Patents by Inventor Hans-Peter Maerki

Hans-Peter Maerki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted cyclohexane derivatives
    Publication number: 20030199550
    Abstract: The present invention provides compounds of formula (I) 1
    Type: Application
    Filed: December 10, 2002
    Publication date: October 23, 2003
    Inventors: Jean Ackermann, Johannes Aebi, Henrietta Dehmlow, Georges Hirth, Hans-Peter Maerki, Olivier Morand
  • Substituted cyclohexane derivatives
    Publication number: 20030186984
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: December 5, 2002
    Publication date: October 2, 2003
    Inventors: Jean Ackermann, Johannes Aebi, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand
  • Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno [d] azepine
    Patent number: 6586422
    Abstract: The invention relates to compounds which are represented by the formula wherein R1, R2, R3, R4, X and Y are as defined in the specification, as well as pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing these compounds and to a process for their preparation. The compounds possess affinity towards metabotropic glutamate receptors and are therefore useful in the treatment or prevention of acute and/or chronic neurological disorders.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: July 1, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Pyrimidine, pyrazine and triazine derivatives
    Publication number: 20030060466
    Abstract: The present invention is a pyrimidine, triazine or pyrazine derivative of the formula 1
    Type: Application
    Filed: May 29, 2002
    Publication date: March 27, 2003
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Thierry Masquelin, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Oxazole derivatives
    Publication number: 20030055265
    Abstract: The present invention relates to novel oxazole compounds which act as PPAR&agr; and PPAR&ggr; agonists and are accordingly useful for the treatment of diseases modulated by PPAR&agr; and PPAR&ggr; such as diabetes.
    Type: Application
    Filed: May 9, 2002
    Publication date: March 20, 2003
    Inventors: Alfred Binggeli, Markus Boehringer, Uwe Grether, Hans Hilpert, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Fabienne Ricklin
  • Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno [d] azepine
    Publication number: 20020123488
    Abstract: The invention relates to compounds which are represented by the formula 1
    Type: Application
    Filed: December 12, 2001
    Publication date: September 5, 2002
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Heteroaromate OSC inhibitors
    Publication number: 20020086891
    Abstract: The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Application
    Filed: October 31, 2001
    Publication date: July 4, 2002
    Inventors: Johannes Aebi, Jean Ackermann, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand
  • Naphthalenylmethoxypiperidines as renin inhibitors
    Patent number: 6376672
    Abstract: The present invention relates to compound of formula (I) wherein R1, R2 and R3 are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for treating diseases associated with restenosis, glaucoma, cardiac infarct, high blood pressure and end organ damage, e.g. cardiac insufficiency and kidney insufficiency.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: April 23, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Volker Breu, Hans-Peter Märki, Eric Vieira, Wolfgang Wostl
  • 2,3-oxidosqualene-lanosterol cyclase inhibitors
    Publication number: 20020045777
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Application
    Filed: August 9, 2001
    Publication date: April 18, 2002
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • Novel mGluR antagonists and a method for their synthesis
    Publication number: 20020045635
    Abstract: The invention relates to nitro- and cyano-1,2,4,5-tetrahydro-heterocycloazepinyl pyrimidine derivatives as well as their pharmaceutically acceptable salts. The invention further relates to medicaments containing such compounds and a process for the preparation of such compounds. The compounds of the invention are group I mGluR antagonists and are therefore useful for the control or prevention of acute and/or chronic neurological disorders.
    Type: Application
    Filed: July 11, 2001
    Publication date: April 18, 2002
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • mGluR antagonists and a method for their synthesis
    Patent number: 6369222
    Abstract: The invention relates to nitro- and cyano-1,2,4,5-tetrahydro-heterocycloazepinyl pyrimidine derivatives as well as their pharmaceutically acceptable salts. The invention further relates to medicaments containing such compounds and a process for the preparation of such compounds. The compounds of the invention are group I mGluR antagonists and are therefore useful for the control or prevention of acute and/or chronic neurological disorders.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: April 9, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Vincent Mutel, Wolfgang Wostl
  • Pharmaceutical compositions containing lipase inhibitor
    Patent number: 6358522
    Abstract: The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, one (or more) additive(s) of the group consisting of substantially non-digestible, substantially non-fermentable, hydrophilic and/or hydrocolloidal food grade thickeners and emulsifiers, and auxiliary excipients. Methods are provided for preventing and treating anal leakage of oil in a patient by administering the compositions of the present invention to the patient.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: March 19, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Manuela Hug, Hans-Peter Märki, Marcel Meier
  • 1,2,4,5-Tetrahydro-benzo[D]azepin derivatives
    Patent number: 6218385
    Abstract: The present invention is concerned with 1,2,4,5-tetrahydro-benzo[d]azepin derivatives as well as with their pharmaceutically acceptable salts in their racemic and optically active form, which compounds are antagonists at metabotropic glutamate receptors and therefore useful for the treatment of diseases related to these receptors.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: April 17, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Alfred Binggeli, Hans-Peter Märki, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Piperidine derivatives
    Patent number: 6197959
    Abstract: Compounds of formula (I) wherein R1 and R2 are as defined in the description and claims and pharmaceutically acceptable salts thereof, are useful for the treating diseases associated with restenosis, glaucoma, cardiac infarct, high blood pressure and end organ damage, for example, cardiac insufficiency and kidney insufficiency.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: March 6, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Volker Breu, Daniel Bur, Hans-Peter Märki, Eric Vieira, Wolfgang Wostl