Abstract: An exemplary embodiment of this invention relates to a method of inspection of a filled hard capsule sealed with a solvent sealing agent, including a process for determining the quality of the seal. The process may include: supplying a filled hard capsule sealed with a solvent sealing agent; supplying a microwave resonator wherein a measuring field having a resonance curve is generated; directing the capsule through the measuring field; measuring characteristics related to the modification of the resonance curve produced by the presence of the capsule in the measuring field, in comparison with a reference resonance curve corresponding to an empty state of the resonator; and using the measured characteristics to determine a value associated with the quality of the seal. Other exemplary embodiments of this invention relates to a method for sorting capsules on the basis of the result of the inspection method and to an associated equipment able to carry out such methods.

Abstract: A single-use injector is disclosed comprising a housing (10), arranged in which are at least one mechanical spring energy store (50), at least one piston-cylinder unit (100), which can be effectively filled at least for a certain time, at least one piston-actuating ram (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram (60) has at least one retaining rod or hook (62), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit (80) releases the supporting portion to allow it to move away from the resting surface.

Abstract: A closure system is provided for containers used for storing or administering substances in the form of liquids, pastes or powders, which includes a cap, provided with a through-hole, and a closure element, wherein the cap holds the closure element with a force fit and/or form fit on the container, in the area of the container opening that is to be closed, by a catch element present on the container. The end face which surrounds the container opening, and on which the closure element bears, comprises a depression. The closure element is a virus-proof, bacteria-proof and spore-proof film that lies on the end face and, at least in some areas, over the depression. The cap is then fitted in place, an elastomer ring or adhesive ring is arranged between the closure element and the depression and fills the depression.

Abstract: A piston ring having a base body, which comprises a running surface provided with at least one chamber, an upper and a lower flank surface, and an inner circumferential surface, wherein the running surface is provided with at least one PVD layer such that the same is adjusted to the contour of the running surface without completely filling the chamber, wherein the respective edge region is provided with a layer thickness, b that is reduced compared to the layer thickness, a of the chamber as a function of the configuration of the chamber.

Abstract: A cylinder/piston unit is disclosed for pre-fill, storage and release when desired of an active substance, such as a medicament. The cylinder/piston unit is provided with a cylinder and with a piston which is guided therein and which is sealed off in a sterile manner by a rubber seal, the cylinder and the piston enclosing a chamber that can be filled at least temporarily with active substance, and the cylinder having at least one discharge element at its front end. For this purpose, the piston resting in a rear position is sealed off relative to the cylinder in a sterile manner by a static front sealing element and by a static rear sealing element. Arranged spatially behind each static sealing element, there is a parking area for receiving the respective sealing element.

Abstract: The invention relates to N-hydroxylated amidines, guanidines and aminohydrazones for application on the skin. In particular, the invention relates to transdermal therapeutic systems containing N-hydroxylated amidines, guanidines and aminohydrazones as a prodrug, and to methods for producing and using such systems.

Abstract: The invention relates to a transdermal therapeutic system (TTS), preferably in the form of a transdermal plaster, that contains an active substance and an agent which can destroy the active substance. The TTS further includes a means of bringing the active substance, e.g. buprenorphine, and the agent, e.g. potassium permanganate, into contact when the TTS is removed from the skin of the patient, thereby causing the active substance to be destroyed.

Abstract: A preparation having at least one unsaturated fatty acid and the use of at least one unsaturated fatty acid having a chain length of 18 or 20 carbon atoms and of plant drugs containing the unsaturated fatty acid as a free fatty acid or a fatty acid radical of a triglyceride. The fatty acid has a chain length of 18 carbon atoms which are provided with 1 to 3 double bonds and the fatty acid has a chain length of 20 carbon atoms which are provided with 1 to 4 double bonds. The double bond or one of the double bonds are located in position 9 or 11 of the carbon chain. The unsaturated fatty acid is supplied in the all-cis configuration. The at least one unsaturated fatty acid prevents and/or treats or is used for producing a preparation for preventing and/or treating thrombosis and thromboembolic diseases.

Abstract: The invention relates to a needle-less, disposable injector comprising a housing (10), which has at least one compression bar, a cylinder-piston unit (100), a plunger-actuating ram (60), a trigger unit (80) and a spring energy reservoir (50), wherein the trigger unit locks the pre-tensioned spring energy reservoir by means of the compression bar. During triggering, the compression bar slides along at least one trigger element (82) of the trigger unit and, after triggering the trigger unit, the spring energy reservoir displaces the compression bar by means of the plunger-actuating ram and actuates the cylinder-piston unit. When loaded by the pre-tensioned spring energy reservoir, the pairing formed by the mutually facing inner wall of the trigger element and the contact surface of the compression bar has at least in areas a higher sliding friction coefficient than the pairing formed by the mutually facing collar surface of the plunger-actuating ram and the support surface of the compression bar.

Abstract: The invention relates to a biopsy needle for obtaining material for histological examination of body tissue, in particular, of bone marrow, or for the isolation, culture and modification of body cells, comprising a cannula with a cutting edge and a manual turning handle and a stylet running in the cannula. At the end of the cannula is an internal thread and preferably an outer thread. An easily visible marking is preferably provided on the manual turning handle. On withdrawing the biopsy needle the biopsy sample is thus held in position in the cannula and the advancing is precisely controllable.

Abstract: The invention relates to a transdermal therapeutic system (TTS), preferably in the form of a transdermal plaster, that contains an active substance and an agent which can destroy the active substance. The TTS further includes a means of bringing the active substance, e.g. buprenorphine, and the agent, e.g. potassium permanganate, into contact when the TTS is removed from the skin of the patient, thereby causing the active substance to be destroyed.

Abstract: The invention relates to a method and to a device for carrying out a manufacturing process in which all magnet cores to be produced are first continuously crystallized. Depending on whether the required hysteresis loops should be round, flat or rectangular, the magnet cores are either immediately finished, that is enclosed in housings, conditioned to a rectangular hysteresis loop in a direct-axis magnetic field or to a flat hysteresis loop in a magnetic cross-field and then finished.

Abstract: Disclosed is a sealing assembly for metal components, wherein the sealing assembly has an electrical insulating effect, and wherein the sealing assembly comprises a ceramic layer and a base brazing material disposed thereon, to which germanium is added. The addition of germanium advantageously ranges from 0.1 to 5.0 mol %, and preferably between 0.5 and 2.5 mol %. A particular embodiment provides for the use of a brazing material which additionally comprises silicon in the range of>0 to 2.5 mol %, and preferably between 0.1 and 0.9 mol %. Furthermore, a brazing material having a further addition of 10 to 40% by volume of Al2TiO5, and preferably between 20 and 30% by volume of Al2TiO5, has proven to be particularly suited for the sealing assembly.

Abstract: In order to provide a sealing assembly for a fuel cell stack comprising a plurality of fuel cell units, which are arranged consecutively in a stacking direction, wherein each of the fuel cell units comprises a housing with at least one housing part made of a metallic material, which also has an adequate electrical insulation effect and an adequate mechanical strength at a high operating temperature of the fuel cell stack, it is proposed that the sealing assembly comprises at least one intermediate element made of a metallic material, wherein the intermediate element is soldered to a housing part of a first fuel cell unit at least one location by means of a metal solder and is secured to a housing part of a second fuel cell unit at least another location, wherein the intermediate element and/or the housing part of the first fuel cell unit is provided with a coating made of a ceramic material.

Abstract: The present invention relates to a quickly decomposing oral drug preparation, for the application of active ingredient combinations for smoking withdrawal, which contains nicotine, a nicotine salt, a nicotine derivative, or a substance that reacts to nicotine, in combination with another active ingredient, and the use of such a drug preparation for the treatment of smoking withdrawal, and the use of nicotine, and/or nicotine salts or derivatives, for the production of medications for the treatment of smoking withdrawal. The active ingredient that is to be administered, in combination, for this purpose is a centrally active ingredient, preferably an antidepressant for the fighting of psychic dependency in terms of a smoking withdrawal therapy. The administration of the active ingredient combination to the patient should be handled in a simple and reliable way and should exclude side effects to a large extent.

Abstract: The present invention concerns a solution and methods to reduce, treat and/or prevent oxidative stress and cell activation. According to the invention the solution gives rise to the following concentrations of constituents within a blood flow of 0.1-18 mM N-acetyl-cysteine, optionally of 0.01-0.21 mM vitamin C, optionally of 2-26 mM gluconic acid and optionally of 0.01-5 mM glutathione. According to the invention the methods comprises adding a solution according to the invention in an extracorporeal setting through the membrane by adding the solution to the dialysis fluid, or by infusion of a solution according to the invention, either by bolus injection, continuous injection or a combination thereof.

Abstract: A one-way injector having a housing in which at least one mechanical spring energy store, at least one piston/cylinder unit, which can be at least temporarily filled with an active substance, at least one piston-actuating plunger and at least one tripping unit are arranged. To this end, the spring energy store comprises a preloaded spring element. The spring element is held in the preloaded position by a tension means surrounding at least a region of the spring. The tripping unit comprises a cutting tool which, in order to release the energy of the spring energy store, severs or weakens the tension means at least one point, the weakening immediately tearing the tension means. With the present invention, a one-way injector is developed which, with a small overall size, has only a few components and ensures reliable mounting and functioning with simple manipulation.

Abstract: A method for varying the flight path of a missile, in particular of a spin-stabilized projectile, which has an outer wall and which is provided with at least one impulse device. The impulse device can be activated deliberately at a defined time during the flight of the missile. The impulse device is arranged with respect to the longitudinal axis of the missile such that, when it is activated, it generates an impulse that initiates a tumbling movement which causes the flight-path of the missile to be shortened or varied. A spin-stabilized projectile is provided with such an impulse device and it is configured so that the impulse device may be triggered during flight so as to initiate the flight-altering tumbling movement.

Abstract: An object detection system has an image detection system with an imaging detector, a position detection system with a position detector, and optics which guide incident radiation onto both detectors. The two detectors are arranged one behind the other, in particular adjacent to one another, in the beam path. This makes it possible to achieve a simple, compact and reliable object detection system.

Abstract: A process for isolating N-butylbenzenesulfonamide (NBBS) from biological material, the chemical synthesis of benzenesulfonamide derivatives, the use of NBBS and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma, the production of medicaments for the treatment thereof, and the use of NBBS and benzenesulfonamide derivatives as a lead substance in the development of active substances for treating benign prostatic hyperplasia and/or prostate carcinoma are provided.