Abstract: The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.

Abstract: The invention relates to the application of a projection to a metal layer of a metallic cylinder-head gasket for an internal-combustion engine having at least one elastic metal sheet, which is provided with one opening or a plurality of adjacent openings depending on the number of combustion chambers of the internal-combustion engine, a bead being provided in the at least one elastic metal sheet around each opening, at a distance from the latter, so that a straight section of sheet metal is left clear in the region of the edge of the opening, for which bead a spring travel limiter or stopper, which runs coaxially with respect to the bead and is formed by the projection, is provided, the projection being produced from a mixture which contains a plastic with a high mineral filler content. A mixture of an elastomer in particular with a filler which has been surface-treated by means of a silane is used.

Abstract: The present invention describes a device for the controlled release of active compounds in the gastrointestinal tract with delayed pyloric passage, having a component expandable on contact with gastric juice, which is surrounded by a polymer covering which is permeable to gastric juice and active compounds. The device contains at least one active compound which is present in a multiparticulate preparation which releases the active compound into the gastric juice with a delay. Compared with conventional pharmaceutical forms with delayed pyloric passage, the release of active compound from a device according to the invention can be better controlled; likewise the device can be easily rolled or folded and can be introduced into capsules without problems.

Abstract: The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.

Abstract: The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.

Abstract: A device for the release of substances from pressure sensitive hot-melt adhesives with a uniform or non-uniform distribution of said substances is characterized by the fact that the pressure sensitive hot-melt adhesive is hydrophilic and comprises at least one water-soluble, or at least water-swellable, polymer, at least one water-soluble, meltable adhesive resin, as well as substance to be released.

Abstract: A process for the administration of a flowable solid, semisolid, or liquid medium exhibiting a controlled release of at least one active substance to plants by means of injection using needle-free, pressure-actuated devices is characterized in that the medium comprises active substance-containing microparticles of a maximum size of 100 .mu.m including the following components:a) 0.5-70%-wt. of at least one active substance,b) 10-70%-wt. of at least one biodegradable polymer,c) up to 20%-wt. of formulation adjuvants.

Abstract: A sprayable, film-forming active substance preparation for the application to plants is characterized by the fact that films which can be produced thereof are pressure-sensitive adhesive, water-insoluble, and at least partially biodegradable.

Abstract: A process and a device for clearing out joints in masonry is disclosed. The clearing out is effected by producing a groove by high-pressure water jets that are so oriented and guided relative to one another and relative to the desired groove. Further, a groove with a determined cross section of determined width and depth results.

Abstract: Implantable, partially biodegradable, polymer-containing molded articles for the administration of active substances to plants are characterized by the fact that they comprise at least one hydrophobic polymer.

Abstract: A drug for the release of active substances to the skin, which has an increased deuterium portion as compared to the natural isotope distribution.

Abstract: The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.

Abstract: In an implantable device for the release of active substances to plants, wherein said device is a ceramic molded article that is interspersed with pores and in which the active substance is distributed in open pores, the pore volume at the time of implantation is dimensioned such that it comprises the total active substance amount to be released, with the kind of the total porosity, its volume, size and scattering as well as the distribution of the pores being determinable within given limits.

Abstract: An electrosurgical instrument is useful for therapeutic treatment of varices, especially small varicose dilatations of the cutaneous veins. A surgical instrument is provided for rapid, reliable and minimally discomforting therapy of small varicose dilatations of the cutaneous veins and similar disorders, ensuring the lowest possible rate of recidivism while minimizing side effects. The instrument has two fork-shaped protruding needle electrodes which connect to different poles of an electrical power source and which are each partially enclosed in an electrical insulating layer. The forward tip region of the needle electrodes is left open.

Abstract: In a process for reprocessing devices for the transdermal application of active substances or their process waste, active substance-containing components are brought into solution and the active substances are recovered therefrom.

Abstract: A tampon printing process which uses a printing plate having at least one printing form at its surface, wherein the printing form is filled with printing medium at time intervals and the printing medium is subsequently transferred from the printing form onto a support by means of a tampon.

Abstract: The invention relates to a sequin delivery system (1) for embroidery and/or sewing machines, in which a pusher (6) delivers sequins (3) from a sequin strip (2), which is at least partly guided laterally, in increments to a needle penetration point (24). A drive mechanism periodically moves the pusher (6) toward and away from the needle penetration point (24), and the pusher (6) has a slaving device, which on the motion of the pusher (6) in the direction of the needle penetration point (24) engages a hole (4) in a sequin (3). The pusher (6) is at least partially elastic, and in particular is a leaf spring, and presses the sequin strip (2) against a contact pressure plate (8).

Abstract: The present invention provides a pharmaceutical composition for the transdermal systemic administration of an active agent characterized in that the active agent is bopindolol or methysergide. Also the present invention provides a pharmaceutical composition for the transdermal systemic administration of a pharmacologically active agent characterized in that it contains bopindolol, tizanidine, clemastine, ketotifen or methysergide as active agent in a reservoir comprising a hydrophilic polymer. Furthermore a pharmaceutical composition for the transdermal systemic administration of pharmacologically active agents characterized in that the pharmacologically active agent is in a reservoir comprising a polyacrylate polymer containing cationic ester groups.

Abstract: The invention relates to a self-adhesive, plasticizer-containing laminate consisting ofa) a film-forming polymeric layer containing dyestuffs and/or pigments,b) a pressure-sensitive adhesive layer, andc) a removable, preferably siliconized protective film covering the pressure-sensitive adhesive layer,the film-forming polymeric layer a) of which is at least entirely covered by a layer being resistant towards the other components of the laminate and towards the materials used in the production of the laminate. The invention further relates to the use of said laminate as artificial nails applicable to toenails or fingernails.

Abstract: The invention relates to a patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature which comprises a multi-element system comprising(a) a matrix having distributed therein as the drug said volatile active ingredient or a physiologically acceptable salt thereof, the matrix comprising a pressure-sensitive adhesive,(b) an element of a pressure-sensitive adhesive composition which--where (a) contains a salt--contains basic groups to liberate the free base from its salt,(c) a backing layer impermeable to the diffusable ingredients of (a) and (b), and(d) a release liner impermeable to the diffusable ingredients of (a) and (b),matrix (a) or at least a part of (b), whichever is in contact with release liner (d), having a tack sufficient for affixing the patch to the skin, any part of (b) positioned between matrix (a) and release liner (d) being permeable for the deprenyl or the salt thereof or both.