Abstract: Compositions and methods for modulating Brd9, Ankib1, Cacng1, and/or Gtl3 (Cfap20) gene or a gene product thereof in a subject in need thereof are disclosed. For example, methods of inducing or increasing white adipose tissue beiging in a subject in need thereof are provided. The methods typically include administering to the subject an effective amount of an inhibitor of Brd9, Ankib1, Cacng1, and/or Gtl3 (Cfap20) gene or a gene product thereof to increase differentiation of white adipose progenitor cells into beige or brown adipose cells. Methods of de-repressing the Pgc1? gene can include administering a subject in need thereof an effective amount of an inhibitor of the Brd9 gene or a gene product thereof to increase expression of the Pgc1? gene in the subject. Treated subjects have or be at risk of developing a metabolic disorder, obesity, reduced endurance or physical activity, muscle loss, or cardiovascular disease.

Abstract: Compositions and methods for modulating HIF-2? to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2? inhibitor. The HIF-2? inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.

Abstract: Compositions and methods for modulating HIF-2? to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2? inhibitor. The HIF-2? inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.

Abstract: A method includes upon sensing a touch to a first location on a touch display, reporting first coordinates of the touch. After sensing movement of the touch along a first path from the first location to a second location more than a tolerance distance away, intermediate coordinates of the touch along the first path that are not more than a cutoff distance away are reported such that there is a first gap between a last reported intermediate coordinate and the second location. After sensing movement of the touch along a second path from the second location to a third location more, second coordinates of the touch are reported, the second reported coordinates of the touch being a point along the first path that is calculated by subtracting the first gap from a distance between the first location and the third location, and then adding a first compensation difference thereto.

Abstract: A mobile terminal is provided. The mobile terminal includes a display screen on a terminal housing and a periscope optical zoom lens. The display screen and the periscope optical zoom lens are arranged in a non-overlapping manner in a thickness direction of the terminal, and the periscope optical zoom lens is located in a top area of the terminal. Additionally, the periscope optical zoom lens is configured to collect an image in an optical signal form by means of optical zoom, so that an optical-to-electrical conversion chip converts the image in an optical signal form into an image in a digital signal form and the display screen is configured to display the image in a digital signal form.

Abstract: A method for preparing the network-pore polyvinylidene fluoride membrane based on polyvinyl alcohol (PVA) gel includes the steps of (1) mix and stir PVA, masking agent and solvent, heat and dissolve the mixture evenly under 105 degree Celsius to obtain a PVA solution; (2) in the PVA solution, add PVDF and pore-forming agent, where the rest shall be added with the solvent until the total mass fraction sum is 1, stir, heat and dissolve the solution evenly to obtain the homogeneous casting solution; (3) the casting solution is filtered, deaerated, phase-separated and solidified as membrane A; (4) removes the PVA gel from membrane A to obtain membrane B; (5) membrane B is washed with water to remove the residual solvent to obtain the PVDF membrane with network-pore structure. The resulting PVDF membrane is an asymmetric membrane with an ultra-thin cortex and an interpenetrating network-pore sub-cortex structure.

Abstract: Compositions and methods for modulating HIF-2? to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2? inhibitor. The HIF-2? inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.

Abstract: A method for preparing the network-pore polyvinylidene fluoride membrane based on polyvinyl alcohol (PVA) gel includes the steps of (1) mix and stir PVA, masking agent and solvent, heat and dissolve the mixture evenly under 105 degree Celsius to obtain a PVA solution; (2) in the PVA solution, add PVDF and pore-forming agent, where the rest shall be added with the solvent until the total mass fraction sum is 1, stir, heat and dissolve the solution evenly to obtain the homogeneous casting solution; (3) the casting solution is filtered, deaerated, phase-separated and solidified as membrane A; (4) removes the PVA gel from membrane A to obtain membrane B; (5) membrane B is washed with water to remove the residual solvent to obtain the PVDF membrane with network-pore structure. The resulting PVDF membrane is an asymmetric membrane with an ultra-thin cortex and an interpenetrating network-pore sub-cortex structure.

Abstract: An electronic device described herein includes a touch screen for a touch sensitive display carried by a portable housing. The electronic device is configured to operate in a high. detection threshold mode to determine whether an object is in contact with the touch sensitive display, and operate in a low detection threshold mode to determine whether the object is adjacent to the touch sensitive display, based on lack of detection of the object being in contact with the touch sensitive display. The electronic device is further configured to determine whether the object is in contact with a peripheral edge of the portable housing by determining whether the object is adjacent opposite sides of the touch sensitive display, based on detection of the object being adjacent to the touch sensitive display.

Abstract: A mobile terminal is provided. The mobile terminal includes a display screen on a terminal housing and a periscope optical zoom lens. The display screen and the periscope optical zoom lens are arranged in a non-overlapping manner in a thickness direction of the terminal, and the periscope optical zoom lens is located in a top area of the terminal. Additionally, the periscope optical zoom lens is configured to collect an image in an optical signal form by means of optical zoom, so that an optical-to-electrical conversion chip converts the image in an optical signal form into an image in a digital signal form and the display screen is configured to display the image in a digital signal form.

Abstract: Techniques related to a method for manufacturing an integrated circuit is disclosed. According to one embodiment, a method for manufacturing an integrated circuit on a wafer comprises a first device of the integrated circuit is formed on the wafer and a second device of the integrated circuit is formed on the wafer to make a projection area of the second device overlap with a projection area of the first device partially or completely. In one embodiment, two or more devices are formed in different layers of the integrated circuit, or formed at different depths in a same layer of the integrated circuit, so the two or more devices may share an area on the same wafer in a certain manner. Thereby, the area of the chip is saved and the chip cost of the integrated circuit is significantly reduced.

Abstract: Provided are compounds, compositions and methods for treating Toll-like receptor 1/2 complex (TLRI/2) related inflammatory disorders. Small molecules, based on the benzotropolone scaffold, capable of influencing downstream signaling are disclosed as well as methods of making and modifying these molecules. Also provided are methods for treating a subject for a clinical condition associated with Toll-like receptor complex 1/2 activation, comprising administering to the subject an effective amount of a benzotropolone compound.

Abstract: The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex, and methods for using the same. In particular, some aspects of the invention provide compounds of the formula: compositions comprising and methods for using the same, where n, Ar1, Ar2, X1, X2, X3, Z1, and Z2 are those defined herein.

Abstract: Apparatus and methods for testing sediment submerged in liquid and manufacturing the apparatus. The apparatus and methods of the present embodiment can provide for nano/micro characterization of mechanical properties of materials submerged in liquid, facilitating specimen preparation and installation, and can provide hydrated materials. The apparatus can include cell walls with optical magnifying lenses so that the materials can be viewed without the aid of a microscope.

Abstract: A tapping control method and a terminal, which relate to the communications field and can avoid frequent automatic setting of the terminal caused by an unconscious operation of a user, thereby implementing accurate operation control on the terminal and improving a capability of the terminal to interact with the user. A specific solution is as follows. The terminal detects a tapping trigger signal within a preset frequency range by using a shock sensor; after the tapping trigger signal is detected, identifies a tapping action type corresponding to the tapping trigger signal; acquires a tapping response event that matches the identified tapping action type; and executes the tapping response event. The present disclosure can be used in a process of operation control on the terminal.

Abstract: Apparatus and methods for testing sediment submerged in liquid and manufacturing the apparatus.