Abstract: Provided herein are prodrugs comprising targeting moieties that specifically bind extracellular antigens, enzyme-cleavable linkers, and innate immune system activators. An enzyme-cleavable linker can covalently link a targeting moiety to an innate immune system activator. Also provided are methods of treating cancer, methods of imaging cancer, and methods of monitoring treatment of cancer.

Abstract: A refrigeration system having a heat pump function for a motor vehicle. The refrigeration system includes: a refrigerant compressor which is connectable or connected to a primary line; a directly or indirectly acting external heat exchanger, which is arranged in the primary line; a first evaporator, which is arranged in the primary line; a first directly or indirectly acting heat exchanger, in particular a chiller, which is arranged fluidically in parallel to the evaporator; and a refrigerant collector arranged on the low-pressure side. A single sensor device is arranged downstream of the evaporator and the further heat exchanger, in particular the chiller, which is configured to detect the pressure and the temperature of the refrigerant on the low-pressure side of the refrigeration system.

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes, to be precise at least one evaporator tube being a flat tube with a plurality of micro-channels.

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes, to be precise at least one evaporator tube being a flat tube with a plurality of micro-channels, through which the refrigerant is guided, wherein, as a first flat tube, the evaporator flat tube is a constituent part of a first evaporator tube set which guides the refrigerant from the bottom-side inlet chamber counter to the direction of gravity into an upper-side deflecting chamber, and wherein the refrigerant is guided

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes, to be precise at least one evaporator tube being a flat tube with a plurality of micro-channels.

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes. The separator has a distributor tube which extends in the inlet chamber in the evaporator transverse direction.

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes, wherein at least one evaporator tube being a flat tube with a plurality of micro-channels, through which the refrigerant is guided.

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes, to be precise at least one evaporator tube being a flat tube with a plurality of micro-channels.

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes, wherein at least one evaporator tube being a flat tube with a plurality of micro-channels, through which the refrigerant is guided.

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes. The separator has a distributor tube which extends in the inlet chamber in the evaporator transverse direction.

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes, to be precise at least one evaporator tube being a flat tube with a plurality of micro-channels.

Abstract: An evaporator in a refrigerant circuit, having a bottom-side inlet chamber which is connected in flow terms to an evaporator outlet side via evaporator tubes, a separator being integrated into the evaporator inlet chamber, in which separator a refrigerant which is expanded in an expansion member is divided as a two-phase liquid/vapour mixture into a vapour phase and into a liquid phase which is separate therefrom, the vapour phase being conducted via a bypass line to the evaporator outlet side, and the liquid phase being conducted counter to the direction of gravity into the evaporator tubes, to be precise at least one evaporator tube being a flat tube with a plurality of micro-channels, through which the refrigerant is guided, wherein, as a first flat tube, the evaporator flat tube is a constituent part of a first evaporator tube set which guides the refrigerant from the bottom-side inlet chamber counter to the direction of gravity into an upper-side deflecting chamber, and wherein the refrigerant is guided

Abstract: The invention relates to an air conditioning system for conditioning the air of a passenger space of a motor vehicle, the system including a refrigerant circuit with a compressor, a first heat exchanger for the heat exchange between the refrigerant and the environment and a second heat exchanger for supplying heat from the refrigerant to the air supply to be conditioned for the passenger space. The refrigerant circuit further includes, in the flow direction of the refrigerant after the compressor, a valve arrangement. The valve arrangement comprises a branch, a first valve arranged between the branch and the second heat exchanger, and a second valve arranged between the branch and the first heat exchanger. The first valve is designed with a normally open (NO) valve characteristic and the second valve with a normally closed (NC) valve characteristic.

Abstract: The invention relates to a method for operating an air conditioner (1) for treating the air of a passenger compartment of a motor vehicle. The air conditioner (1) exhibits a refrigerant circuit (2) configured for a combined cooling unit and heat-pump mode and for a post-heating mode. In the heat-pump mode with a first and a second heat source, two heat sources differing from each other can be used. A temperature of the first heat source, a temperature of the second heat source, and a regulation characteristic number and a maximum pressure are taken into account in the refrigerant circuit (2) for operating the air conditioner (1) in a heat-pump mode. The invention additionally relates to a method for switching between the two heat-pump modes.

Abstract: The invention relates to a vehicle with an air conditioner for heating inlet air flowing into a vehicle interior, the air conditioner including: a heater heat exchanger thermally coupled through a coolant cycle with a drive unit or similar; and a supplemental heat exchanger which is connected to a refrigerant cycle of the air conditioner and which transfers heat to the inlet air in heating mode, wherein the supplemental heat exchanger is configured with at least two rows including a first heat exchanger row and a second heat exchanger row in a refrigerant flow direction, wherein the first heat exchanger row and the second heat exchanger row are arranged in a refrigerant flow direction so that super cooling of a condensed refrigerant is provided in the second heat exchanger row and at least heat extraction of the refrigerant is provided in the first heat exchanger row.

Abstract: The invention relates to an air conditioning system for conditioning the air of a passenger space of a motor vehicle, the system including a refrigerant circuit with a compressor, a first heat exchanger for the heat exchange between the refrigerant and the environment and a second heat exchanger for supplying heat from the refrigerant to the air supply to be conditioned for the passenger space. The refrigerant circuit further includes, in the flow direction of the refrigerant after the compressor, a valve arrangement. The valve arrangement comprises a branch, a first valve arranged between the branch and the second heat exchanger, and a second valve arranged between the branch and the first heat exchanger. The first valve is designed with a normally open (NO) valve characteristic and the second valve with a normally closed (NC) valve characteristic.

Abstract: The invention relates to a method for operating an air conditioner (1) for treating the air of a passenger compartment of a motor vehicle. The air conditioner (1) exhibits a refrigerant circuit (2) configured for a combined cooling unit and heat-pump mode and for a post-heating mode. In the heat-pump mode with a first and a second heat source, two heat sources differing from each other can be used. A temperature of the first heat source, a temperature of the second heat source, and a regulation characteristic number and a maximum pressure are taken into account in the refrigerant circuit (2) for operating the air conditioner (1) in a heat-pump mode. The invention additionally relates to a method for switching between the two heat-pump modes.

Abstract: The invention includes a refrigerant circuit for a cooling operation and a heat pump operation. The refrigerant circuit has a high pressure area and a low pressure area, including at least one heat source/heat sink, a compressor, an expansion device, at least one thermal interior space module, and an internal heat exchanger. The internal heat exchanger has a high pressure side part and a low pressure side part, wherein the high pressure side part is disposed between the expansion device and the heat source/heat sink. The invention also includes at least one metering device through which the high pressure side part of the internal heat exchanger is operable during the heat pump operation at a medium pressure level intermediate a pressure level in the high pressure area and a pressure level in the low pressure area of the refrigerant circuit.

Abstract: A vehicle includes an air conditioning system for conditioning intake air flowing into a vehicle interior. The air conditioning system has a primary heat exchanger in thermal communication with a drive unit via a coolant circuit, a compressor, and a secondary heat exchanger which is disposed jointly with the compressor in a refrigerant circuit. The secondary heat exchanger operates as a condenser in a heating mode of the air conditioning system and jointly with the primary heat exchanger gives off heat to the intake air. A control device controls operation of the refrigerant circuit in response to an input by a user. The control device includes an evaluation unit to carry out a comparison between a desired heat supply commensurate with the input by the user and a determined actual heat supply, and generates an output signal for operating the compressor in response to the comparison.

Abstract: Process for separating triethanolamine continuously by distillation from a mixture of monoethanolamine, diethanolamine and triethanolamine together with ethanolamine ethers and water obtained by reaction of ammonia with ethylene oxide in the liquid phase under superatmospheric pressure and at elevated temperature, in which the mixture is distilled in two stages. The low-boiling fraction and the high-boiling fraction are taken off and discharged in the first stage and the intermediate-boiling fraction comprising >99.4% by weight of triethanolamine and <0.2% by weight of diethanolamine is distilled in the second stage. The distillation of the mixture is preferably carried out in a first column and a second column connected to this or in a dividing wall column.