Patents by Inventor Hans Hilpert

Hans Hilpert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxazole derivatives
    Publication number: 20030055265
    Abstract: The present invention relates to novel oxazole compounds which act as PPAR&agr; and PPAR&ggr; agonists and are accordingly useful for the treatment of diseases modulated by PPAR&agr; and PPAR&ggr; such as diabetes.
    Type: Application
    Filed: May 9, 2002
    Publication date: March 20, 2003
    Inventors: Alfred Binggeli, Markus Boehringer, Uwe Grether, Hans Hilpert, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Fabienne Ricklin
  • Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
    Patent number: 6504025
    Abstract: Disclosed is a process for the preparation of vinyl-pyrrolidinone cephalosporine derivatives of formula Also disclosed are intermediate compounds of formulas wherein R1 and R2 are as defined herein.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: January 7, 2003
    Assignee: Basilea Pharmaceutica AG
    Inventors: Paul Hebeisen, Hans Hilpert, Roland Humm
  • Process for a phenylthiobutyl-isoquinoline and intermediates therefor
    Patent number: 6437134
    Abstract: A method for making phenylthiobutyl-isoquinoline compounds of formula and novel intermediates therefor.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: August 20, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Hans Hilpert
  • Process for preparing retiferol derivatives
    Patent number: 6437142
    Abstract: A new process prepares retiferol derivatives of formula I: wherein A is —C≡C— or —CH═CH—, and R1 and R2 are independently of each other lower alkyl or lower perfluoroalkyl, one version couples ketones of formula II with compounds of formula III. A second version couples phosphinoxides of formula IV with aldehydes of formula V. Compounds of formula I are useful in the treatment or prevention of hyperproliferative skin diseases and for reversing the conditions associated with photodamage.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: August 20, 2002
    Assignee: Basilea Pharmaceutica AG
    Inventors: Hans Hilpert, Beat Wirz
  • Enzymatic processes for producing intermediates useful in the manufacture of retiferol derivatives
    Patent number: 6403346
    Abstract: Enzymatic processes can produce intermediates for manufacturing retiferol derivatives that are useful for treating or preventing hyperproliferative skin diseases and for reversing conditions associated with photodamage. These processes can use as a starting material trihydroxycyclohexane, which can be chemically modified by a process that includes an enzymatic step, typically involving lipases of EC-class 3.1.1.3 or 3.1.1.34.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: June 11, 2002
    Assignee: Basilea Pharmaceutica AG
    Inventors: Hans Hilpert, Beat Wirz
  • Process for preparing retiferol derivatives
    Publication number: 20020028975
    Abstract: A new process prepares retiferol derivatives of formula I: 1
    Type: Application
    Filed: September 6, 2001
    Publication date: March 7, 2002
    Inventors: Hans Hilpert, Beat Wirz
  • Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
    Publication number: 20020019381
    Abstract: A process is provided for the preparation of vinyl-pyrrolidinone cephalosporine derivatives. Intermediates of the process are also provided.
    Type: Application
    Filed: May 17, 2001
    Publication date: February 14, 2002
    Inventors: Paul Hebeisen, Hans Hilpert, Roland Humm
  • Process for manufacture of chiral succinic acid derivatives
    Patent number: 6316633
    Abstract: The present invention is concerned with a process for the manufacture of chiral succinic acid derivatives of formula (I) wherein R1 is (C1-C6) alkyl or benzyl, and the novel intermediates used therein.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: November 13, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventor: Hans Hilpert
  • Process for preparing retiferol derivatives
    Patent number: 6310262
    Abstract: A new process prepares retiferol derivatives of formula I: wherein A is —C ≡C— or —CH═CH—, and R1 and R2 are independently of each other lower alkyl or lower perfluoroalkyl, one version couples ketones of formula 1I with compounds of formula III A second version couples phosphinoxides of formula IV with aldehydes of formula V. Compounds of formula I are useful in the treatment or prevention of hyperproliferative skin diseases and for reversing the conditions associated with photodamage.
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: October 30, 2001
    Assignee: Basilea Pharmaceutica AG
    Inventor: Hans Hilpert
  • Process for the preparation of pyridine derivatives
    Patent number: 6303790
    Abstract: A process is described for preparing certain 4-alkyl- or 4-aryl-pyridine derivatives.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: October 16, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventors: Hans Hilpert, Fabienne Hoffmann-Emery, Goesta Rimmler, Mark Rogers-Evans, Helmut Werner Stahr, Pius Waldmeier
  • New process for a phenylthiobutyl-isoquinoline and intermediates therefor
    Publication number: 20010018538
    Abstract: A method for making phenylthiobutyl-isoquinoline compounds of formula 1
    Type: Application
    Filed: March 29, 2001
    Publication date: August 30, 2001
    Inventor: Hans Hilpert
  • Process for a phenylthiobutyl-isoquinoline and intermediates therefor
    Patent number: 6239296
    Abstract: Intermediate compounds useful for making phenylthiobutyl-isoquinoline compounds of formula
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: May 29, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Hans Hilpert
  • Process for manufacture of chiral succinic acid derivatives
    Patent number: 6197995
    Abstract: The present invention is concerned with a process for the manufacture of chiral succinic acid derivatives of formula (I) wherein R1 is (C1-C6) alkyl or benzyl, and the novel intermediates used therein.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: March 6, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventor: Hans Hilpert
  • Process for manufacturing 1-[3-cyclopentyl-2(R)-[1(R)-hydroxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]propionyl]piperidine
    Patent number: 6172238
    Abstract: A process manufactures of a compound of formula: and unique intermediates.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: January 9, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Paul Anthony Brown, Hans Hilpert
  • Process for a phenylthiobutyl-isoquinoline and intermediates therefor
    Patent number: 6130348
    Abstract: The present invention relates to a new method for making compounds of formula ##STR1## and intermediates for making compounds of formual II. The compounds of this invention are useful intermediates for the manufacture of pharmacologically active compounds suitable for the treatment of viral infections, particularly, those caused by HIV and other retroviruses.
    Type: Grant
    Filed: March 19, 1998
    Date of Patent: October 10, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Hans Hilpert
  • Process for manufacturing 1-[3-cyclopentyl -2(R)-[1(R)-hydroxycarbamoyl)-2-(3, 4, 4-trimethyl -2, 5-D ioxo-1-imidazolidinyl) ethyl] propionyl] piperidine
    Patent number: 6031103
    Abstract: A process manufactures of a compound of formula: ##STR1## and unique intermediates.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: February 29, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Paul Anthony Brown, Hans Hilpert
  • Process for the production of a .beta.-amino alcohol
    Patent number: 5994555
    Abstract: A process for producing 2-[3(S)-amino-2-(R)-hydroxyl-4-phenyl butyl]-N-tert,butyl decahydro-(4aS,8aS)-isoquinoline-e(S)-carboxamide of the formula (I) via 3(S)-[lower alkoxy carbonyl amino, phenoxy carbonyl amino or benzyl oxycarbonyl amino]-2-hydroxy-4-phenyl butyric acid and process for producing said acid.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: November 30, 1999
    Assignees: F. Hoffman-LaRoche AG, Degussa-Huls AG
    Inventors: Matthias Kottenhahn, Karlheinz Drauz, Hans Hilpert
  • Compounds useful for preparing an .alpha.,.alpha.'-diaminoalcohol
    Patent number: 5977388
    Abstract: A process for the manufacture of the .alpha.,.alpha.'-diaminoalcohol of formula ##STR1## is via N-protected L-phenylalanine lower alkyl esters, corresponding N-protected .alpha.-amino-.alpha.'-haloketones, and .alpha.-amino-.alpha.'-haloalcohols.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: November 2, 1999
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Hans Hilpert
  • Process for manufacturing an .alpha..alpha.'-diaminoalcohol
    Patent number: 5965733
    Abstract: A process for the manufacture of the .alpha.,.alpha.'-diaminoalcohol of formula ##STR1## is via N-protected L-phenylalanine lower alkyl esters, corresponding N-protected .alpha.-amino-.alpha.'-haloketones, and .alpha.-amino-.alpha.'-haloalcohols.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: October 12, 1999
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Hans Hilpert
  • Process for manufacture of chiral succinic acid derivatives
    Patent number: 5952507
    Abstract: The present invention is concerned with a process for the manufacture of chiral succinic acid derivatives of formula (I) ##STR1## wherein R.sup.1 is (C.sub.1 -C.sub.6) alkyl or benzyl, and the novel intermediates used therein.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: September 14, 1999
    Inventor: Hans Hilpert