Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R5, A1, A2, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: A method for generation of a radio-frequency (RF) pulse for excitation of nuclear spins in a predetermined layer of a specimen for magnetic resonance imaging and a magnetic resonance imaging device for performing the method are provided. The method includes determining a variation of a magnetic field in a measuring volume, and defining a spectral frequency distribution of the RF pulse. The RF pulse with the spectral frequency distribution is configured to excite nuclear spins in the specimen. The nuclear spins are polarized by the magnetic field at a predetermined flip angle in the measuring volume under a boundary condition of a substantially minimum energy content. The method also includes generating the RF pulse with the defined spectral frequency distribution.

Abstract: The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.

Abstract: The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.

Abstract: A stator component of a turbomachine includes at least one axially extending outer ring which serves as a frame of an inner ring composed of partial segments. The partial segments are arranged on one another such that, on the rotor side, to form a coherent circular circumferential surface in relation to the rotational movement of rotor blades. The individual partial segment is composed of a material of uniform construction or, at least in a radial direction, of multiple partial bodies constructed from different materials, such as for example ceramic, wherein a partial segment thus formed exhibits predetermined stress and/or expansion behavior as a function of the load ranges of the turbomachine.

Abstract: Described are balls for a ball sport, wherein the ball includes at least one heating element.

Abstract: A mechanical and electric drive train of a motor vehicle having an internal combustion engine and an electric motor, includes a conventional drive train which is driven by the internal combustion engine, an electric motor drive train which is driven by an electric motor, a shift gearbox arranged in the conventional drive train, and at least one axle drive unit for driving axle drive members which are connected or are connectable via a clutch to driving wheels of at least one axle of the motor vehicle. The electric motor drive train is connected between the shift gearbox and the axle drive members to the drive train via at least one first clutch device, wherein the connection can be produced and eliminated by actuation of the first clutch device.

Abstract: A watercraft with a hull has a flow channel, or is associated with a flow channel, a motor-driven water-acceleration arrangement is associated with the flow channel and the motor is connected to an energy accumulator. In order to improve user convenience, two energy accumulators are integrated into the hull. The energy accumulators are arranged on both sides of the center longitudinal plane running in the longitudinal direction of the hull.

Abstract: A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold comprised of collagen and a secondary scaffold comprising a soluble collagen solution in combination with a surfactant generated and positioned within the primary scaffold. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.

Abstract: A drive device for a motor vehicle includes a primary powertrain and a secondary powertrain, wherein the primary powertrain includes a combustion engine for generating a total torque; a torque distribution device coupled to the combustion engine and including a first and a second output, wherein the torque distribution device is designed to provide a first partial torque in mechanical form at its first output derived from the total torque, and to provide a second partial torque in electrical form at its second output derived from the total torque; and a transmission which is coupled to the first output of the torque distribution device; wherein the secondary powertrain includes an electric machine which is coupled to the second output of the torque distribution device; wherein the torque distribution device includes a torque limiting device which is designed to limit the first partial torque to a presettable threshold value.

Abstract: A method and apparatus for the sterilization of plastics material pre-forms, wherein the plastics material pre-forms are conveyed by a conveying device along a pre-determined conveying path and are sterilized at least for a time during this conveying by being acted upon with a flowable sterilization agent, wherein the plastics material pre-forms are conveyed at least for a time inside a housing. According to the method and apparatus, at least one portion of the housing is heated at least for a time and/or during the sterilization procedure by a heating source independent of the sterilization agent.

Abstract: A sealed bag containing a reference fluid for the calibration and/or quality control of a creatine and/or creatinine sensor, the bag comprising: an inner polymer layer and an outer polymer layer; and an aluminium oxide gas barrier layer there between; and wherein the inner polymer layer is in contact with the reference fluid.

Abstract: The invention relates to a pyrotechnical actuator for a vehicle safety system comprising a cylinder (10) and a hollow piston (20) being displaceable relative to each other from an idle state to an activated state, wherein an igniter unit (30) being tightly connected to the hollow piston (20) is arranged inside the hollow piston (20). The invention excels by the fact that in the idle state the hollow piston (20) is received in the cylinder (10) and in the activated state it protrudes at least partially from the cylinder (10) so that the actuator has a larger total length in the activated state than in the idle state. The invention further relates to an actuator and a vehicle safety system comprising such actuator as well as to an actuating method.

Abstract: An electromechanical actuator includes a drive motor having rotatable drive shaft. A magnetic element is disposed on the drive shaft. A rotary-to-linear motion converter is driven by the rotatable drive shaft and includes a non-rotating actuator body that is linearly movable in a traveling direction. A Hall-effect sensor is disposed in a stationary manner proximal to the magnetic element disposed on the drive shaft. A controller is in electronic communication with the Hall-effect sensor. The controller counts the number of impulses output by the Hall-effect sensor when the drive shaft rotates relative to the Hall-effect sensor, and turns off the drive motor after a predetermined number of impulses have been counted since the start-up of the non-rotating actuator body. The controller may also count the number of times that the current of the drive motor exceeds a predetermined maximum value and store this counted value in a memory element.

Abstract: The invention relates to a turbofan aircraft engine that comprises a primary duct including a combustion chamber; a first turbine disposed downstream of the combustion chamber; a compressor disposed upstream of the combustion chamber and coupled to the first turbine; and a second turbine disposed downstream of the first turbine and coupled to a fan for feeding a secondary duct of the turbofan aircraft engine. The bypass ratio of the inlet area of the secondary duct to the inlet area of the primary duct is at least 7 and the second turbine comprises at least two stages. The mean outer radius of the last stage of the second turbine divided by the length of the second turbine is at least 1.4.

Abstract: An electronic circuit unit (1) comprising at least one electrical or electronic device (8) with at least one terminal contact (101), the at least one terminal contact (101) being connected in an electrically conducting manner to at least one terminal pad (100), at least one terminal contact (101) and at least one terminal pad (100) are surrounded in the region of the electrical point of contact by an electrically insulating compound (9), the electrical or electronic device (8) being arranged outside the electrically insulating compound (9).

Abstract: A semiconductor device is provided including a fully depleted silicon-on-insulator (FDSOI) substrate and a charge pump device, wherein the FDSOI substrate comprises a semiconductor bulk substrate, and the charge pump device comprises a transistor device formed in and on the FDSOI substrate, and a trench capacitor formed in the semiconductor bulk substrate and electrically connected to the transistor device.

Abstract: The invention relates to a turbofan aircraft engine that comprises a primary duct including a combustion chamber; a first turbine disposed downstream of the combustion chamber; a compressor disposed upstream of the combustion chamber and coupled to the first turbine; and a second turbine disposed downstream of the first turbine and coupled to a fan for feeding a secondary duct of the turbofan aircraft engine. The bypass ratio of the inlet area of the secondary duct to the inlet area of the primary duct is at least 7 and the second turbine comprises at least two stages. For the first stage the mean radius r of a stator vane expressed in inch divided by the number of stator vanes is at least 0.18.