Abstract: Disclosed are instruments and methods for acquiring co-registered orthogonal fluorescence and photoacoustic volumetric projections of an interrogated object. In an embodiment, an instrument includes a rotary mechanism configured to rotate an interrogated object relative to an array of photoacoustic transducers and an optical detector. An optical excitation unit is configured to irradiate the interrogated object with pulses of light, inducing both fluorescence and photoacoustic responses inside the interrogated object at each of a plurality of rotational positions. The array of photoacoustic transducers includes unfocused elements arranged in a pattern along an axis of rotation, the elements configured to detect photoacoustic signals generated inside the volume of the interrogated object. The optical detector is arranged opposite to the array of photoacoustic transducers with respect to the axis of rotation and is configured to register sources of fluorescence excited inside the interrogated object.

Abstract: A method for producing a packaging body (51) from a web material that comprises paper, wherein the packaging body (51) comprises an indentation (53) for receiving an item to be packaged, the method comprising: pre-tensioning the web material (14); fixing the web material (14) between a holding-down device (32) and a die (31); molding the indentation (53) in the web material (14); and removing the molded indentation (53) from the die (31).

Abstract: The invention describes a belt buckle (10) for a motor vehicle comprising a belt buckle housing (12) as well as a lighting unit (20) present in the area of a tongue insertion opening (36) and including a lamp (22) and a light conductor (16). A front panel (14) surrounding the tongue insertion opening (36) is provided which limits the belt buckle (10) on the end face. The front panel (14) is coupled to the belt buckle housing (12) via at least one detent mechanism (24, 30) such that the light conductor (16) provided at least partially between the front panel (14) and the belt buckle housing (12) is aligned. The invention further describes a method for manufacturing a belt buckle (10).

Abstract: Strategies to assess and/or produce cell populations with predictive engraftment potential are described. The cell populations can be used for a variety of therapeutic and research purposes.

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

Abstract: The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

Abstract: The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

Abstract: A method for implementing source-free domain adaptive detection is presented. The method includes, in a pretraining phase, applying strong data augmentation to labeled source images to produce perturbed labeled source images and training an object detection model by using the perturbed labeled source images to generate a source-only model. The method further includes, in an adaptation phase, training a self-trained mean teacher model by generating a weakly augmented image and multiple strongly augmented images from unlabeled target images, generating a plurality of region proposals from the weakly augmented image, selecting a region proposal from the plurality of region proposals as a pseudo ground truth, detecting, by the self-trained mean teacher model, object boxes and selecting pseudo ground truth boxes by employing a confidence constraint and a consistency constraint, and training a student model by using one of the multiple strongly augmented images jointly with an object detection loss.

Abstract: A method is provided that includes training a CLIP model to learn embeddings of images and text from matched image-text pairs. The text represents image attributes. The method trains a StyleGAN on images in a training dataset of matched image-text pairs. The method also trains, using a CLIP model guided contrastive loss which attracts matched text embedding pairs and repels unmatched pairs, a text-to-direction model to predict a text direction that is semantically aligned with an input text responsive to the input text and a random latent code. A triplet loss is used to learn text directions using the embeddings learned by the trained CLIP model. The method generates, by the trained StyleGAN, positive and negative synthesized images by respectively adding and subtracting the text direction in the latent space of the trained StyleGAN corresponding to a word for each of the words in the training dataset.

Abstract: The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

Abstract: A curable silicone elastomer composition is disclosed. The composition comprises one or more non-fluorinated polydiorganosiloxane polymers and silica filler. The silica filler is at least partially treated with a fluorinated hydrophobing treating agent. Also provided is a method of making the composition and its use in the manufacture of insulators for high voltage applications, especially high voltage direct current (HVDC) applications and accessories such as cable joints, cable terminal applications, and connectors. The fluorinated hydrophobing treating agents are selected from one or more silanol terminated fluorinated siloxane oligomer(s) having from 2 to 20 siloxane units, and/or one or more fluorinated silane diol(s), and/or one or more fluorinated trialkoxy silane(s), and/or one or more fluorinated silazane(s), or a mixture thereof.

Abstract: A method for compositional reasoning of group activity in videos with keypoint-only modality is presented. The method includes obtaining video frames from a video stream received from a plurality of video image capturing devices, extracting keypoints all of persons detected in the video frames to define keypoint data, tokenizing the keypoint data with time and segment information, clustering groups of keypoint persons in the video frames and passing the clustering groups through multi-scale prediction, and performing a prediction to provide a group activity prediction of a scene in the video frames.

Abstract: What is proposed is a closure unit consisting of a glass container (50) with external, circumferentially offset threaded elements (54, 55) on a container neck (52) of the glass container, and a closure cover made of sheet metal, wherein the closure cover (1, 2) has an encircling plastics layer (30; 30h, 30v) on the inside of the cover. The closure cover is pressed onto the container neck (52) and can be opened with a rotational movement via the threaded elements (54, 55) and a vertical section (30v) of the plastics layer. The container neck (52) has a horizontal end surface (52a) on which a horizontal section (30h) of the plastics layer rests under pressure in a sealing manner. A central region (11) of the closure cover passes with an adjoining, circumferentially oriented transition zone (11a, 11b, 11c) into an axially downwardly projecting skirt section (12) which ends in a roll-up region (21a, 21; 22).

Abstract: The present disclosure provides, among other things, immune suppression regimens for in vivo gene therapy and uses thereof. In various embodiments of the present disclosure, in vivo gene therapy includes delivery of at least one exogenous coding nucleic acid sequence to a stem cell of the subject. Success of in vivo gene therapy can be inhibited or reduced by immunotoxicity. The present disclosure provides compositions and methods, including among other things immune suppression regimens, that reduce immunotoxicity of in vivo gene therapy, e.g., in vivo gene therapy including administration of a viral gene therapy vector to a subject.

Abstract: The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized formulations of ADAMTS13 that are suitable for pharmaceutical administration. Among other aspects, the present invention also provides methods of treating various diseases and conditions related to VWF and/or ADAMTS13 dysfunction in a subject. Also provided herein are kits comprising ADAMTS13 formulations useful for the treatment of various diseases and conditions.

Abstract: Systems and methods for predicting T-Cell receptor (TCR)-peptide interaction, including training a deep learning model for the prediction of TCR-peptide interaction by determining a multiple sequence alignment (MSA) for TCR-peptide pair sequences from a dataset of TCR-peptide pair sequences using a sequence analyzer, building TCR structures and peptide structures using the MSA and corresponding structures from a Protein Data Bank (PDB) using a MODELLER, and generating an extended TCR-peptide training dataset based on docking energy scores determined by docking peptides to TCRs using physical modeling based on the TCR structures and peptide structures built using the MODELLER. TCR-peptide pairs are classified and labeled as positive or negative pairs using pseudo-labels based on the docking energy scores, and the deep learning model is iteratively retrained based on the extended TCR-peptide training dataset and the pseudo-labels until convergence.

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

Abstract: An insect trap is provided. The insect trap includes a trap portion and a base portion. The trap portion includes an enclosure with an adhesive surface and a first opening, wherein the adhesive surface is at least partially contained within the enclosure and is configured to adhere to an insect. The base portion includes a lighting element and a mounting portion, wherein the lighting element is configured to provide light to the trap portion and wherein the mounting portion is configured to communicate with and receive power from a power source. The trap portion is configured to removably engage the base portion and receive light from the base portion when engaged therewith. The base portion includes a snap protrusion and the trap portion includes a snap recess for receiving the snap protrusion, wherein when the snap protrusion is received by the trap portion, the base portion and trap portion are engaged in a snap fit.

Abstract: A rotor assembly may be used in a gas turbine. The rotor assembly includes rotor segments arranged in succession in an axial direction and interconnected in the axial direction by a tie-rod, and a rotor segment disposed forwardly in the axial direction having a first contact surface and a rotor segment disposed rearwardly in the axial direction having a second contact surface. The first and second contact surfaces are at least partially in contact with each other, are substantially annular in shape, and extend in a radial direction and in a circumferential direction. The first contact surface and/or the second contact surface extend at least partially obliquely relative to the radial direction. An angle is formed between the first contact surface and the second contact surface when viewed in a sectional plane defined by the axial direction and the radial direction.

Abstract: A fastening assembly for fastening an axle support on a vehicle body. The axle support is screwed onto the vehicle body on multiple attachment points. On at least one of the attachment points, a bearing bracket for mounting a unit for the axle drive is arranged between the axle support and the vehicle body and also screwed on. A method for installing and fastening an axle support on a vehicle body in the mass production of motor vehicles is further disclosed.