Abstract: The present disclosure provides antibodies and antibody fragments thereof that bind to human TNFR2. The disclosed antibodies, inhibit the TNF-TNFR2 signaling axis and enhance cytokine secretion in T effector cells and are therefore useful for the treatment of cancer, either alone or in combination with other agents.

Abstract: An emergency lighting assembly is provided having a housing with one or more adjustable lamp assemblies for aiming the light at selected areas. The lamp assembly is mounted in the housing by a ball and socket arrangement. The lamp assembly has a substantially spherical shape with a front section made of a heat conducting material and a rear section made of a plastic material. The front section has an opening on a front side having a lens and a base spaced from the front side supporting the light source. The light source in one embodiment is an LED which is coupled to the front section to conduct heat from the LED away from the LED and the housing. The rear section has an opening in the rear side that receives a fixed stop member to limit pivoting movement of the lamp assembly with respect to the housing. The rear section also includes a projection oriented to contact the stop member to limit rotation of the lamp assembly with respect to the housing.

Abstract: In the invention described here, the approach is to formulate an edible vaccine based on N-terminal yeast surface display expression systems including S. cerevisiae EBY100/pYD5-VP28, S. cerevisiae EBY100/pYD5-VP28-VP24 and S. cerevisiae EBY100/pYD5-VP24 for preventing shrimps such as L. vannamei, P. monodon and M. rosenbergii species from white spot syndrome virus (WSSV) infection, suggesting that yeast surface display expression system expressing WSSV antigen has potential as a prophylactic treatment for WSSV in shrimps via oral vaccination. The technology developed in this patent application can also be used to produce edible (oral) vaccines for preventing and treating other infectious diseases in animals and human.

Abstract: In the invention described here, the approach is to formulate an edible vaccine based on N-terminal yeast surface display expression systems including S. cerevisiae EBY100/pYD5-VP28, S. cerevisiae EBY100/pYD5-VP28-VP24 and S. cerevisiae EBY100/pYD5-VP24 for preventing shrimps such as L. vannamei, P. monodon and M. rosenbergii species from white spot syndrome virus (WSSV) infection, suggesting that yeast surface display expression system expressing WSSV antigen has potential as a prophylactic treatment for WSSV in shrimps via oral vaccination. The technology developed in this patent application can also be used to produce edible (oral) vaccines for preventing and treating other infectious diseases in animals and human.

Abstract: In the invention described here, the approach is to formulate an edible vaccine based on N-terminal yeast surface display expression platform that producing S.cerevisiae EBY100/pYD5-preS2/S(adw) and S.cerevisiae EBY100/pYD5-preS2/S(adr) for protecting and treating human against hepatitis B virus (HBV) infection, suggesting that yeast surface display expression system expressing HBsAg antigen has potential as a prophylactic treatment for HBV in human via oral vaccination. The technology developed in this patent application can also be used to produce edible (oral) vaccines for preventing and treating other infectious diseases in human.

Abstract: An emergency lighting assembly is provided having a housing with one or more adjustable lamp assemblies for aiming the light at selected areas. The lamp assembly is mounted in the housing by a ball and socket arrangement. The lamp assembly has a substantially spherical shape with a front section made of a heat conducting material and a rear section made of a plastic material. The front section has an opening on a front side having a lens and a base spaced from the front side supporting the light source. The light source in one embodiment is an LED which is coupled to the front section to conduct heat from the LED away from the LED and the housing. The rear section has an opening in the rear side that receives a fixed stop member to limit pivoting movement of the lamp assembly with respect to the housing. The rear section also includes a projection oriented to contact the stop member to limit rotation of the lamp assembly with respect to the housing.

Abstract: In the invention described here, the approach is to formulate an edible vaccine based on N-terminal yeast surface display expression systems including S. cerevisiae EBY100/pYD5-VP28, S. cerevisiae EBY100/pYD5-VP28-VP24 and S. cerevisiae EBY100/pYD5-VP24 for preventing shrimps such as L. vannamei, P. monodon and M. rosenbergii species from white spot syndrome virus (WSSV) infection, suggesting that yeast surface display expression system expressing WSSV antigen has potential as a prophylactic treatment for WSSV in shrimps via oral vaccination. The technology developed in this patent application can also be used to produce edible (oral) vaccines for preventing and treating other infectious diseases in animals and human.

Abstract: An emergency lighting assembly is provided having a housing with one or more adjustable lamp assemblies for aiming the light at selected areas. The lamp assembly is mounted in the housing by a ball and socket arrangement. The lamp assembly has a substantially spherical shape with a front section made of a heat conducting material and a rear section made of a plastic material. The front section has an opening on a front side having a lens and a base spaced from the front side supporting the light source. The light source in one embodiment is an LED which is coupled to the front section to conduct heat from the LED away from the LED and the housing. The rear section has an opening in the rear side that receives a fixed stop member to limit pivoting movement of the lamp assembly with respect to the housing. The rear section also includes a projection oriented to contact the stop member to limit rotation of the lamp assembly with respect to the housing.

Abstract: In the invention described here, the approach is to formulate an edible vaccine based on N-terminal yeast surface display expression systems including S. cerevisiae EBY100/pYD5-VP28, S. cerevisiae EBY100/pYD5-VP28-VP24 and S. cerevisiae EBY100/pYD5-VP24 for preventing shrimps such as L. vannamei, P. monodon and M. rosenbergii species from white spot syndrome virus (WSSV) infection, suggesting that yeast surface display expression system expressing WSSV antigen has potential as a prophylactic treatment for WSSV in shrimps via oral vaccination. The technology developed in this patent application can also be used to produce edible (oral) vaccines for preventing and treating other infectious diseases in animals and human.

Abstract: In the invention described here, the approach is to formulate an edible vaccine based on N-terminal yeast surface display expression platform that producing S.cerevisiae EBY100/pYD5-preS2/S(adw) and S.cerevisiae EBY100/pYD5-preS2/S(adr) for protecting and treating human against hepatitis B virus (HBV) infection, suggesting that yeast surface display expression system expressing HBsAg antigen has potential as a prophylactic treatment for HBV in human via oral vaccination. The technology developed in this patent application can also be used to produce edible (oral) vaccines for preventing and treating other infectious diseases in human.

Abstract: An emergency lighting assembly is provided having a housing with one or more adjustable lamp assemblies for aiming the light at selected areas. The lamp assembly is mounted in the housing by a ball and socket arrangement. The lamp assembly has a substantially spherical shape with a front section made of a heat conducting material and a rear section made of a plastic material. The front section has an opening on a front side having a lens and a base spaced from the front side supporting the light source. The light source in one embodiment is an LED which is coupled to the front section to conduct heat from the LED away from the LED and the housing. The rear section has an opening in the rear side that receives a fixed stop member to limit pivoting movement of the lamp assembly with respect to the housing. The rear section also includes a projection oriented to contact the stop member to limit rotation of the lamp assembly with respect to the housing.

Abstract: An emergency lighting assembly is provided having a housing with one or more adjustable lamp assemblies for aiming the light at selected areas. The lamp assembly is mounted in the housing by a ball and socket arrangement. The lamp assembly has a substantially spherical shape with a front section made of a heat conducting material and a rear section made of a plastic material. The front section has an opening on a front side having a lens and a base spaced from the front side supporting the light source. The light source in one embodiment is an LED which is coupled to the front section to conduct heat from the LED away from the LED and the housing. The rear section has an opening in the rear side that receives a fixed stop member to limit pivoting movement of the lamp assembly with respect to the housing. The rear section also includes a projection oriented to contact the stop member to limit rotation of the lamp assembly with respect to the housing.

Abstract: A skincare stimulant having an effective dose of platelets and pharmaceutically acceptable solvents and/or excipients, wherein the effective dose refers to the presence of at least 1000 platelets in every milligram of skincare stimulant.

Abstract: A skincare stimulant having an effective dose of platelets and pharmaceutically acceptable solvents and/or excipients, where the effective dose refers to the presence of at least 1000 platelets in every milliliter of skincare stimulant. A method for treating a skin condition selected wrinkles, amyloidosis and keratosis pilaris includes spraying or spreading the skincare stimulant having over a body area, where the skincare stimulant is a solution having a concentration of 1000-10000 platelets per milliliter of the solution, wherein a source of the platelets is a platelet dry powder having less than 30% of plasma protein, based on the weight of the platelet dry powder.

Abstract: A reset level in a pixel cell is boosted by switching ON a reset transistor of the pixel cell to charge the floating diffusion to a first reset level during a reset operation. A select transistor is switched from OFF to ON during the floating diffusion reset operation to discharge an output terminal of an amplifier transistor. The reset transistor is switched OFF after the output terminal of the amplifier transistor has been discharged in response to the switching ON of the select transistor. The output terminal of the amplifier transistor charges to a static level after being discharged. The floating diffusion coupled to the input terminal of the amplifier transistor follows the output terminal of the amplifier transistor across an amplifier capacitance coupled between the input terminal and the output terminal of the amplifier transistor to boost the reset level of the floating diffusion.

Abstract: A reduced random telegraph signal (RTS)-noise CMOS image sensor includes a pixel and a correlated double sampling (CDS) circuit electrically connected to the pixel. The CDS circuit is characterized by a CDS period that includes a reference sample period and an image data sample period. The image sensor also includes a bitline, a bitline connection switch between the pixel and a readout circuit connected to the pixel, and a bitline switch controller. The bitline transmits a transfer gate signal as a bitline signal having a non-zero value during a first time period entirely between the reference sample period and the image data sample period. The bitline switch controller is electrically connected to and configured to control the bitline connection switch such that the bitline connection switch is closed during the entire CDS period except for a single continuous open period that includes the first time period.

Abstract: A reset level in a pixel cell is boosted by switching ON a reset transistor of the pixel cell to charge the floating diffusion to a first reset level during a reset operation. A select transistor is switched from OFF to ON during the floating diffusion reset operation to discharge an output terminal of an amplifier transistor. The reset transistor is switched OFF after the output terminal of the amplifier transistor has been discharged in response to the switching ON of the select transistor. The output terminal of the amplifier transistor charges to a static level after being discharged. The floating diffusion coupled to the input terminal of the amplifier transistor follows the output terminal of the amplifier transistor across an amplifier capacitance coupled between the input terminal and the output terminal of the amplifier transistor to boost the reset level of the floating diffusion.

Abstract: A hair growth composition prepared from a platelet dry powder and a pharmaceutically acceptable solvent and/or excipient, which has from 1,000 to 15,000 platelets in every milliliter of the hair growth composition. The present invention also provides a method for treating a bald or thin hair area due to hair loss on the head of a human by administering the hair growth composition to the area with a dosage of 6-562 platelets per square centimeter of the area.

Abstract: An electrochemical storage cell is disclosed that comprises a cathode sheet, an anode sheet, and a separator sheet between the cathode and anode sheets. A metal foil current collector extends from a longitudinal edge of the cathode sheet. A further metal foil current collector extends from a longitudinal edge of the anode sheet. The anode sheet, cathode sheet, and separator sheet are wound in a flattened coil shape to produce a core in which the metal foil current collector of the cathode sheet extends beyond the separator sheet at one end of the core and the metal current collector of the anode sheet extends beyond the separator sheet at an opposite end of the core. Overlying layers of the metal foil current collector of the cathode sheet are compressed together and placed in electrical communication with a positive terminal of the cell while overlying layers of the metal foil current collector of the anode sheet are compressed together and placed in electrical communication a negative terminal of the cell.

Abstract: A hair growth agent having an effective dose of a platelet dry powder and a pharmaceutically acceptable solvent and/or excipient, wherein the effective dose refers to the presence of at least 1,000 platelets in every milliliter of the hair growth agent.