Patents by Inventor Hans-Ulrich Petereit
Hans-Ulrich Petereit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10537530Abstract: The invention provides a gastric resistant, enteric-coated solid dosage form including a core containing a pharmaceutically active ingredient, an inner coating for the core, and an outer enteric coating. The inner coating comprises an anionic polymeric material or a water-soluble neutral polymeric material, and further comprises a water soluble inorganic salt which is not a carbonate or bicarbonates. The outer enteric coating comprises an anionic polymeric material which is less neutralized than the polymeric material comprising the inner coating and disintegrates rapidly at a pH of 5.5 to 7.0 upon entering the small intestine.Type: GrantFiled: September 5, 2012Date of Patent: January 21, 2020Assignee: Evonik Operations GmbHInventors: Fang Liu, Abdul W. Basit, Rosario Lizio, Hans-Ulrich Petereit, Christian Meier, Michael Damm
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Patent number: 10172807Abstract: The invention refers to a nanoparticle with a diameter which is the maximum in the nanoparticle size distribution, in the range of 10-300 nm, comprising a) a calcium phosphate nanoparticle core a), b) an active ingredient coating b) on the calcium phosphate nanoparticle core a), c) a lactic acid polymer coating c) on the active ingredient coating b), d) a cationic polymer coating d) on the lactic acid polymer coating c) selected from the group of polyethylene-imines, chitosan and human lactoferrin-derived peptides with a length of 14 to 30 amino acids.Type: GrantFiled: May 26, 2015Date of Patent: January 8, 2019Assignee: Evonik Röhm GmbHInventors: Rosario Lizio, Silko Grimm, Hans-Ulrich Petereit, Matthias Epple, Gregor Doerdelmann
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Patent number: 10113050Abstract: A powdery or granulated composition, containing: (a) a copolymer containing, in polymerized form, a C1- to C4-alkyl ester of acrylic or methacrylic acid and an alkyl(meth)acrylate monomer containing a tertiary amino group in an alkyl radical; (b) 0.5 to 10% by weight based on (a) of a dicarboxylic acid having 3 to 10 carbon atoms; and (c) 5 to 20% by weight based on (a) of a fatty monocarboxylic acid having 8 to 18 carbon atoms, where the composition contains at least by 30% by weight of (a), (b), and (c).Type: GrantFiled: July 30, 2009Date of Patent: October 30, 2018Assignee: Evonik Roehm GmbHInventors: Erna Roth, Ruediger Alexowsky, Hans-Ulrich Petereit, Christian Meier
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Publication number: 20180256606Abstract: The invention relates to a multilayer dosage form comprised of: a) a neutral core; b) an inner coating consisting of a methacrylate copolymer; c) an outer coating consisting of a copolymer of which 40 to 95% by weight is composed of radically polymerized C1 to C4 alkyl esters of acrylic acid or of methacrylic acid and of which 5 to 60% by weight is composed of (meth)acrylate monomers having an anionic group in the alkyl radical. The invention is characterized in that the inner coating is essentially comprised of a methacrylate copolymer, of which at least up to 90% by weight consists of (meth)acrylate monomers with neutral radicals, which, in accordance with DIN 53 787, has a minimum film formation temperature of no higher than 30° C., and which contains the pharmaceutical active substance in bound form.Type: ApplicationFiled: May 9, 2018Publication date: September 13, 2018Applicant: Evonik Roehm GmbHInventors: Hans-Ulrich PETEREIT, Markus RUDOLPH, Jennifer DRESSMAN, Thomas BECKERT
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Publication number: 20170333361Abstract: The invention refers to a nanoparticle with a diameter which is the maximum in the nanoparticle size distribution, in the range of 10-300 nm, comprising a) a calcium phosphate nanoparticle core a), b) an active ingredient coating b) on the calcium phosphate nanoparticle core a), c) a lactic acid polymer coating c) on the active ingredient coating b), d) a cationic polymer coating d) on the lactic acid polymer coating c) selected from the group of polyethylene-imines, chitosan and human lactoferrin-derived peptides with a length of 14 to 30 amino acids.Type: ApplicationFiled: May 26, 2015Publication date: November 23, 2017Applicant: Evonik Roehm GmbHInventors: Rosario LIZIO, Silko GRIMM, Hans-Ulrich PETEREIT, Matthias EPPLE, Gregor DOERDELMANN
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Patent number: 9700520Abstract: The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising a core, comprising at least one pharmaceutical active ingredient, which is an opioid, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40-95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer, and ii) 5-60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0, characterized in that the coating layer further contains 110 to 250% by weight, calculated on dry weight of the polymer mixture, of a non-porous inert lubricant and the coating layer is present in an amount of at least 60% by weight calculated on the weight of core.Type: GrantFiled: September 25, 2007Date of Patent: July 11, 2017Assignee: Evonik Roehm GmbHInventors: Hans-Ulrich Petereit, Hema Ravishankar, Ashwini Samel
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Patent number: 9597293Abstract: The present invention provides a solid dosage form including an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating; wherein the inner coating includes a partially neutralized anionic polymeric material, and at least a carboxylic acid having 2 to 16 carbon atoms the salts thereof or mixtures of the acid and its salt; wherein the outer coating includes an anionic polymeric material which is less or not at all neutralized than the material of the inner coating.Type: GrantFiled: May 7, 2007Date of Patent: March 21, 2017Assignee: EVONIK RÖHM GmbHInventors: Fang Liu, Abdul W. Basit, Rosario Lizio, Hans-Ulrich Petereit, Christian Meier, Michael Damm
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Patent number: 9555006Abstract: The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising at least one pharmaceutical active ingredient, with the exception of opioids, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40-95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer or copolymer, and ii) 5-60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0. characterized in that the coating layer further contains 110 to 250% by weight, calculated on dry weight of the polymer mixture, of a non-porous inert lubricant and the is present in an amount of at least 60% by weight calculated on the weight of core.Type: GrantFiled: September 25, 2007Date of Patent: January 31, 2017Assignee: EVONIK ROEHM GmbHInventors: Hans-Ulrich Petereit, Hema Ravishankar, Ashwini Samel
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Patent number: 9492394Abstract: The invention relates to a gastric resistant pharmaceutical or nutraceutical composition, comprising a core, comprising a pharmaceutical or nutraceutical active ingredient and a gastric resistant coating layer onto the core, wherein the release of the pharmaceutical or nutraceutical active ingredient is not more than 15% under in-vitro conditions at pH 1.2 for 2 hours in medium according to USP with and without the addition of 40% (v/v) ethanol, wherein the gastric resistant coating layer comprises 10 to 100% by weight of one or more salts of alginic acid with a viscosity of 30 to 720 cP of a 1% aqueous solution.Type: GrantFiled: April 13, 2011Date of Patent: November 15, 2016Assignee: Evonik Roehm GmbHInventors: Shraddha Ashok Bodinge, Priyanka Bansilal Haksar, Seema Yashwant Gawde, Hemant Karbhari Pagar, Hans-Ulrich Petereit
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Patent number: 9480654Abstract: The invention relates to novel particulate drug-delivery systems based on a polymer support containing at least one linear, branched or cross-linked polymer in a fraction of over 50 percent by weight in relation to the total weight of the support. The system is characterized in that at least one signal substance for transport through a biological barrier and at least one active ingredient are stored, the support, signal substance and active ingredient having no covalent links and no active-ingredient specific and signal substance specific coordinative links between one another.Type: GrantFiled: October 10, 2012Date of Patent: November 1, 2016Assignee: EVONIK ROEHM GmbHInventors: Matthias Seiler, Norbert Windhab, Manfred Stickler, Hans-Ulrich Petereit
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PROCESS FOR STABILIZING THE DRUG RELEASE PROFILES OF POLYMER FILM COATED PHARMACEUTICAL COMPOSITIONS
Publication number: 20160081933Abstract: The invention relates to a process for stabilizing the drug release profile of a polymer film coated pharmaceutical composition, wherein the pharmaceutical composition comprises a core comprising an active pharmaceutical ingredient and a polymer film coating onto the core which was applied by a spray coating process, including a subsequent drying step, by applying microwave-irradiation, infrared-irradiation, UV-irradiation or ultra sonic wave irradiation to the polymer film coated pharmaceutical compositions.Type: ApplicationFiled: August 19, 2013Publication date: March 24, 2016Applicant: EVONIK ROEHM GMBHInventors: Odette HENSEL, Shraddha Sanjeev Joshi, Smitha SHETTY, Takayuki MORITA, Tatsuya ISHII, Hans-Ulrich PETEREIT -
Patent number: 9284416Abstract: The present invention provides a process for converting a solid (meth)acrylate copolymer into a dispersed form by preparing an aqueous dispersion comprising the components (a) a (meth)acrylate copolymer which is composed of free-radical polymerized methyl methacrylate, ethylacrylate and a salt of 2-trimethylammoniumethyl methacrylate, present in solid form as a powder or as a granulate, (b) up to 50% by weight calculated on the (meth)acrylate copolymer (a) of a dispersing agent selected from the groups of (b) i) plasticizers in combination with emulsifiers and/or (b) ii) pharmaceutically acceptable carbohydrates having 6 to 18 carbon atoms with a functional group and (c) water by mixing the components (a), (b) and (c) to give a suspension which becomes an aqueous dispersion during the conversion of the solid (meth)acrylate copolymer into the dispersed form, characterized in that, the (meth)acrylate copolymer is converted into the dispersed form by means of the presence of the dispersing agent at a temperatureType: GrantFiled: November 16, 2009Date of Patent: March 15, 2016Assignee: Evonik Roehm GmbHInventors: Erna Roth, Ruediger Alexowsky, Hans-Ulrich Petereit, Kathrin Nollenberger, Christian Meier
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Patent number: 9237760Abstract: The present invention relates to a pharmaceutical or nutraceutical preparation comprising a) a core containing a pharmaceutically or nutraceutically active substance; and b) an inner controlling layer surrounding the core comprising i) one or a mixture of a plurality of (meth)acrylate copolymers bearing a cationic group or a group that can be converted to a cationic group; and ii) one or a mixture of a plurality of polymers or copolymers bearing an anionic group or group that can be converted to an anionic group; and c) an outer controlling layer comprising one or a mixture of a plurality of polymers or copolymers bearing an anionic group or group that can be converted to an anionic group and to tablets or capsules comprising same.Type: GrantFiled: February 1, 2008Date of Patent: January 19, 2016Assignee: EVONIK RÖHM GmbHInventors: Hema Ravishankar, Shraddha Bodinge, Hans-Ulrich Petereit
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Patent number: 9107451Abstract: A coating composition for the enteric coating of capsule halves made of water-soluble or water-swellable polymer material in a dipping process is provided. The composition is an aqueous dispersion or solution, containing a polymer mixture of at least one first (meth)acrylate copolymer, which is enteric, and at least one further (meth)acrylate copolymer, which is enteric or water-insoluble, and also auxiliaries which influence the viscosity of the dispersion and the elasticity of the dried polymer film. The solids content of the dispersion or solution is more than 25% by weight and the viscosity is 150 to 1500 mPa·s and a dried film produced from the dispersion or solution has an elongation at break of at least 200%. Also provided is a capsule composed of two capsule halves coated with the dispersion or solution in a dipping process does. The enteric capsule does not dissolve in 0.1 N HCl at pH 1.2 after two hours, but completely dissolves in buffer at pH 6.8 in less than 30 minutes.Type: GrantFiled: July 29, 2010Date of Patent: August 18, 2015Assignee: Evonik Röhm GmbHInventors: Brigitte Skalsky, Manfred Aβmus, Odette Hensel, Hans-Ulrich Petereit
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Patent number: 9011907Abstract: The present invention relates to a pharmaceutical or nutraceutical preparation comprising a) a core containing a pharmaceutically or nutraceutically active substance and a substance that acts in a modulatory manner with regard of the release of pharmaceutically or nutraceutically active substances; and b) a controlling layer surrounding the core comprising i) 55 to 92% by weight based on the total weight of (meth)acrylic copolymers present in the layer of one or a mixture of a plurality of (meth)acrylate copolymers composed of 80 to 98% by weight based on the weight of the (meth)acrylic copolymer of structural units derived from C1 to C4 alkyl esters of (meth)acrylic acid and 2 to 20% by weight based on the weight of the (meth)acrylic copolymer of structural units derived from (meth)acrylate monomers with a quaternary ammonium group in the alkyl radical; and ii) 8 to 45% by weight based on the total weight of (meth)acrylic copolymers present in the layer of one or a mixture of a plurality of (meth)acrylate coType: GrantFiled: February 1, 2008Date of Patent: April 21, 2015Assignee: Evonik Röhm GmbHInventors: Hema Ravishankar, Shradda Bodinge, Hans-Ulrich Petereit
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Patent number: 8999385Abstract: The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth. According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerized C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass; the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 ?m or less; and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein.Type: GrantFiled: November 15, 2012Date of Patent: April 7, 2015Assignee: EVONIK RÖHM GmbHInventors: Hans-Ulrich Petereit, Christian Meier, Andreas Gryczke
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Patent number: 8951558Abstract: The invention relates to an aqueous medium containing an amino(meth)acrylate polymer or copolymer which is not soluble in dematerialised water, characterized in that the medium has a content of an aqueous phase of at least 60% by weight and a content of up to 40% by weight of solids comprising the amino(meth)acrylate polymer or copolymer, whereby the aqueous phase is charged by a sufficient amount of carbon dioxide that effects the amino(meth)acrylate polymer or copolymer to be present in solute form in the medium. The aqueous medium may be used beneficially as a coating or binding solution for the spray coating or binding of pharmaceutical compositions or nutraceutical compositions or cosmetical compositions.Type: GrantFiled: July 30, 2009Date of Patent: February 10, 2015Assignee: Evonik Röhm GmbHInventors: Rosario Lizio, Michael Damm, Hans-Ulrich Petereit
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Patent number: 8734849Abstract: The invention relates to an oral, multiparticle pharmaceutical dosage form containing pellets, the size of which ranges from 50 to 2500 ?m and which essentially consist of: a) an inner matrix layer containing an active substance which is a peptide or a protein, including the derivatives or conjugates thereof, and which is embedded in a matrix consisting of a polymer with mucoadhesive effect, and b) an outer film coating essentially consisting of an anionic polymer or copolymer, which can be optionally formulated with pharmaceutically conventional adjuvants, more particularly softening agents.Type: GrantFiled: July 15, 2004Date of Patent: May 27, 2014Assignee: Evonik Roehm GmbHInventors: Rosario Lízio, Hans-Ulrich Petereit, Erna Roth, Inès Andres, Michael Damm
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Patent number: 8642089Abstract: The invention relates to a method for producing active ingredient-containing granules or powders involving the following steps: a) melting a mixture consisting of a pharmaceutical active ingredient and of a (meth)acrylate copolymer, which is comprised of 40 to 75 wt. % of radically polymerized C1 to C4 alkyl esters of acrylic acid or of methacrylic acid and can be comprised of 25 to 60 wt. % (meth)acrylate monomers having an anionic group in the alkyl radial; b) extruding the mixture, and; c) comminuting the extrudate to form a granule or powder. The inventive method is characterized in that the active ingredient is the salt of an alkaline substance, and in that the pH value, which can be measured on the obtained powder or granule, is equal to or less than pH 7.0. The invention also relates to pharmaceutical dosage forms or precursors thereof, which can be produced using the inventive method.Type: GrantFiled: January 30, 2003Date of Patent: February 4, 2014Assignee: Evonik Roehm GmbHInventors: Hans-Ulrich Petereit, Christian Meier, Andreas Gryczke
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Patent number: 8568778Abstract: The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix layer containing nanoparticles that contain a nucleic acid active ingredient and being embedded in a matrix of a polymer having a mucoadhesive effect, and b) an outer film coating, substantially consisting of an anionic polymer or copolymer that is optionally formulated with pharmaceutically conventional adjuvants, especially emollients.Type: GrantFiled: November 5, 2005Date of Patent: October 29, 2013Assignee: Evonik Röhm GmbHInventors: Rosario Lizio, Hans-Ulrich Petereit, Dave Trupti, Michael Gottschalk