Patents by Inventor Hans Hilpert

Hans Hilpert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vinylogous acid derivatives
    Patent number: 7705034
    Abstract: The invention is concerned with novel vinylogous acid derivatives of formula I: wherein A and R1 to R5 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are useful as chymase inhibitors.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: April 27, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Banner, Hans Hilpert, Bernd Kuhn, Harald Mauser
  • Fused pyrrole derivatives
    Patent number: 7696240
    Abstract: The invention is concerned with novel fused pyrrole derivatives of formula (I) wherein A, Ar, R1, R2, R2? and R2? and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit chymase and can be used as medicaments.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: April 13, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Banner, Hans Hilpert, Bernd Kuhn, Harald Mauser
  • Factor Xa inhibitors
    Patent number: 7678917
    Abstract: The invention is concerned with novel cycloalkane carboxamides of formula (I) wherein X, X1, Y, Y1, R1?, R1?, R2, R3, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: March 16, 2010
    Assignee: Hoffman-La Roche Inc.
    Inventors: Katrin Gröbke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • Vinylogous acid derivatives
    Patent number: 7612099
    Abstract: The invention is concerned with vinylogous acids derivatives of formula (I) wherein A and R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit chymase and can be used as medicaments.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: November 3, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Banner, Hans Hilpert, Bernd Kuhn, Harald Mauser
  • DICARBOXAMIDE DERIVATIVES
    Publication number: 20090270360
    Abstract: The invention is concerned with novel dicarboxamide derivatives of formula (I) wherein A, B, Rc, D and E are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Application
    Filed: January 16, 2009
    Publication date: October 29, 2009
    Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Jacques Himber, Roland Humm, Hans Iding, Dietmar Knopp, Narendra Panday, Fabienne Ricklin, Christoph Martin Stahl
  • Pyrrolidine derivatives
    Patent number: 7601752
    Abstract: The invention is concerned with novel pyrrolidine derivatives of formula (I) wherein X, Y, R1, R2 and R3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: October 13, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lilli Anselm, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Jacques Himber, Bernd Kuhn, Narendra Panday, Fabienne Ricklin, Stefan Thomi
  • Dicarboxamide derivatives
    Patent number: 7501413
    Abstract: The invention is concerned with novel dicarboxamide derivatives of formula (I) wherein A, B, Rc, D and E are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: March 10, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Jacques Himber, Roland Humm, Hans Iding, Dietmar Knopp, Narendra Panday, Fabienne Ricklin, Christoph Martin Stahl
  • Factor Xa inhibitors
    Patent number: 7417144
    Abstract: The invention is concerned with novel heteroaryl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: August 26, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • HETEROARYLACETAMIDE INHIBITORS OF FACTOR Xa
    Publication number: 20080146550
    Abstract: The invention is concerned with novel heteroarylacetamides of formula (I) R—C(O)—N(Re)—Rc—CH2—C(O)—N(Ra)(Rb) ??(I) wherein Ra to Re are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Application
    Filed: February 4, 2008
    Publication date: June 19, 2008
    Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • TETRONIC AND TETRAMIC ACIDS
    Publication number: 20080132562
    Abstract: This invention relates to new tetronic and tetramic acid derivatives with beta-secretase inhibitory activity of formula I: wherein R1, R2, R3, R4, R5, R5?, R6 and R6? are as defined hereinabove, to processes for their preparation, compositions containing said tetronic and tetramic acid derivatives and their use in the treatment and prevention of diseases modulated by an inhibitor of ?-secretase, such as Alzheimer's disease.
    Type: Application
    Filed: January 31, 2008
    Publication date: June 5, 2008
    Inventors: Thierry Godel, Hans Hilpert, Roland Humm, Mark Rogers-Evans, Didier Rombach, Christopher Martin Stahl, Peter Weiss, Wolfgang Wostl
  • NOVEL HETEROARYL CARBOXAMIDES
    Publication number: 20080103143
    Abstract: The invention is concerned with novel heteroaryl carboxamides of formula (I) wherein A, R1, R2, X, Y, Z and m are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used for the treatment or prevention of thrombotic disorders.
    Type: Application
    Filed: October 19, 2007
    Publication date: May 1, 2008
    Inventors: Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Bernd Kuhn, Narendra Panday, Fabienne Ricklin
  • Vinylogous acid derivatives
    Publication number: 20080096953
    Abstract: The invention is concerned with novel vinylogous acid derivatives of formula I: wherein A and R1 to R5 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are useful as chymase inhibitors.
    Type: Application
    Filed: September 24, 2007
    Publication date: April 24, 2008
    Inventors: David Banner, Hans Hilpert, Bernd Kuhn, Harald Mauser
  • Heteroarylacetamide inhibitors of factor Xa
    Patent number: 7361672
    Abstract: The invention is concerned with novel heteroarylacetamides of formula (I) Rd—C(O)—N(Re)—Rc—CH2—C(O)—N(Ra)(Rb)??(I) wherein Ra to Re are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: April 22, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • Oxazole derivatives
    Patent number: 7348349
    Abstract: The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present invention can be used as medicaments for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists. Examples of such diseases are diabetes, particularly non-insulin dependent diabetes mellitus, elevated blood pressure, increased lipid and cholesterol levels, atherosclerotic diseases, metabolic syndrome, endothelial dysfunction, procoagulant state, dyslipidemia, polycystic ovary syndrome, inflammatory diseases (such as e.g. crown disease, inflammatory bowel disease, collitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as e.g. Alzheimer's disease or impaired/improvable cognitive function) and proliferative diseases.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: March 25, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Markus Boehringer, Uwe Grether, Hans Hilpert, Georges Hirth, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Fabienne Ricklin
  • Phosphinic acids
    Patent number: 7345082
    Abstract: The present invention relates to phosphinic acid derivatives of formula I wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prevention of a disease related to the inhibition of ?-secretase, inter alia for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: March 18, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Hilpert, Roland Humm, Dietmar Knopp, Peter Weiss
  • Dicarboxamide derivatives
    Publication number: 20070249683
    Abstract: The invention is concerned with dicarboxamide derivatives of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used in pharmaceutical compositions.
    Type: Application
    Filed: April 11, 2007
    Publication date: October 25, 2007
    Inventors: Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • Fused pyrrole derivatives
    Publication number: 20070142452
    Abstract: The invention is concerned with novel fused pyrrole derivatives of formula (I) wherein A, Ar, R1, R2, R2? and R2? and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit chymase and can be used as medicaments.
    Type: Application
    Filed: December 5, 2006
    Publication date: June 21, 2007
    Inventors: David Banner, Hans Hilpert, Bernd Kuhn, Harald Mauser
  • Vinylogous acid derivatives
    Publication number: 20070129421
    Abstract: The invention is concerned with vinylogous acids derivatives of formula (I) wherein A and R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit chymase and can be used as medicaments.
    Type: Application
    Filed: November 28, 2006
    Publication date: June 7, 2007
    Inventors: David Banner, Hans Hilpert, Bernd Kuhn, Harald Mauser
  • Pyrrolidine derivatives
    Publication number: 20070112001
    Abstract: The invention is concerned with novel pyrrolidine derivatives of formula (I) wherein X, Y, R1, R2 and R3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Application
    Filed: November 6, 2006
    Publication date: May 17, 2007
    Inventors: Lilli Anselm, Katrin Zbinden, Wolfgang Haap, Hans Hilpert, Jacques Himber, Bernd Kuhn, Narendra Panday, Fabienne Ricklin, Stefan Thomi
  • Factor Xa inhibitors
    Publication number: 20070049587
    Abstract: The invention is concerned with novel cycloalkane carboxamides of formula (I) wherein X, X1, Y, Y1, R1?, R1?, R2, R3, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Application
    Filed: August 25, 2006
    Publication date: March 1, 2007
    Inventors: Katrin Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin