Abstract: A sample injector for injecting a fluid into a fluidic path, wherein the sample injector comprises a robot arm configured for moving an injection needle, when being connected to the robot arm, between a fluid container containing the fluid and a seat in fluid communication with the fluidic path, the needle configured for aspirating the fluid from the fluid container, when the needle has been moved to the fluid container, and for injecting aspirated fluid into the fluidic path, when the needle is accommodated in the seat, and the seat configured for accommodating the needle and providing fluid communication with the fluidic path, wherein the robot arm is configured for selectively disconnecting the needle from the robot arm when the needle is accommodated in the seat, and wherein the robot arm is configured for performing a further task while the needle is disconnected from the robot arm.

Abstract: An electrical circuit includes a signal processing chain and a controller. The signal processing chain includes an integrator configured to integrate an input signal over an integration time. The controller is connected to a signal output of the signal processing chain to receive and evaluate an output signal of the signal processing chain. The controller is further configured to adapt the integration time based on the output signal.

Abstract: The present invention relates to a method and a device for inspecting a volume and/or a composition of at least one, especially fluid, sample. The method comprises the steps of making available at least one pipette, in which an interface is formed between a sample and a fluid which is adjacent to the sample. That interface being optically perceptible outside the pipette as an interface line between the sample and at least one fluid that extends approximately (about) horizontally A camera is arranged in an image so that the marking and at least a first section of the at least one pipette is shown in a recorded image The present invention thus provides an apparatus and method for a singular approach to detecting, evaluation and recording results.

Abstract: Illumination systems are described for illuminating a target area, e.g., a floor of a room, using active illumination devices in optical communication with passive illumination devices. The active and passive illumination devices of the illumination system are configured and arranged relative to each other in a variety of ways so a variety of intensity distributions can be provided by the illumination system. Such illumination system is implemented to provide light for particular lighting applications, including office lighting, garage lighting, or cabinet lighting.

Abstract: The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation.

Abstract: An injection needle cartridge for a sample injector for injecting a sample fluid into a mobile phase in a fluidic path of a fluid separation system between a mobile phase drive and a separation unit, the injection needle cartridge comprising an injection needle configured for aspirating the sample fluid from a fluid container when the injection needle has been moved to the fluid container, and for injecting aspirated sample fluid into the fluidic path when the injection needle is sealingly accommodated in a needle seat, and a sealing force generator configured for applying a sealing force to the injection needle for sealingly accommodating the injection needle in the needle seat, wherein the injection needle cartridge is configured for being substitutably mountable on a handling robot of the sample injector for handling the injection needle cartridge between the fluid container and the needle seat.

Abstract: A method and a device are disclosed for making thin plastic films having two or more layers, which are subdivided and separated in the form of tubular bags for portioned reception of different products, wherein the plastic films are provided with welding seams running substantially transversely to the longitudinal direction with predetermined spacing between one another to form bag-like containers, and the containers are separated from one another by a cutting or separating process, the method being characterized by the steps: a) welding the films with predetermined spacing by means of an ultrasound welding process, maintaining a defined, film-dependent distance between a processing tool and a counter tool while welding; and b) separating the tubular bags welded in this way by means of a mechanical cutting process, with or without reduced ultrasound excitation at the point of the respective weld seams.

Abstract: A method of manufacturing a semiconductor device including a capacitor structure is provided, including the steps of providing an SOI wafer comprising a substrate, a buried oxide (BOX) layer formed over the substrate and a semiconductor layer formed over the BOX layer, removing the semiconductor layer in a first region of the wafer to expose the BOX layer, forming a dielectric layer over the exposed BOX layer in the first region, and forming a conductive layer over the dielectric layer. Moreover, a semiconductor device including a capacitor formed on a wafer is provided, wherein the capacitor comprises a first capacitor electrode comprising a doped semiconductor substrate of the wafer, a capacitor insulator comprising an ultra-thin BOX layer of the wafer and a high-k dielectric layer formed on the ultra-thin BOX layer, and a second capacitor electrode comprising a conductive layer formed over the high-k dielectric layer.

Abstract: The present invention relates to a device useful for inspecting a sample. The device includes a camera in order to arrange that camera in an image field so that an interface line and a marker of the camera can be imaged as a recorded image. The device also has an evaluation unit which allows an evaluation of the recorded image and the marking in order to provide information to the observer.

Abstract: A machining machine includes an annular bottom working disk and a top counter bearing element. The bottom working disk and top counter bearing element are driven to rotate relative to each other. A working gap is defined between the bottom working disk and the top counter bearing to machine flat work pieces on at least one side. A means for generating a local deformation of the bottom working disk are also provided.

Abstract: A genetically engineered micro-organism having an operative metabolic pathway producing cinnamoyl-CoA and producing pinosylvin therefrom by the action of a stilbene synthase is used for pinosylvin production. Said cinnamic acid may be formed from L-phenylalanine by a L-phenylalanine ammonia lyase (PAL) which is one accepting phenylalanine as a substrate and producing cinammic acid therefrom, preferably such that if the PAL also accepts tyrosine as a substrate and forms coumaric acid therefrom, the ratio Km(phenylalanine)/Km(tyrosine) for said PAL is less than 1:1 and if said micro-organism produces a cinammate-4 -hydroxylase enzyme (C4H), the ratio Kcat(PAL)/Kcat(C4H) is at least 2:1.

Abstract: In magnetic resonance imaging using a measurement sequence of the “free precession of transverse magnetization in the steady state”-type i.e., an SSFP measurement sequence, during the SSFP measurement sequence, the implementation of a preparation sequence takes place to reduce a signal contribution of the transverse magnetization in an outer region surrounding a measurement region in the MR imaging. The implementation of the preparation sequence includes the radiation of a multidimensional, spatially selective RF pulse that acts in a spatially selective manner on the transverse magnetization in the outer region. Saturation of the transverse magnetization and/or dephasing of the transverse magnetization in the outer region can be achieved by the multidimensional, spatially selective RF pulse.

Abstract: A method for semi-continuous casting of a strand (1) of steel in a strand casting machine and a strand casting machine for such casting. The strand has little segregation of the center and porosity. Yet it is castable rapidly. The method steps are: at a casting start of the strand casting machine, pouring liquid steel into an open-ended mold (2). The mold is closed by a cold strand (6). The liquid steel forms, together with the cold strand, a completely solidified strand start (1a) and subsequently forms a semi-solidified strand (1b). Then extracting the semi-solidified strand (1b) from the open-ended mold (2). Supporting and guiding the semi-solidified strand (1b) in a strand guide (3). Cooling the semi-solidified strand (1b) by secondary cooling (4) at the casting end of the strand casting machine, ending the pouring of liquid steel into the open-ended mold (2) and forming a strand end (1c). Extracting the strand end (1c) from the open-ended mold (2).

Abstract: A process for the preparation of a compound of formula (I) including all isomers, stereoisomers, enantiomers and diastereomers thereof (I), and salts thereof; the process comprising providing a mixture comprising a compound of formula (II) and a compound of formula (III) subjecting the mixture provided in a) to reaction conditions in the presence of one or more Lewis acids to the mixture provided in a), obtaining a mixture comprising the compound of formula (I).

Abstract: The invention relates to a web guiding device (3) for guiding a material web (2), in particular a film web, with a first and a second frame element (31, 32), which are pivotably mounted on a first spindle (33) in respective first end areas (311, 321), are connected via a rotatably mounted web guide roller (34) in respective second end areas (321, 322) and are connected via a second spindle (35) which is connected to the first spindle (33) by means of a fixing element (37).

Abstract: The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A?, anti-RAGE, and anti-?-synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-A?, anti-RAGE, and anti-?-synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A?, anti-RAGE, and anti-?-synuclein antibodies), are also provided.

Abstract: Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof (“PUFAs”) to modulate Iks channels to treat conditions associated with a disruption in Iks channel activity, such as cardiac arrhythmias. In particular, disclosed herein are negatively charged PUFAs having decreased pKa values, which can activate (i.e., open) IKs channels, and positively charged PUFAs that can inhibit (i.e., close) IKS channels.

Abstract: The present invention relates to a multi-layered drink in which the adjacent layers have a difference in density of 0.4 to 10 kg/m3 and each layer contains at least one hydrocolloid.

Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.