Patents by Inventor Hans-Peter Maerki

Hans-Peter Maerki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaromate OSC inhibitors
    Patent number: 6951879
    Abstract: The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: October 4, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Jean Ackermann, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand
  • Indolyl derivatives
    Publication number: 20050203160
    Abstract: This invention relates to compounds of the formula I: wherein one of R6, R7 and R8 is and R1 to R15 and n are as defined in the description, and all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR ? and/or PPAR? agonists.
    Type: Application
    Filed: March 8, 2005
    Publication date: September 15, 2005
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Matthew Wright
  • 2,3-Oxidosqualene-lanosterol cyclase inhibitors
    Publication number: 20050176766
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Application
    Filed: December 15, 2004
    Publication date: August 11, 2005
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • Indolyl derivatives
    Patent number: 6890947
    Abstract: Compounds of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R8, A, A1 and n have the significance indicated in the specification.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: May 10, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Beat Wirz, Uwe Grether, Hans Hilpert, Roland Humm, Hans Iding, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr
  • Benzannelated derivatives, their manufacture and use as pharmaceutical agents
    Publication number: 20050096336
    Abstract: There are presented compounds of the formula wherein R6 and R7 is R4 and R5 or R5 and R6 together with the carbon atoms to which they are attached, form a ring as defined in the description and X1, X2, Y1 to Y4, R1 to R13 and n are as specified in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.
    Type: Application
    Filed: October 29, 2004
    Publication date: May 5, 2005
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Matthew Wright
  • Indolyl and dihydroindolyl derivatives, their manufacture and use as pharmaceutical agents
    Publication number: 20050096353
    Abstract: This invention relates to compounds of the formula wherein one of R6, R7 and R8 is and X, Y1 to Y4, R1 to R14 and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.
    Type: Application
    Filed: October 29, 2004
    Publication date: May 5, 2005
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Matthew Blake Wright
  • Phenyl derivatives, their manufacture and use as pharmaceutical agents
    Publication number: 20050096337
    Abstract: This invention relates to compounds of the formula wherein one of R5, R6 and R7 is and X1, X2, Y1 to Y4, R1 to R13 and m and n are defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.
    Type: Application
    Filed: October 29, 2004
    Publication date: May 5, 2005
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Matthew Wright
  • Aminoalkylamide substituted cyclohexyl derivatives
    Publication number: 20050065210
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, U, V, W, k and m are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Application
    Filed: September 16, 2004
    Publication date: March 24, 2005
    Inventors: Jean Ackermann, Johannes Aebi, Henrietta Dehmlow, Georges Hirth, Hans-Peter Maerki, Olivier Morand, Narendra Panday
  • 2,3-oxidosqualene-lanosterol cyclase inhibitors
    Patent number: 6858651
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: February 22, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents
    Publication number: 20050004187
    Abstract: This invention relates to compounds of the formula wherein one of R6, R7 or R8 is and all enantiomers and pharmaceutically acceptable salts and/or esters thereof as well as pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.
    Type: Application
    Filed: June 28, 2004
    Publication date: January 6, 2005
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Matthew Wright
  • Aniline derivatives, their manufacture and use as pharmaceuticals
    Publication number: 20040248951
    Abstract: This invention relates to compounds of the formula 1
    Type: Application
    Filed: June 1, 2004
    Publication date: December 9, 2004
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Mathew Blake Wright
  • Thiazole derivatives
    Patent number: 6809110
    Abstract: The present invention provides compounds of formula (I) wherein R1 to R10, X, Y and n are indicated in the specification, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of non-insulin dependent diabetes mellitus.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: October 26, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Uwe Grether, Hans Hilpert, Georges Hirth, Hans-Peter Maerki, Markus Meyer, Peter Mohr
  • Novel substituted oxazole derivatives
    Publication number: 20040157898
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: November 4, 2003
    Publication date: August 12, 2004
    Inventors: Alfred Binggeli, Uwe Grether, Hans Hilpert, Georges Hirth, Hans-Peter Maerki, Markus Meyer, Peter Mohr
  • Novel oxazole derivatives
    Publication number: 20040116487
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: October 6, 2003
    Publication date: June 17, 2004
    Inventors: Alfred Binggeli, Markus Boehringer, Uwe Grether, Hans Hilpert, Georges Hirth, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Fabienne Ricklin
  • Thiazole derivatives
    Publication number: 20040110807
    Abstract: The present invention provides compounds of formula (I) 1
    Type: Application
    Filed: August 28, 2003
    Publication date: June 10, 2004
    Inventors: Alfred Binggeli, Uwe Grether, Hans Hilpert, Georges Hirth, Hans-Peter Maerki, Markus Meyer, Peter Mohr
  • Indolyl derivatives
    Publication number: 20040106657
    Abstract: The present invention provides compounds of formula I 1
    Type: Application
    Filed: November 21, 2003
    Publication date: June 3, 2004
    Inventors: Alfred Binggeli, Uwe Grether, Hans Hilpert, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr
  • Indolyl derivatives
    Publication number: 20040053979
    Abstract: Compounds of formula I are provided 1
    Type: Application
    Filed: September 10, 2003
    Publication date: March 18, 2004
    Inventors: Alfred Binggeli, Beat Wirz, Uwe Grether, Hans Hilpert, Roland Humm, Hans Iding, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr
  • Naphthalenyl piperidines as renin inhibitors
    Patent number: 6673931
    Abstract: Piperidine derivatives, their manufacture and use as medicaments is described. The compounds are useful for treating diseases associated with restenosis, glaucoma, cardiac infarct, high blood pressure and end organ damage, e.g. cardiac insufficiency and kidney insufficiency.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: January 6, 2004
    Assignee: Hoffman-La Roche Inc.
    Inventors: Volker Breu, Hans-Peter Märki, Eric Vieira, Wolfgang Wostl
  • Pyrimidine, pyrazine and triazane derivatives
    Patent number: 6673795
    Abstract: The present invention is a pyrimidine, triazine or pyrazine derivative of the formula or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4, X, Y and Z are as defined in the specification. The invention is a pharmaceutical composition containing an effective amount of the compound of formula 1, its preparation and to a method of treatment, control or prevention of acute and/or chronic neurological disorders by administering a therapeutically effective amount of a compound of formula 1.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: January 6, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Thierry Masquelin, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Oxazole derivatives
    Patent number: 6642389
    Abstract: The present invention relates to novel oxazole compounds which act as PPAR&agr; and PPAR&ggr; agonists and are accordingly useful for the treatment of diseases modulated by PPAR&agr; and PPAR&ggr; such as diabetes.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: November 4, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Markus Boehringer, Uwe Grether, Hans Hilpert, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Fabienne Ricklin