine compound of general formula (I). The compound can be used in treating a cell proliferative disorder and is a cyclin-dependent kinase (CDK) inhibitor with broad-spectrum and strong activity.

Abstract: The disclosed technology includes a universal tree stand for supporting trees with tree trunks of various sizes. The universal tree stand may include a clamping element to flexibly receive and secure tree trunks of different sizes. The universal tree stand may further include a fastening element that can tighten the grip of the clamping element around the tree trunk.

Abstract: The disclosed technology includes an illumination system for a tree trunk of an artificial tree. The system may include a cylindrical shaped body, such that the outer surface of the body has a cylindrical shape. The inner surface of the body may include one or more diameters. One or more lighting modules may be positioned along the tree trunk to impart an internal lighting and/or glowing effect radiating therefrom.

Abstract: A flame simulation method including: identifying, by a computing device, a maximum brightness level value and a primary event generation level; setting, in response to determining that a first event occurred based on the primary event generation level, a secondary event generation level; adjusting the secondary event generation level towards a baseline secondary event generation level; adjusting a current brightness value of a lighting element of a flame simulation apparatus towards the maximum brightness level value; setting, in response to determining that a second event occurred based on the secondary event generation level, the current brightness level value of the lighting element to a value less than the maximum brightness level; and controlling, by the computing device, a brightness level of the lighting element to correspond to the current brightness level value of the lighting element.

Abstract: The present disclosure relates to a method for controlling thermoplasticity and toughness of a redox-modified plant fiber, comprising following steps: (1) pretreating a plant fiber; (2) obtaining an oxidation-modified plant fiber by adding an oxidant solution, then filtering, and washing; and obtaining the redox-modified plant fiber by adding a reductant solution, then filtering, and washing; and (3) fully mixing a plasticizer with the redox-modified plant fiber; the plasticizer being a hydroxyl plasticizer, an ionic liquid plasticizer, a deep eutectic solvent, an ester plasticizer, an amine plasticizer, a glycidyl plasticizer, or an inorganic salt plasticizer. The method according to the present disclosure can improve the toughness of the redox-modified plant fiber material, reduce the processing temperature of the plant fiber material, and broaden the processing window of the plant fiber material.

Abstract: Cell-free DNA fragments often include jagged ends, where one end of one strand of double-stranded DNA extends beyond the other end of the other strand. The length and amount of these jagged ends may be used to determine a level of a condition of an individual, a fractional concentration of clinically-relevant DNA in a biological sample, an age of individual, or a tissue type exhibiting cancer. The jagged end length and amount may be determined using various techniques described herein.

Abstract: The disclosed systems and methods relate to improved tamper-proof cases for securely storing and shipping products. In one example, a tamper-proof case comprises a unibody frame constructed from a single piece of material. The unibody frame can comprise six sides and include one or more living hinges that allow the unibody frame to fold into a completed case. Various sides can be configured to receive panels to give the crate additional structure, rigidity, and security. Additionally, the frame can comprise a split-top lid with a self-locking mechanism with a tamper-proof pull tab for opening the lid.

Abstract: The disclosed technology includes an illumination system for a tree trunk of an artificial tree. The system may include a cylindrical shaped body, such that the outer surface of the body has a cylindrical shape. The inner surface of the body may include one or more diameters. One or more lighting modules may be positioned along the tree trunk to impart an internal lighting and/or glowing effect radiating therefrom.

Abstract: The disclosed technology includes an illumination system for a tree trunk of an artificial tree. The system may include a cylindrical shaped body, such that the outer surface of the body has a cylindrical shape. The inner surface of the body may include one or more diameters. One or more lighting modules may be positioned along the tree trunk to impart an internal lighting and/or glowing effect radiating therefrom.

Abstract: The disclosed technology includes a universal tree stand for supporting trees with tree trunks of various sizes. The universal tree stand may include a clamping element to flexibly receive and secure tree trunks of different sizes. The universal tree stand may further include a fastening element that can tighten the grip of the clamping element around the tree trunk.

Abstract: The disclosed systems and methods relate to improved tamper-proof cases for securely storing and shipping products. In one example, a tamper-proof case comprises a unibody frame constructed from a single piece of material. The unibody frame can comprise six sides and include one or more living hinges that allow the unibody frame to fold into a completed case. Various sides can be configured to receive panels to give the crate additional structure, rigidity, and security. Additionally, the frame can comprise a split-top lid with a self-locking mechanism with a tamper-proof pull tab for opening the lid.

Abstract: The disclosed technology includes a universal tree stand for supporting trees with tree trunks of various sizes. The universal tree stand may include a clamping element to flexibly receive and secure tree trunks of different sizes. The universal tree stand may further include a fastening element that can tighten the grip of the clamping element around the tree trunk.

Abstract: The present invention relates to a high speed shatterproof contamination proof refrigerated centrifuge for cell extraction, comprising a housing, a central console disposed inside a chamber of the housing, a refrigerating mechanism disposed inside the housing, a separation mechanism, a pair of roll wheels disposed at a bottom of the housing and a shatterproof recollection device; a ring shaped working sink for installing the separation mechanism is disposed at a top wall of the housing; a ventilation hole and a control panel is disposed at two sides of the housing respectively; the separation mechanism comprises a centrifuge rotor disposed inside the ring shaped working sink and a rotational motor for driving the centrifuge rotor.

Abstract: The present invention relates to a jointed coldproof building rack railway system with braking feature, comprising a number of jointed rack rails fixed to a building, connection components for connecting the rack rails together, a lift device and a number of electrically heated infrared ice melting device. An installation plate is disposed at an inner side of the rack rail, a rail plate is disposed at an outer side of the rack rail, connection poles are disposed at four peripheral locations of the rack rail. Two rows of rack teeth are uniformly and vertically disposed on the rail plate. A connection hole is disposed at the connection pole for mounting the connection components. A limiter stand is disposed at a central portion of the connection component, bolt holes are disposed at a top portion and a bottom portion of a side wall of the connection component. Through holes are disposed at a side wall of the connection hole for allowing bolts to penetrate through and correspond to the bolt holes.

Abstract: A flame simulation method including: identifying, by a computing device, a maximum brightness level value and a primary event generation level; setting, in response to determining that a first event occurred based on the primary event generation level, a secondary event generation level; adjusting the secondary event generation level towards a baseline secondary event generation level; adjusting a current brightness value of a lighting element of a flame simulation apparatus towards the maximum brightness level value; setting, in response to determining that a second event occurred based on the secondary event generation level, the current brightness level value of the lighting element to a value less than the maximum brightness level; and controlling, by the computing device, a brightness level of the lighting element to correspond to the current brightness level value of the lighting element.

Abstract: The disclosed technology includes an illumination system for a tree trunk of an artificial tree. The system may include a cylindrical shaped body, such that the outer surface of the body has a cylindrical shape. The inner surface of the body may include one or more diameters. One or more lighting modules may be positioned along the tree trunk to impart an internal lighting and/or glowing effect radiating therefrom.

Abstract: The disclosed technology includes a universal tree stand for supporting trees with tree trunks of various sizes. The universal tree stand may include a clamping element to flexibly receive and secure tree trunks of different sizes. The universal tree stand may further include a fastening element that can tighten the grip of the clamping element around the tree trunk.

Abstract: A system that evaluates Boolean expressions receives a first set of Boolean expressions that include one or more Boolean expressions, and receives a second set of Boolean expressions that includes one or more Boolean expressions. The system determines one or more overlapping Boolean expressions between the first set and the second set. Each Boolean expression has a corresponding identifier and priority, and two or more Boolean expressions overlap when the Boolean expressions have an identical identifier. Each set of Boolean expressions includes a corresponding index.

Abstract: Embodiments may include a method of determining a nucleic acid sequence. The method may include receiving a plurality of DNA fragments. The method may also include concatemerizing a first set of the DNA fragments to obtain a concatemer. The method may include performing single-molecule sequencing of the concatemer to obtain a first sequence of the concatemer. In some embodiments, single-molecule sequencing may be performed using a nanopore, and the method may include passing the concatemer through a nanopore. A first electrical signal may then be detected as the concatemer passes through the nanopore. The first electrical signal may correspond to a first sequence of the concatemer. In addition, the method may include analyzing the first electrical signal to determine the first sequence. Subsequences of the first sequence may be aligned to identify sequences corresponding to each of the first set of the DNA fragments.

Abstract: Embodiments of the present invention provide a charging and power supplying circuit, method and application device, which relate to the field of smart charging, so as to improve efficiencies of battery charging and system power supplying. The charging and power supplying circuit includes a power supplying tributary and a charging tributary. An end of the power supplying tributary is connected to a power supply, and another end is connected to a system. An end of the charging tributary is connected to the power supply, and another end is connected to a battery. A first transistor, a second transistor, a third transistor, a first amplifier, a second amplifier, a third amplifier, a fourth amplifier, a first comparator, a second comparator, a charging controller, a logical switch, an adder and a first control module are connected to the power supplying tributary and the charging tributary.